Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 86749462

GI number: 86749462

Start: 2690126

End: 2691658

Strand: Direct

Name: pccB [H]

Synonym: RPB_2342

Alternate gene names: 86749462

Gene position: 2690126-2691658 (Clockwise)

Preceding gene: 86749460

Following gene: 86749464

Centisome position: 50.46

GC content: 65.17

Gene sequence:

>1533_bases
ATGAAACACATCCTTGAAGCACTCGACGAACGCCGGGCGGCGGCCAAACTCGGCGGCGGCGAGAAGCGCATCGACGCGCA
GCACGCCCGCGGCCGGCTCACCGCTCGGGAGCGCATCGACCTGCTGCTCGACAAGCATTCGTTCGAGGAGATGGACATGT
TCGTCCAGCACCGCTCGACCGAATTCGGGATGGAGAACACCAAAATTCCGGGTGACGGTGTGGTCACCGGCTGGGGCACC
GTCAACGGCCGCAAGACCTTCGTGTTCGCCAAGGACTTCACCGTGTTCGGCGGCTCGCTGTCGGAGACCCACGCCGCCAA
GATCACCAAGATCCAGGACATGGCGCTGAAGGCCCGCGCCCCGATCATCGGCCTGTACGACGCCGGCGGCGCGCGCATCC
AGGAGGGCGTCGCGGCCCTCGCCGGTTACTCTTACGTGTTCCGCCGGGTGGTGCAGGCCTCCGGCGTGATCCCGCAGATC
AGCGTCATCATGGGCCCCTGCGCCGGCGGCGACGTCTACGCCCCGGCGATGACCGACTTCATCTTCATGGTGAAGAACAC
CAGCTACATGTTCGTCACCGGCCCCGACGTGGTGAAGACCGTGACCAACGAAGTCGTCACGCCGGAAGAGCTCGGCGGCG
CCTCGGTCCACGCCACCCGCTCCTCGATCGCCGACGGCGCGTTCGAGAACGACGTCGAGACGCTGCTGCAGATGCGCCGG
CTGCTCGACTTCCTGCCCGCCAATTCGTCGGACGGCGTGCCGGAATGGCCGAGCTTCGACGATATCGAGCGCGAGGACTT
CTCGCTCGACACGCTGATCCCGGACAATCCGAACAAGCCCTACGACATGAAGGAGCTGATCCTGAAGGTCGTCGACGAGG
GCGACTTCTTCGAATTGTCGGACGCCTTCGCCAAGAACATCATCACCGGTTTCGGCCGTATCGCCGGCCGCACCGTCGGC
TTCGTCGCCAACCAGCCGATGGTGCTGGCGGGCGTGCTCGACTCGGACGCCTCGCGCAAGGCGGCGCGGTTCGTGCGGTT
CTGCGACAGCTTCAACATCCCGATCGTCACCTTCGTCGACGTGCCGGGCTTCCTGCCCGGCACCGCGCAGGAATATGGCG
GGCTGATCAAGCACGGCGCGAAGCTCCTGTTCGCGTTCTCGCAATGCACCGTGCCGCTGGTGACGCTGATCACCCGCAAG
GCCTATGGCGGCGCGTTCGACGTGATGGCCTCCAAGGAAATCGGCGCCGATATCAACTACGCTTGGCCGACCGCGCAGAT
CGCGGTGATGGGCGCCAAGGGCGCGGTCGAGATCATCTTCCGTCAGGACATGAACGATCCCGACAAGATCGCCGCCCGCA
CCAAGGAATACGAAGACCGCTTCCTGTCGCCCTTCATCGCCGCCGAACGCGGCTACATCGACGACGTGATCATGCCGCAT
GCGACGCGGCGGAGGATCGCGCGCGCGCTGGCGATGCTGCGCGACAAGCACGTCGACCTGCCGCTGAAGAAGCACGACAA
TATGCCGTTGTGA

Upstream 100 bases:

>100_bases
GCCCCGTGCTAGAAGGCCTTGATTATCGCGGCGATCCGGGGGCACAAATCCGGCACGCCATGCGGCGGGACAACGACATC
AAGAAGCGCGGCTCAACCTC

Downstream 100 bases:

>100_bases
GGGAAGTTTGAATCCTGAAGAATTGGCTCGTTATTTGGTGGATCGGCTTGAAGAAGCGCGTAGCGAACGCCTTCAGGCGT
TGCTTGACGAGTCTTTTGTT

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKHILEALDERRAAAKLGGGEKRIDAQHARGRLTARERIDLLLDKHSFEEMDMFVQHRSTEFGMENTKIPGDGVVTGWGT
VNGRKTFVFAKDFTVFGGSLSETHAAKITKIQDMALKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRVVQASGVIPQI
SVIMGPCAGGDVYAPAMTDFIFMVKNTSYMFVTGPDVVKTVTNEVVTPEELGGASVHATRSSIADGAFENDVETLLQMRR
LLDFLPANSSDGVPEWPSFDDIEREDFSLDTLIPDNPNKPYDMKELILKVVDEGDFFELSDAFAKNIITGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDSFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAFSQCTVPLVTLITRK
AYGGAFDVMASKEIGADINYAWPTAQIAVMGAKGAVEIIFRQDMNDPDKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
ATRRRIARALAMLRDKHVDLPLKKHDNMPL

Sequences:

>Translated_510_residues
MKHILEALDERRAAAKLGGGEKRIDAQHARGRLTARERIDLLLDKHSFEEMDMFVQHRSTEFGMENTKIPGDGVVTGWGT
VNGRKTFVFAKDFTVFGGSLSETHAAKITKIQDMALKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRVVQASGVIPQI
SVIMGPCAGGDVYAPAMTDFIFMVKNTSYMFVTGPDVVKTVTNEVVTPEELGGASVHATRSSIADGAFENDVETLLQMRR
LLDFLPANSSDGVPEWPSFDDIEREDFSLDTLIPDNPNKPYDMKELILKVVDEGDFFELSDAFAKNIITGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDSFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAFSQCTVPLVTLITRK
AYGGAFDVMASKEIGADINYAWPTAQIAVMGAKGAVEIIFRQDMNDPDKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
ATRRRIARALAMLRDKHVDLPLKKHDNMPL
>Mature_510_residues
MKHILEALDERRAAAKLGGGEKRIDAQHARGRLTARERIDLLLDKHSFEEMDMFVQHRSTEFGMENTKIPGDGVVTGWGT
VNGRKTFVFAKDFTVFGGSLSETHAAKITKIQDMALKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRVVQASGVIPQI
SVIMGPCAGGDVYAPAMTDFIFMVKNTSYMFVTGPDVVKTVTNEVVTPEELGGASVHATRSSIADGAFENDVETLLQMRR
LLDFLPANSSDGVPEWPSFDDIEREDFSLDTLIPDNPNKPYDMKELILKVVDEGDFFELSDAFAKNIITGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDSFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAFSQCTVPLVTLITRK
AYGGAFDVMASKEIGADINYAWPTAQIAVMGAKGAVEIIFRQDMNDPDKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
ATRRRIARALAMLRDKHVDLPLKKHDNMPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=60.9467455621302, Blast_Score=628, Evalue=1e-180,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=58.8235294117647, Blast_Score=616, Evalue=1e-176,
Organism=Homo sapiens, GI11545863, Length=524, Percent_Identity=31.1068702290076, Blast_Score=228, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=58.974358974359, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=58.974358974359, Blast_Score=633, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=512, Percent_Identity=31.0546875, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71997163, Length=328, Percent_Identity=24.0853658536585, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24586065, Length=506, Percent_Identity=31.4229249011858, Blast_Score=232, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55987; Mature: 55987

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHILEALDERRAAAKLGGGEKRIDAQHARGRLTARERIDLLLDKHSFEEMDMFVQHRST
CHHHHHHHHHHHHHHHCCCCCHHCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
EFGMENTKIPGDGVVTGWGTVNGRKTFVFAKDFTVFGGSLSETHAAKITKIQDMALKARA
CCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHCC
PIIGLYDAGGARIQEGVAALAGYSYVFRRVVQASGVIPQISVIMGPCAGGDVYAPAMTDF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEECHHHHHE
IFMVKNTSYMFVTGPDVVKTVTNEVVTPEELGGASVHATRSSIADGAFENDVETLLQMRR
EEEEECCCEEEEECCHHHHHHHHCCCCHHHCCCCEEEHHHHHHHCCCHHHHHHHHHHHHH
LLDFLPANSSDGVPEWPSFDDIEREDFSLDTLIPDNPNKPYDMKELILKVVDEGDFFELS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCHHH
DAFAKNIITGFGRIAGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDSFNIPIVTFVD
HHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAFSQCTVPLVTLITRKAYGGAFDVMASKEIGADINY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHCCCCCCC
AWPTAQIAVMGAKGAVEIIFRQDMNDPDKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
ATRRRIARALAMLRDKHVDLPLKKHDNMPL
HHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKHILEALDERRAAAKLGGGEKRIDAQHARGRLTARERIDLLLDKHSFEEMDMFVQHRST
CHHHHHHHHHHHHHHHCCCCCHHCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
EFGMENTKIPGDGVVTGWGTVNGRKTFVFAKDFTVFGGSLSETHAAKITKIQDMALKARA
CCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHCC
PIIGLYDAGGARIQEGVAALAGYSYVFRRVVQASGVIPQISVIMGPCAGGDVYAPAMTDF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEECHHHHHE
IFMVKNTSYMFVTGPDVVKTVTNEVVTPEELGGASVHATRSSIADGAFENDVETLLQMRR
EEEEECCCEEEEECCHHHHHHHHCCCCHHHCCCCEEEHHHHHHHCCCHHHHHHHHHHHHH
LLDFLPANSSDGVPEWPSFDDIEREDFSLDTLIPDNPNKPYDMKELILKVVDEGDFFELS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCHHH
DAFAKNIITGFGRIAGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDSFNIPIVTFVD
HHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAFSQCTVPLVTLITRKAYGGAFDVMASKEIGADINY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHCCCCCCC
AWPTAQIAVMGAKGAVEIIFRQDMNDPDKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
ATRRRIARALAMLRDKHVDLPLKKHDNMPL
HHHHHHHHHHHHHHHCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]