Click here to switch to the map view.

The map label for this gene is livH [H]

Identifier: 86748918

GI number: 86748918

Start: 2055888

End: 2057516

Strand: Direct

Name: livH [H]

Synonym: RPB_1795

Alternate gene names: 86748918

Gene position: 2055888-2057516 (Clockwise)

Preceding gene: 86748917

Following gene: 86748919

Centisome position: 38.56

GC content: 66.79

Gene sequence:

>1629_bases
GTGCCGTTGATCCATTTGCTGCGCCCCTTGCTGTCGCGCCTGTTATTCGCCGCCGTCGCGCTCGTTGTGCTTCATGTCGC
GACCCAGCCGGCGCTGGCCGGTCCCTATGAGGATGCCGTCGCGCAGTTCGCCGCGGGTTCGTTCTCCGACACCGAGGAAG
CGATCGGCAGACTGGTCGCGTCGGCACATCCGCGCGCCGCCACCATCATCGTCGCGCTGCAGGACGGTCGATTGTTCGCC
GACCCCGACGCCAAGACCGTGTTCATCAAGGCCGGGGACGGCGCGATCAGCAATGCGGTGACCGGCGAGGCCGTTGCCGC
GCTGCCGGCGAAGGCCGAGGCGGTTCGCCTCAACAACAAGCTGCGTCGCGCGGTGTCCGGCGCGATGGCCGGGCTGACGC
TGCTGTCGCCGGATCTGACCAAGCGCATCCAGGCGGCGCAGTCGGTGTTCAAGACCCACGACGAGACCATGCTGCCGACG
GTCGAGACCGCGCTGCAGGCCGAGAAAAACGCCGCCGCCCGACAGGCCTTCGCCGAGGCGCGCGCGTCGATCCTGCTGTT
CAAAACGGACGCCTCCGACGTCGACAAGCTCGACGCCATCGCCACCCTCAAGGCGCGCGGCGATCAGGAGGCGATGGCGC
TCCTGACCGGTGTGCCGGGCGGGCAGAGCGCGGCGGTGGCGAGCGGCATCGCATCCGCCAAGGCCGCGATCGAGCGCAAT
CTGGCGCTGTGGTCGATGGTGCAGAACGCCTGGTACGGGCTGTCGCTCGGCTCGGTGCTGCTGCTGGCCGCGATCGGCCT
CGCCATCACCTTCGGGGTGATGGGCGTGATCAATATGGCGCATGGCGAGATGGTGATGCTCGGCGCCTACACCACCTTCG
TGGTGCAGGAGACCATCCGCACCTCCTATCCGGCGCTGTTCGACTATTCGCTGCTGATCGCGGTGCCGCTGGCCTTCCTG
GTTGCGGGCGCGATCGGCGTGCTGATCGAGCGCAGCGTGATCCGCTTCCTCTACGGTCGCCCGCTGGAGACGCTGCTGGC
GACCTGGGGCCTGTCGCTGATTCTGCAGCAGGCGGTGCGCACGCTGTTCGGCCCGACCAATCGCGAGGTCGGCAATCCGT
CCTGGATGAGCGGCGCGTTCGAGCTCGGCCAGATTACCATCACCTATAACCGGCTGTGGATTCTGTGCTTCACGCTCGCC
GTGTTCGTCATTCTCTTGGCGATGCTGCGCTACACCGCGCTTGGCCTCGAAATGCGCGCGGTGACACAGAACCGCCGGAT
GGCGGCGTCGATGGGCATCGCCACCTCACGGGTCGATGCGCTGACCTTCGGATTGGGTTCCGGCATCGCCGGCATCGCCG
GGGTGGCGCTGTCGCAGATCGATAACGTCAGCCCCAATCTCGGCCAGAGCTACATCATCGACTCTTTCATGGTCGTGGTG
TTCGGCGGCGTCGGCAATCTGTGGGGCACGCTGGTCGGTGCCTTCACGCTCGGCATCGCCAATAAATTCCTGGAGCCGGT
CGCCGGCGCGGTGCTGGCCAAGATCGCGATCCTGGTGCTGATCATCCTGTTCATCCAGAAACGCCCCCGCGGCCTGTTCG
CGCTCAAGGGCAGGGCGGTGGAGGCATGA

Upstream 100 bases:

>100_bases
GAGAGGGCGGCGACGCCGGTTCCGCGCCGCCCTCTCGCCCTTCGACGCTACGCCTCGTTTCTCCGACGCACCGCACCTTC
ATCCTTGCCGGGACATTTCA

Downstream 100 bases:

>100_bases
GGATGGTTAGTTCGGTGCCATTGAGAATCTGCGAGTCGCAGCCGAACTCCCTCTCCCGCTTGCGGGAGAGGGCTGGGGTG
AGGGCACTTGCCACGAGCTC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MPLIHLLRPLLSRLLFAAVALVVLHVATQPALAGPYEDAVAQFAAGSFSDTEEAIGRLVASAHPRAATIIVALQDGRLFA
DPDAKTVFIKAGDGAISNAVTGEAVAALPAKAEAVRLNNKLRRAVSGAMAGLTLLSPDLTKRIQAAQSVFKTHDETMLPT
VETALQAEKNAAARQAFAEARASILLFKTDASDVDKLDAIATLKARGDQEAMALLTGVPGGQSAAVASGIASAKAAIERN
LALWSMVQNAWYGLSLGSVLLLAAIGLAITFGVMGVINMAHGEMVMLGAYTTFVVQETIRTSYPALFDYSLLIAVPLAFL
VAGAIGVLIERSVIRFLYGRPLETLLATWGLSLILQQAVRTLFGPTNREVGNPSWMSGAFELGQITITYNRLWILCFTLA
VFVILLAMLRYTALGLEMRAVTQNRRMAASMGIATSRVDALTFGLGSGIAGIAGVALSQIDNVSPNLGQSYIIDSFMVVV
FGGVGNLWGTLVGAFTLGIANKFLEPVAGAVLAKIAILVLIILFIQKRPRGLFALKGRAVEA

Sequences:

>Translated_542_residues
MPLIHLLRPLLSRLLFAAVALVVLHVATQPALAGPYEDAVAQFAAGSFSDTEEAIGRLVASAHPRAATIIVALQDGRLFA
DPDAKTVFIKAGDGAISNAVTGEAVAALPAKAEAVRLNNKLRRAVSGAMAGLTLLSPDLTKRIQAAQSVFKTHDETMLPT
VETALQAEKNAAARQAFAEARASILLFKTDASDVDKLDAIATLKARGDQEAMALLTGVPGGQSAAVASGIASAKAAIERN
LALWSMVQNAWYGLSLGSVLLLAAIGLAITFGVMGVINMAHGEMVMLGAYTTFVVQETIRTSYPALFDYSLLIAVPLAFL
VAGAIGVLIERSVIRFLYGRPLETLLATWGLSLILQQAVRTLFGPTNREVGNPSWMSGAFELGQITITYNRLWILCFTLA
VFVILLAMLRYTALGLEMRAVTQNRRMAASMGIATSRVDALTFGLGSGIAGIAGVALSQIDNVSPNLGQSYIIDSFMVVV
FGGVGNLWGTLVGAFTLGIANKFLEPVAGAVLAKIAILVLIILFIQKRPRGLFALKGRAVEA
>Mature_541_residues
PLIHLLRPLLSRLLFAAVALVVLHVATQPALAGPYEDAVAQFAAGSFSDTEEAIGRLVASAHPRAATIIVALQDGRLFAD
PDAKTVFIKAGDGAISNAVTGEAVAALPAKAEAVRLNNKLRRAVSGAMAGLTLLSPDLTKRIQAAQSVFKTHDETMLPTV
ETALQAEKNAAARQAFAEARASILLFKTDASDVDKLDAIATLKARGDQEAMALLTGVPGGQSAAVASGIASAKAAIERNL
ALWSMVQNAWYGLSLGSVLLLAAIGLAITFGVMGVINMAHGEMVMLGAYTTFVVQETIRTSYPALFDYSLLIAVPLAFLV
AGAIGVLIERSVIRFLYGRPLETLLATWGLSLILQQAVRTLFGPTNREVGNPSWMSGAFELGQITITYNRLWILCFTLAV
FVILLAMLRYTALGLEMRAVTQNRRMAASMGIATSRVDALTFGLGSGIAGIAGVALSQIDNVSPNLGQSYIIDSFMVVVF
GGVGNLWGTLVGAFTLGIANKFLEPVAGAVLAKIAILVLIILFIQKRPRGLFALKGRAVEA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=302, Percent_Identity=32.1192052980132, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 57114; Mature: 56983

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIHLLRPLLSRLLFAAVALVVLHVATQPALAGPYEDAVAQFAAGSFSDTEEAIGRLVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
SAHPRAATIIVALQDGRLFADPDAKTVFIKAGDGAISNAVTGEAVAALPAKAEAVRLNNK
CCCCCEEEEEEEEECCEEEECCCCCEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHH
LRRAVSGAMAGLTLLSPDLTKRIQAAQSVFKTHDETMLPTVETALQAEKNAAARQAFAEA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RASILLFKTDASDVDKLDAIATLKARGDQEAMALLTGVPGGQSAAVASGIASAKAAIERN
HCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LALWSMVQNAWYGLSLGSVLLLAAIGLAITFGVMGVINMAHGEMVMLGAYTTFVVQETIR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
TSYPALFDYSLLIAVPLAFLVAGAIGVLIERSVIRFLYGRPLETLLATWGLSLILQQAVR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TLFGPTNREVGNPSWMSGAFELGQITITYNRLWILCFTLAVFVILLAMLRYTALGLEMRA
HHCCCCCCCCCCCCHHCCCEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
VTQNRRMAASMGIATSRVDALTFGLGSGIAGIAGVALSQIDNVSPNLGQSYIIDSFMVVV
HHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FGGVGNLWGTLVGAFTLGIANKFLEPVAGAVLAKIAILVLIILFIQKRPRGLFALKGRAV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
EA
CC
>Mature Secondary Structure 
PLIHLLRPLLSRLLFAAVALVVLHVATQPALAGPYEDAVAQFAAGSFSDTEEAIGRLVA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
SAHPRAATIIVALQDGRLFADPDAKTVFIKAGDGAISNAVTGEAVAALPAKAEAVRLNNK
CCCCCEEEEEEEEECCEEEECCCCCEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHH
LRRAVSGAMAGLTLLSPDLTKRIQAAQSVFKTHDETMLPTVETALQAEKNAAARQAFAEA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RASILLFKTDASDVDKLDAIATLKARGDQEAMALLTGVPGGQSAAVASGIASAKAAIERN
HCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LALWSMVQNAWYGLSLGSVLLLAAIGLAITFGVMGVINMAHGEMVMLGAYTTFVVQETIR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
TSYPALFDYSLLIAVPLAFLVAGAIGVLIERSVIRFLYGRPLETLLATWGLSLILQQAVR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TLFGPTNREVGNPSWMSGAFELGQITITYNRLWILCFTLAVFVILLAMLRYTALGLEMRA
HHCCCCCCCCCCCCHHCCCEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
VTQNRRMAASMGIATSRVDALTFGLGSGIAGIAGVALSQIDNVSPNLGQSYIIDSFMVVV
HHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FGGVGNLWGTLVGAFTLGIANKFLEPVAGAVLAKIAILVLIILFIQKRPRGLFALKGRAV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
EA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]