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The map label for this gene is livM [H]

Identifier: 86748919

GI number: 86748919

Start: 2057773

End: 2058978

Strand: Direct

Name: livM [H]

Synonym: RPB_1796

Alternate gene names: 86748919

Gene position: 2057773-2058978 (Clockwise)

Preceding gene: 86748918

Following gene: 86748920

Centisome position: 38.6

GC content: 64.93

Gene sequence:

>1206_bases
ATGACCCCGCACATCCTCACCCGCTCGCTCAATCGCAGCGCGACGATTTTCCTGCTGGTGCTCGCCGTGGTCGGCGTGCT
GCTGCCGCTGTCGAATCTGCTGCTGCCGGAAGGCTCGCTGCTGCACGTGCCGACCTATCTGATCTCGCTGTTCGGCAAAT
ATGTCTGCTACGCGCTGCTAGCGCTATCGATCGACCTGATCTGGGGCTATTGCGGCATCCTCTCGCTCGGCCACGGCGCG
TTCTTCGCGCTCGGCGGCTACGCCATGGGGATGTATCTGATGCGCCAGATCGGCGATCGCGGCGTCTATGCCAATCCGGT
GCTGCCGGACTTCATGGTGTTCCTGAACTACAAGGAACTGCCGTGGTACTGGCACGGCTTCGACATGTTCTGGTTCGCCG
CGCTGATGGTGCTGGTGGTGCCGGGCCTCTTGGCGTTCTGCTTCGGCTGGCTGGCGTTCCGCTCGCGCGTCACCGGCGTG
TATCTGTCGATCATCACCCAGGCGATGACCTACGCGCTGCTGCTCGCGTTCTTCCGCAACGATTTCGGTTTCGGCGGCAA
CAACGGCCTGACCGACTTCAAGGACATCCTCGGCTTCAACGTTCAGGCCGACGGCACCCGCGCCGCGCTGTTCGTGCTGA
GTTGTCTCGCGCTCGGCATCGGCTTCCTGATCTGCCGCGCGGTGGTGACCTCCAAGCTCGGCAAGGTGCTGATCGCGATC
CGCGACGCGGAATCGCGCACGCGGTTCCTCGGCTACCGCGTCGAATCCTACAAGTTGTTCGTGTTCACGCTGTCGGCCTG
CATGGCCGGCGTCGCCGGCGCGCTGTATGTGCCTCAAGTGGGGATCATCAATCCGGGTGAATTCGCTCCGGCGAACTCGA
TCGAGGCGGTGATCTGGGTCGCGGTCGGCGGCCGCGGCACGCTGGTCGGCGCGGCGCTCGGCGCCATCGTGGTCAACTAC
GCCAAGACGGTGTTCACCTCCGGCCCCTTGGCGCCGTACTGGCTGTTCATGCTCGGCGCGCTGTTCGTGCTGGTGACGCT
GCTGCTGCCCAAGGGGATCATCGGCACCTTCAACGCCTGGTGGGAAGGCCGCAAGGAGGAGGGCGCGGAGAGAGACAAGG
CGCAGCGCGACAGCGGGATCGCCGCCGCAGCCGACAGTGCTGCGCGCGAGGACGGCGTGATCGAACCGACCATGGTGAAG
CGATGA

Upstream 100 bases:

>100_bases
GTGCTCGGCGGGACTCCACGTTGCTTCACGGCACAGCCGTCATCCTGAGGTGCCCGCGCGGCGCGCGGGCCTCGAAGGAT
GACAGCCGCGGGGGCCTGTC

Downstream 100 bases:

>100_bases
GCCTGCTGGAAACCCGCACCACCTCGGCGATGCTGTATCTCGACGGCGTCCACGTCTCGTTCGACGGCTTCCACGCCATC
AACAATCTGTCGCTGACGCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTPHILTRSLNRSATIFLLVLAVVGVLLPLSNLLLPEGSLLHVPTYLISLFGKYVCYALLALSIDLIWGYCGILSLGHGA
FFALGGYAMGMYLMRQIGDRGVYANPVLPDFMVFLNYKELPWYWHGFDMFWFAALMVLVVPGLLAFCFGWLAFRSRVTGV
YLSIITQAMTYALLLAFFRNDFGFGGNNGLTDFKDILGFNVQADGTRAALFVLSCLALGIGFLICRAVVTSKLGKVLIAI
RDAESRTRFLGYRVESYKLFVFTLSACMAGVAGALYVPQVGIINPGEFAPANSIEAVIWVAVGGRGTLVGAALGAIVVNY
AKTVFTSGPLAPYWLFMLGALFVLVTLLLPKGIIGTFNAWWEGRKEEGAERDKAQRDSGIAAAADSAAREDGVIEPTMVK
R

Sequences:

>Translated_401_residues
MTPHILTRSLNRSATIFLLVLAVVGVLLPLSNLLLPEGSLLHVPTYLISLFGKYVCYALLALSIDLIWGYCGILSLGHGA
FFALGGYAMGMYLMRQIGDRGVYANPVLPDFMVFLNYKELPWYWHGFDMFWFAALMVLVVPGLLAFCFGWLAFRSRVTGV
YLSIITQAMTYALLLAFFRNDFGFGGNNGLTDFKDILGFNVQADGTRAALFVLSCLALGIGFLICRAVVTSKLGKVLIAI
RDAESRTRFLGYRVESYKLFVFTLSACMAGVAGALYVPQVGIINPGEFAPANSIEAVIWVAVGGRGTLVGAALGAIVVNY
AKTVFTSGPLAPYWLFMLGALFVLVTLLLPKGIIGTFNAWWEGRKEEGAERDKAQRDSGIAAAADSAAREDGVIEPTMVK
R
>Mature_400_residues
TPHILTRSLNRSATIFLLVLAVVGVLLPLSNLLLPEGSLLHVPTYLISLFGKYVCYALLALSIDLIWGYCGILSLGHGAF
FALGGYAMGMYLMRQIGDRGVYANPVLPDFMVFLNYKELPWYWHGFDMFWFAALMVLVVPGLLAFCFGWLAFRSRVTGVY
LSIITQAMTYALLLAFFRNDFGFGGNNGLTDFKDILGFNVQADGTRAALFVLSCLALGIGFLICRAVVTSKLGKVLIAIR
DAESRTRFLGYRVESYKLFVFTLSACMAGVAGALYVPQVGIINPGEFAPANSIEAVIWVAVGGRGTLVGAALGAIVVNYA
KTVFTSGPLAPYWLFMLGALFVLVTLLLPKGIIGTFNAWWEGRKEEGAERDKAQRDSGIAAAADSAAREDGVIEPTMVKR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=326, Percent_Identity=24.8466257668712, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 43601; Mature: 43470

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCHHCCC
>Mature Secondary Structure 
TPHILTRSLNRSATIFLLVLAVVGVLLPLSNLLLPEGSLLHVPTYLISLFGKYVCYALL
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
ALSIDLIWGYCGILSLGHGAFFALGGYAMGMYLMRQIGDRGVYANPVLPDFMVFLNYKEL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCC
PWYWHGFDMFWFAALMVLVVPGLLAFCFGWLAFRSRVTGVYLSIITQAMTYALLLAFFRN
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFGFGGNNGLTDFKDILGFNVQADGTRAALFVLSCLALGIGFLICRAVVTSKLGKVLIAI
CCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
RDAESRTRFLGYRVESYKLFVFTLSACMAGVAGALYVPQVGIINPGEFAPANSIEAVIWV
ECCHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEE
AVGGRGTLVGAALGAIVVNYAKTVFTSGPLAPYWLFMLGALFVLVTLLLPKGIIGTFNAW
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
WEGRKEEGAERDKAQRDSGIAAAADSAAREDGVIEPTMVKR
HCCCHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]