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The map label for this gene is acdA [H]

Identifier: 86748811

GI number: 86748811

Start: 1922830

End: 1924077

Strand: Direct

Name: acdA [H]

Synonym: RPB_1688

Alternate gene names: 86748811

Gene position: 1922830-1924077 (Clockwise)

Preceding gene: 86748810

Following gene: 86748812

Centisome position: 36.06

GC content: 65.3

Gene sequence:

>1248_bases
ATGAATTTCGACGACACCCCGCAGGAAGCCGAATTCCGCGCCAAGGCGCGTGCCTGGATCGACGCCAACGCGCCGAAGCA
ATATGAAGAGGAACTGCGCAAGGCCTCGCTCGGCCGCGTTCAGCTCAAGGGCGCCAACATTCTCGAGGTCGCCAAGGCTT
GGCAGAAGAAGAAGGCCGACGCCGGCTGGGCCGTGCCGCATTGGCCGAAGGATTACGGCGGCCGCGGCGCGACGCCGATC
GAGCGGGTGATCTGGCAGCAGGAAGAGGGCGTCTACGGCAAGCTCGGCGCGCTGTTCATCATCGGCCAGGGCATGTGCGG
GCCGACCATGATGGCGTTCGCCTCGGAGGACCAGAAGCGATACTATTTGCCGCCGCTGGCGTCGGGCGAGAACATCTGGT
GTCAGTTGTTCTCGGAGCCCGCCGGCGGTTCGGACGTCGCCGGCCTGCGCACGCGCGCGGAGAAGGACGGCGACGACTGG
ATCATCAACGGCCAGAAGATCTGGACCTCCGGCGCGCATTATTCGGACTACGGCATCCTGATCACCCGCACCGACCCGAC
CGTGCCCAAGCACAAGGGCCTGACGATGTTCTTCCTCGACATGAGGAGCAAGGGCGTCGAGATCAAGCCGATCAAGCAGG
CCAACGGCAATTCCGACTTCAATGAAGTGTACTTCACCGACGTGCGGATTCCGGACAGTCAGCGGTTGGGCGCCGTCGGC
GACGGCTGGAACGTGTCGCTGACGACGCTGATGAACGAGCGGATGTCGATCGGCGCCAATGTGGCGACTGGGTTTCCGGA
GTTGTTCGAGTACTGCAATTCGCTGATGCTCGACGGCGGCCCCGCGATCGAGGACCGAGCGGTGCGCAGTAAGCTCGCCA
ACTGGGCGGTGCGCGCCAGCGGGTTGAAATACACCAGCTTCCGCGCGATCTCGGCGCTGTCGAAGGGCGAACGCCCGGGG
CCGGAGAATTCGATCGGCAAGCTCGTCGCGGGTTCGATGATTCAGGACGTCGCAATGTATGCGCTCGACCTGCAGGGCGC
CGGCGGCGTGCTGAGCGGCCCCGAGGATGCGGAAGCCGCCGGCAAGTTCCAGGCGATGCTGCTGCGTTCGCCGGCGACGC
GTGTGGAAGGCGGCACCGACGAGATCCTGCGCAACATCATCGCCGAGCGCGTGCTCGGTCTGCCCGGCGACATCCGCGTC
GACAAGGACGTGCCGTTCAACCAGATCCCGACGCGGGGGCGGGCCTAA

Upstream 100 bases:

>100_bases
GAAGGATGAGGCTGTCCATCCTCATGGTTCGAGACGCGCGCAAGGGCGCGCTCCTCACCATGCGGTTCTGAATTTGCCTC
GCTTAGAAAGGCTCGAACAG

Downstream 100 bases:

>100_bases
CAACGTAGGAACAGTCTGAGTAGTTGATGGGTATCGCCGGAACTCAACACATCCTACGAGTTTCGCCGTCGCGGACCGTC
ACCCTGAGGTGCTCGCCGTC

Product: Acyl-CoA dehydrogenase-like

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNFDDTPQEAEFRAKARAWIDANAPKQYEEELRKASLGRVQLKGANILEVAKAWQKKKADAGWAVPHWPKDYGGRGATPI
ERVIWQQEEGVYGKLGALFIIGQGMCGPTMMAFASEDQKRYYLPPLASGENIWCQLFSEPAGGSDVAGLRTRAEKDGDDW
IINGQKIWTSGAHYSDYGILITRTDPTVPKHKGLTMFFLDMRSKGVEIKPIKQANGNSDFNEVYFTDVRIPDSQRLGAVG
DGWNVSLTTLMNERMSIGANVATGFPELFEYCNSLMLDGGPAIEDRAVRSKLANWAVRASGLKYTSFRAISALSKGERPG
PENSIGKLVAGSMIQDVAMYALDLQGAGGVLSGPEDAEAAGKFQAMLLRSPATRVEGGTDEILRNIIAERVLGLPGDIRV
DKDVPFNQIPTRGRA

Sequences:

>Translated_415_residues
MNFDDTPQEAEFRAKARAWIDANAPKQYEEELRKASLGRVQLKGANILEVAKAWQKKKADAGWAVPHWPKDYGGRGATPI
ERVIWQQEEGVYGKLGALFIIGQGMCGPTMMAFASEDQKRYYLPPLASGENIWCQLFSEPAGGSDVAGLRTRAEKDGDDW
IINGQKIWTSGAHYSDYGILITRTDPTVPKHKGLTMFFLDMRSKGVEIKPIKQANGNSDFNEVYFTDVRIPDSQRLGAVG
DGWNVSLTTLMNERMSIGANVATGFPELFEYCNSLMLDGGPAIEDRAVRSKLANWAVRASGLKYTSFRAISALSKGERPG
PENSIGKLVAGSMIQDVAMYALDLQGAGGVLSGPEDAEAAGKFQAMLLRSPATRVEGGTDEILRNIIAERVLGLPGDIRV
DKDVPFNQIPTRGRA
>Mature_415_residues
MNFDDTPQEAEFRAKARAWIDANAPKQYEEELRKASLGRVQLKGANILEVAKAWQKKKADAGWAVPHWPKDYGGRGATPI
ERVIWQQEEGVYGKLGALFIIGQGMCGPTMMAFASEDQKRYYLPPLASGENIWCQLFSEPAGGSDVAGLRTRAEKDGDDW
IINGQKIWTSGAHYSDYGILITRTDPTVPKHKGLTMFFLDMRSKGVEIKPIKQANGNSDFNEVYFTDVRIPDSQRLGAVG
DGWNVSLTTLMNERMSIGANVATGFPELFEYCNSLMLDGGPAIEDRAVRSKLANWAVRASGLKYTSFRAISALSKGERPG
PENSIGKLVAGSMIQDVAMYALDLQGAGGVLSGPEDAEAAGKFQAMLLRSPATRVEGGTDEILRNIIAERVLGLPGDIRV
DKDVPFNQIPTRGRA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=397, Percent_Identity=25.6926952141058, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI187960098, Length=397, Percent_Identity=25.6926952141058, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4557233, Length=345, Percent_Identity=25.5072463768116, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI4501857, Length=352, Percent_Identity=25.2840909090909, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI4501859, Length=270, Percent_Identity=27.037037037037, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7656849, Length=344, Percent_Identity=24.7093023255814, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI226958412, Length=193, Percent_Identity=32.6424870466321, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226958414, Length=193, Percent_Identity=32.6424870466321, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI76496475, Length=222, Percent_Identity=29.7297297297297, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI4557235, Length=222, Percent_Identity=29.7297297297297, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI21361497, Length=209, Percent_Identity=31.1004784688995, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38505218, Length=147, Percent_Identity=29.9319727891156, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081958, Length=403, Percent_Identity=25.5583126550869, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786223, Length=335, Percent_Identity=22.6865671641791, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=405, Percent_Identity=26.9135802469136, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17569725, Length=342, Percent_Identity=27.7777777777778, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17551932, Length=330, Percent_Identity=25.4545454545455, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17538396, Length=339, Percent_Identity=25.9587020648968, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17508101, Length=272, Percent_Identity=28.3088235294118, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17534899, Length=291, Percent_Identity=28.5223367697594, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17505929, Length=330, Percent_Identity=24.5454545454545, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=196, Percent_Identity=31.6326530612245, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17506239, Length=198, Percent_Identity=28.7878787878788, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI32563615, Length=198, Percent_Identity=28.7878787878788, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17533517, Length=349, Percent_Identity=24.3553008595989, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=204, Percent_Identity=28.921568627451, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=154, Percent_Identity=33.1168831168831, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=154, Percent_Identity=33.1168831168831, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17534353, Length=247, Percent_Identity=27.1255060728745, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24660351, Length=352, Percent_Identity=26.9886363636364, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24646207, Length=285, Percent_Identity=29.1228070175439, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356377, Length=332, Percent_Identity=24.3975903614458, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355753, Length=373, Percent_Identity=24.3967828418231, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=25.2906976744186, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666513, Length=286, Percent_Identity=24.8251748251748, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19920834, Length=255, Percent_Identity=27.843137254902, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 45377; Mature: 45377

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDDTPQEAEFRAKARAWIDANAPKQYEEELRKASLGRVQLKGANILEVAKAWQKKKAD
CCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCC
AGWAVPHWPKDYGGRGATPIERVIWQQEEGVYGKLGALFIIGQGMCGPTMMAFASEDQKR
CCCCCCCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCCCE
YYLPPLASGENIWCQLFSEPAGGSDVAGLRTRAEKDGDDWIINGQKIWTSGAHYSDYGIL
EECCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCEEECCEEEEECCCCCCCCEEE
ITRTDPTVPKHKGLTMFFLDMRSKGVEIKPIKQANGNSDFNEVYFTDVRIPDSQRLGAVG
EECCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCC
DGWNVSLTTLMNERMSIGANVATGFPELFEYCNSLMLDGGPAIEDRAVRSKLANWAVRAS
CCCCEEHHHHHHHHHHCCCCHHCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHC
GLKYTSFRAISALSKGERPGPENSIGKLVAGSMIQDVAMYALDLQGAGGVLSGPEDAEAA
CCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHH
GKFQAMLLRSPATRVEGGTDEILRNIIAERVLGLPGDIRVDKDVPFNQIPTRGRA
HHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MNFDDTPQEAEFRAKARAWIDANAPKQYEEELRKASLGRVQLKGANILEVAKAWQKKKAD
CCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCC
AGWAVPHWPKDYGGRGATPIERVIWQQEEGVYGKLGALFIIGQGMCGPTMMAFASEDQKR
CCCCCCCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCCCE
YYLPPLASGENIWCQLFSEPAGGSDVAGLRTRAEKDGDDWIINGQKIWTSGAHYSDYGIL
EECCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCEEECCEEEEECCCCCCCCEEE
ITRTDPTVPKHKGLTMFFLDMRSKGVEIKPIKQANGNSDFNEVYFTDVRIPDSQRLGAVG
EECCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCC
DGWNVSLTTLMNERMSIGANVATGFPELFEYCNSLMLDGGPAIEDRAVRSKLANWAVRAS
CCCCEEHHHHHHHHHHCCCCHHCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHC
GLKYTSFRAISALSKGERPGPENSIGKLVAGSMIQDVAMYALDLQGAGGVLSGPEDAEAA
CCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHH
GKFQAMLLRSPATRVEGGTDEILRNIIAERVLGLPGDIRVDKDVPFNQIPTRGRA
HHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]