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The map label for this gene is acdA [H]

Identifier: 86748810

GI number: 86748810

Start: 1921545

End: 1922672

Strand: Direct

Name: acdA [H]

Synonym: RPB_1687

Alternate gene names: 86748810

Gene position: 1921545-1922672 (Clockwise)

Preceding gene: 86748809

Following gene: 86748811

Centisome position: 36.04

GC content: 67.64

Gene sequence:

>1128_bases
ATGAATTTCGATTTCTCCGACGACCAGAAGCAACTGCGCGATCAGGCGCGGCGGTTTCTTGCCGAGAAGTGCCCGCCGAA
GGCGGTGCGTGCCGTGCTCGAAGGCAAGGCGGATTACGACCGCGACCTTTGGAAGGGACTCGCCGAGATGGGCTTCCTCG
GCGTCGCGATTCCGGAGGAATACGGCGGGACCGGCGCGGGCCATCTCGAGCTCTGCGTGATCGCCGAGGAGCTCGGCCGC
GCGCTGGCGCCGGTGCCGTTCTCGTCGACCGTGTACCTCGCCGCCGAGGTGCTGCTGCTGGCCGGCTCGGAAGAGCAGAA
GCAGAAATGGCTGCCGAAGATCTCGTCGGGCGAGGCGATCGGCACGCTGGCGCTGTTCGAAGGCACCGGCAATCCGTCGC
CGCAGGCGATCAAGGTTGCGGCTGCGAACGGCACCCTCACCGGCACCAAGAAGCCGGTCGCCGACGGCGCGATCGCCGAC
TTCGCGATCGTCGCGGCGCGTAGCGGCAACAGCGGGCGTGAGACCGATATCTCGCTGTTCCTGGTCGATCTCAAGGCCGG
CGGCGTCGACGCCAAGCCGCTGCAGAATGTCGATCCGTCGCGGCAGCAGGCCGAACTGACCTTCGCCGGCGCCAAGGCCG
AGCCGCTCGGCGCGGCGAACGAAGGCTGGAGCATCCTGTCGCGCGTGATGGACCGCGCCGCGGTGCTGATCGCCTTCGAG
CAGGTCGGCGGCGCCGACCGCGCGCTCGAGATGGGCCGCGACTACGCTCTCGATCGCATCGCCTTCGGCCGGCCGATCGG
CTCGTTCCAGGCGGTCAAGCACATCCTCGCCGACATGTACGTCTCGGCGACGCTGGCGCGCTCGAATTGCTACTACGGCG
CCTGGGCGCTCTCGACTGATGCCGGTGAACTGCCGGAGGCAGCCGCAGCCGCGCGGATCAGCGCGACGCAGGCGTTCCAG
CATTGTTCGAAGCAGAACATCCAGGTCCACGGCGGCATGGGCTTCACCTGGGAGTTCGACTGCCACCTGTACTATCGCCG
CTCCAACGCGCTGGCGCTGGCGCTGGGCAGCCAGTCGTACTGGGAAGACCAACTGATCGACCGCATGCGGAAGAAGAACG
CGGCGTGA

Upstream 100 bases:

>100_bases
GCGCGAACCCGGAATCTCGAGATTCCGGGCTCTCGCCTGTCGGCGAGCCCCGGAATGACGGTGCCGAAGACCAACACCTA
ACAACCAACGAGACACGCCC

Downstream 100 bases:

>100_bases
GGAAGCCCCTCATCCTCAGGAGCCCAGCGTAGCTCGCAGAGCGAAGCCGGACGTCTCGAAGGATGAGGCTGTCCATCCTC
ATGGTTCGAGACGCGCGCAA

Product: Acyl-CoA dehydrogenase-like

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MNFDFSDDQKQLRDQARRFLAEKCPPKAVRAVLEGKADYDRDLWKGLAEMGFLGVAIPEEYGGTGAGHLELCVIAEELGR
ALAPVPFSSTVYLAAEVLLLAGSEEQKQKWLPKISSGEAIGTLALFEGTGNPSPQAIKVAAANGTLTGTKKPVADGAIAD
FAIVAARSGNSGRETDISLFLVDLKAGGVDAKPLQNVDPSRQQAELTFAGAKAEPLGAANEGWSILSRVMDRAAVLIAFE
QVGGADRALEMGRDYALDRIAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALSTDAGELPEAAAAARISATQAFQ
HCSKQNIQVHGGMGFTWEFDCHLYYRRSNALALALGSQSYWEDQLIDRMRKKNAA

Sequences:

>Translated_375_residues
MNFDFSDDQKQLRDQARRFLAEKCPPKAVRAVLEGKADYDRDLWKGLAEMGFLGVAIPEEYGGTGAGHLELCVIAEELGR
ALAPVPFSSTVYLAAEVLLLAGSEEQKQKWLPKISSGEAIGTLALFEGTGNPSPQAIKVAAANGTLTGTKKPVADGAIAD
FAIVAARSGNSGRETDISLFLVDLKAGGVDAKPLQNVDPSRQQAELTFAGAKAEPLGAANEGWSILSRVMDRAAVLIAFE
QVGGADRALEMGRDYALDRIAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALSTDAGELPEAAAAARISATQAFQ
HCSKQNIQVHGGMGFTWEFDCHLYYRRSNALALALGSQSYWEDQLIDRMRKKNAA
>Mature_375_residues
MNFDFSDDQKQLRDQARRFLAEKCPPKAVRAVLEGKADYDRDLWKGLAEMGFLGVAIPEEYGGTGAGHLELCVIAEELGR
ALAPVPFSSTVYLAAEVLLLAGSEEQKQKWLPKISSGEAIGTLALFEGTGNPSPQAIKVAAANGTLTGTKKPVADGAIAD
FAIVAARSGNSGRETDISLFLVDLKAGGVDAKPLQNVDPSRQQAELTFAGAKAEPLGAANEGWSILSRVMDRAAVLIAFE
QVGGADRALEMGRDYALDRIAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALSTDAGELPEAAAAARISATQAFQ
HCSKQNIQVHGGMGFTWEFDCHLYYRRSNALALALGSQSYWEDQLIDRMRKKNAA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=366, Percent_Identity=30.327868852459, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI4557233, Length=315, Percent_Identity=31.4285714285714, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4501857, Length=350, Percent_Identity=26.8571428571429, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI226958414, Length=330, Percent_Identity=30, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501859, Length=353, Percent_Identity=25.7790368271955, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI7656849, Length=369, Percent_Identity=27.3712737127371, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=25.6484149855908, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI76496475, Length=356, Percent_Identity=24.7191011235955, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI21361497, Length=379, Percent_Identity=25.8575197889182, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI187960098, Length=370, Percent_Identity=24.5945945945946, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4557231, Length=370, Percent_Identity=24.5945945945946, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI7669494, Length=299, Percent_Identity=27.7591973244147, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4503943, Length=299, Percent_Identity=27.7591973244147, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1786223, Length=342, Percent_Identity=26.0233918128655, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081958, Length=355, Percent_Identity=22.8169014084507, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=350, Percent_Identity=30.5714285714286, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17534899, Length=397, Percent_Identity=25.9445843828715, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508101, Length=356, Percent_Identity=26.685393258427, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17570075, Length=373, Percent_Identity=23.8605898123324, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=25.6544502617801, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17506239, Length=353, Percent_Identity=24.929178470255, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71985184, Length=322, Percent_Identity=25.1552795031056, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=300, Percent_Identity=25.6666666666667, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71985192, Length=297, Percent_Identity=23.9057239057239, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71990804, Length=263, Percent_Identity=24.3346007604563, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32563615, Length=234, Percent_Identity=23.9316239316239, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355753, Length=353, Percent_Identity=31.1614730878187, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21356377, Length=355, Percent_Identity=29.0140845070423, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646207, Length=365, Percent_Identity=28.4931506849315, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24666513, Length=382, Percent_Identity=25.130890052356, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24660351, Length=370, Percent_Identity=25.1351351351351, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281363737, Length=314, Percent_Identity=24.203821656051, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19920834, Length=304, Percent_Identity=25.3289473684211, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 40235; Mature: 40235

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDFSDDQKQLRDQARRFLAEKCPPKAVRAVLEGKADYDRDLWKGLAEMGFLGVAIPEE
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCHH
YGGTGAGHLELCVIAEELGRALAPVPFSSTVYLAAEVLLLAGSEEQKQKWLPKISSGEAI
HCCCCCCCEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCE
GTLALFEGTGNPSPQAIKVAAANGTLTGTKKPVADGAIADFAIVAARSGNSGRETDISLF
EEEEEEECCCCCCCCEEEEEECCCEECCCCCCCCCCCHHHEEEEEECCCCCCCCCEEEEE
LVDLKAGGVDAKPLQNVDPSRQQAELTFAGAKAEPLGAANEGWSILSRVMDRAAVLIAFE
EEEEECCCCCCCCCCCCCCCCHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEH
QVGGADRALEMGRDYALDRIAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALSTD
HCCCHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
AGELPEAAAAARISATQAFQHCSKQNIQVHGGMGFTWEFDCHLYYRRSNALALALGSQSY
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEECCEEEEEECCCCC
WEDQLIDRMRKKNAA
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFDFSDDQKQLRDQARRFLAEKCPPKAVRAVLEGKADYDRDLWKGLAEMGFLGVAIPEE
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCHH
YGGTGAGHLELCVIAEELGRALAPVPFSSTVYLAAEVLLLAGSEEQKQKWLPKISSGEAI
HCCCCCCCEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCE
GTLALFEGTGNPSPQAIKVAAANGTLTGTKKPVADGAIADFAIVAARSGNSGRETDISLF
EEEEEEECCCCCCCCEEEEEECCCEECCCCCCCCCCCHHHEEEEEECCCCCCCCCEEEEE
LVDLKAGGVDAKPLQNVDPSRQQAELTFAGAKAEPLGAANEGWSILSRVMDRAAVLIAFE
EEEEECCCCCCCCCCCCCCCCHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEH
QVGGADRALEMGRDYALDRIAFGRPIGSFQAVKHILADMYVSATLARSNCYYGAWALSTD
HCCCHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
AGELPEAAAAARISATQAFQHCSKQNIQVHGGMGFTWEFDCHLYYRRSNALALALGSQSY
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEECCEEEEEECCCCC
WEDQLIDRMRKKNAA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]