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The map label for this gene is hldE

Identifier: 86748728

GI number: 86748728

Start: 1806268

End: 1807740

Strand: Direct

Name: hldE

Synonym: RPB_1603

Alternate gene names: 86748728

Gene position: 1806268-1807740 (Clockwise)

Preceding gene: 86748727

Following gene: 86748729

Centisome position: 33.88

GC content: 69.11

Gene sequence:

>1473_bases
ATGAACAATTTCGACACCCTGCTGCAATCGATCGCCCGGACGACCGTGGTGTGCGTCGGTGACCTGATGCTCGACGAGTT
CGTCTATGGCGAGGTGTCACGGATCTCGCCCGAGGCGCCGGCGCCGGTGATCGCGGTTCAGCGCAGCGAGATCAATGTCG
GCGGCGCCGGCAACGTCGCGCGCAACATCGCTGCGCTCGGTGCGCGCTGCATCTTCGTCGGCCTGATCGGCGACGACGAG
GCGGGCCGAACGCTGAATGCGGAGCTCGCGAGCGAAGCCCGGATCGAGCCGCTGCTGGTGTGCGACCCGGCGCGGCCGAC
CACGCGCAAGGTGCGCTTCGTCTCCGAGCATTTCTCCACTCACATGCTGCGTGCCGATTGGGAGACTGCGGCGGCCGCGT
CGGCCGAGATCGAACAGCGCCTGCTCGACGCTATCCTGTCGCAACTCGAGCGCGCCGACATCGTGTTGCTGTCCGACTAC
GCCAAGGGCGTGCTGACGGTCCGCGTGATCGCCACCGTGATCGAGGCCGCGCGAAAACTCGGGAAGCGGGTGATCGTCGA
CCCCAAGAGCGCCAATTTCGCGATCTATCGCGGCGCGACGCTGCTGACGCCCAACCGCAAGGAATTCGTCACCGCGACGC
GCTGCGCGGCGGACTCCATGGACGAGATCGCCACGGCGGCGCAGGAAGCGATCGCATTCGCCGATTGCGAGGCGATGCTG
GTGACGCAGAGCGAGCACGGTATGACGCTGGTGCCGCGCGCCGGCGAGCCGATCCACGTGCCGGCGATGCCGGCGAAAGT
GCGCGACGTCTCCGGCGCCGGCGACACCGTCGCCGCCGTGCTGGCGGTGGCGCTGGCGGCTGGGGCCGATTGGGGCACCG
CGATGCGGGCGGCGAGCGCTGCGGCTGCCGTTGCTGTCAGCAAGAACGGCACCGCGGTGGTGACGCCGGCGGAGCTGCGA
CGCAAGATCCTGCCGCACGCCTCGCTCGCGGCCGAAGACAAGATCATCGGCAGCGACGCCGAACTCGATCTTCGCCTCGC
CGAGTGGCGCCGCGACGGGCTGCGGGTCGGCTTCACCAACGGCTGCTTCGACATTCTGCATCCGGGCCACGTCAAGGTGC
TGACGGCGGCGCGCGGCGCCTGCGACCGGCTGATCGTCGGCCTCAACAGCGACGCCTCGGTGCGCCGGCTCAAGGGCGAG
AGCCGTCCGGTGCAGAACGAGCGCGCCCGTGCCGAAGTGCTGGCGGCGCTCGAGGCGGTCGATCTGGTGGCGATCTTCGA
GGAGGACACGCCGCTGAAGCTGATCACCCGAATCGAACCGAGCGTGCTGGTCAAGGGCGGCGACTACACCCGTGAGCAGG
TGGTCGGCCACGAGATCGTCGCGGCCAGGGGCGGCGAGGTGCTGCTGATCGACGTGCTGCCGGGTTTCAGCACGACCTCG
CTGGTCGAGAAGGCACGCGAGGGGACGTCGTGA

Upstream 100 bases:

>100_bases
GGCTTCACGCCGCTCGAAGATGCGGTCGCTTGCTATGTCAGGGGGTACCTTGACGGCAGTGATCGCTTCCGCTGATGCCG
CTCCAACCGCGTCGAGTTCG

Downstream 100 bases:

>100_bases
ACAATCTCAGGTTCCAATCGGGGAATAGTCGATGCTGACTGGGATCCGTTCATTTTCGTATCGCAACTGGATGATCGCAA
TTCACGACGCCGTTGCGACC

Product: bifunctional D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenosyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MNNFDTLLQSIARTTVVCVGDLMLDEFVYGEVSRISPEAPAPVIAVQRSEINVGGAGNVARNIAALGARCIFVGLIGDDE
AGRTLNAELASEARIEPLLVCDPARPTTRKVRFVSEHFSTHMLRADWETAAAASAEIEQRLLDAILSQLERADIVLLSDY
AKGVLTVRVIATVIEAARKLGKRVIVDPKSANFAIYRGATLLTPNRKEFVTATRCAADSMDEIATAAQEAIAFADCEAML
VTQSEHGMTLVPRAGEPIHVPAMPAKVRDVSGAGDTVAAVLAVALAAGADWGTAMRAASAAAAVAVSKNGTAVVTPAELR
RKILPHASLAAEDKIIGSDAELDLRLAEWRRDGLRVGFTNGCFDILHPGHVKVLTAARGACDRLIVGLNSDASVRRLKGE
SRPVQNERARAEVLAALEAVDLVAIFEEDTPLKLITRIEPSVLVKGGDYTREQVVGHEIVAARGGEVLLIDVLPGFSTTS
LVEKAREGTS

Sequences:

>Translated_490_residues
MNNFDTLLQSIARTTVVCVGDLMLDEFVYGEVSRISPEAPAPVIAVQRSEINVGGAGNVARNIAALGARCIFVGLIGDDE
AGRTLNAELASEARIEPLLVCDPARPTTRKVRFVSEHFSTHMLRADWETAAAASAEIEQRLLDAILSQLERADIVLLSDY
AKGVLTVRVIATVIEAARKLGKRVIVDPKSANFAIYRGATLLTPNRKEFVTATRCAADSMDEIATAAQEAIAFADCEAML
VTQSEHGMTLVPRAGEPIHVPAMPAKVRDVSGAGDTVAAVLAVALAAGADWGTAMRAASAAAAVAVSKNGTAVVTPAELR
RKILPHASLAAEDKIIGSDAELDLRLAEWRRDGLRVGFTNGCFDILHPGHVKVLTAARGACDRLIVGLNSDASVRRLKGE
SRPVQNERARAEVLAALEAVDLVAIFEEDTPLKLITRIEPSVLVKGGDYTREQVVGHEIVAARGGEVLLIDVLPGFSTTS
LVEKAREGTS
>Mature_490_residues
MNNFDTLLQSIARTTVVCVGDLMLDEFVYGEVSRISPEAPAPVIAVQRSEINVGGAGNVARNIAALGARCIFVGLIGDDE
AGRTLNAELASEARIEPLLVCDPARPTTRKVRFVSEHFSTHMLRADWETAAAASAEIEQRLLDAILSQLERADIVLLSDY
AKGVLTVRVIATVIEAARKLGKRVIVDPKSANFAIYRGATLLTPNRKEFVTATRCAADSMDEIATAAQEAIAFADCEAML
VTQSEHGMTLVPRAGEPIHVPAMPAKVRDVSGAGDTVAAVLAVALAAGADWGTAMRAASAAAAVAVSKNGTAVVTPAELR
RKILPHASLAAEDKIIGSDAELDLRLAEWRRDGLRVGFTNGCFDILHPGHVKVLTAARGACDRLIVGLNSDASVRRLKGE
SRPVQNERARAEVLAALEAVDLVAIFEEDTPLKLITRIEPSVLVKGGDYTREQVVGHEIVAARGGEVLLIDVLPGFSTTS
LVEKAREGTS

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family

Homologues:

Organism=Escherichia coli, GI1789432, Length=481, Percent_Identity=45.1143451143451, Blast_Score=351, Evalue=8e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLDE_RHOP2 (Q2IZP7)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_485224.1
- ProteinModelPortal:   Q2IZP7
- SMR:   Q2IZP7
- STRING:   Q2IZP7
- GeneID:   3910074
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1603
- eggNOG:   COG2870
- HOGENOM:   HBG545535
- OMA:   LTPNRKE
- ProtClustDB:   CLSK820002
- BioCyc:   RPAL316058:RPB_1603-MONOMER
- HAMAP:   MF_01603
- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR02198
- TIGRFAMs:   TIGR02199

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB

EC number: 2.7.-.-

Molecular weight: Translated: 52025; Mature: 52025

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: ACT_SITE 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNFDTLLQSIARTTVVCVGDLMLDEFVYGEVSRISPEAPAPVIAVQRSEINVGGAGNVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCEEEEEECEECCCCCCHHH
RNIAALGARCIFVGLIGDDEAGRTLNAELASEARIEPLLVCDPARPTTRKVRFVSEHFST
HHHHHHCCEEEEEEEECCCCCCCEECHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH
HMLRADWETAAAASAEIEQRLLDAILSQLERADIVLLSDYAKGVLTVRVIATVIEAARKL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHC
GKRVIVDPKSANFAIYRGATLLTPNRKEFVTATRCAADSMDEIATAAQEAIAFADCEAML
CCEEEECCCCCCEEEEECEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEE
VTQSEHGMTLVPRAGEPIHVPAMPAKVRDVSGAGDTVAAVLAVALAAGADWGTAMRAASA
EEECCCCEEEECCCCCCEECCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
AAAVAVSKNGTAVVTPAELRRKILPHASLAAEDKIIGSDAELDLRLAEWRRDGLRVGFTN
HEEEEEECCCCEEEEHHHHHHHHCCCCCCCCCCCEECCCCCEEEEHHHHHCCCCEEEECC
GCFDILHPGHVKVLTAARGACDRLIVGLNSDASVRRLKGESRPVQNERARAEVLAALEAV
CCHHHCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
DLVAIFEEDTPLKLITRIEPSVLVKGGDYTREQVVGHEIVAARGGEVLLIDVLPGFSTTS
HEEEEECCCCCEEEEEECCCEEEEECCCCCHHHHHCHHHEEECCCCEEEEEECCCCCHHH
LVEKAREGTS
HHHHHHCCCC
>Mature Secondary Structure
MNNFDTLLQSIARTTVVCVGDLMLDEFVYGEVSRISPEAPAPVIAVQRSEINVGGAGNVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCEEEEEECEECCCCCCHHH
RNIAALGARCIFVGLIGDDEAGRTLNAELASEARIEPLLVCDPARPTTRKVRFVSEHFST
HHHHHHCCEEEEEEEECCCCCCCEECHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH
HMLRADWETAAAASAEIEQRLLDAILSQLERADIVLLSDYAKGVLTVRVIATVIEAARKL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHC
GKRVIVDPKSANFAIYRGATLLTPNRKEFVTATRCAADSMDEIATAAQEAIAFADCEAML
CCEEEECCCCCCEEEEECEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEE
VTQSEHGMTLVPRAGEPIHVPAMPAKVRDVSGAGDTVAAVLAVALAAGADWGTAMRAASA
EEECCCCEEEECCCCCCEECCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
AAAVAVSKNGTAVVTPAELRRKILPHASLAAEDKIIGSDAELDLRLAEWRRDGLRVGFTN
HEEEEEECCCCEEEEHHHHHHHHCCCCCCCCCCCEECCCCCEEEEHHHHHCCCCEEEECC
GCFDILHPGHVKVLTAARGACDRLIVGLNSDASVRRLKGESRPVQNERARAEVLAALEAV
CCHHHCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
DLVAIFEEDTPLKLITRIEPSVLVKGGDYTREQVVGHEIVAARGGEVLLIDVLPGFSTTS
HEEEEECCCCCEEEEEECCCEEEEECCCCCHHHHHCHHHEEECCCCEEEEEECCCCCHHH
LVEKAREGTS
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA