Click here to switch to the map view.

The map label for this gene is hldD [H]

Identifier: 86748727

GI number: 86748727

Start: 1805262

End: 1806242

Strand: Direct

Name: hldD [H]

Synonym: RPB_1602

Alternate gene names: 86748727

Gene position: 1805262-1806242 (Clockwise)

Preceding gene: 86748723

Following gene: 86748728

Centisome position: 33.86

GC content: 64.12

Gene sequence:

>981_bases
ATGCTGCTGGTAACCGGAGGCGCCGGCTTTATCGGATCGAACATCGCTGCGGCGCTGAACGATGCGGGGCGCAGTGATGT
GGCGGTGTGCGACTTTCTCGGCCACGAGGGCAAATGGAAGAACCTCGCCAAGCGCCAGCTCGCCGATGTCGTGCCGCCCG
CCGAACTCTCGGAATGGCTGAGGGGTCGCCGGCTCGACGCGGTGTTTCACATGGGCGCGATCTCGGAAACGACCGCGACC
GATGGCGATCTGGTGATCGACACCAACTTCCGGTTGTCGATGCGGCTGCTCGACTGGTGCACTGAAAACCGGGTGCCGTT
CATCTATGCCTCCTCCGCCGCCACCTATGGCGACGGCGCGCAGGGCTTCAGCGATGATCCATCGCTCGCCGCGCTGAAGC
AATTGCGGCCGATGAATCTCTACGGCTGGAGCAAGCACCTGTTCGATCTCGTGGTGGCCGAGCGCGCCGCACGCGGCGAG
CGGCTGCCGCCGCAATGGGCCGGGTTGAAGTTCTTCAACGTGTTCGGCCCCAACGAGTATCACAAGGGGACGATGGCGAG
CGTGCTGGCGCGGCGCTTCGACGACATCAGGGCCGGGCGCGTGGTGCAGCTGTTCAAGTCGCATCGCGACGGCATCGCCG
ATGGCGACCAGCGCCGCGATTTCATCTATGTCGACGACGTGGTCCGGGTGATGATGTGGCTGTTCGCGACGCCGTCGGTG
AGCGGCCTGTTCAATGTCGGCACCAGCCACGCCCGCAGTTTCCGGGATCTGATCCTCGCCGCCTATTCGGCGCTCGGAAC
CCCGCCGCAAATCGACTACATCGACATGCCGGAACAGATTCGCGGCAGCTATCAGTATTTCACCGAGAGCGAAGGCGACC
GGTTGCGCGCCGCAGGCTACAATGGCGGCTTCACGCCGCTCGAAGATGCGGTCGCTTGCTATGTCAGGGGGTACCTTGAC
GGCAGTGATCGCTTCCGCTGA

Upstream 100 bases:

>100_bases
TTTCGGCCGTGACGCTGGTTCCCGTTGTGCGGAAAGTCAGCCGTTGCCTGCCCGGGCGGACTGGGGCAAAGGTGACCGCG
CAAATTGGGGCGGGGGACTT

Downstream 100 bases:

>100_bases
TGCCGCTCCAACCGCGTCGAGTTCGATGAACAATTTCGACACCCTGCTGCAATCGATCGCCCGGACGACCGTGGTGTGCG
TCGGTGACCTGATGCTCGAC

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MLLVTGGAGFIGSNIAAALNDAGRSDVAVCDFLGHEGKWKNLAKRQLADVVPPAELSEWLRGRRLDAVFHMGAISETTAT
DGDLVIDTNFRLSMRLLDWCTENRVPFIYASSAATYGDGAQGFSDDPSLAALKQLRPMNLYGWSKHLFDLVVAERAARGE
RLPPQWAGLKFFNVFGPNEYHKGTMASVLARRFDDIRAGRVVQLFKSHRDGIADGDQRRDFIYVDDVVRVMMWLFATPSV
SGLFNVGTSHARSFRDLILAAYSALGTPPQIDYIDMPEQIRGSYQYFTESEGDRLRAAGYNGGFTPLEDAVACYVRGYLD
GSDRFR

Sequences:

>Translated_326_residues
MLLVTGGAGFIGSNIAAALNDAGRSDVAVCDFLGHEGKWKNLAKRQLADVVPPAELSEWLRGRRLDAVFHMGAISETTAT
DGDLVIDTNFRLSMRLLDWCTENRVPFIYASSAATYGDGAQGFSDDPSLAALKQLRPMNLYGWSKHLFDLVVAERAARGE
RLPPQWAGLKFFNVFGPNEYHKGTMASVLARRFDDIRAGRVVQLFKSHRDGIADGDQRRDFIYVDDVVRVMMWLFATPSV
SGLFNVGTSHARSFRDLILAAYSALGTPPQIDYIDMPEQIRGSYQYFTESEGDRLRAAGYNGGFTPLEDAVACYVRGYLD
GSDRFR
>Mature_326_residues
MLLVTGGAGFIGSNIAAALNDAGRSDVAVCDFLGHEGKWKNLAKRQLADVVPPAELSEWLRGRRLDAVFHMGAISETTAT
DGDLVIDTNFRLSMRLLDWCTENRVPFIYASSAATYGDGAQGFSDDPSLAALKQLRPMNLYGWSKHLFDLVVAERAARGE
RLPPQWAGLKFFNVFGPNEYHKGTMASVLARRFDDIRAGRVVQLFKSHRDGIADGDQRRDFIYVDDVVRVMMWLFATPSV
SGLFNVGTSHARSFRDLILAAYSALGTPPQIDYIDMPEQIRGSYQYFTESEGDRLRAAGYNGGFTPLEDAVACYVRGYLD
GSDRFR

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=319, Percent_Identity=39.8119122257053, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36158; Mature: 36158

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLVTGGAGFIGSNIAAALNDAGRSDVAVCDFLGHEGKWKNLAKRQLADVVPPAELSEWL
CEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
RGRRLDAVFHMGAISETTATDGDLVIDTNFRLSMRLLDWCTENRVPFIYASSAATYGDGA
HCCCHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCC
QGFSDDPSLAALKQLRPMNLYGWSKHLFDLVVAERAARGERLPPQWAGLKFFNVFGPNEY
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
HKGTMASVLARRFDDIRAGRVVQLFKSHRDGIADGDQRRDFIYVDDVVRVMMWLFATPSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCC
SGLFNVGTSHARSFRDLILAAYSALGTPPQIDYIDMPEQIRGSYQYFTESEGDRLRAAGY
CHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHCCCCCCEEEECCC
NGGFTPLEDAVACYVRGYLDGSDRFR
CCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLLVTGGAGFIGSNIAAALNDAGRSDVAVCDFLGHEGKWKNLAKRQLADVVPPAELSEWL
CEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
RGRRLDAVFHMGAISETTATDGDLVIDTNFRLSMRLLDWCTENRVPFIYASSAATYGDGA
HCCCHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCC
QGFSDDPSLAALKQLRPMNLYGWSKHLFDLVVAERAARGERLPPQWAGLKFFNVFGPNEY
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
HKGTMASVLARRFDDIRAGRVVQLFKSHRDGIADGDQRRDFIYVDDVVRVMMWLFATPSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCC
SGLFNVGTSHARSFRDLILAAYSALGTPPQIDYIDMPEQIRGSYQYFTESEGDRLRAAGY
CHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHCCCCCCEEEECCC
NGGFTPLEDAVACYVRGYLDGSDRFR
CCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]