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The map label for this gene is livH [H]

Identifier: 86748705

GI number: 86748705

Start: 1780132

End: 1780998

Strand: Direct

Name: livH [H]

Synonym: RPB_1580

Alternate gene names: 86748705

Gene position: 1780132-1780998 (Clockwise)

Preceding gene: 86748704

Following gene: 86748706

Centisome position: 33.39

GC content: 65.05

Gene sequence:

>867_bases
ATGACCTTCCTCACCATCCTGTTCGACGGCGTGGCCTACGGCATGTTGCTGTTCGTACTGGCGTGCGGGCTGGCGGTGAC
GCTGGGGCTGATGAATTTCGTCAACCTCGCCCACGGCGCCTTCGCGATGGCCGGCGGCTATGTCTGTGCGGTGCTGGTCA
ACACCAGCGGCTGGCCGTTCTTCGCGGCGCTGCCGATCGCCTTCCTCGCCAGCGCGCTGATCGGCGCGGTGTTCGAACGG
CTGCTGTACCGCCACCTCTACGACCGCTCGCATCTCGACCAGGTGCTGTTCAGCGTCGGTCTCGTCTTCATGTCGGTCGC
CGCGGTCGATTTCATCATGGGATCGTCGCGGATCTTCATCAAATTGCCCGACGCGCTGCAGGGCCAGATCGACCTGTTCG
GCATCGGCATCGGCCGCTACCGGCTGATGATCATCGTGATCTGCGGGCTGCTGACGGTGGCGCTGCAATTGACGCTGGCC
AAGACCCGGTTCGGCAGCCGGCTGCGCGCCGCGGTCGACGATCCGCGCGTCGCAGCCGGCCTCGGCATCAACGTGCCGCA
GGTGTTCGCGCTGACATTTGCATTCGGGTGCGGGCTGGCCGGCTTCGGCGGCGCGCTCTCCGCCGAGATCCTCGGGCTCG
ATCCGTATTTCCCGCTGAAATTCATGATCTACTTCCTGATCGTCGTCACCGTCGGCGGCTCGTCGTCGATCACCGGGCCG
TTCCTCGCCTCCTTGCTGCTCGGCATCGGCGACGTCGCCGGCAAGTACTATTTTCCCAAGCTCGGCCCGTTCGTGATCTA
CACCATCATGATCGTGATCCTGATCTGGCGCCCCAACGGCCTGTTCGGCCGCACCGCGGCGCGGTGA

Upstream 100 bases:

>100_bases
AGGATGACATGCTCCGGCAGAACATCGCCGCCGCCCTTCGAGGGCCGCGAAGACGCGGCCACCTCAGGGTGACGGCGCCC
CCCCGATCGGCGCGCCTCTC

Downstream 100 bases:

>100_bases
CGGCATGACCGCGCCCGCAGATAATGTCGGCTTTCACGCCCGCCGCACCGCTCGCTGGCATGCCGGCGAGTTCGTGTTCT
GGATCGCGCTGATCGGCTGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTFLTILFDGVAYGMLLFVLACGLAVTLGLMNFVNLAHGAFAMAGGYVCAVLVNTSGWPFFAALPIAFLASALIGAVFER
LLYRHLYDRSHLDQVLFSVGLVFMSVAAVDFIMGSSRIFIKLPDALQGQIDLFGIGIGRYRLMIIVICGLLTVALQLTLA
KTRFGSRLRAAVDDPRVAAGLGINVPQVFALTFAFGCGLAGFGGALSAEILGLDPYFPLKFMIYFLIVVTVGGSSSITGP
FLASLLLGIGDVAGKYYFPKLGPFVIYTIMIVILIWRPNGLFGRTAAR

Sequences:

>Translated_288_residues
MTFLTILFDGVAYGMLLFVLACGLAVTLGLMNFVNLAHGAFAMAGGYVCAVLVNTSGWPFFAALPIAFLASALIGAVFER
LLYRHLYDRSHLDQVLFSVGLVFMSVAAVDFIMGSSRIFIKLPDALQGQIDLFGIGIGRYRLMIIVICGLLTVALQLTLA
KTRFGSRLRAAVDDPRVAAGLGINVPQVFALTFAFGCGLAGFGGALSAEILGLDPYFPLKFMIYFLIVVTVGGSSSITGP
FLASLLLGIGDVAGKYYFPKLGPFVIYTIMIVILIWRPNGLFGRTAAR
>Mature_287_residues
TFLTILFDGVAYGMLLFVLACGLAVTLGLMNFVNLAHGAFAMAGGYVCAVLVNTSGWPFFAALPIAFLASALIGAVFERL
LYRHLYDRSHLDQVLFSVGLVFMSVAAVDFIMGSSRIFIKLPDALQGQIDLFGIGIGRYRLMIIVICGLLTVALQLTLAK
TRFGSRLRAAVDDPRVAAGLGINVPQVFALTFAFGCGLAGFGGALSAEILGLDPYFPLKFMIYFLIVVTVGGSSSITGPF
LASLLLGIGDVAGKYYFPKLGPFVIYTIMIVILIWRPNGLFGRTAAR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=300, Percent_Identity=27, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30833; Mature: 30702

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLTILFDGVAYGMLLFVLACGLAVTLGLMNFVNLAHGAFAMAGGYVCAVLVNTSGWPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCH
FAALPIAFLASALIGAVFERLLYRHLYDRSHLDQVLFSVGLVFMSVAAVDFIMGSSRIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
KLPDALQGQIDLFGIGIGRYRLMIIVICGLLTVALQLTLAKTRFGSRLRAAVDDPRVAAG
ECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCC
LGINVPQVFALTFAFGCGLAGFGGALSAEILGLDPYFPLKFMIYFLIVVTVGGSSSITGP
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHCCCCCCCCHH
FLASLLLGIGDVAGKYYFPKLGPFVIYTIMIVILIWRPNGLFGRTAAR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TFLTILFDGVAYGMLLFVLACGLAVTLGLMNFVNLAHGAFAMAGGYVCAVLVNTSGWPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCH
FAALPIAFLASALIGAVFERLLYRHLYDRSHLDQVLFSVGLVFMSVAAVDFIMGSSRIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
KLPDALQGQIDLFGIGIGRYRLMIIVICGLLTVALQLTLAKTRFGSRLRAAVDDPRVAAG
ECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCC
LGINVPQVFALTFAFGCGLAGFGGALSAEILGLDPYFPLKFMIYFLIVVTVGGSSSITGP
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHCCCCCCCCHH
FLASLLLGIGDVAGKYYFPKLGPFVIYTIMIVILIWRPNGLFGRTAAR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]