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The map label for this gene is neuC [H]

Identifier: 86748660

GI number: 86748660

Start: 1728992

End: 1730149

Strand: Direct

Name: neuC [H]

Synonym: RPB_1535

Alternate gene names: 86748660

Gene position: 1728992-1730149 (Clockwise)

Preceding gene: 86748659

Following gene: 86748661

Centisome position: 32.43

GC content: 61.4

Gene sequence:

>1158_bases
ATGACCAAACGGAAAATCTGCGTGGTCGTCGGGTCGCGTGCCAATTACAGTTCCATCAAATCGGCGATGCGTGCGATCCA
GGATCATCCTGCGCTCGAACTGCAATTGATCGTCGCCGCCTCCGCGGTCCTCGATCGATACGGATCGGTGGTGAACCTGA
TCGAGAAGGACGGCTTCCGGCCGCACGCGCGGGTCACCATGCTGATCGAGGGCGAGACCCCCGCGACCATGGCGAAATCG
ACCGGGCTCGGGCTCATCGAACTTCCGACTTTGTTCGAGCAACTCGGGCCGGACGTCGTGCTCACCGTGGGCGATCGTTT
CGAAACGATGGCCACGACGTTGGCTGCCGCCTACATGAATATTCCCGTCGCTCACACCATGGGCGGTGAAGTCAGCGGTA
CCATCGACGAGAGCATCAGGCACGCCGTCACCAAGTTCGCTCATATCCATTTCCCGGCGAGCCAGGGCGCGGCCGAACGC
ATCATCAAGCTCGGCGAACTGCCTCGGCACGTCCATATGGTCGGCTGTCCGCGCATCGACCTGGTTGCGGAAATCCTCGG
GCGTTCGAGCGGCGGACTCGATGCCGGTCTGTTTGATCTGGGGGTCGGCCAGCAGTTTTCGGTCGATGAGCCCTTCGCTC
TGGTTTCCCAGCATCCCGTGACCACCGAATACGGAACCGGCGAGGCGCAGATCACGCTGACGCTCGAGGCGGTTCGCGAA
CAGGGCCTCGCGGCCATCGTGCTGTGGCCGAATGCCGACGCGGGGTCCGACGATATCTCCCGTGGTATTCGGAAGTGGCG
CGAGCGCAAGCTGGACGACCGAATGCACTTCTTCAAGAATTTGCCGATCGAGACCTACGTCAATCTGATGCGTTCCGCGG
CGTGCCTGGTCGGCAATTCGAGCAGCGGCATCAGGGAGGGCGCCTATATCGGCACTCCGGTCGTCAATATCGGCACCCGG
CAGCACATGCGTGACCGCGGCGACAACGTGATCGACGTCGGCTACGACAAGAAACAGATTTCCGATGCGATCGCCAGGCA
AGTCGAGCACGGCCGCTACGCGATGGATCCGATTTACGGAGACGGAACCGCGGGCACGAAGATCGCCGACATACTCGTCA
CGGAGAGGGTGGACGTCCAAAAGTGTATCACCTATTGA

Upstream 100 bases:

>100_bases
CGGGCGACGGGATCTCTGCGGCAAAGTACAAGGACGTGATCGGGCGACGCATCGTTCGGGCGTTGCCGCGCGACCACAAG
TTCGCATACGAGGACTTCGA

Downstream 100 bases:

>100_bases
GTCACGGCCTCCGGACGCGGACGCTGGTGAGATGACGCTCGCTGCTGTCATCCCGGCACGCGGCGGGTCGAAGGGCATCC
CGCGTAAGAATCTCGCGCTG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTKRKICVVVGSRANYSSIKSAMRAIQDHPALELQLIVAASAVLDRYGSVVNLIEKDGFRPHARVTMLIEGETPATMAKS
TGLGLIELPTLFEQLGPDVVLTVGDRFETMATTLAAAYMNIPVAHTMGGEVSGTIDESIRHAVTKFAHIHFPASQGAAER
IIKLGELPRHVHMVGCPRIDLVAEILGRSSGGLDAGLFDLGVGQQFSVDEPFALVSQHPVTTEYGTGEAQITLTLEAVRE
QGLAAIVLWPNADAGSDDISRGIRKWRERKLDDRMHFFKNLPIETYVNLMRSAACLVGNSSSGIREGAYIGTPVVNIGTR
QHMRDRGDNVIDVGYDKKQISDAIARQVEHGRYAMDPIYGDGTAGTKIADILVTERVDVQKCITY

Sequences:

>Translated_385_residues
MTKRKICVVVGSRANYSSIKSAMRAIQDHPALELQLIVAASAVLDRYGSVVNLIEKDGFRPHARVTMLIEGETPATMAKS
TGLGLIELPTLFEQLGPDVVLTVGDRFETMATTLAAAYMNIPVAHTMGGEVSGTIDESIRHAVTKFAHIHFPASQGAAER
IIKLGELPRHVHMVGCPRIDLVAEILGRSSGGLDAGLFDLGVGQQFSVDEPFALVSQHPVTTEYGTGEAQITLTLEAVRE
QGLAAIVLWPNADAGSDDISRGIRKWRERKLDDRMHFFKNLPIETYVNLMRSAACLVGNSSSGIREGAYIGTPVVNIGTR
QHMRDRGDNVIDVGYDKKQISDAIARQVEHGRYAMDPIYGDGTAGTKIADILVTERVDVQKCITY
>Mature_384_residues
TKRKICVVVGSRANYSSIKSAMRAIQDHPALELQLIVAASAVLDRYGSVVNLIEKDGFRPHARVTMLIEGETPATMAKST
GLGLIELPTLFEQLGPDVVLTVGDRFETMATTLAAAYMNIPVAHTMGGEVSGTIDESIRHAVTKFAHIHFPASQGAAERI
IKLGELPRHVHMVGCPRIDLVAEILGRSSGGLDAGLFDLGVGQQFSVDEPFALVSQHPVTTEYGTGEAQITLTLEAVREQ
GLAAIVLWPNADAGSDDISRGIRKWRERKLDDRMHFFKNLPIETYVNLMRSAACLVGNSSSGIREGAYIGTPVVNIGTRQ
HMRDRGDNVIDVGYDKKQISDAIARQVEHGRYAMDPIYGDGTAGTKIADILVTERVDVQKCITY

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=383, Percent_Identity=35.2480417754569, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI298566312, Length=383, Percent_Identity=35.2480417754569, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI4885285, Length=383, Percent_Identity=35.2480417754569, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI298566325, Length=332, Percent_Identity=35.5421686746988, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI298566315, Length=332, Percent_Identity=31.6265060240964, Blast_Score=162, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14

Molecular weight: Translated: 41835; Mature: 41704

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRKICVVVGSRANYSSIKSAMRAIQDHPALELQLIVAASAVLDRYGSVVNLIEKDGFR
CCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
PHARVTMLIEGETPATMAKSTGLGLIELPTLFEQLGPDVVLTVGDRFETMATTLAAAYMN
CCCEEEEEEECCCCHHHHHHCCCCEEHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHC
IPVAHTMGGEVSGTIDESIRHAVTKFAHIHFPASQGAAERIIKLGELPRHVHMVGCPRID
CCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCEEEEECCCHHH
LVAEILGRSSGGLDAGLFDLGVGQQFSVDEPFALVSQHPVTTEYGTGEAQITLTLEAVRE
HHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEEHHHHHH
QGLAAIVLWPNADAGSDDISRGIRKWRERKLDDRMHFFKNLPIETYVNLMRSAACLVGNS
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCC
SSGIREGAYIGTPVVNIGTRQHMRDRGDNVIDVGYDKKQISDAIARQVEHGRYAMDPIYG
CCCCCCCCEECCCEEECCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCEEECCCCC
DGTAGTKIADILVTERVDVQKCITY
CCCCCCHHHHHHHHCCCCHHHHHCC
>Mature Secondary Structure 
TKRKICVVVGSRANYSSIKSAMRAIQDHPALELQLIVAASAVLDRYGSVVNLIEKDGFR
CCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
PHARVTMLIEGETPATMAKSTGLGLIELPTLFEQLGPDVVLTVGDRFETMATTLAAAYMN
CCCEEEEEEECCCCHHHHHHCCCCEEHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHC
IPVAHTMGGEVSGTIDESIRHAVTKFAHIHFPASQGAAERIIKLGELPRHVHMVGCPRID
CCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCEEEEECCCHHH
LVAEILGRSSGGLDAGLFDLGVGQQFSVDEPFALVSQHPVTTEYGTGEAQITLTLEAVRE
HHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEEHHHHHH
QGLAAIVLWPNADAGSDDISRGIRKWRERKLDDRMHFFKNLPIETYVNLMRSAACLVGNS
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCC
SSGIREGAYIGTPVVNIGTRQHMRDRGDNVIDVGYDKKQISDAIARQVEHGRYAMDPIYG
CCCCCCCCEECCCEEECCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCEEECCCCC
DGTAGTKIADILVTERVDVQKCITY
CCCCCCHHHHHHHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine

Specific reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]