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The map label for this gene is msrA2 [H]

Identifier: 86748642

GI number: 86748642

Start: 1711728

End: 1712438

Strand: Direct

Name: msrA2 [H]

Synonym: RPB_1517

Alternate gene names: 86748642

Gene position: 1711728-1712438 (Clockwise)

Preceding gene: 86748638

Following gene: 86748643

Centisome position: 32.1

GC content: 64.84

Gene sequence:

>711_bases
ATGCGCTTCATCAGCCGTCTTGCTCGTAGCGCCGCCGCCCTGAGCGCGCTGGCCCTGTCCGCGAGTTTCACGCCCAGCCT
TGCCGCCGAGGACGCGGTGGTGATCCCGCCGCCAGCGCTCGACGTCAGTTCGGCGGACGGCACCCAGACCGCGGTGTTCG
CGGGCGGCTGTTTCTGGGGCGTGCAGGGCGTGTTCCAGCACACGGCGGGCGTGCTCAACGCGGTGTCGGGCTATTCGGGC
GGCAGCCAGGCGACCGCGAACTACACGGCGATTTCGACCGGCGCCACCGGCCACGCCGAGGCGGTGGAGATCAAGTACAA
TCCGAAACAGATCAGCTACGGCCAGCTGCTGCAGATCTTCTTCTCGGTGGTGCACGATCCGACCCAGCTCAACCGGCAGG
GCCCCGACGTCGGTACGCAATATCGCTCGGCGATCTTCACCGTGAACGACGAGCAGAAGAAGGTCGCGGACGCCTATATC
GCCCAGCTCGACGCCGCGCGGGTCTACAAGAAGCCGATCGTCACCAAGGTCGGCCCGCTGGACGGCTTCTATGCCGCGGA
GGCGTATCATCAGGACTACCTGACGCTGCACCCGACCCAGCCCTATATCGTCTATAATGATCTCCCGAAGATCGAGAACC
TGAAGAAGCTGTTCCCGAAGGACTATCTCACCAAGCCGACGCTGGTGAGCAGCGCCAGGGCCACGAACTAG

Upstream 100 bases:

>100_bases
CACGGAGCTGCGTATCTTGGACAGCCGCGGGTGGAGCGGCAGGGGCCCGCCCGCCCGCTGCCTGCCCCCGCACCGTCCGT
CGAATCCGCGAGGAACCCCC

Downstream 100 bases:

>100_bases
CGGCGATCGCCCACACGTTCAGGAGTTGCCATGACCGATACCAAGACGATACCCGGCAAGGTCGCCAAGAGCGAGGCCGA
GTGGCGCAAGGAACTGACCC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MRFISRLARSAAALSALALSASFTPSLAAEDAVVIPPPALDVSSADGTQTAVFAGGCFWGVQGVFQHTAGVLNAVSGYSG
GSQATANYTAISTGATGHAEAVEIKYNPKQISYGQLLQIFFSVVHDPTQLNRQGPDVGTQYRSAIFTVNDEQKKVADAYI
AQLDAARVYKKPIVTKVGPLDGFYAAEAYHQDYLTLHPTQPYIVYNDLPKIENLKKLFPKDYLTKPTLVSSARATN

Sequences:

>Translated_236_residues
MRFISRLARSAAALSALALSASFTPSLAAEDAVVIPPPALDVSSADGTQTAVFAGGCFWGVQGVFQHTAGVLNAVSGYSG
GSQATANYTAISTGATGHAEAVEIKYNPKQISYGQLLQIFFSVVHDPTQLNRQGPDVGTQYRSAIFTVNDEQKKVADAYI
AQLDAARVYKKPIVTKVGPLDGFYAAEAYHQDYLTLHPTQPYIVYNDLPKIENLKKLFPKDYLTKPTLVSSARATN
>Mature_236_residues
MRFISRLARSAAALSALALSASFTPSLAAEDAVVIPPPALDVSSADGTQTAVFAGGCFWGVQGVFQHTAGVLNAVSGYSG
GSQATANYTAISTGATGHAEAVEIKYNPKQISYGQLLQIFFSVVHDPTQLNRQGPDVGTQYRSAIFTVNDEQKKVADAYI
AQLDAARVYKKPIVTKVGPLDGFYAAEAYHQDYLTLHPTQPYIVYNDLPKIENLKKLFPKDYLTKPTLVSSARATN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=162, Percent_Identity=40.1234567901235, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI208609995, Length=162, Percent_Identity=40.1234567901235, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=41.9642857142857, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1790665, Length=156, Percent_Identity=45.5128205128205, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=160, Percent_Identity=36.875, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=33.9622641509434, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24664627, Length=183, Percent_Identity=32.7868852459016, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24664631, Length=183, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=35.5072463768116, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25307; Mature: 25307

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFISRLARSAAALSALALSASFTPSLAAEDAVVIPPPALDVSSADGTQTAVFAGGCFWG
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECHHHHH
VQGVFQHTAGVLNAVSGYSGGSQATANYTAISTGATGHAEAVEIKYNPKQISYGQLLQIF
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHH
FSVVHDPTQLNRQGPDVGTQYRSAIFTVNDEQKKVADAYIAQLDAARVYKKPIVTKVGPL
HHHHCCHHHHCCCCCCCCHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
DGFYAAEAYHQDYLTLHPTQPYIVYNDLPKIENLKKLFPKDYLTKPTLVSSARATN
CCHHHHHHHCCCCEEECCCCCEEEECCCCCHHHHHHHCCHHHCCCCCHHCCCCCCC
>Mature Secondary Structure
MRFISRLARSAAALSALALSASFTPSLAAEDAVVIPPPALDVSSADGTQTAVFAGGCFWG
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECHHHHH
VQGVFQHTAGVLNAVSGYSGGSQATANYTAISTGATGHAEAVEIKYNPKQISYGQLLQIF
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHH
FSVVHDPTQLNRQGPDVGTQYRSAIFTVNDEQKKVADAYIAQLDAARVYKKPIVTKVGPL
HHHHCCHHHHCCCCCCCCHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
DGFYAAEAYHQDYLTLHPTQPYIVYNDLPKIENLKKLFPKDYLTKPTLVSSARATN
CCHHHHHHHCCCCEEECCCCCEEEECCCCCHHHHHHHCCHHHCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]