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The map label for this gene is coaE

Identifier: 86747523

GI number: 86747523

Start: 442274

End: 442873

Strand: Direct

Name: coaE

Synonym: RPB_0397

Alternate gene names: 86747523

Gene position: 442274-442873 (Clockwise)

Preceding gene: 86747522

Following gene: 86747524

Centisome position: 8.3

GC content: 66.5

Gene sequence:

>600_bases
ATGCTGGTACTCGGGCTCACCGGGTCGATCGGAATGGGGAAATCCACCACCGCGAAGCTGTTCGGGGAGGCCGGGGTGCC
GGTCTACGACGCCGACGCCACCGTGCATCAGATCTACGAAGGCGAAGCGGTGCCGGCGATCGAAGCGGCGTTTCCAGGCA
CCACGGTCGACGGCAAGGTCGACCGCGCGCTGTTGTCGGAGAAGGTCGTGCATGATTCCGATGCGATGAAGCGGCTGGAG
CAAATCGTGCATCCGATGCTGCGCAGCCATCACCAGAACTTCCTCGACGACGCCGAGGCCTCCGGCGCACCGGTCGCGGT
GGTCGATGTGCCGCTGCTGTTCGAAACCGGCGGCGAGAAGCGGGTCGATGCGGTCGTCGTCGTCACCACCTCGCCCGAGG
TGCAGCGCGAGCGAATCCTGGCGCGTGAGAACATGACTCCCGAAAAGCTCGACGCCATCCTGGCGCGGCAGATGCCCGAC
GCCGAAAAGCGCCGGCGCGCGGATTTCGTGGTGGATACCTCGCACGGACTCGATCCGGTGCGCGCGCAGATCCGCGAAAT
CCTCGACGCGGCTGCTAGGATGCCTCGCCGGCGGCCGTGA

Upstream 100 bases:

>100_bases
CACCATTCTGGGCCTGCCGCTGTTGCCCTTGCTCGGCTTTCTGCGTAGCCAGAAACTGCTGGCGTTCTGACGAGAGCCGG
CCAAAAAGCGGAGGGGCGGA

Downstream 100 bases:

>100_bases
TTCGCCGGCGACAACCGGCGGCCCTTCTGCAATGCGCGAAATCGTTCTCGATACCGAAACCACCGGCCTCGATCCGCTGC
GCGGCGACCGGCTGGTCGAG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLVLGLTGSIGMGKSTTAKLFGEAGVPVYDADATVHQIYEGEAVPAIEAAFPGTTVDGKVDRALLSEKVVHDSDAMKRLE
QIVHPMLRSHHQNFLDDAEASGAPVAVVDVPLLFETGGEKRVDAVVVVTTSPEVQRERILARENMTPEKLDAILARQMPD
AEKRRRADFVVDTSHGLDPVRAQIREILDAAARMPRRRP

Sequences:

>Translated_199_residues
MLVLGLTGSIGMGKSTTAKLFGEAGVPVYDADATVHQIYEGEAVPAIEAAFPGTTVDGKVDRALLSEKVVHDSDAMKRLE
QIVHPMLRSHHQNFLDDAEASGAPVAVVDVPLLFETGGEKRVDAVVVVTTSPEVQRERILARENMTPEKLDAILARQMPD
AEKRRRADFVVDTSHGLDPVRAQIREILDAAARMPRRRP
>Mature_199_residues
MLVLGLTGSIGMGKSTTAKLFGEAGVPVYDADATVHQIYEGEAVPAIEAAFPGTTVDGKVDRALLSEKVVHDSDAMKRLE
QIVHPMLRSHHQNFLDDAEASGAPVAVVDVPLLFETGGEKRVDAVVVVTTSPEVQRERILARENMTPEKLDAILARQMPD
AEKRRRADFVVDTSHGLDPVRAQIREILDAAARMPRRRP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=191, Percent_Identity=28.7958115183246, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI191252795, Length=191, Percent_Identity=28.7958115183246, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI110227607, Length=204, Percent_Identity=28.4313725490196, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI110227605, Length=204, Percent_Identity=28.4313725490196, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI110227603, Length=204, Percent_Identity=28.4313725490196, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI110227601, Length=204, Percent_Identity=28.4313725490196, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI205277394, Length=204, Percent_Identity=28.4313725490196, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786292, Length=186, Percent_Identity=31.7204301075269, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17554944, Length=198, Percent_Identity=29.2929292929293, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320402, Length=197, Percent_Identity=28.9340101522843, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644728, Length=181, Percent_Identity=30.939226519337, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_RHOP2 (Q2J352)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_484019.1
- ProteinModelPortal:   Q2J352
- SMR:   Q2J352
- STRING:   Q2J352
- GeneID:   3908835
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_0397
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   LSAKVVH
- ProtClustDB:   PRK00081
- BioCyc:   RPAL316058:RPB_0397-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21695; Mature: 21695

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLGLTGSIGMGKSTTAKLFGEAGVPVYDADATVHQIYEGEAVPAIEAAFPGTTVDGKV
CEEEEECCCCCCCCCHHHHHHCCCCCEEEECCCHHHHHHCCCCCCCHHHCCCCCCCCCHH
DRALLSEKVVHDSDAMKRLEQIVHPMLRSHHQNFLDDAEASGAPVAVVDVPLLFETGGEK
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCC
RVDAVVVVTTSPEVQRERILARENMTPEKLDAILARQMPDAEKRRRADFVVDTSHGLDPV
CEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCCHH
RAQIREILDAAARMPRRRP
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLVLGLTGSIGMGKSTTAKLFGEAGVPVYDADATVHQIYEGEAVPAIEAAFPGTTVDGKV
CEEEEECCCCCCCCCHHHHHHCCCCCEEEECCCHHHHHHCCCCCCCHHHCCCCCCCCCHH
DRALLSEKVVHDSDAMKRLEQIVHPMLRSHHQNFLDDAEASGAPVAVVDVPLLFETGGEK
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCC
RVDAVVVVTTSPEVQRERILARENMTPEKLDAILARQMPDAEKRRRADFVVDTSHGLDPV
CEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCCHH
RAQIREILDAAARMPRRRP
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA