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The map label for this gene is sdhA [H]

Identifier: 86609574

GI number: 86609574

Start: 2220623

End: 2222338

Strand: Direct

Name: sdhA [H]

Synonym: CYB_2127

Alternate gene names: 86609574

Gene position: 2220623-2222338 (Clockwise)

Preceding gene: 86609573

Following gene: 86609575

Centisome position: 72.89

GC content: 60.37

Gene sequence:

>1716_bases
ATGCTGGAACACGACATTGTCATCATCGGGGGAGGGCTGGCCGGTTGCCGAGCGGCTTTGGAGGTTATGCGACGGGATCC
CAGCCTCGACCTGGCCTTGGTGTCCAAAACCCATCCCATTCGCAGCCACTCGGTAGCAGCCCAAGGGGGCATTGCCGCCG
CCTTACAAAATGTTGATCCGCAAGATTCCTGGGAGGCTCATGCCTTCGATACCGTCAAGGGATCCGATTACCTAGCGGAT
CAAGATGCGGTGGAGATTCTAGCCCGGGAAGCCCCTGAGGTGATCATCGACCTAGAACACTTGGGGGTCTTGTTCTCCCG
CCTGCCGGATGGCCGCATTGCCCAGCGGGCCTTTGGGGGACACAGCCACCCGCGCACCTGCTATGCCGCCGACAAAACTG
GGCAGGCCATTCTACACGAGTTGGTGAGCAACCTCAAGCGCTTTGGGGTCAAACTCTACAGCGAATGGTATGTGCTGGAT
CTGATCCTGGAGGACAACCAAGTCCAGGGCGTAGTGATGTTGGAGCAGGCCAGCGGACGGCTGGAAGTGCTGCGGGCCAA
GGCGGTTATGTTGGCTACAGGCGGCTATGGGCGCATCTACAACTCCACGTCCAACGACTTTGCTTCCACCGGCGATGGCA
TGGCAATGGTGGCGCGGGCCGGCCTGCCTCTGCAGGATATGGAGTTTGTGCAGTTTCATCCCACGGGCCTGTATCCGGTG
GGGGTGTTGATCTCAGAGGCAGTGCGCGGAGAGGGGGCCTATCTGATCAATGGGAAGGGGGAGCGCTTTATGGCCGCCTA
TGCCCCCAGCCAGATGGAATTGGCCCCACGGGACATCACCTCGCGGGCGATTGTTACGGAGGTGCGGGCCGGGCGCGGTA
TTGACGGCAAAGATTTTGTCTACTTAGACCTGCGGCATCTGGGGGCAGAAAAGATCCACACTCGGCTGCCCTTCTGTTGG
GAGGAGGCCCATCGCCACTTGGGCATCGATGCGGTTGTCGATCCCATTCCAGTGCGACCGACGGTGCACTACTGCATGGG
CGGGATCCCGGTGACGGTGGAGGGGCAGGTACTGCGGGATGCCCAAACCCGTGTGGAAGGGCTGTTCGCTGCCGGTGAAA
CGGCCTGTGTTTCGGTGCATGGGGCTAATCGGCTGGGCAGCAACTCTCTCCTGGAGTGCGTTGTTTTCGGGCGGCGCACA
GGGGCAGCCATGGTAGAGGCCGTCAGAGGTCGAGCCTTGCCGAAAGTGGACGAGGGATCCCTACTCAAACAGGCCGCCAG
CCGGATTGCCGGGCTCCTGGAACGATCAGGGAAGAGCCGCATTGATCAGGTGCGGCGGCAATTTCAAGATTGCATGACCG
AGCATTGCGGCGTTTACCGCACCGAATCGGTTCTCCAAGAAGGGATCCAAAAATGGCAGCAGATCCGCCAGCGTTACGAG
CGGGATTTGCATTTGGACGATCGGGGCAAGGTGTGGAACACCGAGCTGATCGAAGCGCTGGAGCTGGACAACCTCATGAC
GGTGGGGGCTTTGATCCTCGCCAGCGCCCTGGAACGGCGGGAAAGCCGTGGCTCCCACGCGCGGGAAGATTACCCCCAAC
GGGATGATCAACGGTTTTTACAACACACCTTGGCTGCCTTTCGCGAGGGATCCCCTCAGATCAGCTATCGCCCCGTGGTG
ATCACCCGGTTTCCCCCTCAGGAGCGAAAATACTAA

Upstream 100 bases:

>100_bases
CTATACTCAGCTGCTGCTGGAGAGGCTGCTGGGGCCGGCCATAATGGGAAAACGCCATCCTGGCTGTGGCGGAATCCTTT
GCGAGAGCTTGCCTGCATCC

Downstream 100 bases:

>100_bases
CTTTCCAGAGGCCTCCCAGGCCGATTAGGATTGCTCTATCGTTCCCGTTAGCAGGATGGAGCCCCTTTCAAAATTATCCA
ATATCCAGGGATTCCATCTT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MLEHDIVIIGGGLAGCRAALEVMRRDPSLDLALVSKTHPIRSHSVAAQGGIAAALQNVDPQDSWEAHAFDTVKGSDYLAD
QDAVEILAREAPEVIIDLEHLGVLFSRLPDGRIAQRAFGGHSHPRTCYAADKTGQAILHELVSNLKRFGVKLYSEWYVLD
LILEDNQVQGVVMLEQASGRLEVLRAKAVMLATGGYGRIYNSTSNDFASTGDGMAMVARAGLPLQDMEFVQFHPTGLYPV
GVLISEAVRGEGAYLINGKGERFMAAYAPSQMELAPRDITSRAIVTEVRAGRGIDGKDFVYLDLRHLGAEKIHTRLPFCW
EEAHRHLGIDAVVDPIPVRPTVHYCMGGIPVTVEGQVLRDAQTRVEGLFAAGETACVSVHGANRLGSNSLLECVVFGRRT
GAAMVEAVRGRALPKVDEGSLLKQAASRIAGLLERSGKSRIDQVRRQFQDCMTEHCGVYRTESVLQEGIQKWQQIRQRYE
RDLHLDDRGKVWNTELIEALELDNLMTVGALILASALERRESRGSHAREDYPQRDDQRFLQHTLAAFREGSPQISYRPVV
ITRFPPQERKY

Sequences:

>Translated_571_residues
MLEHDIVIIGGGLAGCRAALEVMRRDPSLDLALVSKTHPIRSHSVAAQGGIAAALQNVDPQDSWEAHAFDTVKGSDYLAD
QDAVEILAREAPEVIIDLEHLGVLFSRLPDGRIAQRAFGGHSHPRTCYAADKTGQAILHELVSNLKRFGVKLYSEWYVLD
LILEDNQVQGVVMLEQASGRLEVLRAKAVMLATGGYGRIYNSTSNDFASTGDGMAMVARAGLPLQDMEFVQFHPTGLYPV
GVLISEAVRGEGAYLINGKGERFMAAYAPSQMELAPRDITSRAIVTEVRAGRGIDGKDFVYLDLRHLGAEKIHTRLPFCW
EEAHRHLGIDAVVDPIPVRPTVHYCMGGIPVTVEGQVLRDAQTRVEGLFAAGETACVSVHGANRLGSNSLLECVVFGRRT
GAAMVEAVRGRALPKVDEGSLLKQAASRIAGLLERSGKSRIDQVRRQFQDCMTEHCGVYRTESVLQEGIQKWQQIRQRYE
RDLHLDDRGKVWNTELIEALELDNLMTVGALILASALERRESRGSHAREDYPQRDDQRFLQHTLAAFREGSPQISYRPVV
ITRFPPQERKY
>Mature_571_residues
MLEHDIVIIGGGLAGCRAALEVMRRDPSLDLALVSKTHPIRSHSVAAQGGIAAALQNVDPQDSWEAHAFDTVKGSDYLAD
QDAVEILAREAPEVIIDLEHLGVLFSRLPDGRIAQRAFGGHSHPRTCYAADKTGQAILHELVSNLKRFGVKLYSEWYVLD
LILEDNQVQGVVMLEQASGRLEVLRAKAVMLATGGYGRIYNSTSNDFASTGDGMAMVARAGLPLQDMEFVQFHPTGLYPV
GVLISEAVRGEGAYLINGKGERFMAAYAPSQMELAPRDITSRAIVTEVRAGRGIDGKDFVYLDLRHLGAEKIHTRLPFCW
EEAHRHLGIDAVVDPIPVRPTVHYCMGGIPVTVEGQVLRDAQTRVEGLFAAGETACVSVHGANRLGSNSLLECVVFGRRT
GAAMVEAVRGRALPKVDEGSLLKQAASRIAGLLERSGKSRIDQVRRQFQDCMTEHCGVYRTESVLQEGIQKWQQIRQRYE
RDLHLDDRGKVWNTELIEALELDNLMTVGALILASALERRESRGSHAREDYPQRDDQRFLQHTLAAFREGSPQISYRPVV
ITRFPPQERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=589, Percent_Identity=45.1612903225806, Blast_Score=470, Evalue=1e-132,
Organism=Escherichia coli, GI1786942, Length=593, Percent_Identity=44.8566610455312, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1790597, Length=562, Percent_Identity=43.0604982206406, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1788928, Length=545, Percent_Identity=35.7798165137615, Blast_Score=256, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17505833, Length=584, Percent_Identity=42.8082191780822, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17550100, Length=586, Percent_Identity=41.8088737201365, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71986328, Length=457, Percent_Identity=28.2275711159737, Blast_Score=111, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322416, Length=565, Percent_Identity=44.7787610619469, Blast_Score=482, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6322701, Length=564, Percent_Identity=44.6808510638298, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6320788, Length=471, Percent_Identity=29.2993630573248, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322511, Length=471, Percent_Identity=28.0254777070064, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17137288, Length=580, Percent_Identity=43.448275862069, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24655642, Length=580, Percent_Identity=43.448275862069, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24655647, Length=580, Percent_Identity=43.448275862069, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24663005, Length=582, Percent_Identity=40.5498281786942, Blast_Score=417, Evalue=1e-116,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63143; Mature: 63143

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHDIVIIGGGLAGCRAALEVMRRDPSLDLALVSKTHPIRSHSVAAQGGIAAALQNVDP
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHCCCHHHHHHCCCC
QDSWEAHAFDTVKGSDYLADQDAVEILAREAPEVIIDLEHLGVLFSRLPDGRIAQRAFGG
CCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCHHHHHHCCC
HSHPRTCYAADKTGQAILHELVSNLKRFGVKLYSEWYVLDLILEDNQVQGVVMLEQASGR
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEECCCCC
LEVLRAKAVMLATGGYGRIYNSTSNDFASTGDGMAMVARAGLPLQDMEFVQFHPTGLYPV
HHHHHHEEEEEEECCCCEEECCCCCCCCCCCCCCEEHHHCCCCCCCCCEEEECCCCCCHH
GVLISEAVRGEGAYLINGKGERFMAAYAPSQMELAPRDITSRAIVTEVRAGRGIDGKDFV
HHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEE
YLDLRHLGAEKIHTRLPFCWEEAHRHLGIDAVVDPIPVRPTVHYCMGGIPVTVEGQVLRD
EEEHHHCCHHHHHHCCCHHHHHHHHHCCCHHHCCCCCCCCHHHHHCCCEEEEECCHHHHH
AQTRVEGLFAAGETACVSVHGANRLGSNSLLECVVFGRRTGAAMVEAVRGRALPKVDEGS
HHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCH
LLKQAASRIAGLLERSGKSRIDQVRRQFQDCMTEHCGVYRTESVLQEGIQKWQQIRQRYE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RDLHLDDRGKVWNTELIEALELDNLMTVGALILASALERRESRGSHAREDYPQRDDQRFL
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHH
QHTLAAFREGSPQISYRPVVITRFPPQERKY
HHHHHHHHCCCCCCEECCEEEEECCCCCCCC
>Mature Secondary Structure
MLEHDIVIIGGGLAGCRAALEVMRRDPSLDLALVSKTHPIRSHSVAAQGGIAAALQNVDP
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHCCCHHHHHHCCCC
QDSWEAHAFDTVKGSDYLADQDAVEILAREAPEVIIDLEHLGVLFSRLPDGRIAQRAFGG
CCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCHHHHHHCCC
HSHPRTCYAADKTGQAILHELVSNLKRFGVKLYSEWYVLDLILEDNQVQGVVMLEQASGR
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEECCCCC
LEVLRAKAVMLATGGYGRIYNSTSNDFASTGDGMAMVARAGLPLQDMEFVQFHPTGLYPV
HHHHHHEEEEEEECCCCEEECCCCCCCCCCCCCCEEHHHCCCCCCCCCEEEECCCCCCHH
GVLISEAVRGEGAYLINGKGERFMAAYAPSQMELAPRDITSRAIVTEVRAGRGIDGKDFV
HHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEE
YLDLRHLGAEKIHTRLPFCWEEAHRHLGIDAVVDPIPVRPTVHYCMGGIPVTVEGQVLRD
EEEHHHCCHHHHHHCCCHHHHHHHHHCCCHHHCCCCCCCCHHHHHCCCEEEEECCHHHHH
AQTRVEGLFAAGETACVSVHGANRLGSNSLLECVVFGRRTGAAMVEAVRGRALPKVDEGS
HHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCH
LLKQAASRIAGLLERSGKSRIDQVRRQFQDCMTEHCGVYRTESVLQEGIQKWQQIRQRYE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RDLHLDDRGKVWNTELIEALELDNLMTVGALILASALERRESRGSHAREDYPQRDDQRFL
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHH
QHTLAAFREGSPQISYRPVVITRFPPQERKY
HHHHHHHHCCCCCCEECCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA