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The map label for this gene is trx-3 [C]

Identifier: 86609378

GI number: 86609378

Start: 2006634

End: 2006954

Strand: Reverse

Name: trx-3 [C]

Synonym: CYB_1922

Alternate gene names: 86609378

Gene position: 2006954-2006634 (Counterclockwise)

Preceding gene: 86609380

Following gene: 86609377

Centisome position: 65.87

GC content: 54.21

Gene sequence:

>321_bases
ATGGCGCACAAACAGCAATTCAAAAGTTTTGCCGACATGATTCAGGGATCCAAAACCCCGATCCTGGTGGATTTTTATGC
TTCCTGGTGCGGCCCTTGTCAGGTTATGGCGCAAGTGTTGGAGCAGGTAAAACCTCAGGTGGGGGATGCGGTTACTTTTG
TGAAGGTTGACACCGAAAAGTACCCAACCATCGCTGCTCGCTGGGGCATTCAAGCGGTGCCAACGCTGATCCTCTTCAAA
GATGGGAAGCCGATTGACCGCATTGAGGGGCTGTTGCAGCCGCGGGCCCTGTTGGAGCGGTTGCGGGCGCAGGTTAACTA
A

Upstream 100 bases:

>100_bases
AGCAGGCCGTAGCGGGATCCCTACCTAATTTTTAGTCTCAAACAGTTAGCTTACAAATAGATTTCATTTCAGGCTTTTCA
GAACACTCTGGGAGTTTCCT

Downstream 100 bases:

>100_bases
ACCTGTAAGCTAGGTGAACTTTTCTGGATCCCCCGTGCAACTGCCGCTTCTGCAGGTTCACCTGCCGGGTGAAGTGCCCT
ACCGCACTGCCTGGGCTTGG

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MAHKQQFKSFADMIQGSKTPILVDFYASWCGPCQVMAQVLEQVKPQVGDAVTFVKVDTEKYPTIAARWGIQAVPTLILFK
DGKPIDRIEGLLQPRALLERLRAQVN

Sequences:

>Translated_106_residues
MAHKQQFKSFADMIQGSKTPILVDFYASWCGPCQVMAQVLEQVKPQVGDAVTFVKVDTEKYPTIAARWGIQAVPTLILFK
DGKPIDRIEGLLQPRALLERLRAQVN
>Mature_105_residues
AHKQQFKSFADMIQGSKTPILVDFYASWCGPCQVMAQVLEQVKPQVGDAVTFVKVDTEKYPTIAARWGIQAVPTLILFKD
GKPIDRIEGLLQPRALLERLRAQVN

Specific function: Efficient Electron Donor For The Essential Enzyme Ribonucleotide Reductase. Is Also Able To Reduce The Interchain Disulfide Bridges Of Insulin. [C]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=100, Percent_Identity=34, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=37.6470588235294, Blast_Score=75, Evalue=7e-16,
Organism=Escherichia coli, GI87082331, Length=97, Percent_Identity=35.0515463917526, Blast_Score=72, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=82, Percent_Identity=37.8048780487805, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=90, Percent_Identity=34.4444444444444, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=36.9047619047619, Blast_Score=67, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=92, Percent_Identity=38.0434782608696, Blast_Score=63, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573567, Length=84, Percent_Identity=34.5238095238095, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24658597, Length=80, Percent_Identity=38.75, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17648013, Length=93, Percent_Identity=29.0322580645161, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583090, Length=93, Percent_Identity=29.0322580645161, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 11900; Mature: 11769

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHKQQFKSFADMIQGSKTPILVDFYASWCGPCQVMAQVLEQVKPQVGDAVTFVKVDTEK
CCCHHHHHHHHHHHCCCCCCEEEEHHHHCCCHHHHHHHHHHHHCHHCCCEEEEEEECCCC
YPTIAARWGIQAVPTLILFKDGKPIDRIEGLLQPRALLERLRAQVN
CCHHHHHCCHHHHCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AHKQQFKSFADMIQGSKTPILVDFYASWCGPCQVMAQVLEQVKPQVGDAVTFVKVDTEK
CCHHHHHHHHHHHCCCCCCEEEEHHHHCCCHHHHHHHHHHHHCHHCCCEEEEEEECCCC
YPTIAARWGIQAVPTLILFKDGKPIDRIEGLLQPRALLERLRAQVN
CCHHHHHCCHHHHCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]