Definition Synechococcus sp. JA-2-3B'a(2-13), complete genome.
Accession NC_007776
Length 3,046,682

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The map label for this gene is serS

Identifier: 86609248

GI number: 86609248

Start: 1877968

End: 1879275

Strand: Direct

Name: serS

Synonym: CYB_1790

Alternate gene names: 86609248

Gene position: 1877968-1879275 (Clockwise)

Preceding gene: 86609247

Following gene: 86609261

Centisome position: 61.64

GC content: 60.86

Gene sequence:

>1308_bases
GTGCTGGATCTGAAGCTGCTGCGGGATCGCCCTGAACAAGTACGCCAAGCCCTGCAAAATCGCCGGGCCACAGTCGATCT
GGACGGGATCCTGCAGTTGGATCGGGAGCGGCGGCAGTTGGAGACCCGCAAGGGATCCCTGCAGGCCGAAAGCAACAGCC
TCGGCAAAAAAGTCGGCGAGATCATCCGCCAGGGGGCGGATCCCCAAGGCCCCGAAGTGGCGGCCCTGCGGCAGCGGGGG
GTGGATCTCAAGGCCGAGATTGCCCAACTGGAGCAGCAGGAACGGGAGCTGGAAGAGGAGATTCGTGCTCGGCTGCTTAC
CCTGCCCAATTTGCCCCTGCCCAGCGTGCCGGTTGGCCGAGATGAGGCCGACAATGTAGAGGTGCGCCGCTGGGGTGAGG
AGCTAAAGCCGGCCCATCCTGTCCTTCCCCATGACGAGATTGCCGAAAAACTGGGGTTGCTGGAGATTGGCCGTGCGGTC
AAAGTGGCCCAAAGCCGCTTTGTGGCTATGGTAGGGGCGGGCGCGGCCCTGGAACGGGCCTTGATTGCCATGATGCTGGA
GCGCCACATTGCAGCCGGCTACACCGAGGTGATCCCGCCCTTTTTGGTCAACAGCGCTGCTTTACAGGGGACGGGGCAAT
TGCCCAAGTTCGCCGAAGATAGTTTTCGCTGTGCTGATGACGACCTGTGGCTGATCCCGACCGCGGAAGTTCCCCTCACC
AACCTGTACCGGGATGAGATGATCCCTGCAGAGTCTCTTCCTCTCTACTTCTGTGCTTACACCCCATGTTTTCGCCGCGA
GGCGGGCAGCTATGGCCGCGACACCAAGGGGCTGATCCGATTGCACCAATTTCAAAAAGTGGAGCTGGTCAAGGTCACTC
GCCCAGATCAATCGGAAGCCGAACACGAGAAGCTGGTGCAGGATGCCGAGGCCATCTTACAGATGCTGGAGCTGCCCTAC
CGGGTGGTGGAGCTGTGTAGCGGCGATTTGGGCTTTGCGGCAGCCCGCTGCTTTGACTTGGAGGTGTGGTTCCCCTCCCA
AAATCAATACCGCGAGATCTCCAGTTGCTCCAACTGCTGGGACTTTCAGGCCCGCCGTGCTAACCTGCGCTACAAAGAAG
CCGGCCAGAAAGGCACCCAGTTTGTCCACACCCTGAACGGATCTGGCTTGGCGGTGGGGCGCTCTCTGGCTGCCCTGCTG
GAAAATCACCAACAGCCGGATGGCTCGATTCGCATTCCCAAGGCGCTGCGTCCCTTTCTCAGCTCCCGGTTTCTCTCGGA
AGACGGGATCCTCATTCCTGCTGCCTGA

Upstream 100 bases:

>100_bases
GGCCGAACACCCCATTGAACAGGTGGGCAGGGAGCTGCGGGCCATGTTTAGCTGGCTAAAGAAATAGTCGGGTATCTGGA
GCTGAGGGTAGACCATCTCT

Downstream 100 bases:

>100_bases
GCTCAAACTCAACAAGATTGGATTGAGATGCTCCTGCCCAGATAGGCGGGTGTTCCCATCTTTTCTCCGACGACGGAGAA
TTGCAAGCTGTCTCACGGCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLDLKLLRDRPEQVRQALQNRRATVDLDGILQLDRERRQLETRKGSLQAESNSLGKKVGEIIRQGADPQGPEVAALRQRG
VDLKAEIAQLEQQERELEEEIRARLLTLPNLPLPSVPVGRDEADNVEVRRWGEELKPAHPVLPHDEIAEKLGLLEIGRAV
KVAQSRFVAMVGAGAALERALIAMMLERHIAAGYTEVIPPFLVNSAALQGTGQLPKFAEDSFRCADDDLWLIPTAEVPLT
NLYRDEMIPAESLPLYFCAYTPCFRREAGSYGRDTKGLIRLHQFQKVELVKVTRPDQSEAEHEKLVQDAEAILQMLELPY
RVVELCSGDLGFAAARCFDLEVWFPSQNQYREISSCSNCWDFQARRANLRYKEAGQKGTQFVHTLNGSGLAVGRSLAALL
ENHQQPDGSIRIPKALRPFLSSRFLSEDGILIPAA

Sequences:

>Translated_435_residues
MLDLKLLRDRPEQVRQALQNRRATVDLDGILQLDRERRQLETRKGSLQAESNSLGKKVGEIIRQGADPQGPEVAALRQRG
VDLKAEIAQLEQQERELEEEIRARLLTLPNLPLPSVPVGRDEADNVEVRRWGEELKPAHPVLPHDEIAEKLGLLEIGRAV
KVAQSRFVAMVGAGAALERALIAMMLERHIAAGYTEVIPPFLVNSAALQGTGQLPKFAEDSFRCADDDLWLIPTAEVPLT
NLYRDEMIPAESLPLYFCAYTPCFRREAGSYGRDTKGLIRLHQFQKVELVKVTRPDQSEAEHEKLVQDAEAILQMLELPY
RVVELCSGDLGFAAARCFDLEVWFPSQNQYREISSCSNCWDFQARRANLRYKEAGQKGTQFVHTLNGSGLAVGRSLAALL
ENHQQPDGSIRIPKALRPFLSSRFLSEDGILIPAA
>Mature_435_residues
MLDLKLLRDRPEQVRQALQNRRATVDLDGILQLDRERRQLETRKGSLQAESNSLGKKVGEIIRQGADPQGPEVAALRQRG
VDLKAEIAQLEQQERELEEEIRARLLTLPNLPLPSVPVGRDEADNVEVRRWGEELKPAHPVLPHDEIAEKLGLLEIGRAV
KVAQSRFVAMVGAGAALERALIAMMLERHIAAGYTEVIPPFLVNSAALQGTGQLPKFAEDSFRCADDDLWLIPTAEVPLT
NLYRDEMIPAESLPLYFCAYTPCFRREAGSYGRDTKGLIRLHQFQKVELVKVTRPDQSEAEHEKLVQDAEAILQMLELPY
RVVELCSGDLGFAAARCFDLEVWFPSQNQYREISSCSNCWDFQARRANLRYKEAGQKGTQFVHTLNGSGLAVGRSLAALL
ENHQQPDGSIRIPKALRPFLSSRFLSEDGILIPAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=462, Percent_Identity=31.8181818181818, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI8923421, Length=436, Percent_Identity=34.1743119266055, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI225579074, Length=442, Percent_Identity=32.8054298642534, Blast_Score=198, Evalue=1e-50,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=49.6503496503497, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17539260, Length=467, Percent_Identity=30.406852248394, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17542084, Length=341, Percent_Identity=31.3782991202346, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=441, Percent_Identity=34.0136054421769, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6321799, Length=433, Percent_Identity=30.2540415704388, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24581334, Length=478, Percent_Identity=31.7991631799163, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17737985, Length=368, Percent_Identity=28.804347826087, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_SYNJB (Q2JKN4)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_478010.1
- ProteinModelPortal:   Q2JKN4
- SMR:   Q2JKN4
- STRING:   Q2JKN4
- GeneID:   3901138
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_1790
- TIGR:   CYB_1790
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q2JKN4
- ProtClustDB:   PRK05431
- BioCyc:   SSP321332:CYB_1790-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48710; Mature: 48710

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 288-288 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLDLKLLRDRPEQVRQALQNRRATVDLDGILQLDRERRQLETRKGSLQAESNSLGKKVGE
CCCHHHHHCCHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IIRQGADPQGPEVAALRQRGVDLKAEIAQLEQQERELEEEIRARLLTLPNLPLPSVPVGR
HHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEADNVEVRRWGEELKPAHPVLPHDEIAEKLGLLEIGRAVKVAQSRFVAMVGAGAALERA
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LIAMMLERHIAAGYTEVIPPFLVNSAALQGTGQLPKFAEDSFRCADDDLWLIPTAEVPLT
HHHHHHHHHHHCCHHHHCCHHHHCCHHHCCCCCCCCHHCCCCCCCCCCEEEEECCCCCHH
NLYRDEMIPAESLPLYFCAYTPCFRREAGSYGRDTKGLIRLHQFQKVELVKVTRPDQSEA
HHHHHHCCCCCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCHH
EHEKLVQDAEAILQMLELPYRVVELCSGDLGFAAARCFDLEVWFPSQNQYREISSCSNCW
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEEECCCCHHHHHHHHHHHHH
DFQARRANLRYKEAGQKGTQFVHTLNGSGLAVGRSLAALLENHQQPDGSIRIPKALRPFL
HHHHHHCCCCHHHCCCHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHH
SSRFLSEDGILIPAA
HHHHCCCCCEEECCC
>Mature Secondary Structure
MLDLKLLRDRPEQVRQALQNRRATVDLDGILQLDRERRQLETRKGSLQAESNSLGKKVGE
CCCHHHHHCCHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IIRQGADPQGPEVAALRQRGVDLKAEIAQLEQQERELEEEIRARLLTLPNLPLPSVPVGR
HHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEADNVEVRRWGEELKPAHPVLPHDEIAEKLGLLEIGRAVKVAQSRFVAMVGAGAALERA
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LIAMMLERHIAAGYTEVIPPFLVNSAALQGTGQLPKFAEDSFRCADDDLWLIPTAEVPLT
HHHHHHHHHHHCCHHHHCCHHHHCCHHHCCCCCCCCHHCCCCCCCCCCEEEEECCCCCHH
NLYRDEMIPAESLPLYFCAYTPCFRREAGSYGRDTKGLIRLHQFQKVELVKVTRPDQSEA
HHHHHHCCCCCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCHH
EHEKLVQDAEAILQMLELPYRVVELCSGDLGFAAARCFDLEVWFPSQNQYREISSCSNCW
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEEECCCCHHHHHHHHHHHHH
DFQARRANLRYKEAGQKGTQFVHTLNGSGLAVGRSLAALLENHQQPDGSIRIPKALRPFL
HHHHHHCCCCHHHCCCHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHH
SSRFLSEDGILIPAA
HHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA