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The map label for this gene is ilvC [H]

Identifier: 86609247

GI number: 86609247

Start: 1876942

End: 1877934

Strand: Direct

Name: ilvC [H]

Synonym: CYB_1789

Alternate gene names: 86609247

Gene position: 1876942-1877934 (Clockwise)

Preceding gene: 86609246

Following gene: 86609248

Centisome position: 61.61

GC content: 60.12

Gene sequence:

>993_bases
ATGGCCCGCCTCTACTACGACACCGACGCCAATCTGGAGCCTTTGGCCGATAAAACCGTTGCCATCATCGGCTATGGCAG
CCAAGGCCACGCCCACGCCCTCAATTTGCGCGATAGCGGTGTCCAGGTCATCGTTGGCCTTTACCCTGGCAGCCCTTCCT
GGCCCAAAGCCGAGCAAGACGGCTTGATGGTCAAAACGGTGGCGGATGCTGCCGCTGCCGCCGACTGGGTGATGATTTTA
CTGCCCGATGAAGTGCAAAAGGCCGTTTTCCAGGGCGAAATCCGTCCCCACCTGCAGCCGGGGAACGTGCTCCTCTTTGC
CCATGGCTTCAACATTCACTTCGGGCAGATCCAGCCGCCGGCAAACGTGGATGTCATCATGGTTGCCCCCAAAGGCCCTG
GGCACTTGGTGCGGCGCACCTACCAAGCGGGGGAAGGGGTGCCCTGCCTGTTTGCCGTCTATCAAGATGCCTCGGGAATG
GCACGGGAGCGGGCCATGGCCTATGCCAAAGCCATCGGTGGCACGCGGGCCGGCATTTTGGAAACCACCTTCCGGGAAGA
GACCGAAACCGACCTCTTTGGCGAGCAGGTGGTGCTCTGCGGTGGTCTGACGGCTCTGATCAAAGCGGGGTTTGAAACCT
TGGTGGAAGCGGGCTACCAGCCGGAACTGGCCTACTTCGAGTGCCTGCACGAGGTGAAGCTGATCGTGGATCTCATTGTC
GAGGGGGGCTTGGAGAAAATGCGCCACAGCATCTCCAACACGGCAGAATACGGCGACTACACCCGTGGCCCCCGCATCAT
CACGGAGCAAACCCGCGCTGAAATGAAACGGATCCTCGCCGAGATTCAAAGCGGCCAATTTGCCCGTGAATTTGTCTTGG
AAAATCAGGCCGGCAAGCCAGGGCTTACTGCGATGCGGCGCCGCGAGGCCGAACACCCCATTGAACAGGTGGGCAGGGAG
CTGCGGGCCATGTTTAGCTGGCTAAAGAAATAG

Upstream 100 bases:

>100_bases
CCTAAGGTGGGTGAAAACTGTTCATCACGGCGCTTGAGGTCAGCAAGTTGGATCCAATCCTGCTATCCTAGTCAAGCACC
TGCTCACGCCCTGCTCGACC

Downstream 100 bases:

>100_bases
TCGGGTATCTGGAGCTGAGGGTAGACCATCTCTGTGCTGGATCTGAAGCTGCTGCGGGATCGCCCTGAACAAGTACGCCA
AGCCCTGCAAAATCGCCGGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MARLYYDTDANLEPLADKTVAIIGYGSQGHAHALNLRDSGVQVIVGLYPGSPSWPKAEQDGLMVKTVADAAAAADWVMIL
LPDEVQKAVFQGEIRPHLQPGNVLLFAHGFNIHFGQIQPPANVDVIMVAPKGPGHLVRRTYQAGEGVPCLFAVYQDASGM
ARERAMAYAKAIGGTRAGILETTFREETETDLFGEQVVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLIV
EGGLEKMRHSISNTAEYGDYTRGPRIITEQTRAEMKRILAEIQSGQFAREFVLENQAGKPGLTAMRRREAEHPIEQVGRE
LRAMFSWLKK

Sequences:

>Translated_330_residues
MARLYYDTDANLEPLADKTVAIIGYGSQGHAHALNLRDSGVQVIVGLYPGSPSWPKAEQDGLMVKTVADAAAAADWVMIL
LPDEVQKAVFQGEIRPHLQPGNVLLFAHGFNIHFGQIQPPANVDVIMVAPKGPGHLVRRTYQAGEGVPCLFAVYQDASGM
ARERAMAYAKAIGGTRAGILETTFREETETDLFGEQVVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLIV
EGGLEKMRHSISNTAEYGDYTRGPRIITEQTRAEMKRILAEIQSGQFAREFVLENQAGKPGLTAMRRREAEHPIEQVGRE
LRAMFSWLKK
>Mature_329_residues
ARLYYDTDANLEPLADKTVAIIGYGSQGHAHALNLRDSGVQVIVGLYPGSPSWPKAEQDGLMVKTVADAAAAADWVMILL
PDEVQKAVFQGEIRPHLQPGNVLLFAHGFNIHFGQIQPPANVDVIMVAPKGPGHLVRRTYQAGEGVPCLFAVYQDASGMA
RERAMAYAKAIGGTRAGILETTFREETETDLFGEQVVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLIVE
GGLEKMRHSISNTAEYGDYTRGPRIITEQTRAEMKRILAEIQSGQFAREFVLENQAGKPGLTAMRRREAEHPIEQVGREL
RAMFSWLKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=287, Percent_Identity=36.9337979094077, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=255, Percent_Identity=38.4313725490196, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36278; Mature: 36147

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLYYDTDANLEPLADKTVAIIGYGSQGHAHALNLRDSGVQVIVGLYPGSPSWPKAEQD
CCEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCC
GLMVKTVADAAAAADWVMILLPDEVQKAVFQGEIRPHLQPGNVLLFAHGFNIHFGQIQPP
CEEEEHHHHHHHHCCEEEEEECHHHHHHHHHCCCCCCCCCCCEEEEEECCEEEECCCCCC
ANVDVIMVAPKGPGHLVRRTYQAGEGVPCLFAVYQDASGMARERAMAYAKAIGGTRAGIL
CCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHH
ETTFREETETDLFGEQVVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLIV
HHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLEKMRHSISNTAEYGDYTRGPRIITEQTRAEMKRILAEIQSGQFAREFVLENQAGKP
HCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
GLTAMRRREAEHPIEQVGRELRAMFSWLKK
CHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARLYYDTDANLEPLADKTVAIIGYGSQGHAHALNLRDSGVQVIVGLYPGSPSWPKAEQD
CEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCC
GLMVKTVADAAAAADWVMILLPDEVQKAVFQGEIRPHLQPGNVLLFAHGFNIHFGQIQPP
CEEEEHHHHHHHHCCEEEEEECHHHHHHHHHCCCCCCCCCCCEEEEEECCEEEECCCCCC
ANVDVIMVAPKGPGHLVRRTYQAGEGVPCLFAVYQDASGMARERAMAYAKAIGGTRAGIL
CCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHH
ETTFREETETDLFGEQVVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLIV
HHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLEKMRHSISNTAEYGDYTRGPRIITEQTRAEMKRILAEIQSGQFAREFVLENQAGKP
HCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
GLTAMRRREAEHPIEQVGRELRAMFSWLKK
CHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA