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The map label for this gene is mscL [H]

Identifier: 86608873

GI number: 86608873

Start: 1472583

End: 1472981

Strand: Reverse

Name: mscL [H]

Synonym: CYB_1404

Alternate gene names: 86608873

Gene position: 1472981-1472583 (Counterclockwise)

Preceding gene: 86608874

Following gene: 86608872

Centisome position: 48.35

GC content: 47.12

Gene sequence:

>399_bases
ATGCGGGCATTTCTGGAGGAGTTCAAAAACTTTATTAGCCGGGGCAATGCCTTAGATTTGGCTGTTGGCGTTGTTATTGG
AGGTGCTTTTGGGAAGATAGTGACTTCTTTCGTAGCAGATCTATTTACTCCGGTTTTAGGCTTGATGATTGGTGGAGTGA
ACTTCCAGCACTTGGCCTGGGAAATCGGTGGAAGTCCTGAAGACCCAGTTACGATTAACTACGGTAGCTTTCTGCAAGCT
GTGTTTGATTTTGTGATTATCGCTTTTGCCATCTTCTTACTGGTGAAGGCGATCAACACCCTACAGCGAAAGGAGGAAGA
ATCTCCTCCCACATTGCCCCCACCAGAAGTGGTTTTGCTGACAGAGATCCGGGATATCCTCAATCGCCACTCCCAATAG

Upstream 100 bases:

>100_bases
GCTGGGGAGAGGCTACTGACATCAGTGGGATTTCAGGAGAGGGGTGACTCCCAAGGCAGAGAGGTTTTGAACTATAAAGG
CTAGGCAGGAGAAGTTCCCT

Downstream 100 bases:

>100_bases
AGCTATAGGGGATCCTTAGGCCCAAAATCCAAACCTGGTTTAGGGATCCCTTAACTTTTCAGCTCCTGCCCTTCGGTGTC
AACCCTAGAGTCTAGCCATG

Product: large conductance mechanosensitive channel protein

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MRAFLEEFKNFISRGNALDLAVGVVIGGAFGKIVTSFVADLFTPVLGLMIGGVNFQHLAWEIGGSPEDPVTINYGSFLQA
VFDFVIIAFAIFLLVKAINTLQRKEEESPPTLPPPEVVLLTEIRDILNRHSQ

Sequences:

>Translated_132_residues
MRAFLEEFKNFISRGNALDLAVGVVIGGAFGKIVTSFVADLFTPVLGLMIGGVNFQHLAWEIGGSPEDPVTINYGSFLQA
VFDFVIIAFAIFLLVKAINTLQRKEEESPPTLPPPEVVLLTEIRDILNRHSQ
>Mature_132_residues
MRAFLEEFKNFISRGNALDLAVGVVIGGAFGKIVTSFVADLFTPVLGLMIGGVNFQHLAWEIGGSPEDPVTINYGSFLQA
VFDFVIIAFAIFLLVKAINTLQRKEEESPPTLPPPEVVLLTEIRDILNRHSQ

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=134, Percent_Identity=52.2388059701493, Blast_Score=133, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001185
- InterPro:   IPR015089 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 14487; Mature: 14487

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFLEEFKNFISRGNALDLAVGVVIGGAFGKIVTSFVADLFTPVLGLMIGGVNFQHLAW
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EIGGSPEDPVTINYGSFLQAVFDFVIIAFAIFLLVKAINTLQRKEEESPPTLPPPEVVLL
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
TEIRDILNRHSQ
HHHHHHHHHCCC
>Mature Secondary Structure
MRAFLEEFKNFISRGNALDLAVGVVIGGAFGKIVTSFVADLFTPVLGLMIGGVNFQHLAW
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EIGGSPEDPVTINYGSFLQAVFDFVIIAFAIFLLVKAINTLQRKEEESPPTLPPPEVVLL
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
TEIRDILNRHSQ
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA