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The map label for this gene is hisS [H]

Identifier: 86608180

GI number: 86608180

Start: 711908

End: 713206

Strand: Reverse

Name: hisS [H]

Synonym: CYB_0694

Alternate gene names: 86608180

Gene position: 713206-711908 (Counterclockwise)

Preceding gene: 86608181

Following gene: 86608179

Centisome position: 23.41

GC content: 62.59

Gene sequence:

>1299_bases
ATGGAGATGATCCAGGCGGTGCGGGGCACCCGAGATATTCTGCCGCAGGAGGTGCGGCTCTGGCAGCAGGTGGAAGCCAG
CGCCCGAGAGATCCTGGGACGGGCCAACTACCAAGAAATTCGCACCCCCATCCTGGAGTTGACGGAGCTCTTTGCCCGCA
GCATTGGCAGTGCCACTGACGTGGTGGGCAAGGAGATGTACTCCTTCAGCACCCGTGGCGAGCAAGAGGTGAGCCTGCGC
CCAGAGAACACAGCAGGTGTGGTGCGGGCCTACATCCAGCACGGGCTGCAAACGGCTGGAGATGTGCAACGCCTCTGGTA
TTGTGGGCCGATGTTTCGCTATGAGCGTCCCCAGGCGGGGCGGCAACGCCAGTTCCACCAGTTGGGGGTAGAGCTGCTGG
GCAGCCGGGATCCCCGCGCCGATGCGGAAGTCATCGCCTTGGCCTGGGAGCTGTTGCAAGCGGTGGGGGCGGAGAACCTG
AGCTTGCGGCTCAATTCCCTGGGGGATCTGCAGGATCGGCGGGCCTATCGCCAGGCCCTGGTGGACTACCTCACTCCCTT
GCGGGAGAAGCTGGATCCTGACTCCCAAGAGCGTCTCACCCGCAACCCGCTGCGCATTCTGGATAGCAAGGATCCCCGCA
CCCGCGAGATTGCCGAGGGGGCCCCCAAGCTGCCGGATTACCTCGGCCCAGAATCGCGGGCTTTCTTCGAGCAGGTGCAA
GCTCACCTGCAGATGTTGGATATTCCCTACCAGTTGGATCCCTACTTGGTGCGGGGCCTGGACTACTACACCGACACCGC
CTTTGAGATCGTCTCACCTGACTTGGGATCCCAGAGTACCGTCTGTGGGGGTGGTCGCTACGACGGCTTGGTGGAAGAGC
TGGGCGGACCTTCTACCCCAGCGGTGGGCTGGGCCGTCGGCATGGAGCGGCTGGTGCTGCTGTTGCAAAAGAAACAAGGG
GAGGCTCCGCCAGCACCGGTCGAGGTTTACGTGATCTCCCGTGGGGCGAAGGCTGAGGCCCAATCCCTCCGGATCGCTCA
AGCGCTGCGCCGAGCCGGTTTCTGCACCGAGCTGGATCTGAGCGGCAGCGCCTTTGGCAAGCAGTTCAAACGGGCCAGCC
GCAGCGGCGCAACTTGGGCTGTTGTGCTAGGGGATGCGGAAGCTGCAGCCGGAGAGGTACAGCTTAAGCACCTGCCTACA
GGGCAACAGCAAACCCTTTTGCAAGCCGATCTGGTTAAGTATCTGGCATCCCATTCGGGTCAGCAGTGCGGAGCACCTAA
GGTGATGGAGCTATGTTAA

Upstream 100 bases:

>100_bases
CAATAACTAGGCCGTTTGCGTCAGCGGGACGGAGTCCTTTGACGAGAACAGCCATTGGCATAGCAGGCGGCCAGGCCCAC
CCCAGGGAGGGAGAACGAGA

Downstream 100 bases:

>100_bases
ATTTCTGGGTTCGGCGGGACGGCCAGGAAGACTGGCAGCCAGTACCAGCCGAGGGAGCAGTTCTGGAAGAAGATACCTAC
ACCATTGTTGCCCGTTCGCC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MEMIQAVRGTRDILPQEVRLWQQVEASAREILGRANYQEIRTPILELTELFARSIGSATDVVGKEMYSFSTRGEQEVSLR
PENTAGVVRAYIQHGLQTAGDVQRLWYCGPMFRYERPQAGRQRQFHQLGVELLGSRDPRADAEVIALAWELLQAVGAENL
SLRLNSLGDLQDRRAYRQALVDYLTPLREKLDPDSQERLTRNPLRILDSKDPRTREIAEGAPKLPDYLGPESRAFFEQVQ
AHLQMLDIPYQLDPYLVRGLDYYTDTAFEIVSPDLGSQSTVCGGGRYDGLVEELGGPSTPAVGWAVGMERLVLLLQKKQG
EAPPAPVEVYVISRGAKAEAQSLRIAQALRRAGFCTELDLSGSAFGKQFKRASRSGATWAVVLGDAEAAAGEVQLKHLPT
GQQQTLLQADLVKYLASHSGQQCGAPKVMELC

Sequences:

>Translated_432_residues
MEMIQAVRGTRDILPQEVRLWQQVEASAREILGRANYQEIRTPILELTELFARSIGSATDVVGKEMYSFSTRGEQEVSLR
PENTAGVVRAYIQHGLQTAGDVQRLWYCGPMFRYERPQAGRQRQFHQLGVELLGSRDPRADAEVIALAWELLQAVGAENL
SLRLNSLGDLQDRRAYRQALVDYLTPLREKLDPDSQERLTRNPLRILDSKDPRTREIAEGAPKLPDYLGPESRAFFEQVQ
AHLQMLDIPYQLDPYLVRGLDYYTDTAFEIVSPDLGSQSTVCGGGRYDGLVEELGGPSTPAVGWAVGMERLVLLLQKKQG
EAPPAPVEVYVISRGAKAEAQSLRIAQALRRAGFCTELDLSGSAFGKQFKRASRSGATWAVVLGDAEAAAGEVQLKHLPT
GQQQTLLQADLVKYLASHSGQQCGAPKVMELC
>Mature_432_residues
MEMIQAVRGTRDILPQEVRLWQQVEASAREILGRANYQEIRTPILELTELFARSIGSATDVVGKEMYSFSTRGEQEVSLR
PENTAGVVRAYIQHGLQTAGDVQRLWYCGPMFRYERPQAGRQRQFHQLGVELLGSRDPRADAEVIALAWELLQAVGAENL
SLRLNSLGDLQDRRAYRQALVDYLTPLREKLDPDSQERLTRNPLRILDSKDPRTREIAEGAPKLPDYLGPESRAFFEQVQ
AHLQMLDIPYQLDPYLVRGLDYYTDTAFEIVSPDLGSQSTVCGGGRYDGLVEELGGPSTPAVGWAVGMERLVLLLQKKQG
EAPPAPVEVYVISRGAKAEAQSLRIAQALRRAGFCTELDLSGSAFGKQFKRASRSGATWAVVLGDAEAAAGEVQLKHLPT
GQQQTLLQADLVKYLASHSGQQCGAPKVMELC

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=471, Percent_Identity=22.7176220806794, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1788861, Length=416, Percent_Identity=49.0384615384615, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71993686, Length=454, Percent_Identity=26.431718061674, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71993693, Length=456, Percent_Identity=26.9736842105263, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643061, Length=466, Percent_Identity=24.4635193133047, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24643059, Length=481, Percent_Identity=24.3243243243243, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47864; Mature: 47864

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00070 ALDEHYDE_DEHYDR_CYS ; PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMIQAVRGTRDILPQEVRLWQQVEASAREILGRANYQEIRTPILELTELFARSIGSATD
CCHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHH
VVGKEMYSFSTRGEQEVSLRPENTAGVVRAYIQHGLQTAGDVQRLWYCGPMFRYERPQAG
HHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCCCH
RQRQFHQLGVELLGSRDPRADAEVIALAWELLQAVGAENLSLRLNSLGDLQDRRAYRQAL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
VDYLTPLREKLDPDSQERLTRNPLRILDSKDPRTREIAEGAPKLPDYLGPESRAFFEQVQ
HHHHHHHHHHCCCCHHHHHHCCCHHHHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHH
AHLQMLDIPYQLDPYLVRGLDYYTDTAFEIVSPDLGSQSTVCGGGRYDGLVEELGGPSTP
HHHHHHCCCCCCCHHHHHCCHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
AVGWAVGMERLVLLLQKKQGEAPPAPVEVYVISRGAKAEAQSLRIAQALRRAGFCTELDL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEECC
SGSAFGKQFKRASRSGATWAVVLGDAEAAAGEVQLKHLPTGQQQTLLQADLVKYLASHSG
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
QQCGAPKVMELC
CCCCCCHHHHCC
>Mature Secondary Structure
MEMIQAVRGTRDILPQEVRLWQQVEASAREILGRANYQEIRTPILELTELFARSIGSATD
CCHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHH
VVGKEMYSFSTRGEQEVSLRPENTAGVVRAYIQHGLQTAGDVQRLWYCGPMFRYERPQAG
HHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCCCH
RQRQFHQLGVELLGSRDPRADAEVIALAWELLQAVGAENLSLRLNSLGDLQDRRAYRQAL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
VDYLTPLREKLDPDSQERLTRNPLRILDSKDPRTREIAEGAPKLPDYLGPESRAFFEQVQ
HHHHHHHHHHCCCCHHHHHHCCCHHHHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHH
AHLQMLDIPYQLDPYLVRGLDYYTDTAFEIVSPDLGSQSTVCGGGRYDGLVEELGGPSTP
HHHHHHCCCCCCCHHHHHCCHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
AVGWAVGMERLVLLLQKKQGEAPPAPVEVYVISRGAKAEAQSLRIAQALRRAGFCTELDL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEECC
SGSAFGKQFKRASRSGATWAVVLGDAEAAAGEVQLKHLPTGQQQTLLQADLVKYLASHSG
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
QQCGAPKVMELC
CCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA