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The map label for this gene is adk

Identifier: 86605847

GI number: 86605847

Start: 1181893

End: 1182474

Strand: Reverse

Name: adk

Synonym: CYA_1159

Alternate gene names: 86605847

Gene position: 1182474-1181893 (Counterclockwise)

Preceding gene: 86605848

Following gene: 86605846

Centisome position: 40.32

GC content: 62.54

Gene sequence:

>582_bases
GTGCCGAGGTTAATCTTTTTGGGGCCGCCGGGAGCGGGCAAGGGCACCCAGGCAGAGCGGCTGGCAGCGATCTACCACAC
GCCCAAAATTTCTACAGGCGACCTGCTGCGGGCAGAGGTGAAAGCCCAAACGCCGCTGGGGTGCCAGGCTAAGGTGTACA
TGGATGCGGGAGAGCTGGTGCCTGACGAGGTGTTAATTGGGATGGTGAAGGGCCAGTTGCAACACTCGCCAGCGCAGGGC
TGGATCCTGGACGGCTTCCCCCGCACCCTGGCGCAGGCGGAGGCTTTAGAAGAGCTGTTGCGGGAGTTGGGGCAAGACTA
CGACCACGTTCTCAACCTGGAAGTGCCGGACGACGTGGTGGTGGCACGGCTGTTGGCCCGCGGCAAGGAGCAGGGGCGCA
GCGACGATGCCGATGAGGCGGTGATCCTCAAACGCTTGCAGGTGTATCGGGAGCAGACGGCTCCGCTGATCGACTTTTAC
GAGGCCAGGGGTCGTCTGCGACGGATCGATGGCAACCAGCCGATGGAATCGGTACAAGAACATCTGCGGGCTCTCTTGGA
AGGCTTCAGGAGGACAGCGTGA

Upstream 100 bases:

>100_bases
CAACTTCGCTGCTGATCCTGGTGGGGGTGGCGATCGAGACCTCCAAACAGATCCAGACCTACGTCATTTCGCAGCGTTAC
GAAGGGATGGTCAAGCAATA

Downstream 100 bases:

>100_bases
TCAAGACGGGGGCGGGAAATCTCTCCCCGCGGCGGGGCATGCAGCTCATTGAGATCAAGTCCCGCCGGGAGGTGGAGAAG
ATGCGGCGGGCCGGGCGGGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MPRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELVPDEVLIGMVKGQLQHSPAQG
WILDGFPRTLAQAEALEELLRELGQDYDHVLNLEVPDDVVVARLLARGKEQGRSDDADEAVILKRLQVYREQTAPLIDFY
EARGRLRRIDGNQPMESVQEHLRALLEGFRRTA

Sequences:

>Translated_193_residues
MPRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELVPDEVLIGMVKGQLQHSPAQG
WILDGFPRTLAQAEALEELLRELGQDYDHVLNLEVPDDVVVARLLARGKEQGRSDDADEAVILKRLQVYREQTAPLIDFY
EARGRLRRIDGNQPMESVQEHLRALLEGFRRTA
>Mature_192_residues
PRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELVPDEVLIGMVKGQLQHSPAQGW
ILDGFPRTLAQAEALEELLRELGQDYDHVLNLEVPDDVVVARLLARGKEQGRSDDADEAVILKRLQVYREQTAPLIDFYE
ARGRLRRIDGNQPMESVQEHLRALLEGFRRTA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=198, Percent_Identity=36.8686868686869, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI4502013, Length=216, Percent_Identity=35.1851851851852, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI4502011, Length=190, Percent_Identity=37.3684210526316, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=33.9622641509434, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=34.3434343434343, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=34.3434343434343, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=34.3434343434343, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=34.3434343434343, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI7706497, Length=184, Percent_Identity=34.2391304347826, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI28144897, Length=179, Percent_Identity=32.9608938547486, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI28144899, Length=179, Percent_Identity=32.9608938547486, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI22749187, Length=128, Percent_Identity=35.9375, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI209915597, Length=187, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=5e-13,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=38.8888888888889, Blast_Score=139, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=36.4485981308411, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17567503, Length=181, Percent_Identity=37.0165745856354, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=32.0855614973262, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=33.5135135135135, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537943, Length=226, Percent_Identity=27.4336283185841, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147457, Length=182, Percent_Identity=25.2747252747253, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=204, Percent_Identity=38.2352941176471, Blast_Score=143, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=184, Percent_Identity=33.695652173913, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=32.8205128205128, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=35.0710900473934, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221459597, Length=180, Percent_Identity=33.8888888888889, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356893, Length=180, Percent_Identity=33.8888888888889, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=34, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=34, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24663208, Length=164, Percent_Identity=29.8780487804878, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=164, Percent_Identity=29.8780487804878, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_SYNJA (Q2JV96)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_474610.1
- HSSP:   P16304
- ProteinModelPortal:   Q2JV96
- SMR:   Q2JV96
- STRING:   Q2JV96
- GeneID:   3898868
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1159
- TIGR:   CYA_1159
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- ProtClustDB:   CLSK750347
- BioCyc:   SSP321327:CYA_1159-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21446; Mature: 21315

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELV
CCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCC
PDEVLIGMVKGQLQHSPAQGWILDGFPRTLAQAEALEELLRELGQDYDHVLNLEVPDDVV
HHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCHHHH
VARLLARGKEQGRSDDADEAVILKRLQVYREQTAPLIDFYEARGRLRRIDGNQPMESVQE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCHHHHHH
HLRALLEGFRRTA
HHHHHHHHHHCCC
>Mature Secondary Structure 
PRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELV
CCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCC
PDEVLIGMVKGQLQHSPAQGWILDGFPRTLAQAEALEELLRELGQDYDHVLNLEVPDDVV
HHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCHHHH
VARLLARGKEQGRSDDADEAVILKRLQVYREQTAPLIDFYEARGRLRRIDGNQPMESVQE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCHHHHHH
HLRALLEGFRRTA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA