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The map label for this gene is mutY

Identifier: 86605515

GI number: 86605515

Start: 820043

End: 821119

Strand: Reverse

Name: mutY

Synonym: CYA_0809

Alternate gene names: 86605515

Gene position: 821119-820043 (Counterclockwise)

Preceding gene: 86605516

Following gene: 86605514

Centisome position: 28.0

GC content: 62.02

Gene sequence:

>1077_bases
TTGCAGCGCCTGCGGCAGTCCTTGCAGCGTTGGTACTGCCAGCAGGGTCGAGATCTGCCCTGGCGACGCACGCGGGATCC
CTATGCCATTTGGGTGGCGGAGGTGATGCTGCAACAGACCCAGGTGGCAACCGTGATCCCCTACTTTCAGCGCTGGATGG
AGGCTCTGCCCGGGATCCCAGAGTTGGCGACGGCTCCGCAGCAACAAGTGCTGAAACTGTGGGAAGGGCTGGGCTACTAC
CGGCGGGCGCTGAATCTGCACAGAGCTGCTCAAATCCTGATGCAGGAACACGGGGGCCAGTTTCCCAGGAATCTGGAGCA
GGTGCTGGCGCTGCCGGGGATCGGGCGCACCACCGCTGGCGGCATTCTCAGCGCCGCCTTTGACCTGCCCCTGCCGATTT
TGGAGGGCAACGTCAAGCGGGTGTTGGCCCGCCTGGTGGCTTTGCCCCAGCCGCCGGCCCGTTGTCTGCCCCTGTTGTGG
CGGCTTTCGCAGCAGTTGCTGGATCCCGAGCAGCCGCGCACCTTTAACCAGGCCCTGATGGACTTGGGCGCGACCATCTG
CCGGCCCCGGCAGCCTCGCTGTGGCCAATGTCCTTGGCAGGCCGATTGCGCTGCCTACAATCGAGGTCAACAGCAACACC
TGCCTATGTCTGAGCACCGTCCCTCGCGCCCTCACAAACAGATCGCGGTGGCCATCGTTTTGCGAGGGAAAGAGATCCTC
ATCGATCGGCGGCTGGAAAGCTCCATGCTCAGCGGCCTGTGGGAGTTCCCCGGCGGCAAAATCGAGCCGGGAGAAACCCC
TGCGGAGTGTGTGGTGCGGGAGGTGAAAGAAGAAATCGGCATCGACATTGAGGTGGTGGCTCCGCTGGCCACCATCGAAC
ATGCCTACACCCATTTCACCATCACCCTTATTGCTTTTATCTGCCGCTATTTGCGCGGAGAAGCTCAAGCCCTGCAATGC
AGCGAAGTGCGCTGGGTCGAGCCGGCGGAGCTGTCGCAATTTCCCTTTCCGGCAGCCAACCAAAAGCTATTTCCCTACCT
GTACGCTTGGCTGGAAGCGCGAGGGCATCTCTTATAA

Upstream 100 bases:

>100_bases
CTTACGCGGCTTGAGATCCCAGGTTCCTTCTCGACGGACTGGAAGAGAGTCCGAGGTTGCGGTTGCTGGCGAGCAGTCGC
TAGGTTGGAGCAGCGCAGTT

Downstream 100 bases:

>100_bases
TCCGCCAAACTGCTTAAATCCCTCCGGCTTTGCTCGCACAAGACATCCGATAGGATGATAGGTTTCCTGCTGAGGTGAGC
ATGACTCTAGTCAATGATAT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MQRLRQSLQRWYCQQGRDLPWRRTRDPYAIWVAEVMLQQTQVATVIPYFQRWMEALPGIPELATAPQQQVLKLWEGLGYY
RRALNLHRAAQILMQEHGGQFPRNLEQVLALPGIGRTTAGGILSAAFDLPLPILEGNVKRVLARLVALPQPPARCLPLLW
RLSQQLLDPEQPRTFNQALMDLGATICRPRQPRCGQCPWQADCAAYNRGQQQHLPMSEHRPSRPHKQIAVAIVLRGKEIL
IDRRLESSMLSGLWEFPGGKIEPGETPAECVVREVKEEIGIDIEVVAPLATIEHAYTHFTITLIAFICRYLRGEAQALQC
SEVRWVEPAELSQFPFPAANQKLFPYLYAWLEARGHLL

Sequences:

>Translated_358_residues
MQRLRQSLQRWYCQQGRDLPWRRTRDPYAIWVAEVMLQQTQVATVIPYFQRWMEALPGIPELATAPQQQVLKLWEGLGYY
RRALNLHRAAQILMQEHGGQFPRNLEQVLALPGIGRTTAGGILSAAFDLPLPILEGNVKRVLARLVALPQPPARCLPLLW
RLSQQLLDPEQPRTFNQALMDLGATICRPRQPRCGQCPWQADCAAYNRGQQQHLPMSEHRPSRPHKQIAVAIVLRGKEIL
IDRRLESSMLSGLWEFPGGKIEPGETPAECVVREVKEEIGIDIEVVAPLATIEHAYTHFTITLIAFICRYLRGEAQALQC
SEVRWVEPAELSQFPFPAANQKLFPYLYAWLEARGHLL
>Mature_358_residues
MQRLRQSLQRWYCQQGRDLPWRRTRDPYAIWVAEVMLQQTQVATVIPYFQRWMEALPGIPELATAPQQQVLKLWEGLGYY
RRALNLHRAAQILMQEHGGQFPRNLEQVLALPGIGRTTAGGILSAAFDLPLPILEGNVKRVLARLVALPQPPARCLPLLW
RLSQQLLDPEQPRTFNQALMDLGATICRPRQPRCGQCPWQADCAAYNRGQQQHLPMSEHRPSRPHKQIAVAIVLRGKEIL
IDRRLESSMLSGLWEFPGGKIEPGETPAECVVREVKEEIGIDIEVVAPLATIEHAYTHFTITLIAFICRYLRGEAQALQC
SEVRWVEPAELSQFPFPAANQKLFPYLYAWLEARGHLL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=400, Percent_Identity=36, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI115298654, Length=400, Percent_Identity=36, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI115298652, Length=400, Percent_Identity=36, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI115298650, Length=400, Percent_Identity=36, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI6912520, Length=400, Percent_Identity=36, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI190358497, Length=400, Percent_Identity=36, Blast_Score=211, Evalue=8e-55,
Organism=Escherichia coli, GI1789331, Length=297, Percent_Identity=41.4141414141414, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786288, Length=122, Percent_Identity=35.2459016393443, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788056, Length=128, Percent_Identity=33.59375, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40851; Mature: 40851

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00893 NUDIX ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLRQSLQRWYCQQGRDLPWRRTRDPYAIWVAEVMLQQTQVATVIPYFQRWMEALPGIP
CHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELATAPQQQVLKLWEGLGYYRRALNLHRAAQILMQEHGGQFPRNLEQVLALPGIGRTTAG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHH
GILSAAFDLPLPILEGNVKRVLARLVALPQPPARCLPLLWRLSQQLLDPEQPRTFNQALM
HHHHHHHHCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DLGATICRPRQPRCGQCPWQADCAAYNRGQQQHLPMSEHRPSRPHKQIAVAIVLRGKEIL
HHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHEEEHEEECCHHHH
IDRRLESSMLSGLWEFPGGKIEPGETPAECVVREVKEEIGIDIEVVAPLATIEHAYTHFT
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
ITLIAFICRYLRGEAQALQCSEVRWVEPAELSQFPFPAANQKLFPYLYAWLEARGHLL
HHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQRLRQSLQRWYCQQGRDLPWRRTRDPYAIWVAEVMLQQTQVATVIPYFQRWMEALPGIP
CHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELATAPQQQVLKLWEGLGYYRRALNLHRAAQILMQEHGGQFPRNLEQVLALPGIGRTTAG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHH
GILSAAFDLPLPILEGNVKRVLARLVALPQPPARCLPLLWRLSQQLLDPEQPRTFNQALM
HHHHHHHHCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DLGATICRPRQPRCGQCPWQADCAAYNRGQQQHLPMSEHRPSRPHKQIAVAIVLRGKEIL
HHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHEEEHEEECCHHHH
IDRRLESSMLSGLWEFPGGKIEPGETPAECVVREVKEEIGIDIEVVAPLATIEHAYTHFT
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
ITLIAFICRYLRGEAQALQCSEVRWVEPAELSQFPFPAANQKLFPYLYAWLEARGHLL
HHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]