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The map label for this gene is proA [H]

Identifier: 86605214

GI number: 86605214

Start: 510982

End: 512283

Strand: Reverse

Name: proA [H]

Synonym: CYA_0496

Alternate gene names: 86605214

Gene position: 512283-510982 (Counterclockwise)

Preceding gene: 86605215

Following gene: 86605213

Centisome position: 17.47

GC content: 61.9

Gene sequence:

>1302_bases
GTGACCGATTTTGGTTCAGCCTTTGACCTCAGCACCACCCTGCGCCAGGTGCGCCGCTTACTGCCTCAGCTCCAGCGCTT
GAGCGGCGAAACCAAACGCCAGGCCCTGCTGGCTCTCTCGCGCCGTTTGCTGGAGCGCTCCGATCTGCTGTTGGAGGCCA
ATACCCTCGACCTGGAAAGCTGCCGCGAGCAAACCCTGCCGGAGTGGATCCTCAACGGCCTCAAGCTTACCCCCGAGCGC
CTGCAGCGATCCGCCCAGTTGCTTGCTCTCCTGGCCCAACAGCCGGATCCCATCGGGAGCCTGGAGAGGGGGTGCCGTCA
GGACAACGGGCTGTTTATTGGCCGCTACCGCGTCCCTTTGGGGCTGATCGCCTTGGTCTACGAGATCTACCCCGAGTTTG
CCTTGAATGGCATTGGCATGTGTCTCAAGACGAGCAATGGCGTGATCTTGGCCGGCAGCGGCCCCATCCAGAAAACCCAT
CAGGCCCTGGTCAACCTGTTGGCAGAGACCGCCTACGAGCACGGGATCCCGGAAGGGGCCATTCAAACCCTCCCCGCCCA
AGACCAAGCGACCGATCCCCAGGCCGATTCCCCACTGTTGCTGTTGTTGCAGCAAACCCGCTATGTGGATCTGGTGATCC
CCTGCGGTCGCCCCGGCTGGGTGGAGTTCCTGTTGCAGGCCAGCAAAGTGCCGACTCTGGTCACGCATCTGGGGTACGGC
CACATCTATGTGGATCGCACCGCTCCTTGGCCTTTGGTGAAGTCGGTTTTGTTGGATCCCTTGGCTCGCTATGGCCCAGA
AGGGATCCCGATCTATCAGCCCCTCACCCTTTGGCTGCTGATCCACACCGATTGGGCCGCCCATCATCTGACCGCCCTGA
TTGAAGACTTGCTGGGTCAAGGGATCGATATACAGGCAGCAGCCCCCATTCTGGAGCGATTCCCCCAGCTTCAGCCGCTG
GGGGAAGGCTTTGACTCCACAGAACGGCCTCATCTGCGCCTCCAGCCCGTTGCCGACCTGACGGAGGCGATCGCCTGGAT
CAACAAAAATGGCTGTCGTCAATCGGAGACGATCCTCACCGACAGCCAATCGGCAGCCCAGCGCTTTCTCCAGGAGGTGG
ATGCCGCCCTGATCCACATCAACACCTCTCCCCTCTCGGCAGGCCGGGGAGCCGGGATCCCCACCTTGGGAGCGTTTCGC
GACCTGTCTTTGGGCATTTCCACCCAGCGGCTGCACGTGCGCGGGCCCATCGACCTGGAAGCCTTGACAACGGTGAAGGT
AGTGGCTCAGGGTGACCTGTAG

Upstream 100 bases:

>100_bases
CCAGGGATCCCTAGTTTCAGCCCTTGTGGATCTAGCCATTTCTTGTTAGCAGTGGTCAGGAGCAGGTCTGTCGTCGGTCA
GCCGGGCAGGAGGGAAGCGA

Downstream 100 bases:

>100_bases
CAGGGGAAAGTTGGGATACCGAACTGCTGTTCTCCCCAAAAGCCAAGAGATGGCGTGAGACTAGAAAGGGAGGAATGCCG
GCCCCGTCGTCCGACGTCCA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTDFGSAFDLSTTLRQVRRLLPQLQRLSGETKRQALLALSRRLLERSDLLLEANTLDLESCREQTLPEWILNGLKLTPER
LQRSAQLLALLAQQPDPIGSLERGCRQDNGLFIGRYRVPLGLIALVYEIYPEFALNGIGMCLKTSNGVILAGSGPIQKTH
QALVNLLAETAYEHGIPEGAIQTLPAQDQATDPQADSPLLLLLQQTRYVDLVIPCGRPGWVEFLLQASKVPTLVTHLGYG
HIYVDRTAPWPLVKSVLLDPLARYGPEGIPIYQPLTLWLLIHTDWAAHHLTALIEDLLGQGIDIQAAAPILERFPQLQPL
GEGFDSTERPHLRLQPVADLTEAIAWINKNGCRQSETILTDSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFR
DLSLGISTQRLHVRGPIDLEALTTVKVVAQGDL

Sequences:

>Translated_433_residues
MTDFGSAFDLSTTLRQVRRLLPQLQRLSGETKRQALLALSRRLLERSDLLLEANTLDLESCREQTLPEWILNGLKLTPER
LQRSAQLLALLAQQPDPIGSLERGCRQDNGLFIGRYRVPLGLIALVYEIYPEFALNGIGMCLKTSNGVILAGSGPIQKTH
QALVNLLAETAYEHGIPEGAIQTLPAQDQATDPQADSPLLLLLQQTRYVDLVIPCGRPGWVEFLLQASKVPTLVTHLGYG
HIYVDRTAPWPLVKSVLLDPLARYGPEGIPIYQPLTLWLLIHTDWAAHHLTALIEDLLGQGIDIQAAAPILERFPQLQPL
GEGFDSTERPHLRLQPVADLTEAIAWINKNGCRQSETILTDSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFR
DLSLGISTQRLHVRGPIDLEALTTVKVVAQGDL
>Mature_432_residues
TDFGSAFDLSTTLRQVRRLLPQLQRLSGETKRQALLALSRRLLERSDLLLEANTLDLESCREQTLPEWILNGLKLTPERL
QRSAQLLALLAQQPDPIGSLERGCRQDNGLFIGRYRVPLGLIALVYEIYPEFALNGIGMCLKTSNGVILAGSGPIQKTHQ
ALVNLLAETAYEHGIPEGAIQTLPAQDQATDPQADSPLLLLLQQTRYVDLVIPCGRPGWVEFLLQASKVPTLVTHLGYGH
IYVDRTAPWPLVKSVLLDPLARYGPEGIPIYQPLTLWLLIHTDWAAHHLTALIEDLLGQGIDIQAAAPILERFPQLQPLG
EGFDSTERPHLRLQPVADLTEAIAWINKNGCRQSETILTDSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFRD
LSLGISTQRLHVRGPIDLEALTTVKVVAQGDL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=414, Percent_Identity=28.743961352657, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI21361368, Length=414, Percent_Identity=28.743961352657, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1786438, Length=420, Percent_Identity=30.952380952381, Blast_Score=184, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17569967, Length=418, Percent_Identity=26.7942583732057, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17569969, Length=418, Percent_Identity=26.7942583732057, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6324899, Length=443, Percent_Identity=25.2821670428894, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21357643, Length=438, Percent_Identity=26.027397260274, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 47577; Mature: 47445

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFGSAFDLSTTLRQVRRLLPQLQRLSGETKRQALLALSRRLLERSDLLLEANTLDLES
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCHHH
CREQTLPEWILNGLKLTPERLQRSAQLLALLAQQPDPIGSLERGCRQDNGLFIGRYRVPL
HHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEEHHHH
GLIALVYEIYPEFALNGIGMCLKTSNGVILAGSGPIQKTHQALVNLLAETAYEHGIPEGA
HHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCH
IQTLPAQDQATDPQADSPLLLLLQQTRYVDLVIPCGRPGWVEFLLQASKVPTLVTHLGYG
HHCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHCCCC
HIYVDRTAPWPLVKSVLLDPLARYGPEGIPIYQPLTLWLLIHTDWAAHHLTALIEDLLGQ
EEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCC
GIDIQAAAPILERFPQLQPLGEGFDSTERPHLRLQPVADLTEAIAWINKNGCRQSETILT
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEEC
DSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFRDLSLGISTQRLHVRGPIDLE
CCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCHH
ALTTVKVVAQGDL
HHHEEEEEECCCC
>Mature Secondary Structure 
TDFGSAFDLSTTLRQVRRLLPQLQRLSGETKRQALLALSRRLLERSDLLLEANTLDLES
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCHHH
CREQTLPEWILNGLKLTPERLQRSAQLLALLAQQPDPIGSLERGCRQDNGLFIGRYRVPL
HHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEEHHHH
GLIALVYEIYPEFALNGIGMCLKTSNGVILAGSGPIQKTHQALVNLLAETAYEHGIPEGA
HHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCH
IQTLPAQDQATDPQADSPLLLLLQQTRYVDLVIPCGRPGWVEFLLQASKVPTLVTHLGYG
HHCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHCCCC
HIYVDRTAPWPLVKSVLLDPLARYGPEGIPIYQPLTLWLLIHTDWAAHHLTALIEDLLGQ
EEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCC
GIDIQAAAPILERFPQLQPLGEGFDSTERPHLRLQPVADLTEAIAWINKNGCRQSETILT
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEEC
DSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFRDLSLGISTQRLHVRGPIDLE
CCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCHH
ALTTVKVVAQGDL
HHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]