Click here to switch to the map view.

The map label for this gene is emrK [H]

Identifier: 86361279

GI number: 86361279

Start: 616375

End: 617526

Strand: Reverse

Name: emrK [H]

Synonym: RHE_PF00551

Alternate gene names: 86361279

Gene position: 617526-616375 (Counterclockwise)

Preceding gene: 86361280

Following gene: 86361278

Centisome position: 96.11

GC content: 63.45

Gene sequence:

>1152_bases
ATGGACACCCATCCCAACCATGTTTCGAAGCACTTTCCTTCGGCTCCCGCCAAGGCGGCTGTCCAAGCCGAGCCGCTGGC
AGCTCCCGAACGTCCTGCGGTGACGGCGGCCGACCTCAGGCGTCTTGTTATTCCATTCGCCGCGGTTGCCGCCGCCAGCG
CAGCCGTTGCCTGGGCGATCGTCGACTGGAACAGCTGGGTTGCGGGCGCGGACCGCCAAGCCACCGACGATGCCGTTGTC
AGCGCCGACGTCTCGACGCTGAGCGCGCAGATCAGCGGGATCATCAAACGCACGCCGGTCGCCGATTATCAGAAAGTGAC
GAAAGGTCAGGTGCTGGCAGAGATAGACTCCCGCGAATATGACGCCGCGGTCGAAGCGGCGGGCGCCAATCTCGCCTCGG
CACAGGCCTCTCTCGCCAATCTCGCCAATCAGATCGAATTGCAGAGGGCGGTCGTGCGGGCGGCAGAGGCGCAGAATGCC
TCGGCGCTTGCCCAGCAGACGCAAACTGAGCAGGAATTCCAGCGGCAGAAGCAGCTCGGCGGGGCAACATCCCAGCATGA
ACTTCAGCAAGCCCAATCGGCCTATCTGCAGGCGGTGGCCGCGGTGAATTCCACCGCCGCGGCGATCGAACAACAGCAGG
CGCAGCTTAAGGTTCTGCAGGGCCAGGAGCCCCTCTTGCAGGCGGAGGTCAGGGCGGCACAGGCAAACCTCGACACGGCG
CACATCCGCCAGAGCTACACGCGCATCGAAGCGCCGTTCTATGGGATTCTCGGCCGCAGGTTCGTCCATGAGGGCGATGT
CGTCGGCGCCGGCACCGGCATCGTTTCCGAAATTCCTCTGCCGAACGTCTATATCACTGCCAATTTCAAGGAGACGCAGC
TAGCCCGGATGACGCCCGGCCGAAGCGCCGAGATCACCGTCGATACATTCCCCGGACAGGTACTGCACGGCAAGGTCGCC
GATCTTTCGCCGGCCAGTGGTGCGATCTTCGCCCTCTTGCCGCCCGACAACGCAACCGGAAACTATACGAAAGTCGTCCA
GCGCATTCCTGTCAGGATAGAGCTTGATCCGGATCAGCCCCTGATTGACCAGCTGAGACCGGGAATGTCGGCCATCGTGA
CGGTCGATACCCCTGCGGGAGCCAGCCGGTGA

Upstream 100 bases:

>100_bases
TGCTGGATGCTATTGGCCCGCACCGAACATGTCTCTGTTAGCCCCGCGACCGCGACGAGAAGCGTGTGTGCTGGAACCCG
CAAAACGGTGTGAGGCGGTA

Downstream 100 bases:

>100_bases
GCCAGATGTCGCTCGTTTTCGGTCCGCTGACCAGCGGCAGGACCGCAAGCCGTCCCTATCTCATCGTCGCCGCACTCCTC
CTGGCATCTTTCGTGGTCGG

Product: putative multidrug resistance efflux pump protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MDTHPNHVSKHFPSAPAKAAVQAEPLAAPERPAVTAADLRRLVIPFAAVAAASAAVAWAIVDWNSWVAGADRQATDDAVV
SADVSTLSAQISGIIKRTPVADYQKVTKGQVLAEIDSREYDAAVEAAGANLASAQASLANLANQIELQRAVVRAAEAQNA
SALAQQTQTEQEFQRQKQLGGATSQHELQQAQSAYLQAVAAVNSTAAAIEQQQAQLKVLQGQEPLLQAEVRAAQANLDTA
HIRQSYTRIEAPFYGILGRRFVHEGDVVGAGTGIVSEIPLPNVYITANFKETQLARMTPGRSAEITVDTFPGQVLHGKVA
DLSPASGAIFALLPPDNATGNYTKVVQRIPVRIELDPDQPLIDQLRPGMSAIVTVDTPAGASR

Sequences:

>Translated_383_residues
MDTHPNHVSKHFPSAPAKAAVQAEPLAAPERPAVTAADLRRLVIPFAAVAAASAAVAWAIVDWNSWVAGADRQATDDAVV
SADVSTLSAQISGIIKRTPVADYQKVTKGQVLAEIDSREYDAAVEAAGANLASAQASLANLANQIELQRAVVRAAEAQNA
SALAQQTQTEQEFQRQKQLGGATSQHELQQAQSAYLQAVAAVNSTAAAIEQQQAQLKVLQGQEPLLQAEVRAAQANLDTA
HIRQSYTRIEAPFYGILGRRFVHEGDVVGAGTGIVSEIPLPNVYITANFKETQLARMTPGRSAEITVDTFPGQVLHGKVA
DLSPASGAIFALLPPDNATGNYTKVVQRIPVRIELDPDQPLIDQLRPGMSAIVTVDTPAGASR
>Mature_383_residues
MDTHPNHVSKHFPSAPAKAAVQAEPLAAPERPAVTAADLRRLVIPFAAVAAASAAVAWAIVDWNSWVAGADRQATDDAVV
SADVSTLSAQISGIIKRTPVADYQKVTKGQVLAEIDSREYDAAVEAAGANLASAQASLANLANQIELQRAVVRAAEAQNA
SALAQQTQTEQEFQRQKQLGGATSQHELQQAQSAYLQAVAAVNSTAAAIEQQQAQLKVLQGQEPLLQAEVRAAQANLDTA
HIRQSYTRIEAPFYGILGRRFVHEGDVVGAGTGIVSEIPLPNVYITANFKETQLARMTPGRSAEITVDTFPGQVLHGKVA
DLSPASGAIFALLPPDNATGNYTKVVQRIPVRIELDPDQPLIDQLRPGMSAIVTVDTPAGASR

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=311, Percent_Identity=32.7974276527331, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1789041, Length=309, Percent_Identity=34.9514563106796, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1790519, Length=317, Percent_Identity=30.2839116719243, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789637, Length=333, Percent_Identity=28.5285285285285, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790024, Length=308, Percent_Identity=26.9480519480519, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790012, Length=246, Percent_Identity=27.2357723577236, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40487; Mature: 40487

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTHPNHVSKHFPSAPAKAAVQAEPLAAPERPAVTAADLRRLVIPFAAVAAASAAVAWAI
CCCCCCHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEE
VDWNSWVAGADRQATDDAVVSADVSTLSAQISGIIKRTPVADYQKVTKGQVLAEIDSREY
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHEEHHCCCHH
DAAVEAAGANLASAQASLANLANQIELQRAVVRAAEAQNASALAQQTQTEQEFQRQKQLG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
GATSQHELQQAQSAYLQAVAAVNSTAAAIEQQQAQLKVLQGQEPLLQAEVRAAQANLDTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
HIRQSYTRIEAPFYGILGRRFVHEGDVVGAGTGIVSEIPLPNVYITANFKETQLARMTPG
HHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCHHHHHHCCCC
RSAEITVDTFPGQVLHGKVADLSPASGAIFALLPPDNATGNYTKVVQRIPVRIELDPDQP
CCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCEEEEECCCCC
LIDQLRPGMSAIVTVDTPAGASR
HHHHHCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MDTHPNHVSKHFPSAPAKAAVQAEPLAAPERPAVTAADLRRLVIPFAAVAAASAAVAWAI
CCCCCCHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEE
VDWNSWVAGADRQATDDAVVSADVSTLSAQISGIIKRTPVADYQKVTKGQVLAEIDSREY
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHEEHHCCCHH
DAAVEAAGANLASAQASLANLANQIELQRAVVRAAEAQNASALAQQTQTEQEFQRQKQLG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
GATSQHELQQAQSAYLQAVAAVNSTAAAIEQQQAQLKVLQGQEPLLQAEVRAAQANLDTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
HIRQSYTRIEAPFYGILGRRFVHEGDVVGAGTGIVSEIPLPNVYITANFKETQLARMTPG
HHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCHHHHHHCCCC
RSAEITVDTFPGQVLHGKVADLSPASGAIFALLPPDNATGNYTKVVQRIPVRIELDPDQP
CCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCEEEEECCCCC
LIDQLRPGMSAIVTVDTPAGASR
HHHHHCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]