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The map label for this gene is proC [H]

Identifier: 86361139

GI number: 86361139

Start: 461937

End: 462731

Strand: Direct

Name: proC [H]

Synonym: RHE_PF00409

Alternate gene names: 86361139

Gene position: 461937-462731 (Clockwise)

Preceding gene: 86361138

Following gene: 86361140

Centisome position: 71.89

GC content: 62.77

Gene sequence:

>795_bases
ATGAGCGTTTCCTTGAGGATCGGTATCATTGGTGGTGGGGGCTGGCTCGGCGGGGCCATTGCCAGCTCAATCCTCGATTC
CGGCCTGGTCGACCCTCGAAATCTCTCCCTCTCCTATCGTAGCCGGCAGCCCGACCGTTTCCCGGATTCCTTCTGGACCA
CCGACAGTCAGGAACTTGCCGACCGCTCGGATGTGATTCTTCTCTCCATCCGTCCCGATGACTGGTATCCGTTCGCGCTC
GATGCTTCCGACAAGCTCGTGATTTCGGTCATGGCCGGCATTCGCCTGGGCGTCCTTTCGGAGCGCCACAGGACAGGCCG
CGTTGTCCGCGCCCTGCCGAATGCCGCTGCCGAAGTGGGGAAATCCTATACCCCCTGGATCGGTTCGAACGACATCACTA
GCGACGATCGGGCCGTCGTCCGCGCGATCTTCGAAACCTGCGGATCTGAGGACGAGGTCGCAAGCGAAAGCGACATCGAT
TATCTCACAGGCCTTTCCGGCTCCGGGCCGGCATTCCCGGCGCTGCTCGCCGCCGCCATGATGCGCGATGCGGTCGCCAG
CGGCCTGCCGGCCGAGGTAGCGCGCCGCGCCGTCAATACGGTGATATCCGGCGCCGGCCGACTGCTGGAGCGCCGCAACG
ACTGTCCCGACGACGTCGTTCAAACCTTTCTCGACTATCGCGGCACCACCGCGGCAGCCATCGAAGGTATGCGCGCCTCC
GGGTTCGACGCTGCTGTTGCAAACGGACTATCGGCAGCATTCAAGAAATCGGTGAGTATAGGAGACGCTTCCTGA

Upstream 100 bases:

>100_bases
CCGGAATATATTGCGATCTACACCGGCGAAGTGCCGCAGCAGAGGGAGCTCGATCGCTTCTTCGCGCGGCATAGCTATAG
GCCCGACTGAGGAAGCCGAG

Downstream 100 bases:

>100_bases
CGACCGTTGAGGGCGGGTACTGCGGCACCCCGCCTAGCCACATCAGCCGCTAAATAGAGGGAACGAGAATGAAGAAACTA
CTCGCATCGACATGTTTGAC

Product: putative pyrroline-5-carboxylate reductase protein

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSVSLRIGIIGGGGWLGGAIASSILDSGLVDPRNLSLSYRSRQPDRFPDSFWTTDSQELADRSDVILLSIRPDDWYPFAL
DASDKLVISVMAGIRLGVLSERHRTGRVVRALPNAAAEVGKSYTPWIGSNDITSDDRAVVRAIFETCGSEDEVASESDID
YLTGLSGSGPAFPALLAAAMMRDAVASGLPAEVARRAVNTVISGAGRLLERRNDCPDDVVQTFLDYRGTTAAAIEGMRAS
GFDAAVANGLSAAFKKSVSIGDAS

Sequences:

>Translated_264_residues
MSVSLRIGIIGGGGWLGGAIASSILDSGLVDPRNLSLSYRSRQPDRFPDSFWTTDSQELADRSDVILLSIRPDDWYPFAL
DASDKLVISVMAGIRLGVLSERHRTGRVVRALPNAAAEVGKSYTPWIGSNDITSDDRAVVRAIFETCGSEDEVASESDID
YLTGLSGSGPAFPALLAAAMMRDAVASGLPAEVARRAVNTVISGAGRLLERRNDCPDDVVQTFLDYRGTTAAAIEGMRAS
GFDAAVANGLSAAFKKSVSIGDAS
>Mature_263_residues
SVSLRIGIIGGGGWLGGAIASSILDSGLVDPRNLSLSYRSRQPDRFPDSFWTTDSQELADRSDVILLSIRPDDWYPFALD
ASDKLVISVMAGIRLGVLSERHRTGRVVRALPNAAAEVGKSYTPWIGSNDITSDDRAVVRAIFETCGSEDEVASESDIDY
LTGLSGSGPAFPALLAAAMMRDAVASGLPAEVARRAVNTVISGAGRLLERRNDCPDDVVQTFLDYRGTTAAAIEGMRASG
FDAAVANGLSAAFKKSVSIGDAS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=261, Percent_Identity=26.4367816091954, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI24797095, Length=212, Percent_Identity=25.9433962264151, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI24797097, Length=212, Percent_Identity=25.9433962264151, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI21361454, Length=212, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=29.1666666666667, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17569021, Length=270, Percent_Identity=25.1851851851852, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320861, Length=178, Percent_Identity=26.4044943820225, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=29.6992481203008, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=24.6376811594203, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647700, Length=147, Percent_Identity=30.6122448979592, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27858; Mature: 27727

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSLRIGIIGGGGWLGGAIASSILDSGLVDPRNLSLSYRSRQPDRFPDSFWTTDSQELA
CCEEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHH
DRSDVILLSIRPDDWYPFALDASDKLVISVMAGIRLGVLSERHRTGRVVRALPNAAAEVG
CCCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KSYTPWIGSNDITSDDRAVVRAIFETCGSEDEVASESDIDYLTGLSGSGPAFPALLAAAM
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHH
MRDAVASGLPAEVARRAVNTVISGAGRLLERRNDCPDDVVQTFLDYRGTTAAAIEGMRAS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCCCC
GFDAAVANGLSAAFKKSVSIGDAS
CCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVSLRIGIIGGGGWLGGAIASSILDSGLVDPRNLSLSYRSRQPDRFPDSFWTTDSQELA
CEEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHH
DRSDVILLSIRPDDWYPFALDASDKLVISVMAGIRLGVLSERHRTGRVVRALPNAAAEVG
CCCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KSYTPWIGSNDITSDDRAVVRAIFETCGSEDEVASESDIDYLTGLSGSGPAFPALLAAAM
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHH
MRDAVASGLPAEVARRAVNTVISGAGRLLERRNDCPDDVVQTFLDYRGTTAAAIEGMRAS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCCCC
GFDAAVANGLSAAFKKSVSIGDAS
CCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]