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The map label for this gene is fghA [H]

Identifier: 86361131

GI number: 86361131

Start: 453865

End: 454701

Strand: Reverse

Name: fghA [H]

Synonym: RHE_PF00401

Alternate gene names: 86361131

Gene position: 454701-453865 (Counterclockwise)

Preceding gene: 86361132

Following gene: 86361130

Centisome position: 70.77

GC content: 62.13

Gene sequence:

>837_bases
ATGAAAACCATTGCGACCGACAAGTCTTACGGCGGCACTCAGGGCGTTTATGTCAATCGCTCCGAGGCCTGTGACTGCGA
CATGACCTTCGCCGTGTTCGTGCCGCCGCAGGCGACCGAGGGCAAGCTGCCGGTGCTGTGGTACCTGTCCGGCCTGACCT
GCACGCATGCCAATGTCATGGACAAGGGCGAGTATCGGAAGCTTGCCGCCGAGCTGGGCCTGATCGTCGTTTGTCCGGAT
ACCAGTCCCCGCGGTGATCACGTTCCTGACGAGCCCGACAATTGGCAATTCGGCAAGGGGGCCGGCTTTTACGTCGATGC
CACCGAGCCGCCGTTTTCGGCCAATTATCGCATGTACAGCTACATCACCGACGAGCTGCCGCGCCTGCTTGCGGCGGAAT
TCCCTGTCGACATGGATCGCCAGGGGATCTTCGGCCATTCGATGGGCGGACATGGCGCGATCACCATCGCGCTCAAGAAC
CCCGACCGGTTCCGCAGCTGCTCGGCCTTCGCGCCGATCAGCCACCCCTCGGTGTCCGGCTGGTCGAAACCGGCCTTGCG
GAAATATCTCGGCGCCGATGAAAACACCTGGCGGGCCTATGACACCTGCTCGCTGATCGAAGACGGGCATCGCTTCCCCG
AGCTCTTCGTGGACCAGGGGACGGCGGACAGCTTCCTGGAGGATGGGCTGCGTCCAGACGAACTCCGGCAAGCCTGCGAG
GCGTCAGGCATTCCGCTCAGGCTGCGCATGCAGGAAGGCTACGGCCACTCCTACTTTTTCATTTCGACGTTCATGGACGA
TCATCTGCGCTGGCACGCGCAGAGGTTGGAGAACTGA

Upstream 100 bases:

>100_bases
TCCGATGATCACCCACACCATGCCACTCGAAGACATCAACACGGGCTTCGAGCTGATGCACAAGGGCGAAAGCATCCGCG
GCGTGGTGGTGTACTGAGTC

Downstream 100 bases:

>100_bases
TTTTAGCGAGCTCGGCCGGGCATAACGCAAACGGCCAGGGAGGAAGGGAGAAAAGCAATGAGCAGCATAGCCATTCATCC
GGCAGTGGATTCAGGCTTTC

Product: S-formylglutathione hydrolase protein

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKTIATDKSYGGTQGVYVNRSEACDCDMTFAVFVPPQATEGKLPVLWYLSGLTCTHANVMDKGEYRKLAAELGLIVVCPD
TSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYSYITDELPRLLAAEFPVDMDRQGIFGHSMGGHGAITIALKN
PDRFRSCSAFAPISHPSVSGWSKPALRKYLGADENTWRAYDTCSLIEDGHRFPELFVDQGTADSFLEDGLRPDELRQACE
ASGIPLRLRMQEGYGHSYFFISTFMDDHLRWHAQRLEN

Sequences:

>Translated_278_residues
MKTIATDKSYGGTQGVYVNRSEACDCDMTFAVFVPPQATEGKLPVLWYLSGLTCTHANVMDKGEYRKLAAELGLIVVCPD
TSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYSYITDELPRLLAAEFPVDMDRQGIFGHSMGGHGAITIALKN
PDRFRSCSAFAPISHPSVSGWSKPALRKYLGADENTWRAYDTCSLIEDGHRFPELFVDQGTADSFLEDGLRPDELRQACE
ASGIPLRLRMQEGYGHSYFFISTFMDDHLRWHAQRLEN
>Mature_278_residues
MKTIATDKSYGGTQGVYVNRSEACDCDMTFAVFVPPQATEGKLPVLWYLSGLTCTHANVMDKGEYRKLAAELGLIVVCPD
TSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYSYITDELPRLLAAEFPVDMDRQGIFGHSMGGHGAITIALKN
PDRFRSCSAFAPISHPSVSGWSKPALRKYLGADENTWRAYDTCSLIEDGHRFPELFVDQGTADSFLEDGLRPDELRQACE
ASGIPLRLRMQEGYGHSYFFISTFMDDHLRWHAQRLEN

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=51.7857142857143, Blast_Score=306, Evalue=1e-83,
Organism=Escherichia coli, GI1786551, Length=276, Percent_Identity=44.9275362318841, Blast_Score=263, Evalue=7e-72,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=45.3237410071942, Blast_Score=251, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17510185, Length=279, Percent_Identity=46.2365591397849, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=37.1621621621622, Blast_Score=201, Evalue=7e-53,
Organism=Drosophila melanogaster, GI45551932, Length=280, Percent_Identity=48.2142857142857, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24648347, Length=280, Percent_Identity=48.2142857142857, Blast_Score=265, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31097; Mature: 31097

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIATDKSYGGTQGVYVNRSEACDCDMTFAVFVPPQATEGKLPVLWYLSGLTCTHANVM
CCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCEEECCCCC
DKGEYRKLAAELGLIVVCPDTSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYS
CCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEH
YITDELPRLLAAEFPVDMDRQGIFGHSMGGHGAITIALKNPDRFRSCSAFAPISHPSVSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCCCCCCCCCC
WSKPALRKYLGADENTWRAYDTCSLIEDGHRFPELFVDQGTADSFLEDGLRPDELRQACE
CCCHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCHHEECCCCHHHHHHCCCCHHHHHHHHH
ASGIPLRLRMQEGYGHSYFFISTFMDDHLRWHAQRLEN
HCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTIATDKSYGGTQGVYVNRSEACDCDMTFAVFVPPQATEGKLPVLWYLSGLTCTHANVM
CCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCEEECCCCC
DKGEYRKLAAELGLIVVCPDTSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYS
CCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEH
YITDELPRLLAAEFPVDMDRQGIFGHSMGGHGAITIALKNPDRFRSCSAFAPISHPSVSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCCCCCCCCCC
WSKPALRKYLGADENTWRAYDTCSLIEDGHRFPELFVDQGTADSFLEDGLRPDELRQACE
CCCHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCHHEECCCCHHHHHHCCCCHHHHHHHHH
ASGIPLRLRMQEGYGHSYFFISTFMDDHLRWHAQRLEN
HCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]