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The map label for this gene is rsbW [H]

Identifier: 85860921

GI number: 85860921

Start: 3092468

End: 3092914

Strand: Direct

Name: rsbW [H]

Synonym: SYN_00228

Alternate gene names: 85860921

Gene position: 3092468-3092914 (Clockwise)

Preceding gene: 85860920

Following gene: 85860932

Centisome position: 97.27

GC content: 51.68

Gene sequence:

>447_bases
ATGGAACCGGCGGGCAGCAATATCAAGTTGATGATTGAAAGCAGAATAGAGAATGTTTCTCTCGTTGGAGAGGCCGTGCG
AGGCATCGCCAATGCGTTGTCTCTCGACGAACTCAGTTGCTATCAGCTTGAGCTTTGTGTCGTGGAAGCGGTAAGCAACG
CGACGAAGCACGCCTATCACTCCGAGCAGGGACATCCCGTGGAAGTGGATGTTCTGCTTTTTCGGGATCGGATCACATTC
AAAATCTCTGACCAGGGAGACAGTCTGAAGTCACCGAAAGTCAAACTTCTTCGTTTCGACCCTCAGAATCTGGAAACCGT
TCCGGAAAGCGGCATGGGGCTTCCCATCATGCATGCCCTCATGGACGAGGTCAGTTACGAAACCGTGAGCGGGCGCAACA
TCCTCACCATGAGCAAGTATCTGAGAAAACAGGGACCATCCGTATAA

Upstream 100 bases:

>100_bases
GGTCATGAGTCTGTTCCGCCTGACCCGCATGAATCGGGTATTCGATATTTTTCCGTCAGAAGATGAGGCCGTCAGATCTC
TTTCCGGAAAGGCTTGAAAA

Downstream 100 bases:

>100_bases
TTTCAGGAAATTGCCCGGCACAGGAAAGGCCTGCCTTACTATTCATAAACGATGTCCAGCGAATCCAGATAGGTGGACAG
TTCGGCGGTCTTTCTTTTAA

Product: histidine kinase

Products: NA

Alternate protein names: Anti-sigma-B factor; Sigma-B negative effector rsbW [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MEPAGSNIKLMIESRIENVSLVGEAVRGIANALSLDELSCYQLELCVVEAVSNATKHAYHSEQGHPVEVDVLLFRDRITF
KISDQGDSLKSPKVKLLRFDPQNLETVPESGMGLPIMHALMDEVSYETVSGRNILTMSKYLRKQGPSV

Sequences:

>Translated_148_residues
MEPAGSNIKLMIESRIENVSLVGEAVRGIANALSLDELSCYQLELCVVEAVSNATKHAYHSEQGHPVEVDVLLFRDRITF
KISDQGDSLKSPKVKLLRFDPQNLETVPESGMGLPIMHALMDEVSYETVSGRNILTMSKYLRKQGPSV
>Mature_148_residues
MEPAGSNIKLMIESRIENVSLVGEAVRGIANALSLDELSCYQLELCVVEAVSNATKHAYHSEQGHPVEVDVLLFRDRITF
KISDQGDSLKSPKVKLLRFDPQNLETVPESGMGLPIMHALMDEVSYETVSGRNILTMSKYLRKQGPSV

Specific function: Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, rsbV. Upon phosphorylation of rsbV, rsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010193
- InterPro:   IPR003594 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 16373; Mature: 16373

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPAGSNIKLMIESRIENVSLVGEAVRGIANALSLDELSCYQLELCVVEAVSNATKHAYH
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
SEQGHPVEVDVLLFRDRITFKISDQGDSLKSPKVKLLRFDPQNLETVPESGMGLPIMHAL
CCCCCCEEEEEEEEECEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHH
MDEVSYETVSGRNILTMSKYLRKQGPSV
HHHHCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MEPAGSNIKLMIESRIENVSLVGEAVRGIANALSLDELSCYQLELCVVEAVSNATKHAYH
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
SEQGHPVEVDVLLFRDRITFKISDQGDSLKSPKVKLLRFDPQNLETVPESGMGLPIMHAL
CCCCCCEEEEEEEEECEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHH
MDEVSYETVSGRNILTMSKYLRKQGPSV
HHHHCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA