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The map label for this gene is fdhA [H]

Identifier: 85860211

GI number: 85860211

Start: 2409812

End: 2412304

Strand: Direct

Name: fdhA [H]

Synonym: SYN_00603

Alternate gene names: 85860211

Gene position: 2409812-2412304 (Clockwise)

Preceding gene: 85860210

Following gene: 85860212

Centisome position: 75.8

GC content: 55.35

Gene sequence:

>2493_bases
ATGACGAATCACTGGATCGATATCCGTAACAGTGATGTGATATTAATAATGGGCAGCAACCCTGCCTCCAACCACCCCAT
TGCCTTCAAATGGATCACCGCCGCCATGGAAAAAGGGGCCAAGGTGATTTGCGTGGACCCGCGGTTCACGCAGTCGGCGG
CAAAGGCGCACATTTACGCACCTCTCCGTTCGGGGACGGATATCGCCTTCCTCGGCGGGATGATCAGGTACATTATCGAA
AACAAACTCTACTTCGAGGAGTACGTCAGGAATTACACTAATGCGACCTTCCTCGTGAATCCCGAATTTAAGCTGCCCGG
CGACAACAACGGTGTCTTCTCGGGACTTACGGATGGGAAATACGATAAGGCCACCTGGTCATACCAGACCGAAGGGGATG
GAAGGATCAAAAAGGATCCCACCATGCAGGATCCCAACTGCGTCTTCCAGCTCATGAAAAAGCATTATTCCCGCTATACG
CCGGAGGTCGTCAACAAAATCACGGGGACACCTGTAGACAAATTGATTGAAATCTACAAGATCTACGGTTCGACGGGAAC
TCCGGACCGGGCAGGAAACGAGCTATATGCCATGGGCTGGACCCAGCATACCGTCGGCACCCAGAATATCCGTACCATGT
GCATCATTCAGCTTCTCCTGGGCAACATGGGCATCCCAGGCGGCGGCGTGGCAGCCATGCGTGGCGAGTCCAACGTCCAG
GGATCAACGGATCATGGTCTTCTGTTCCACATCTGGCCCGGCTATCTCAACACCCCCAAGGCGTCTCTTGCGACTCTGGC
CGCGTACAATGAAAAAGAGACCCCGACAACAAAGGAACCCAACAGTCTCAACTGGCAGAAAAACAAGCCCAAGTATGTAG
CGAGTTTTCTCCGGGCCATGTACGGGACGAACGCCTCTCTGGACGAGGCATACAATCTGCTTCCCAAAATCGACGACGGC
GCCAACTATTCCTGGCTCAACCTCTTCGATGTGATGTATAAGGGCAAGTTCACGGGATTCTTTGCGTGGGGAATGAACCC
CGCATGCAGCGGAGCCCATTCCAACAAGGTCCGCCAGGCATTGACCAGGCTGGACTGGATGGTCAATGTCAATCTCTATG
ACAACGAGACCGGCTCCTTCTGGCGCGGTCCTGGAATGGATCCGAAAAAGATCAGGACGGAAGTCTTCATGCTGCCCTGC
GCCGCCTCAATTGAAAAAGAGGGGAGCATCATCAACAGCGGCCGCTGGAACCAGTGGCGTTACAAAGCCATTGATCCTCC
GGGCGTCGCTCTTCCTGACGGCGACATATGCTCGGAAATCTATTTCAAGGTCAAAGAACTGTACGAAAAGGAAGGCGGCC
CCAACATGGAGGCCATCACGAAACTGAGTTGGAACTACGGTACGAAGACCTTCGACGGCCATTATCACTTCGATCCCCAT
TCCGTGGCCAAGGAAATCAACGGGTTCTTCCTTGAAGATAAAACGGTGGAAAATCCCACAAAGAAGGGTGAGTTCAAGGA
GTTCAAGAAGGGCGATCCCGTTCCCACCTTTGCCTGGCTCCAGGATGACGGTTCCACGTCCTCCGGCTGCTGGGTCTACT
GCGGCTCCTACACGGACAAGAACATGTCCGCCCGCCGCGACGGAAAGAAAGACCCGACGGGCATCGGCCTTTACCCCGAG
TGGGCATGGGCATGGCCGGTCAACAGAAGGATCATCTATAACGGCGCCTCTGTCGATCCGTCAGGAAAGCCATGGAGTGC
TAAGAAGGCGGTCATCAAGTGGGTCGGCGACAAATGGGTCGGAGATGTTCCGGATGGTGTGGGCGATCCCGGATCCGGCA
GGCCTCCCTTCATCATGAAGCCCGACGGCGTGGCGAGCCTCTTTGGACCGGGTCTGGCTGACGGGCCTTTCCCCGAGCAT
TACGAACCCCTGGAATGTCCAGTGGAGAAGAATTTCCTGTCACCCCAGAAAAGCAACCCGACAATCAAGCGGTTCGACAA
ACCCGGTGTGGGTTCCGATGTGGACGTGTACTCGGGCATCGATTCATGCGATCCCAAATACCCGTTCATCTGCGCGACAT
ACCGCATCAGCGAGCATTGGCAGACCGGCCTCCAGACCCGTTGGTGCCCCTGGCTTTCCGAGATGCAGCCGGAAATGTGG
TGCGAGATGAGCAAGGAGCTGGCGAAGGAGCGGGGAATCTCCAACGGTGACAAGGTCATTGTCAGTTCTCCCAGAGGCGA
AGTGGAGTGTGTAGCCATTGTCACACCCCGTTTCAAGCCGTTTAACATCAACGGAAACATCCTCCATGAGGTCGGCATCC
CCTGGCATTTCGGGTGGATCACGACGAAGGATCGGCAGTACAACCCCGGTGACAAGAAGGCAGAGGTCTTCACATGGGGT
GACGCGGCCAATCTCCTGGTGCCGACGATCGGGGACGCCAACACGACGATCCCGGAAAGCAAGGCCTTCATGGTTAATGT
GGTCAAGAAGTAA

Upstream 100 bases:

>100_bases
ATTTCTGCGGGGGTTGGGTCTGGTCTATATTGAGCACCAGGCCCGTATCTGACACAGCCCGACTGTACCGGCTCTGGGAG
AGTCGTTCGGACGCGGCGCA

Downstream 100 bases:

>100_bases
GGGGGTAAACAAAAATGGCAGAATATATAAAACTTATTGATGTTTCCAAATGTACCGGCTGCCGGGGTTGTCAGCTGGCC
TGCAAACAGTGGAATCAGCA

Product: formate dehydrogenase major subunit

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 830; Mature: 829

Protein sequence:

>830_residues
MTNHWIDIRNSDVILIMGSNPASNHPIAFKWITAAMEKGAKVICVDPRFTQSAAKAHIYAPLRSGTDIAFLGGMIRYIIE
NKLYFEEYVRNYTNATFLVNPEFKLPGDNNGVFSGLTDGKYDKATWSYQTEGDGRIKKDPTMQDPNCVFQLMKKHYSRYT
PEVVNKITGTPVDKLIEIYKIYGSTGTPDRAGNELYAMGWTQHTVGTQNIRTMCIIQLLLGNMGIPGGGVAAMRGESNVQ
GSTDHGLLFHIWPGYLNTPKASLATLAAYNEKETPTTKEPNSLNWQKNKPKYVASFLRAMYGTNASLDEAYNLLPKIDDG
ANYSWLNLFDVMYKGKFTGFFAWGMNPACSGAHSNKVRQALTRLDWMVNVNLYDNETGSFWRGPGMDPKKIRTEVFMLPC
AASIEKEGSIINSGRWNQWRYKAIDPPGVALPDGDICSEIYFKVKELYEKEGGPNMEAITKLSWNYGTKTFDGHYHFDPH
SVAKEINGFFLEDKTVENPTKKGEFKEFKKGDPVPTFAWLQDDGSTSSGCWVYCGSYTDKNMSARRDGKKDPTGIGLYPE
WAWAWPVNRRIIYNGASVDPSGKPWSAKKAVIKWVGDKWVGDVPDGVGDPGSGRPPFIMKPDGVASLFGPGLADGPFPEH
YEPLECPVEKNFLSPQKSNPTIKRFDKPGVGSDVDVYSGIDSCDPKYPFICATYRISEHWQTGLQTRWCPWLSEMQPEMW
CEMSKELAKERGISNGDKVIVSSPRGEVECVAIVTPRFKPFNINGNILHEVGIPWHFGWITTKDRQYNPGDKKAEVFTWG
DAANLLVPTIGDANTTIPESKAFMVNVVKK

Sequences:

>Translated_830_residues
MTNHWIDIRNSDVILIMGSNPASNHPIAFKWITAAMEKGAKVICVDPRFTQSAAKAHIYAPLRSGTDIAFLGGMIRYIIE
NKLYFEEYVRNYTNATFLVNPEFKLPGDNNGVFSGLTDGKYDKATWSYQTEGDGRIKKDPTMQDPNCVFQLMKKHYSRYT
PEVVNKITGTPVDKLIEIYKIYGSTGTPDRAGNELYAMGWTQHTVGTQNIRTMCIIQLLLGNMGIPGGGVAAMRGESNVQ
GSTDHGLLFHIWPGYLNTPKASLATLAAYNEKETPTTKEPNSLNWQKNKPKYVASFLRAMYGTNASLDEAYNLLPKIDDG
ANYSWLNLFDVMYKGKFTGFFAWGMNPACSGAHSNKVRQALTRLDWMVNVNLYDNETGSFWRGPGMDPKKIRTEVFMLPC
AASIEKEGSIINSGRWNQWRYKAIDPPGVALPDGDICSEIYFKVKELYEKEGGPNMEAITKLSWNYGTKTFDGHYHFDPH
SVAKEINGFFLEDKTVENPTKKGEFKEFKKGDPVPTFAWLQDDGSTSSGCWVYCGSYTDKNMSARRDGKKDPTGIGLYPE
WAWAWPVNRRIIYNGASVDPSGKPWSAKKAVIKWVGDKWVGDVPDGVGDPGSGRPPFIMKPDGVASLFGPGLADGPFPEH
YEPLECPVEKNFLSPQKSNPTIKRFDKPGVGSDVDVYSGIDSCDPKYPFICATYRISEHWQTGLQTRWCPWLSEMQPEMW
CEMSKELAKERGISNGDKVIVSSPRGEVECVAIVTPRFKPFNINGNILHEVGIPWHFGWITTKDRQYNPGDKKAEVFTWG
DAANLLVPTIGDANTTIPESKAFMVNVVKK
>Mature_829_residues
TNHWIDIRNSDVILIMGSNPASNHPIAFKWITAAMEKGAKVICVDPRFTQSAAKAHIYAPLRSGTDIAFLGGMIRYIIEN
KLYFEEYVRNYTNATFLVNPEFKLPGDNNGVFSGLTDGKYDKATWSYQTEGDGRIKKDPTMQDPNCVFQLMKKHYSRYTP
EVVNKITGTPVDKLIEIYKIYGSTGTPDRAGNELYAMGWTQHTVGTQNIRTMCIIQLLLGNMGIPGGGVAAMRGESNVQG
STDHGLLFHIWPGYLNTPKASLATLAAYNEKETPTTKEPNSLNWQKNKPKYVASFLRAMYGTNASLDEAYNLLPKIDDGA
NYSWLNLFDVMYKGKFTGFFAWGMNPACSGAHSNKVRQALTRLDWMVNVNLYDNETGSFWRGPGMDPKKIRTEVFMLPCA
ASIEKEGSIINSGRWNQWRYKAIDPPGVALPDGDICSEIYFKVKELYEKEGGPNMEAITKLSWNYGTKTFDGHYHFDPHS
VAKEINGFFLEDKTVENPTKKGEFKEFKKGDPVPTFAWLQDDGSTSSGCWVYCGSYTDKNMSARRDGKKDPTGIGLYPEW
AWAWPVNRRIIYNGASVDPSGKPWSAKKAVIKWVGDKWVGDVPDGVGDPGSGRPPFIMKPDGVASLFGPGLADGPFPEHY
EPLECPVEKNFLSPQKSNPTIKRFDKPGVGSDVDVYSGIDSCDPKYPFICATYRISEHWQTGLQTRWCPWLSEMQPEMWC
EMSKELAKERGISNGDKVIVSSPRGEVECVAIVTPRFKPFNINGNILHEVGIPWHFGWITTKDRQYNPGDKKAEVFTWGD
AANLLVPTIGDANTTIPESKAFMVNVVKK

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=845, Percent_Identity=44.6153846153846, Blast_Score=698, Evalue=0.0,
Organism=Escherichia coli, GI3868720, Length=843, Percent_Identity=42.2301304863582, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI3868721, Length=440, Percent_Identity=25, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI87081797, Length=236, Percent_Identity=25.4237288135593, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1787870, Length=240, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 92876; Mature: 92745

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00932 MOLYBDOPTERIN_PROK_3 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHWIDIRNSDVILIMGSNPASNHPIAFKWITAAMEKGAKVICVDPRFTQSAAKAHIYA
CCCCEEEECCCCEEEEECCCCCCCCCEEEHHHHHHHHCCCEEEEECCCCCHHHCCEEEEE
PLRSGTDIAFLGGMIRYIIENKLYFEEYVRNYTNATFLVNPEFKLPGDNNGVFSGLTDGK
ECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCEECCCCCCCEEECCCCCC
YDKATWSYQTEGDGRIKKDPTMQDPNCVFQLMKKHYSRYTPEVVNKITGTPVDKLIEIYK
CCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHH
IYGSTGTPDRAGNELYAMGWTQHTVGTQNIRTMCIIQLLLGNMGIPGGGVAAMRGESNVQ
HHCCCCCCCCCCCEEEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
GSTDHGLLFHIWPGYLNTPKASLATLAAYNEKETPTTKEPNSLNWQKNKPKYVASFLRAM
CCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
YGTNASLDEAYNLLPKIDDGANYSWLNLFDVMYKGKFTGFFAWGMNPACSGAHSNKVRQA
HCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHH
LTRLDWMVNVNLYDNETGSFWRGPGMDPKKIRTEVFMLPCAASIEKEGSIINSGRWNQWR
HHHCEEEEEEEEEECCCCCCCCCCCCCHHHHCEEEEEECCHHCCCCCCCEECCCCCCCEE
YKAIDPPGVALPDGDICSEIYFKVKELYEKEGGPNMEAITKLSWNYGTKTFDGHYHFDPH
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCEEECCEEECCHH
SVAKEINGFFLEDKTVENPTKKGEFKEFKKGDPVPTFAWLQDDGSTSSGCWVYCGSYTDK
HHHHHHCCEEEECCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCCCCC
NMSARRDGKKDPTGIGLYPEWAWAWPVNRRIIYNGASVDPSGKPWSAKKAVIKWVGDKWV
CCCHHCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCC
GDVPDGVGDPGSGRPPFIMKPDGVASLFGPGLADGPFPEHYEPLECPVEKNFLSPQKSNP
CCCCCCCCCCCCCCCCEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TIKRFDKPGVGSDVDVYSGIDSCDPKYPFICATYRISEHWQTGLQTRWCPWLSEMQPEMW
CCEECCCCCCCCCCHHHCCCCCCCCCCCEEEEEEEEHHHHHCCCCCCCCCCHHHCCHHHH
CEMSKELAKERGISNGDKVIVSSPRGEVECVAIVTPRFKPFNINGNILHEVGIPWHFGWI
HHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCEEEECCCCEEECEE
TTKDRQYNPGDKKAEVFTWGDAANLLVPTIGDANTTIPESKAFMVNVVKK
EECCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
TNHWIDIRNSDVILIMGSNPASNHPIAFKWITAAMEKGAKVICVDPRFTQSAAKAHIYA
CCCEEEECCCCEEEEECCCCCCCCCEEEHHHHHHHHCCCEEEEECCCCCHHHCCEEEEE
PLRSGTDIAFLGGMIRYIIENKLYFEEYVRNYTNATFLVNPEFKLPGDNNGVFSGLTDGK
ECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCEECCCCCCCEEECCCCCC
YDKATWSYQTEGDGRIKKDPTMQDPNCVFQLMKKHYSRYTPEVVNKITGTPVDKLIEIYK
CCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHH
IYGSTGTPDRAGNELYAMGWTQHTVGTQNIRTMCIIQLLLGNMGIPGGGVAAMRGESNVQ
HHCCCCCCCCCCCEEEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
GSTDHGLLFHIWPGYLNTPKASLATLAAYNEKETPTTKEPNSLNWQKNKPKYVASFLRAM
CCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
YGTNASLDEAYNLLPKIDDGANYSWLNLFDVMYKGKFTGFFAWGMNPACSGAHSNKVRQA
HCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHH
LTRLDWMVNVNLYDNETGSFWRGPGMDPKKIRTEVFMLPCAASIEKEGSIINSGRWNQWR
HHHCEEEEEEEEEECCCCCCCCCCCCCHHHHCEEEEEECCHHCCCCCCCEECCCCCCCEE
YKAIDPPGVALPDGDICSEIYFKVKELYEKEGGPNMEAITKLSWNYGTKTFDGHYHFDPH
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCEEECCEEECCHH
SVAKEINGFFLEDKTVENPTKKGEFKEFKKGDPVPTFAWLQDDGSTSSGCWVYCGSYTDK
HHHHHHCCEEEECCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCCCCC
NMSARRDGKKDPTGIGLYPEWAWAWPVNRRIIYNGASVDPSGKPWSAKKAVIKWVGDKWV
CCCHHCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCC
GDVPDGVGDPGSGRPPFIMKPDGVASLFGPGLADGPFPEHYEPLECPVEKNFLSPQKSNP
CCCCCCCCCCCCCCCCEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TIKRFDKPGVGSDVDVYSGIDSCDPKYPFICATYRISEHWQTGLQTRWCPWLSEMQPEMW
CCEECCCCCCCCCCHHHCCCCCCCCCCCEEEEEEEEHHHHHCCCCCCCCCCHHHCCHHHH
CEMSKELAKERGISNGDKVIVSSPRGEVECVAIVTPRFKPFNINGNILHEVGIPWHFGWI
HHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCEEEECCCCEEECEE
TTKDRQYNPGDKKAEVFTWGDAANLLVPTIGDANTTIPESKAFMVNVVKK
EECCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA