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The map label for this gene is fdhA [H]

Identifier: 85860210

GI number: 85860210

Start: 2409203

End: 2409763

Strand: Direct

Name: fdhA [H]

Synonym: SYN_00602

Alternate gene names: 85860210

Gene position: 2409203-2409763 (Clockwise)

Preceding gene: 85860209

Following gene: 85860211

Centisome position: 75.78

GC content: 54.9

Gene sequence:

>561_bases
ATGGTGGATGTCAACAGGAGAGGTTTTTTGAAGATATCCGGAGCGGTGTTGGCGGCCAGCGGGCTCGGAATCAGTCTGAA
GCCCGTTTCCGCCTATGCCCAGCCCCTGAAGATTCAGTATGCCAAAGAGACGACTACGATTTGTCCATACTGTTCTGTGG
GATGCAGCATCATCGTGTCGACCCGCAAAGGGAAGGTGGTCAATACGGAGGGTGATCCGGACAGTCCGATCAATCGCGGC
TCCCTTTGCACCAAAGGGGGGTCCATCTATCAGATGGCAAACAACGAAAACCGGCTGGGCAAACCCCTTTACCGAGCCCC
TTACGCCACGGAATGGAAGGAAGTGGACTGGGAGTGGGCCCTTGAGCGGATTGCGAAAAATGTCAAAACAAGCCGCGACA
AGAGCTTCCGGGCCGCCAATGACAAGGGTGAGTTGGTGAATCGGACGGAAGGAATCGCTTCTGTCGGCAGCGCTGCCATC
GACAACGAAGAGTGCTTCGTTTATCAGAAATTTCTGCGGGGGTTGGGTCTGGTCTATATTGAGCACCAGGCCCGTATCTG
A

Upstream 100 bases:

>100_bases
TCCGGAAAGAACTGATGCCCGGGCATACCGGCGTAACCGGAATAATGAAGGAAAGACCGGAGATGATTGAATTTATTTCA
GTGAAAGGAATGTCTTAATT

Downstream 100 bases:

>100_bases
CACAGCCCGACTGTACCGGCTCTGGGAGAGTCGTTCGGACGCGGCGCAATGACGAATCACTGGATCGATATCCGTAACAG
TGATGTGATATTAATAATGG

Product: formate dehydrogenase major subunit

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MVDVNRRGFLKISGAVLAASGLGISLKPVSAYAQPLKIQYAKETTTICPYCSVGCSIIVSTRKGKVVNTEGDPDSPINRG
SLCTKGGSIYQMANNENRLGKPLYRAPYATEWKEVDWEWALERIAKNVKTSRDKSFRAANDKGELVNRTEGIASVGSAAI
DNEECFVYQKFLRGLGLVYIEHQARI

Sequences:

>Translated_186_residues
MVDVNRRGFLKISGAVLAASGLGISLKPVSAYAQPLKIQYAKETTTICPYCSVGCSIIVSTRKGKVVNTEGDPDSPINRG
SLCTKGGSIYQMANNENRLGKPLYRAPYATEWKEVDWEWALERIAKNVKTSRDKSFRAANDKGELVNRTEGIASVGSAAI
DNEECFVYQKFLRGLGLVYIEHQARI
>Mature_186_residues
MVDVNRRGFLKISGAVLAASGLGISLKPVSAYAQPLKIQYAKETTTICPYCSVGCSIIVSTRKGKVVNTEGDPDSPINRG
SLCTKGGSIYQMANNENRLGKPLYRAPYATEWKEVDWEWALERIAKNVKTSRDKSFRAANDKGELVNRTEGIASVGSAAI
DNEECFVYQKFLRGLGLVYIEHQARI

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=195, Percent_Identity=37.9487179487179, Blast_Score=141, Evalue=2e-35,
Organism=Escherichia coli, GI3868720, Length=195, Percent_Identity=36.9230769230769, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1788534, Length=135, Percent_Identity=31.1111111111111, Blast_Score=71, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 20452; Mature: 20452

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVNRRGFLKISGAVLAASGLGISLKPVSAYAQPLKIQYAKETTTICPYCSVGCSIIVS
CCCCCCCCEEEECCEEEEECCCCEEEECHHHCCCCEEEEECCCCCEECCCCCCCCEEEEE
TRKGKVVNTEGDPDSPINRGSLCTKGGSIYQMANNENRLGKPLYRAPYATEWKEVDWEWA
ECCCEEEECCCCCCCCCCCCCEECCCCCEEEECCCCCCCCCCHHCCCCCCCHHCCCHHHH
LERIAKNVKTSRDKSFRAANDKGELVNRTEGIASVGSAAIDNEECFVYQKFLRGLGLVYI
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEE
EHQARI
ECCCCC
>Mature Secondary Structure
MVDVNRRGFLKISGAVLAASGLGISLKPVSAYAQPLKIQYAKETTTICPYCSVGCSIIVS
CCCCCCCCEEEECCEEEEECCCCEEEECHHHCCCCEEEEECCCCCEECCCCCCCCEEEEE
TRKGKVVNTEGDPDSPINRGSLCTKGGSIYQMANNENRLGKPLYRAPYATEWKEVDWEWA
ECCCEEEECCCCCCCCCCCCCEECCCCCEEEECCCCCCCCCCHHCCCCCCCHHCCCHHHH
LERIAKNVKTSRDKSFRAANDKGELVNRTEGIASVGSAAIDNEECFVYQKFLRGLGLVYI
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEE
EHQARI
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA