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The map label for this gene is gcdA [H]

Identifier: 85859866

GI number: 85859866

Start: 2098959

End: 2100731

Strand: Direct

Name: gcdA [H]

Synonym: SYN_00481

Alternate gene names: 85859866

Gene position: 2098959-2100731 (Clockwise)

Preceding gene: 85859865

Following gene: 85859875

Centisome position: 66.02

GC content: 53.13

Gene sequence:

>1773_bases
ATGAGACAATACTTTGAAAAGATGGACGATCTGGGCAAGCCCCTGAAACCCGCTCAGATTGAAAGAATGAAGGAAAACGT
TGCACAGATTGAGGAAGTGTATGCAGAAGTCGCAGCGGAATTCGAAAAGGCAAAAAATGCAGGCGTTCCCGCCGAGGATG
TCCACAAAAAAGGCGAAATGACCGTATGGGATCGTATCGAATACATCGTGGATCCCGGTACGTTCTGTCCGCTCCACACC
CTTTTCAATCCCGCAGGAAATAAAGAGGGCGTGACGGGCGTCATCGATGGTCTTGCCCGAATCAGCGGCAAATGGTGCGT
CCTGATCGGATTTGACAACAAGGTTACTGTGGGCGCCTGGATTCCCGGTCAGCCGGAAAACAACCTCCGTGCCACCGATA
TGGCCAAGATCCTCAATATTCCCATAGTCTGGCTGGTCAACTGCTCCGGTGCGAGACTGCCCGAGCAGCATAAATTCTAT
GCCAACCGCCGCGGCAGTGGGACCTGCTTCTTCCGCCACGCGGAACTGGAAACGCTGGGGATTCCCGTCCTAGCGGGGAT
TTACGGAACGAATCCGGCCGGCGGCGGCTATCAGGGAATCAGCCCGACCATTCTTCTCGCTCACAAAAACTGCAACATCG
CCGTGGGTGGCGCAGGCATCGTCAGCGGCATGTCCCCCAAGGGATTCTTCGATGAAGAAATAGCTGAAGCGCTTATCGAA
GCAACGCGCAAGTTCAGGGCAACTCCTCCAGGAAGAGTCGCGATTCATCATGATGTGACCGGATTCTTCCGCGCAGTCTA
TGAGGAGGAAACAGGTGTCCTGGATGGATTGAAGCAGTACATGGCTGAAATGCCGGCTTATAATCCCCGTTTCTTCCGGG
TTGCCCAGCCTGCAGAACCCAAGTACGATCCCAAGGAAATCTCTTCCATCATCACCTTCAACCAGAAGATGGTTTATGAT
TTCGATAATATTCTGGCCCGTCTGGTGGACAATTCCGAGCATATGGAATTCCGTCCCGGTTTCGGACCTGAGGTTTACAC
CGGTCTGGTCAAGATCGACGGCTTCCTGATCGGCGCCATCGGCAACCGTCATGGTGTTCTGCCCAACTACCCGGAATATA
CCAATGAGTACATCGGGGTGGGAGGAAAGCTGTATCGCCAGGGTCTGATCAAGATGAGCGAGTTTGTCTCCCTCTGTGAT
CGTGATCGTATTCCCATTGTGTGGTTCCAGGATACTTCAGGAATCGACGTTGGCGACATCGCGGAAAAAGCGGAACTTCT
CGGGCTGGGTCAGGCTCTTATTTATTCCATCGAGCAGACGAAACTTCCCATGATGCTGACGGTCCTCCGCAAGGGATCGG
CAGCGGCCCATTACGTCATGGGCGGCCCCACGGCCAATAACCACACGGCCTTTACGCTGGGCACGGCTACGACGGAAATT
TACGTCATGCACGGCGAAACCGCGGCAACAGCCAGTTTTGCCCGCAGACTGGTCAAGGAAAAGGATGCCGGCAAGTCCCT
GCAGCCTGTCCTTGATAAGATGAATCAGTTGGCAAAGGAATACTATAACAACTCACGTCCGGTATACTGTGCCCAGCAGG
GTTTGGTGGACGAAATCGTTCGTTACGAAGACATCCGCAAATACCTGGTCGCATTTGCCAATGCAGTGTATCAGAATCCG
AAATCCATCTGCCCGCAGCATCACTTGATTCTGCCGCGGATTATCCGTTCTGAGATTGTTAAAGGATTGCCCAGACCAGC
AAAAGAAGCATAA

Upstream 100 bases:

>100_bases
GGCGGAGCTCTGCTGGCCCAGAAATAACCCATAAACCGAGGTTTTCTGACCTCTGTTACGTTACATGTTACAGTGCAGAT
TTACTGGAGGATAGTTATTC

Downstream 100 bases:

>100_bases
ATAAGGACTAACACCCCTTATCTGGTCATTGAGTAACTAAAGAAGGCCGAAGCGTGAATTCTTCATGCTTCGGCCTTTTA
CATTCCCTTTTCGTCCGTCT

Product: glutaconyl-CoA decarboxylasesubunit A

Products: NA

Alternate protein names: Carboxyltransferase [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MRQYFEKMDDLGKPLKPAQIERMKENVAQIEEVYAEVAAEFEKAKNAGVPAEDVHKKGEMTVWDRIEYIVDPGTFCPLHT
LFNPAGNKEGVTGVIDGLARISGKWCVLIGFDNKVTVGAWIPGQPENNLRATDMAKILNIPIVWLVNCSGARLPEQHKFY
ANRRGSGTCFFRHAELETLGIPVLAGIYGTNPAGGGYQGISPTILLAHKNCNIAVGGAGIVSGMSPKGFFDEEIAEALIE
ATRKFRATPPGRVAIHHDVTGFFRAVYEEETGVLDGLKQYMAEMPAYNPRFFRVAQPAEPKYDPKEISSIITFNQKMVYD
FDNILARLVDNSEHMEFRPGFGPEVYTGLVKIDGFLIGAIGNRHGVLPNYPEYTNEYIGVGGKLYRQGLIKMSEFVSLCD
RDRIPIVWFQDTSGIDVGDIAEKAELLGLGQALIYSIEQTKLPMMLTVLRKGSAAAHYVMGGPTANNHTAFTLGTATTEI
YVMHGETAATASFARRLVKEKDAGKSLQPVLDKMNQLAKEYYNNSRPVYCAQQGLVDEIVRYEDIRKYLVAFANAVYQNP
KSICPQHHLILPRIIRSEIVKGLPRPAKEA

Sequences:

>Translated_590_residues
MRQYFEKMDDLGKPLKPAQIERMKENVAQIEEVYAEVAAEFEKAKNAGVPAEDVHKKGEMTVWDRIEYIVDPGTFCPLHT
LFNPAGNKEGVTGVIDGLARISGKWCVLIGFDNKVTVGAWIPGQPENNLRATDMAKILNIPIVWLVNCSGARLPEQHKFY
ANRRGSGTCFFRHAELETLGIPVLAGIYGTNPAGGGYQGISPTILLAHKNCNIAVGGAGIVSGMSPKGFFDEEIAEALIE
ATRKFRATPPGRVAIHHDVTGFFRAVYEEETGVLDGLKQYMAEMPAYNPRFFRVAQPAEPKYDPKEISSIITFNQKMVYD
FDNILARLVDNSEHMEFRPGFGPEVYTGLVKIDGFLIGAIGNRHGVLPNYPEYTNEYIGVGGKLYRQGLIKMSEFVSLCD
RDRIPIVWFQDTSGIDVGDIAEKAELLGLGQALIYSIEQTKLPMMLTVLRKGSAAAHYVMGGPTANNHTAFTLGTATTEI
YVMHGETAATASFARRLVKEKDAGKSLQPVLDKMNQLAKEYYNNSRPVYCAQQGLVDEIVRYEDIRKYLVAFANAVYQNP
KSICPQHHLILPRIIRSEIVKGLPRPAKEA
>Mature_590_residues
MRQYFEKMDDLGKPLKPAQIERMKENVAQIEEVYAEVAAEFEKAKNAGVPAEDVHKKGEMTVWDRIEYIVDPGTFCPLHT
LFNPAGNKEGVTGVIDGLARISGKWCVLIGFDNKVTVGAWIPGQPENNLRATDMAKILNIPIVWLVNCSGARLPEQHKFY
ANRRGSGTCFFRHAELETLGIPVLAGIYGTNPAGGGYQGISPTILLAHKNCNIAVGGAGIVSGMSPKGFFDEEIAEALIE
ATRKFRATPPGRVAIHHDVTGFFRAVYEEETGVLDGLKQYMAEMPAYNPRFFRVAQPAEPKYDPKEISSIITFNQKMVYD
FDNILARLVDNSEHMEFRPGFGPEVYTGLVKIDGFLIGAIGNRHGVLPNYPEYTNEYIGVGGKLYRQGLIKMSEFVSLCD
RDRIPIVWFQDTSGIDVGDIAEKAELLGLGQALIYSIEQTKLPMMLTVLRKGSAAAHYVMGGPTANNHTAFTLGTATTEI
YVMHGETAATASFARRLVKEKDAGKSLQPVLDKMNQLAKEYYNNSRPVYCAQQGLVDEIVRYEDIRKYLVAFANAVYQNP
KSICPQHHLILPRIIRSEIVKGLPRPAKEA

Specific function: Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD) [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=535, Percent_Identity=24.2990654205607, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI119943100, Length=504, Percent_Identity=22.0238095238095, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI295821216, Length=524, Percent_Identity=21.5648854961832, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17552936, Length=547, Percent_Identity=26.3254113345521, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25147362, Length=550, Percent_Identity=20.5454545454545, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25147359, Length=543, Percent_Identity=20.6261510128913, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24586065, Length=504, Percent_Identity=23.8095238095238, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =4.1.1.70 [H]

Molecular weight: Translated: 65368; Mature: 65368

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00445 FGGY_KINASES_2 ; PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQYFEKMDDLGKPLKPAQIERMKENVAQIEEVYAEVAAEFEKAKNAGVPAEDVHKKGEM
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCC
TVWDRIEYIVDPGTFCPLHTLFNPAGNKEGVTGVIDGLARISGKWCVLIGFDNKVTVGAW
CHHHHHHHEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEE
IPGQPENNLRATDMAKILNIPIVWLVNCSGARLPEQHKFYANRRGSGTCFFRHAELETLG
CCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHC
IPVLAGIYGTNPAGGGYQGISPTILLAHKNCNIAVGGAGIVSGMSPKGFFDEEIAEALIE
CHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCHHHCCCCCCCCCHHHHHHHHHH
ATRKFRATPPGRVAIHHDVTGFFRAVYEEETGVLDGLKQYMAEMPAYNPRFFRVAQPAEP
HHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCC
KYDPKEISSIITFNQKMVYDFDNILARLVDNSEHMEFRPGFGPEVYTGLVKIDGFLIGAI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHEEECCEEEEEC
GNRHGVLPNYPEYTNEYIGVGGKLYRQGLIKMSEFVSLCDRDRIPIVWFQDTSGIDVGDI
CCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
AEKAELLGLGQALIYSIEQTKLPMMLTVLRKGSAAAHYVMGGPTANNHTAFTLGTATTEI
HHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCEEEE
YVMHGETAATASFARRLVKEKDAGKSLQPVLDKMNQLAKEYYNNSRPVYCAQQGLVDEIV
EEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
RYEDIRKYLVAFANAVYQNPKSICPQHHLILPRIIRSEIVKGLPRPAKEA
HHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRQYFEKMDDLGKPLKPAQIERMKENVAQIEEVYAEVAAEFEKAKNAGVPAEDVHKKGEM
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCC
TVWDRIEYIVDPGTFCPLHTLFNPAGNKEGVTGVIDGLARISGKWCVLIGFDNKVTVGAW
CHHHHHHHEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEE
IPGQPENNLRATDMAKILNIPIVWLVNCSGARLPEQHKFYANRRGSGTCFFRHAELETLG
CCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHC
IPVLAGIYGTNPAGGGYQGISPTILLAHKNCNIAVGGAGIVSGMSPKGFFDEEIAEALIE
CHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCHHHCCCCCCCCCHHHHHHHHHH
ATRKFRATPPGRVAIHHDVTGFFRAVYEEETGVLDGLKQYMAEMPAYNPRFFRVAQPAEP
HHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCC
KYDPKEISSIITFNQKMVYDFDNILARLVDNSEHMEFRPGFGPEVYTGLVKIDGFLIGAI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHEEECCEEEEEC
GNRHGVLPNYPEYTNEYIGVGGKLYRQGLIKMSEFVSLCDRDRIPIVWFQDTSGIDVGDI
CCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
AEKAELLGLGQALIYSIEQTKLPMMLTVLRKGSAAAHYVMGGPTANNHTAFTLGTATTEI
HHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCEEEE
YVMHGETAATASFARRLVKEKDAGKSLQPVLDKMNQLAKEYYNNSRPVYCAQQGLVDEIV
EEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
RYEDIRKYLVAFANAVYQNPKSICPQHHLILPRIIRSEIVKGLPRPAKEA
HHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8382157; 8365476; 7607244 [H]