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The map label for this gene is acdA [H]

Identifier: 85859865

GI number: 85859865

Start: 2097734

End: 2098885

Strand: Direct

Name: acdA [H]

Synonym: SYN_00480

Alternate gene names: 85859865

Gene position: 2097734-2098885 (Clockwise)

Preceding gene: 85859864

Following gene: 85859866

Centisome position: 65.98

GC content: 53.82

Gene sequence:

>1152_bases
ATGGATTTTGCTTTATCAGAAGAACTTGAAATGCTACGCTCCATGGCGCGGGATTTCGCGGCCGAAAAGATTGCTCCCTT
TGCAGACAAATGGGACGAAGAACACTACTTCCCCTATGAGGAAGTCGTCAAACCGATGGGCGAACTGGGCTTCTTCGGCA
CGGTCATTCCGGAAGAATACGGTGGAACCAACATGGGCTGGCTGGCCGCCATGATCCTCACAGAAGAAATCTCCCGTGCA
TCCAGCGCGCTTCGCGTCCAGATCAACATGGAAGGCCTTGGCTGCGCCTACACCATCTGGAAGTATGGAACGGAAGAAGC
CAAGAAGAAGTACGTTCAGAAGCTGGTTTCAGCCGAATACCTTGGCGGCTTCGGCATCACCGAATTCAACGCCGGTTCCG
ACGTTATGTCTATGAAATCCACTGCCGAGGACAAAGGGGATTATTATCTGCTGAACGGTTCCAAGACCTGGATCTCCAAT
GCCAACTGCGCCGATGTCATCATTTACTATGCCTATACGGATAAGGCAGCAAAAGGCAAGGGTCTGTCCGCATTTGCCGT
GGAATTGAAGAACAACCCCGGCATCCGCACGACGGATCTGGACAAGATGGGAAGCAAATCCTCACCGACCGGTGAAATCT
ATCTCGACAACGTCAAAGTCCCGAAGGAAAATCTCCTCGGCAAACCCGGCGACGGCGCCAAGATCGTTTTCGGTTCTCTC
AATGGAACCCGTCTCTCCGCCGCGGCCGGCGGAATCGGTCTTGCCCAGGCCTGCCTCGACGCCGCCATCAAATACGCCAA
TGAACGTGAACAGTTTGGAAAACCCATCGGAACGTTCCAGGCCAACCAGTTCCTCATCGGCGAAATGGCCACCGAATTGG
AAGCCGCTAGACTGATGGTCTACAGGGCTGCCTGGCAGAAGGATCAGGGCAATCTGGGCAACACAGTTGAAACAGCTCAG
GCCAAATATCTGGCCGGCGAAGTGGCCTACAAGTGCGCTATCGGCGCCATGCGCATTTTCGGCGCCTATGGTTATTCCAC
AGAGTATCCAGTGAACCGTTACTATCGTGACGCTCCCACCTATGCCATGGTGGAAGGTTCAACCAATGTCTGTAAGATGA
TCGTCGGCGGAGCTCTGCTGGCCCAGAAATAA

Upstream 100 bases:

>100_bases
TGCGCGACTTTATCATGACTTCTTTCCGTTAGGGAACGGCGGACACGGACTGAAGCGGTTTTCTGCACCACAATAACATT
ACCAAGGAGGATACATTATT

Downstream 100 bases:

>100_bases
CCCATAAACCGAGGTTTTCTGACCTCTGTTACGTTACATGTTACAGTGCAGATTTACTGGAGGATAGTTATTCATGAGAC
AATACTTTGAAAAGATGGAC

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MDFALSEELEMLRSMARDFAAEKIAPFADKWDEEHYFPYEEVVKPMGELGFFGTVIPEEYGGTNMGWLAAMILTEEISRA
SSALRVQINMEGLGCAYTIWKYGTEEAKKKYVQKLVSAEYLGGFGITEFNAGSDVMSMKSTAEDKGDYYLLNGSKTWISN
ANCADVIIYYAYTDKAAKGKGLSAFAVELKNNPGIRTTDLDKMGSKSSPTGEIYLDNVKVPKENLLGKPGDGAKIVFGSL
NGTRLSAAAGGIGLAQACLDAAIKYANEREQFGKPIGTFQANQFLIGEMATELEAARLMVYRAAWQKDQGNLGNTVETAQ
AKYLAGEVAYKCAIGAMRIFGAYGYSTEYPVNRYYRDAPTYAMVEGSTNVCKMIVGGALLAQK

Sequences:

>Translated_383_residues
MDFALSEELEMLRSMARDFAAEKIAPFADKWDEEHYFPYEEVVKPMGELGFFGTVIPEEYGGTNMGWLAAMILTEEISRA
SSALRVQINMEGLGCAYTIWKYGTEEAKKKYVQKLVSAEYLGGFGITEFNAGSDVMSMKSTAEDKGDYYLLNGSKTWISN
ANCADVIIYYAYTDKAAKGKGLSAFAVELKNNPGIRTTDLDKMGSKSSPTGEIYLDNVKVPKENLLGKPGDGAKIVFGSL
NGTRLSAAAGGIGLAQACLDAAIKYANEREQFGKPIGTFQANQFLIGEMATELEAARLMVYRAAWQKDQGNLGNTVETAQ
AKYLAGEVAYKCAIGAMRIFGAYGYSTEYPVNRYYRDAPTYAMVEGSTNVCKMIVGGALLAQK
>Mature_383_residues
MDFALSEELEMLRSMARDFAAEKIAPFADKWDEEHYFPYEEVVKPMGELGFFGTVIPEEYGGTNMGWLAAMILTEEISRA
SSALRVQINMEGLGCAYTIWKYGTEEAKKKYVQKLVSAEYLGGFGITEFNAGSDVMSMKSTAEDKGDYYLLNGSKTWISN
ANCADVIIYYAYTDKAAKGKGLSAFAVELKNNPGIRTTDLDKMGSKSSPTGEIYLDNVKVPKENLLGKPGDGAKIVFGSL
NGTRLSAAAGGIGLAQACLDAAIKYANEREQFGKPIGTFQANQFLIGEMATELEAARLMVYRAAWQKDQGNLGNTVETAQ
AKYLAGEVAYKCAIGAMRIFGAYGYSTEYPVNRYYRDAPTYAMVEGSTNVCKMIVGGALLAQK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=379, Percent_Identity=39.3139841688654, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=37.6657824933687, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI226958414, Length=362, Percent_Identity=38.3977900552486, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=37.9310344827586, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=37.9310344827586, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=36.7847411444142, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=32.1899736147757, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=34.0845070422535, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4557235, Length=337, Percent_Identity=31.4540059347181, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI76496475, Length=337, Percent_Identity=31.4540059347181, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI4503943, Length=385, Percent_Identity=30.6493506493506, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=27.5590551181102, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=31.3888888888889, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI211971008, Length=294, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI48976061, Length=294, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI38505218, Length=279, Percent_Identity=27.5985663082437, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=28.7206266318538, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=28.5340314136126, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI87082384, Length=262, Percent_Identity=29.7709923664122, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=37.9947229551451, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=39.3229166666667, Blast_Score=257, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=36.2694300518135, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17570075, Length=386, Percent_Identity=34.7150259067358, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=35.9673024523161, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17506239, Length=367, Percent_Identity=35.149863760218, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=32.7176781002639, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=37.7697841726619, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=385, Percent_Identity=30.9090909090909, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=37.5545851528384, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=365, Percent_Identity=29.5890410958904, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=29.144385026738, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=31.728045325779, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=30.1818181818182, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=288, Percent_Identity=32.9861111111111, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=30.0429184549356, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=287, Percent_Identity=29.2682926829268, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=299, Percent_Identity=28.7625418060201, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=299, Percent_Identity=28.7625418060201, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=38.1962864721485, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=36.2433862433862, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24666513, Length=367, Percent_Identity=38.9645776566758, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=37.1352785145889, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=37.3684210526316, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI281363737, Length=345, Percent_Identity=31.304347826087, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI19920834, Length=397, Percent_Identity=30.4785894206549, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41779; Mature: 41779

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFALSEELEMLRSMARDFAAEKIAPFADKWDEEHYFPYEEVVKPMGELGFFGTVIPEEY
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHC
GGTNMGWLAAMILTEEISRASSALRVQINMEGLGCAYTIWKYGTEEAKKKYVQKLVSAEY
CCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEHHHCCHHHHHHHHHHHHHHHHH
LGGFGITEFNAGSDVMSMKSTAEDKGDYYLLNGSKTWISNANCADVIIYYAYTDKAAKGK
HCCCCCEEECCCCCHHHHHHCCCCCCCEEEECCCEEEECCCCCEEEEEEEEEECCCCCCC
GLSAFAVELKNNPGIRTTDLDKMGSKSSPTGEIYLDNVKVPKENLLGKPGDGAKIVFGSL
CCEEEEEEECCCCCCEECCHHHCCCCCCCCCEEEECCCCCCHHHCCCCCCCCCEEEEECC
NGTRLSAAAGGIGLAQACLDAAIKYANEREQFGKPIGTFQANQFLIGEMATELEAARLMV
CCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YRAAWQKDQGNLGNTVETAQAKYLAGEVAYKCAIGAMRIFGAYGYSTEYPVNRYYRDAPT
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
YAMVEGSTNVCKMIVGGALLAQK
EEEEECCCHHHHHHHCCHHHCCC
>Mature Secondary Structure
MDFALSEELEMLRSMARDFAAEKIAPFADKWDEEHYFPYEEVVKPMGELGFFGTVIPEEY
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHC
GGTNMGWLAAMILTEEISRASSALRVQINMEGLGCAYTIWKYGTEEAKKKYVQKLVSAEY
CCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEHHHCCHHHHHHHHHHHHHHHHH
LGGFGITEFNAGSDVMSMKSTAEDKGDYYLLNGSKTWISNANCADVIIYYAYTDKAAKGK
HCCCCCEEECCCCCHHHHHHCCCCCCCEEEECCCEEEECCCCCEEEEEEEEEECCCCCCC
GLSAFAVELKNNPGIRTTDLDKMGSKSSPTGEIYLDNVKVPKENLLGKPGDGAKIVFGSL
CCEEEEEEECCCCCCEECCHHHCCCCCCCCCEEEECCCCCCHHHCCCCCCCCCEEEEECC
NGTRLSAAAGGIGLAQACLDAAIKYANEREQFGKPIGTFQANQFLIGEMATELEAARLMV
CCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YRAAWQKDQGNLGNTVETAQAKYLAGEVAYKCAIGAMRIFGAYGYSTEYPVNRYYRDAPT
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
YAMVEGSTNVCKMIVGGALLAQK
EEEEECCCHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]