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The map label for this gene is hppA

Identifier: 85859735

GI number: 85859735

Start: 1964610

End: 1966676

Strand: Direct

Name: hppA

Synonym: SYN_02772

Alternate gene names: 85859735

Gene position: 1964610-1966676 (Clockwise)

Preceding gene: 85859734

Following gene: 85859736

Centisome position: 61.79

GC content: 56.89

Gene sequence:

>2067_bases
ATGGAATTTTTAGTAAATTTCGCTTGGTTGTGGGGTCTCCTCGGACTGGTGCTGGCGTTCTTCATCTATAAGTACGTCAT
GTCCTTCCCCCCGGGAGACAAATTAATGGTGGAGATCATGGAGAGGATTCATGCCGGCGCCATGGTCTTTTTGAAGAGAG
AATACAAGATTATTTCGATTTTTATCGTCGTCGTATTCATCCTGCTCTACGTCGCCTTGGATAATAAGTGGTCATCAGTG
GCCTTCCTCGTGGGAGCGATCTGCTCCCTGTCAGCCGGCGTGTTCGGCATGCAGGCGGCGACCCTCTCGAATGCGAGAAC
CGCGGAAGCGGCCAAGACGCACGGACAGGCCAAAGCCCTTACGGTGGCCTTCTTCGGTGGATCCGTCATGGGTCTTTCCG
TGGCCTCCCTCGGTCTTCTCGGGCTTGGCATTTTCTTCTATTTCTTCGCCGAAACGGATCCGGTCGTCATCAATGGTTTT
TCCCTTGGCGCCTCGTCGATCGCCCTCTTTGCCCGTGTCGGTGGCGGCATCTTCACCAAGACGGCCGATGTGGGTTCCGA
CCTGGTGGGTAAAGTCGAGGCTGGGATTCCCGAAGACGATCCGAGAAACCCTGGGGTCACCGCGGACAACGTCGGTGACA
ACGTCGGCGATATCGCCGGTATGGGAGCGGACCTTTTTGAATCATACGTCGGCTCCGTCGTTGCCGCCATTGCTATCGGC
GCCACGATGGGGCTCGGGATGGATGGCATGGCGATGCGCTGGATGATGCTGCCGATGCTTTTCATCATCGTCGGAATGCT
GGCATCGGTCATCGGGATCGGAATGTTCAATATGCTCAAGAATATGAAACCCTCTTCGGCACTGAGCAACGGCCTCTATA
TTGCGGGGATTCTTTTCATTATCGCTGCCTACTTCGTTGTCAAGGGCGTTACGGCAGGGATGTCTCCTGAATACCTGGGC
AGCCTCGGAATCAAAGGACCTCTCGGCCCCTTCTGGGCCGTACTTCTTGGAATTGTCGCCGGCATGCTGATCGGTGCTGT
CACGGAATATTACACAGCCCGGGGACCGGTCCACAGGATCGCTGAAGCTTCTCAGACAGGGCCGGCCACTACGATCATCA
GCGGCTTCGCCATTGGTCTCGAGAGCGTTGCCACTCCGGTCTTCTTTATTGCCATGGCGATCTGGGGTTCATACGTCACC
TGCGGTCTCTACGGTATTGCCATTGCCGGTGTCGGCATGCTGGGCACAGTTGGAATGACCATGTCCGTGGACAGCTACGG
TCCGATTTCCGATAATGCCGGCGGTATTGCCGAGCAGGCTCACATGCCCCCGCATGTCCGGGAAATCACGGATGGCCTGG
ACGCGGTCGGAAACACCACCGCCGCGATCGGTAAAGGGTTCGCCATCGGTTCCGCGGCACTTACAGCCCTGGCCATGTTC
GCCGCCTACACCGCAACGGTCAAGACCTTCCCCGGATTTGAAACGTTTACCCTCGACCTGACAGAGGCACACGTGATTAC
GGGTGTCTTCCTCGGCGGGATGATTCCCTGCCTGCTGGCAGCGCTCACGATGACAGCGGTCGGTGAAGCCGCATTCGACA
TGATCAACGAGATCCGGAGACAGTTCAGAGAGATTCCCGGTATCATGGAAGGAACGACTCCTCCCGATACGAACAGATGT
GTCGACATCGCCACCACGGCCGCCCTGAAGAGGATGATCGTCCCCGGCATCGCGTCGGTTATCGCTCCGATCCTGGTCGG
CGTCTTCATCGGCCCCCATGCTCTTGGCGGATTCCTTGCCGGAGCTACGCTTACCGGCGTTATCCTGGGTCTTCTGATGG
CTAACTCCGGTGGTGCGTGGGACAACGCGAAGAAATACATCGAGCAGGGATATTTCGGCGGGAAAGGATCTGAGGCGCAC
AAAGCAGGCGTTATCGGTGACACCGTCGGCGACCCCTTCAAGGATACCTCGGGACCGGCAATGAATATTCTCATCAAGTT
GATGTCGGTTGTGTCCCTCGTGACCGCTCCGGCGATCATTTACCTGTACCATATGGTCTACGGCTAA

Upstream 100 bases:

>100_bases
CGGTGATTAATGTGGTTGCATCTGTCATTCAGGCACCGGTGAACGGATGTAACGCAAGAATCATAAAATACTTTAATCAG
GAGGTACAAAAAACGGGATT

Downstream 100 bases:

>100_bases
TCCGAAAACGTTAGACTCGAACGAAAAAGGGGTGGATTTCTTCCACCCCTTTTTTTATTTAATTAAGGAATCCTCATGGA
TTCCGGCTGGCAATCTCGGC

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound sodium-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; Na(+)-PPase [H]

Number of amino acids: Translated: 688; Mature: 688

Protein sequence:

>688_residues
MEFLVNFAWLWGLLGLVLAFFIYKYVMSFPPGDKLMVEIMERIHAGAMVFLKREYKIISIFIVVVFILLYVALDNKWSSV
AFLVGAICSLSAGVFGMQAATLSNARTAEAAKTHGQAKALTVAFFGGSVMGLSVASLGLLGLGIFFYFFAETDPVVINGF
SLGASSIALFARVGGGIFTKTADVGSDLVGKVEAGIPEDDPRNPGVTADNVGDNVGDIAGMGADLFESYVGSVVAAIAIG
ATMGLGMDGMAMRWMMLPMLFIIVGMLASVIGIGMFNMLKNMKPSSALSNGLYIAGILFIIAAYFVVKGVTAGMSPEYLG
SLGIKGPLGPFWAVLLGIVAGMLIGAVTEYYTARGPVHRIAEASQTGPATTIISGFAIGLESVATPVFFIAMAIWGSYVT
CGLYGIAIAGVGMLGTVGMTMSVDSYGPISDNAGGIAEQAHMPPHVREITDGLDAVGNTTAAIGKGFAIGSAALTALAMF
AAYTATVKTFPGFETFTLDLTEAHVITGVFLGGMIPCLLAALTMTAVGEAAFDMINEIRRQFREIPGIMEGTTPPDTNRC
VDIATTAALKRMIVPGIASVIAPILVGVFIGPHALGGFLAGATLTGVILGLLMANSGGAWDNAKKYIEQGYFGGKGSEAH
KAGVIGDTVGDPFKDTSGPAMNILIKLMSVVSLVTAPAIIYLYHMVYG

Sequences:

>Translated_688_residues
MEFLVNFAWLWGLLGLVLAFFIYKYVMSFPPGDKLMVEIMERIHAGAMVFLKREYKIISIFIVVVFILLYVALDNKWSSV
AFLVGAICSLSAGVFGMQAATLSNARTAEAAKTHGQAKALTVAFFGGSVMGLSVASLGLLGLGIFFYFFAETDPVVINGF
SLGASSIALFARVGGGIFTKTADVGSDLVGKVEAGIPEDDPRNPGVTADNVGDNVGDIAGMGADLFESYVGSVVAAIAIG
ATMGLGMDGMAMRWMMLPMLFIIVGMLASVIGIGMFNMLKNMKPSSALSNGLYIAGILFIIAAYFVVKGVTAGMSPEYLG
SLGIKGPLGPFWAVLLGIVAGMLIGAVTEYYTARGPVHRIAEASQTGPATTIISGFAIGLESVATPVFFIAMAIWGSYVT
CGLYGIAIAGVGMLGTVGMTMSVDSYGPISDNAGGIAEQAHMPPHVREITDGLDAVGNTTAAIGKGFAIGSAALTALAMF
AAYTATVKTFPGFETFTLDLTEAHVITGVFLGGMIPCLLAALTMTAVGEAAFDMINEIRRQFREIPGIMEGTTPPDTNRC
VDIATTAALKRMIVPGIASVIAPILVGVFIGPHALGGFLAGATLTGVILGLLMANSGGAWDNAKKYIEQGYFGGKGSEAH
KAGVIGDTVGDPFKDTSGPAMNILIKLMSVVSLVTAPAIIYLYHMVYG
>Mature_688_residues
MEFLVNFAWLWGLLGLVLAFFIYKYVMSFPPGDKLMVEIMERIHAGAMVFLKREYKIISIFIVVVFILLYVALDNKWSSV
AFLVGAICSLSAGVFGMQAATLSNARTAEAAKTHGQAKALTVAFFGGSVMGLSVASLGLLGLGIFFYFFAETDPVVINGF
SLGASSIALFARVGGGIFTKTADVGSDLVGKVEAGIPEDDPRNPGVTADNVGDNVGDIAGMGADLFESYVGSVVAAIAIG
ATMGLGMDGMAMRWMMLPMLFIIVGMLASVIGIGMFNMLKNMKPSSALSNGLYIAGILFIIAAYFVVKGVTAGMSPEYLG
SLGIKGPLGPFWAVLLGIVAGMLIGAVTEYYTARGPVHRIAEASQTGPATTIISGFAIGLESVATPVFFIAMAIWGSYVT
CGLYGIAIAGVGMLGTVGMTMSVDSYGPISDNAGGIAEQAHMPPHVREITDGLDAVGNTTAAIGKGFAIGSAALTALAMF
AAYTATVKTFPGFETFTLDLTEAHVITGVFLGGMIPCLLAALTMTAVGEAAFDMINEIRRQFREIPGIMEGTTPPDTNRC
VDIATTAALKRMIVPGIASVIAPILVGVFIGPHALGGFLAGATLTGVILGLLMANSGGAWDNAKKYIEQGYFGGKGSEAH
KAGVIGDTVGDPFKDTSGPAMNILIKLMSVVSLVTAPAIIYLYHMVYG

Specific function: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 71519; Mature: 71519

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLVNFAWLWGLLGLVLAFFIYKYVMSFPPGDKLMVEIMERIHAGAMVFLKREYKIISI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHH
FIVVVFILLYVALDNKWSSVAFLVGAICSLSAGVFGMQAATLSNARTAEAAKTHGQAKAL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCHHEE
TVAFFGGSVMGLSVASLGLLGLGIFFYFFAETDPVVINGFSLGASSIALFARVGGGIFTK
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
TADVGSDLVGKVEAGIPEDDPRNPGVTADNVGDNVGDIAGMGADLFESYVGSVVAAIAIG
CHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
ATMGLGMDGMAMRWMMLPMLFIIVGMLASVIGIGMFNMLKNMKPSSALSNGLYIAGILFI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
IAAYFVVKGVTAGMSPEYLGSLGIKGPLGPFWAVLLGIVAGMLIGAVTEYYTARGPVHRI
HHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AEASQTGPATTIISGFAIGLESVATPVFFIAMAIWGSYVTCGLYGIAIAGVGMLGTVGMT
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
MSVDSYGPISDNAGGIAEQAHMPPHVREITDGLDAVGNTTAAIGKGFAIGSAALTALAMF
EECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHH
AAYTATVKTFPGFETFTLDLTEAHVITGVFLGGMIPCLLAALTMTAVGEAAFDMINEIRR
HHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFREIPGIMEGTTPPDTNRCVDIATTAALKRMIVPGIASVIAPILVGVFIGPHALGGFLA
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATLTGVILGLLMANSGGAWDNAKKYIEQGYFGGKGSEAHKAGVIGDTVGDPFKDTSGPA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
MNILIKLMSVVSLVTAPAIIYLYHMVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEFLVNFAWLWGLLGLVLAFFIYKYVMSFPPGDKLMVEIMERIHAGAMVFLKREYKIISI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHH
FIVVVFILLYVALDNKWSSVAFLVGAICSLSAGVFGMQAATLSNARTAEAAKTHGQAKAL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCHHEE
TVAFFGGSVMGLSVASLGLLGLGIFFYFFAETDPVVINGFSLGASSIALFARVGGGIFTK
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
TADVGSDLVGKVEAGIPEDDPRNPGVTADNVGDNVGDIAGMGADLFESYVGSVVAAIAIG
CHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
ATMGLGMDGMAMRWMMLPMLFIIVGMLASVIGIGMFNMLKNMKPSSALSNGLYIAGILFI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
IAAYFVVKGVTAGMSPEYLGSLGIKGPLGPFWAVLLGIVAGMLIGAVTEYYTARGPVHRI
HHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AEASQTGPATTIISGFAIGLESVATPVFFIAMAIWGSYVTCGLYGIAIAGVGMLGTVGMT
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
MSVDSYGPISDNAGGIAEQAHMPPHVREITDGLDAVGNTTAAIGKGFAIGSAALTALAMF
EECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHH
AAYTATVKTFPGFETFTLDLTEAHVITGVFLGGMIPCLLAALTMTAVGEAAFDMINEIRR
HHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFREIPGIMEGTTPPDTNRCVDIATTAALKRMIVPGIASVIAPILVGVFIGPHALGGFLA
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATLTGVILGLLMANSGGAWDNAKKYIEQGYFGGKGSEAHKAGVIGDTVGDPFKDTSGPA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
MNILIKLMSVVSLVTAPAIIYLYHMVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]