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The map label for this gene is dsbC [H]

Identifier: 85859516

GI number: 85859516

Start: 1739692

End: 1740411

Strand: Direct

Name: dsbC [H]

Synonym: SYN_01858

Alternate gene names: 85859516

Gene position: 1739692-1740411 (Clockwise)

Preceding gene: 85859515

Following gene: 85859517

Centisome position: 54.72

GC content: 55.69

Gene sequence:

>720_bases
ATGCTGCTGAAGAAGATCATGCCGGCCGTCATGGCCATGTTCCTGTGCGCCGCGGTTAGTCACGCCGAGGAAAGCATCAC
GATCCAGATTTTACATAAAAGTTTCCCGAACGTGAAGGCGGAGAAGGCCGGGAAATCGGTCATCCCCGGTCTCTACGAAG
TGGAAGCAGGGAACAACGTCTTCTACTTCGAGCCCCGGAACGGCTACCTCATTTTCGGTGACATCATAACAAAGGAAGGG
AAAAATCTCACCGCGGAGAAAAGGCAGGAGCTGCTTGCCCGGAGAGTGAAAGAAATCCCGTTGGAAAAGGGGATCAAGAT
CGGCGGCGGCAAGAACGTCGTGATCGAGTTCACGGATCCAGACTGCCCCTTCTGCCGGAAAGCGGCCGATTGGCTCGAAA
AGAACCGGGAAGGGGTAACGCGATACGTATTCTTGTATCCCATCACGCGTCTCCATCCCGGCGCGGACGCCAAAGCGAAA
TATATCCTCGGGGCCAAGGACCAGGAGAAGGCCTACCATGAAGTCATGAGCGGCGCGCTGGACAGTATCGACGCGGGCAA
GCTCAAGCTCACCGAGAAAGCCGGCACCCTCCTTGAAGAGCACAAGCAACTGGCCATTAAAGCGGGCGTCTTCGCCACCC
CGACCCTGTGGGTCAACGGGAAACACGTACCCGGGGCAGACATACCGCTTATCGAAAAATACCTGAAAGGAGAAAAATGA

Upstream 100 bases:

>100_bases
GGTTTCCGAGGCAAAGGGTGAAGGCAAGCGCAGCCCCGTATCGAAGGTCGGAAAACTGAACAGGCGGGTGGAAATCGAAA
TCATTCATTAAGGAGGTCTC

Downstream 100 bases:

>100_bases
CATGAAGAAACATCCGGGTTCCAAGGAAATGCTGTTGGCAGTCATCGCCGCGCAGGGTCTTCTTATCCTTTTCCATTACG
GGGAGGCGCTCGCCATGACG

Product: protein-disulfide isomerase

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MLLKKIMPAVMAMFLCAAVSHAEESITIQILHKSFPNVKAEKAGKSVIPGLYEVEAGNNVFYFEPRNGYLIFGDIITKEG
KNLTAEKRQELLARRVKEIPLEKGIKIGGGKNVVIEFTDPDCPFCRKAADWLEKNREGVTRYVFLYPITRLHPGADAKAK
YILGAKDQEKAYHEVMSGALDSIDAGKLKLTEKAGTLLEEHKQLAIKAGVFATPTLWVNGKHVPGADIPLIEKYLKGEK

Sequences:

>Translated_239_residues
MLLKKIMPAVMAMFLCAAVSHAEESITIQILHKSFPNVKAEKAGKSVIPGLYEVEAGNNVFYFEPRNGYLIFGDIITKEG
KNLTAEKRQELLARRVKEIPLEKGIKIGGGKNVVIEFTDPDCPFCRKAADWLEKNREGVTRYVFLYPITRLHPGADAKAK
YILGAKDQEKAYHEVMSGALDSIDAGKLKLTEKAGTLLEEHKQLAIKAGVFATPTLWVNGKHVPGADIPLIEKYLKGEK
>Mature_239_residues
MLLKKIMPAVMAMFLCAAVSHAEESITIQILHKSFPNVKAEKAGKSVIPGLYEVEAGNNVFYFEPRNGYLIFGDIITKEG
KNLTAEKRQELLARRVKEIPLEKGIKIGGGKNVVIEFTDPDCPFCRKAADWLEKNREGVTRYVFLYPITRLHPGADAKAK
YILGAKDQEKAYHEVMSGALDSIDAGKLKLTEKAGTLLEEHKQLAIKAGVFATPTLWVNGKHVPGADIPLIEKYLKGEK

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: NA

Molecular weight: Translated: 26492; Mature: 26492

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKKIMPAVMAMFLCAAVSHAEESITIQILHKSFPNVKAEKAGKSVIPGLYEVEAGNNV
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCCCEEEEECCCEE
FYFEPRNGYLIFGDIITKEGKNLTAEKRQELLARRVKEIPLEKGIKIGGGKNVVIEFTDP
EEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHCCEEECCCCEEEEEECCC
DCPFCRKAADWLEKNREGVTRYVFLYPITRLHPGADAKAKYILGAKDQEKAYHEVMSGAL
CCHHHHHHHHHHHHCCCCCEEEEEEEEHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
DSIDAGKLKLTEKAGTLLEEHKQLAIKAGVFATPTLWVNGKHVPGADIPLIEKYLKGEK
CCCCCCCEEEHHHHHHHHHHHHHHHHHCCCEECCEEEECCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MLLKKIMPAVMAMFLCAAVSHAEESITIQILHKSFPNVKAEKAGKSVIPGLYEVEAGNNV
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCCCEEEEECCCEE
FYFEPRNGYLIFGDIITKEGKNLTAEKRQELLARRVKEIPLEKGIKIGGGKNVVIEFTDP
EEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHCCEEECCCCEEEEEECCC
DCPFCRKAADWLEKNREGVTRYVFLYPITRLHPGADAKAKYILGAKDQEKAYHEVMSGAL
CCHHHHHHHHHHHHCCCCCEEEEEEEEHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
DSIDAGKLKLTEKAGTLLEEHKQLAIKAGVFATPTLWVNGKHVPGADIPLIEKYLKGEK
CCCCCCCEEEHHHHHHHHHHHHHHHHHCCCEECCEEEECCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA