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The map label for this gene is dxr [H]

Identifier: 85859436

GI number: 85859436

Start: 1640677

End: 1641840

Strand: Direct

Name: dxr [H]

Synonym: SYN_00916

Alternate gene names: 85859436

Gene position: 1640677-1641840 (Clockwise)

Preceding gene: 85859435

Following gene: 85859437

Centisome position: 51.6

GC content: 49.14

Gene sequence:

>1164_bases
ATGAAAAAGATATCTCTTCTTGGTTCCACAGGTTCCATCGGTTGCAGCGCTCTCGAAGTGATTCGCAGAAATCCGACAAA
GTTTCAGATCGTTTCATTGGCTGCCGGGCGTAATATTGACCTGCTCAAGAAACAGATTGAAGAATTTCATCCGGTTATGG
TTTCCGTTCTCGAACAGGAATGTGCGGCCGCACTGAAAAAGAAACTGAGTCCTTCATCGGGTATCGAGATCCTTTACGGT
TGTGAAGGCTGTTGCAGAGTTGCCTCTGTTGAAGATGCCGACATGGTGATTTCGGCCATAGTTGGAGCGGCAGGGCTTCT
ACCGACACTGGCGGCGATTGACGCAGGCAAGGACATTGCGCTGGCCAACAAGGAAACCCTGGTCATGGCGGGAAAGCTCG
TAACTGAAAAGGCAAAATACAGGGGAGTGACGATTTTTCCTGTGGACAGTGAACACAGTGCTATTTTTCAGTGCCTTGCC
GGCCAGAATTCTAAAACGGTAAGGCGTGTTCTTCTAACGGCATCGGGTGGCCCCTTTTACCGATTTTCTTCGAAACAACT
GGAGTCTGTGAAACCCGGAGATGCCCTGAAACACCCCAACTGGGTCATGGGAAACAAAATTACAATAGATTCGGCAACAA
TGATGAACAAGGGGCTGGAAATCATCGAAGCACACTGGCTTTTCAACATGGATATCGAAAGGATCCATGTTTACATTCAT
CCACAGAGCATTGTTCATTCCATGGTGGAATACATTGATGGTTCCGTTATTGCGCAGCTTGGCATCCCGGACATGAAAAT
TCCCATTGCTTACGCGCTCTCTTTTCCGGAAAGGCTGGATTGCCCGGAACTTTCCCTGGACCTTTTCAGGGTTGGTAAAC
TGGAATTTTTCCCCCCTGATGTCAACCGCTTCCCCTGTCTTTCCCTGGCATGTGAAGCGGTTCGACAGGGAGGGACGATG
CCCGTGGTCCTGAACGCGTCCAATGAAGTCGCCGTTGAAGCGTTTCTCGCGAAGAGACTCCCTTTTACCCGGATTTCCGA
ACTTGTTGATCGGGCCATGAGTTCCCATCAGTGCATGACCTCTCCAGAAATCGAAGATATTCTGGAAGCAGATGGGTGGG
CACGCAAAGAAACTGAAAAACTTCTAAAGAGCATGGGGCATTAA

Upstream 100 bases:

>100_bases
CAGGAACTATCTTTCCCGGACATGGTGGAATTCTTGATCGGTTGGACAGCCTGATCTTTCTCGCACCTTTTGTTTATTAT
TATCGTATTTTTTTGATCGT

Downstream 100 bases:

>100_bases
AATATGATCGGACTCAGTATCATATCAGTTGTCATATTGCTGGGTGTTCTTATTTTTGTACATGAATTCGGGCATTTTAT
CGCGGCGAAATATTCCGGAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKKISLLGSTGSIGCSALEVIRRNPTKFQIVSLAAGRNIDLLKKQIEEFHPVMVSVLEQECAAALKKKLSPSSGIEILYG
CEGCCRVASVEDADMVISAIVGAAGLLPTLAAIDAGKDIALANKETLVMAGKLVTEKAKYRGVTIFPVDSEHSAIFQCLA
GQNSKTVRRVLLTASGGPFYRFSSKQLESVKPGDALKHPNWVMGNKITIDSATMMNKGLEIIEAHWLFNMDIERIHVYIH
PQSIVHSMVEYIDGSVIAQLGIPDMKIPIAYALSFPERLDCPELSLDLFRVGKLEFFPPDVNRFPCLSLACEAVRQGGTM
PVVLNASNEVAVEAFLAKRLPFTRISELVDRAMSSHQCMTSPEIEDILEADGWARKETEKLLKSMGH

Sequences:

>Translated_387_residues
MKKISLLGSTGSIGCSALEVIRRNPTKFQIVSLAAGRNIDLLKKQIEEFHPVMVSVLEQECAAALKKKLSPSSGIEILYG
CEGCCRVASVEDADMVISAIVGAAGLLPTLAAIDAGKDIALANKETLVMAGKLVTEKAKYRGVTIFPVDSEHSAIFQCLA
GQNSKTVRRVLLTASGGPFYRFSSKQLESVKPGDALKHPNWVMGNKITIDSATMMNKGLEIIEAHWLFNMDIERIHVYIH
PQSIVHSMVEYIDGSVIAQLGIPDMKIPIAYALSFPERLDCPELSLDLFRVGKLEFFPPDVNRFPCLSLACEAVRQGGTM
PVVLNASNEVAVEAFLAKRLPFTRISELVDRAMSSHQCMTSPEIEDILEADGWARKETEKLLKSMGH
>Mature_387_residues
MKKISLLGSTGSIGCSALEVIRRNPTKFQIVSLAAGRNIDLLKKQIEEFHPVMVSVLEQECAAALKKKLSPSSGIEILYG
CEGCCRVASVEDADMVISAIVGAAGLLPTLAAIDAGKDIALANKETLVMAGKLVTEKAKYRGVTIFPVDSEHSAIFQCLA
GQNSKTVRRVLLTASGGPFYRFSSKQLESVKPGDALKHPNWVMGNKITIDSATMMNKGLEIIEAHWLFNMDIERIHVYIH
PQSIVHSMVEYIDGSVIAQLGIPDMKIPIAYALSFPERLDCPELSLDLFRVGKLEFFPPDVNRFPCLSLACEAVRQGGTM
PVVLNASNEVAVEAFLAKRLPFTRISELVDRAMSSHQCMTSPEIEDILEADGWARKETEKLLKSMGH

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=47.3282442748092, Blast_Score=347, Evalue=5e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42315; Mature: 42315

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISLLGSTGSIGCSALEVIRRNPTKFQIVSLAAGRNIDLLKKQIEEFHPVMVSVLEQE
CCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
CAAALKKKLSPSSGIEILYGCEGCCRVASVEDADMVISAIVGAAGLLPTLAAIDAGKDIA
HHHHHHHHCCCCCCCEEEECCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LANKETLVMAGKLVTEKAKYRGVTIFPVDSEHSAIFQCLAGQNSKTVRRVLLTASGGPFY
ECCCCEEEEEHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCHHHEEEEEEEECCCCEE
RFSSKQLESVKPGDALKHPNWVMGNKITIDSATMMNKGLEIIEAHWLFNMDIERIHVYIH
EECCHHHHCCCCCCCCCCCCEECCCEEEECHHHHHHCCCHHEEEEEEEECCEEEEEEEEC
PQSIVHSMVEYIDGSVIAQLGIPDMKIPIAYALSFPERLDCPELSLDLFRVGKLEFFPPD
CHHHHHHHHHHHCCCEEEECCCCCCCCCHHEEECCCCCCCCCCCCHHHHEECCEEECCCC
VNRFPCLSLACEAVRQGGTMPVVLNASNEVAVEAFLAKRLPFTRISELVDRAMSSHQCMT
CCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
SPEIEDILEADGWARKETEKLLKSMGH
CCCHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKISLLGSTGSIGCSALEVIRRNPTKFQIVSLAAGRNIDLLKKQIEEFHPVMVSVLEQE
CCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
CAAALKKKLSPSSGIEILYGCEGCCRVASVEDADMVISAIVGAAGLLPTLAAIDAGKDIA
HHHHHHHHCCCCCCCEEEECCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LANKETLVMAGKLVTEKAKYRGVTIFPVDSEHSAIFQCLAGQNSKTVRRVLLTASGGPFY
ECCCCEEEEEHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCHHHEEEEEEEECCCCEE
RFSSKQLESVKPGDALKHPNWVMGNKITIDSATMMNKGLEIIEAHWLFNMDIERIHVYIH
EECCHHHHCCCCCCCCCCCCEECCCEEEECHHHHHHCCCHHEEEEEEEECCEEEEEEEEC
PQSIVHSMVEYIDGSVIAQLGIPDMKIPIAYALSFPERLDCPELSLDLFRVGKLEFFPPD
CHHHHHHHHHHHCCCEEEECCCCCCCCCHHEEECCCCCCCCCCCCHHHHEECCEEECCCC
VNRFPCLSLACEAVRQGGTMPVVLNASNEVAVEAFLAKRLPFTRISELVDRAMSSHQCMT
CCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
SPEIEDILEADGWARKETEKLLKSMGH
CCCHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]