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The map label for this gene is uppS [H]

Identifier: 85859434

GI number: 85859434

Start: 1639018

End: 1639803

Strand: Direct

Name: uppS [H]

Synonym: SYN_00918

Alternate gene names: 85859434

Gene position: 1639018-1639803 (Clockwise)

Preceding gene: 85859433

Following gene: 85859435

Centisome position: 51.55

GC content: 46.06

Gene sequence:

>786_bases
ATGATGGCAGAAAATAAAGAAGCATCCGGAAAGTATTTGAAGGACCTTGATCCTGATAAAATGCCCAGGCATATTGCGAT
CATTATGGATGGAAATGGTCGATGGGCAGAAAAACATACTCTGGGCCGAATCTTCGGGCACAAAAAGGGAGCTGAAGCTG
TTCATGTGGCGGTACGAACCTGTCGAGAATTAGGAGTGAAATATTTGACTCTTTATGCTTTTTCTATTGAAAACTGGTTT
CGACCCACGATTGAAATCAACGCGCTGATGAATCTTCTTGAAGAATACCTGAGCAGCCAGCTTGAAGAGATGATGGAATA
CAGGATTCGGCTGAAGGTCATCGGCGATTTTAATTCTCTCCGGGATTCCGTGAAGAAGAAATTGCGCGATGTCATGGATA
AAACAGCCTCCAACGATGCCATGACACTGACGCTTGCCCTCAGTTACGGAGGGCGGGACGAGATCCTGTCGGCGGTAAAG
CAGATATTGAAGGATGGGATGGAGGGACGCATTAAACCGGAAAATTTGGACCGCGAGCTGTTTTCCCATTATCTTTATAC
GGCTGAAATGCCGGATCCTGACCTTCTGATTCGCACCAGCGGTGAGTACCGCATCAGCAATTTCTGCCTCTGGCAGATCG
CCTATACCGAATTCCATTTTACAGAGGTTTTGTGGCCTGATTTCAGCAGGGATGATATGATCAGAGCGATCGCCGATTAT
CAATCCAGGGAAAGACGGTTTGGAATGACAAGTGAGCAGGTTAGAGTAAATCATTACAAATCTTGA

Upstream 100 bases:

>100_bases
CCAAGAGGCTCCCCCTTTTGTTCAATAGGCGTTTTTTTACAGCCTGATTTATATCCTTTCCCAGGGAATAAGTCATGGGG
GCCGGTAGACAATCTGTTAT

Downstream 100 bases:

>100_bases
GTAATCAATCTATTATGATGGTCATGGTTTTCGGGAGGAGCAGGATACACACTCGCCGATGGAATAGAATATGACGCCGC
ACGTTCAACGATGGGTAACA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MMAENKEASGKYLKDLDPDKMPRHIAIIMDGNGRWAEKHTLGRIFGHKKGAEAVHVAVRTCRELGVKYLTLYAFSIENWF
RPTIEINALMNLLEEYLSSQLEEMMEYRIRLKVIGDFNSLRDSVKKKLRDVMDKTASNDAMTLTLALSYGGRDEILSAVK
QILKDGMEGRIKPENLDRELFSHYLYTAEMPDPDLLIRTSGEYRISNFCLWQIAYTEFHFTEVLWPDFSRDDMIRAIADY
QSRERRFGMTSEQVRVNHYKS

Sequences:

>Translated_261_residues
MMAENKEASGKYLKDLDPDKMPRHIAIIMDGNGRWAEKHTLGRIFGHKKGAEAVHVAVRTCRELGVKYLTLYAFSIENWF
RPTIEINALMNLLEEYLSSQLEEMMEYRIRLKVIGDFNSLRDSVKKKLRDVMDKTASNDAMTLTLALSYGGRDEILSAVK
QILKDGMEGRIKPENLDRELFSHYLYTAEMPDPDLLIRTSGEYRISNFCLWQIAYTEFHFTEVLWPDFSRDDMIRAIADY
QSRERRFGMTSEQVRVNHYKS
>Mature_261_residues
MMAENKEASGKYLKDLDPDKMPRHIAIIMDGNGRWAEKHTLGRIFGHKKGAEAVHVAVRTCRELGVKYLTLYAFSIENWF
RPTIEINALMNLLEEYLSSQLEEMMEYRIRLKVIGDFNSLRDSVKKKLRDVMDKTASNDAMTLTLALSYGGRDEILSAVK
QILKDGMEGRIKPENLDRELFSHYLYTAEMPDPDLLIRTSGEYRISNFCLWQIAYTEFHFTEVLWPDFSRDDMIRAIADY
QSRERRFGMTSEQVRVNHYKS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=35.2678571428571, Blast_Score=154, Evalue=5e-38,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=35.2678571428571, Blast_Score=154, Evalue=6e-38,
Organism=Escherichia coli, GI1786371, Length=233, Percent_Identity=45.0643776824034, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71993029, Length=240, Percent_Identity=35, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=35.981308411215, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=224, Percent_Identity=32.1428571428571, Blast_Score=122, Evalue=5e-29,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=37.9464285714286, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30467; Mature: 30467

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAENKEASGKYLKDLDPDKMPRHIAIIMDGNGRWAEKHTLGRIFGHKKGAEAVHVAVRT
CCCCCCCCCCCHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
CRELGVKYLTLYAFSIENWFRPTIEINALMNLLEEYLSSQLEEMMEYRIRLKVIGDFNSL
HHHCCHHHHHHEEEHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHH
RDSVKKKLRDVMDKTASNDAMTLTLALSYGGRDEILSAVKQILKDGMEGRIKPENLDREL
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
FSHYLYTAEMPDPDLLIRTSGEYRISNFCLWQIAYTEFHFTEVLWPDFSRDDMIRAIADY
HHHHEEECCCCCCCEEEEECCCEEECCEEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHH
QSRERRFGMTSEQVRVNHYKS
HHHHHHCCCCHHHEECCCCCC
>Mature Secondary Structure
MMAENKEASGKYLKDLDPDKMPRHIAIIMDGNGRWAEKHTLGRIFGHKKGAEAVHVAVRT
CCCCCCCCCCCHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
CRELGVKYLTLYAFSIENWFRPTIEINALMNLLEEYLSSQLEEMMEYRIRLKVIGDFNSL
HHHCCHHHHHHEEEHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHH
RDSVKKKLRDVMDKTASNDAMTLTLALSYGGRDEILSAVKQILKDGMEGRIKPENLDREL
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
FSHYLYTAEMPDPDLLIRTSGEYRISNFCLWQIAYTEFHFTEVLWPDFSRDDMIRAIADY
HHHHEEECCCCCCCEEEEECCCEEECCEEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHH
QSRERRFGMTSEQVRVNHYKS
HHHHHHCCCCHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA