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The map label for this gene is hisC

Identifier: 85859114

GI number: 85859114

Start: 1291830

End: 1292915

Strand: Direct

Name: hisC

Synonym: SYN_01517

Alternate gene names: 85859114

Gene position: 1291830-1292915 (Clockwise)

Preceding gene: 85859113

Following gene: 85859115

Centisome position: 40.63

GC content: 57.46

Gene sequence:

>1086_bases
TTGAATGCAAAAGGAGAATCCATGCTTTCCCGCAGACTGGAGGCCCTGACCCCCTACGTTCCCGGCGAACAGCCCCGGGA
CCGGAAATATCTGAAACTCAACACCAATGAAAATCCCTGGCCCCCGTCGCCGCGCATCGAGGCCCTCCTGCGGGAGTATG
ATCCGGACCAGCTGCGCCTCTACCCCGATCCCTGGTCGCTCTCCCTCCGGCAGAAAATAGCCCGGAAGTACAGCGTCGAT
GTGGACAACATCTTCGTCGGCAACGGCTCCGACGAGATACTTTCCTTTGTCTGGTACGCCTTCTTCGACGGTCTGTACGG
CAAGCTCGTTTTTCCGCAGTTCACCTACAGCTTTTACCCCGTTTACTGCGACTTTTATGAAATACCCTACCGGCGGATTC
CGCTCCGACCGGATTTTACTCTCGATCTGGAAGCCATGATCGAAAACGGGGGGGAGCCTTCCTGCGGGATGGCCTTTCCC
AATCCCAACGCCCCCACGGGGATCGCCCTGACGCTGAAACAGATCGAGGATCTCCTGAACCGCTATCCGACCGACCGGGT
TGTGGTCATCGACGAGGCATACATCGATTTCGGCGGAGAAAGCGCCGTCGGTCTGATCGACCGGTATGCCAATCTTCTTG
TCGCCCGGACCTTTTCGAAAAGCTTTTCCCTGGCCGGTCTGCGGCTCGGCTACGCCTTGGGCAGCCCTGAGCTGATCCGG
GCCCTGTTCGTGACGAAGGATTCCTTCAATTCCTACACTGTGGGCCGGCTGACGCAGACCATCGGCGAAATCGCCATCGA
GGATGAAGCGTGGTTCGCGGAAAAGATTGCCCGCATTATCGAGGCCCGTGATTTTTTTTCGGAGGAACTGAAAGGGCAGG
GCTGGCAGGTTCTGCCGTCAAAGGCGAATTTTGTTTTTGTGCGGAAGCCCGGTCTGACGGGGCAGACCATTTATGAGACG
CTGAAAGAGCGGGGCATTCTGGTCCGCTATTTTAACGTGGAGGGCATTCGGGATTTCGTCCGCGTCACCATAGGAAAGCG
GGAGGACATGGCCCGGCTGCTGGAAGAGTTGAAACGGCTGTTCTGA

Upstream 100 bases:

>100_bases
AAGCGGCAAGGCAGAGAGGCGCAGGCCGCGCAGCAGAATGTTGAGGATTCGATAACCAGCCAGGCGAAGAGCGCGCCTTG
AAGTGAAATAGAAATAACAG

Downstream 100 bases:

>100_bases
AGAAAAAGGAGATGAAAAACGATGAAGCGCTGGTTTGTCTGGCTGTTGATGTCGGCTGTGCTGTGGGGTTGCGCCAGTCC
GGGCATGAAGTATGAAACGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNAKGESMLSRRLEALTPYVPGEQPRDRKYLKLNTNENPWPPSPRIEALLREYDPDQLRLYPDPWSLSLRQKIARKYSVD
VDNIFVGNGSDEILSFVWYAFFDGLYGKLVFPQFTYSFYPVYCDFYEIPYRRIPLRPDFTLDLEAMIENGGEPSCGMAFP
NPNAPTGIALTLKQIEDLLNRYPTDRVVVIDEAYIDFGGESAVGLIDRYANLLVARTFSKSFSLAGLRLGYALGSPELIR
ALFVTKDSFNSYTVGRLTQTIGEIAIEDEAWFAEKIARIIEARDFFSEELKGQGWQVLPSKANFVFVRKPGLTGQTIYET
LKERGILVRYFNVEGIRDFVRVTIGKREDMARLLEELKRLF

Sequences:

>Translated_361_residues
MNAKGESMLSRRLEALTPYVPGEQPRDRKYLKLNTNENPWPPSPRIEALLREYDPDQLRLYPDPWSLSLRQKIARKYSVD
VDNIFVGNGSDEILSFVWYAFFDGLYGKLVFPQFTYSFYPVYCDFYEIPYRRIPLRPDFTLDLEAMIENGGEPSCGMAFP
NPNAPTGIALTLKQIEDLLNRYPTDRVVVIDEAYIDFGGESAVGLIDRYANLLVARTFSKSFSLAGLRLGYALGSPELIR
ALFVTKDSFNSYTVGRLTQTIGEIAIEDEAWFAEKIARIIEARDFFSEELKGQGWQVLPSKANFVFVRKPGLTGQTIYET
LKERGILVRYFNVEGIRDFVRVTIGKREDMARLLEELKRLF
>Mature_361_residues
MNAKGESMLSRRLEALTPYVPGEQPRDRKYLKLNTNENPWPPSPRIEALLREYDPDQLRLYPDPWSLSLRQKIARKYSVD
VDNIFVGNGSDEILSFVWYAFFDGLYGKLVFPQFTYSFYPVYCDFYEIPYRRIPLRPDFTLDLEAMIENGGEPSCGMAFP
NPNAPTGIALTLKQIEDLLNRYPTDRVVVIDEAYIDFGGESAVGLIDRYANLLVARTFSKSFSLAGLRLGYALGSPELIR
ALFVTKDSFNSYTVGRLTQTIGEIAIEDEAWFAEKIARIIEARDFFSEELKGQGWQVLPSKANFVFVRKPGLTGQTIYET
LKERGILVRYFNVEGIRDFVRVTIGKREDMARLLEELKRLF

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=349, Percent_Identity=26.3610315186246, Blast_Score=111, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6322075, Length=356, Percent_Identity=30.0561797752809, Blast_Score=119, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SYNAS (Q2LST8)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461316.1
- HSSP:   Q9X0D0
- ProteinModelPortal:   Q2LST8
- SMR:   Q2LST8
- STRING:   Q2LST8
- GeneID:   3883777
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01517
- NMPDR:   fig|56780.10.peg.1254
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   AEMAGYV
- PhylomeDB:   Q2LST8
- ProtClustDB:   PRK05387
- BioCyc:   SACI56780:SYN_01517-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41438; Mature: 41438

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAKGESMLSRRLEALTPYVPGEQPRDRKYLKLNTNENPWPPSPRIEALLREYDPDQLRL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCEEE
YPDPWSLSLRQKIARKYSVDVDNIFVGNGSDEILSFVWYAFFDGLYGKLVFPQFTYSFYP
ECCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCEECCHHCCEEEE
VYCDFYEIPYRRIPLRPDFTLDLEAMIENGGEPSCGMAFPNPNAPTGIALTLKQIEDLLN
EEEEHHHCCCEECCCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHH
RYPTDRVVVIDEAYIDFGGESAVGLIDRYANLLVARTFSKSFSLAGLRLGYALGSPELIR
HCCCCEEEEEEEHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCHHHHH
ALFVTKDSFNSYTVGRLTQTIGEIAIEDEAWFAEKIARIIEARDFFSEELKGQGWQVLPS
HHHHCCCCCCCEEHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
KANFVFVRKPGLTGQTIYETLKERGILVRYFNVEGIRDFVRVTIGKREDMARLLEELKRL
CCCEEEEECCCCCHHHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHH
F
C
>Mature Secondary Structure
MNAKGESMLSRRLEALTPYVPGEQPRDRKYLKLNTNENPWPPSPRIEALLREYDPDQLRL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCEEE
YPDPWSLSLRQKIARKYSVDVDNIFVGNGSDEILSFVWYAFFDGLYGKLVFPQFTYSFYP
ECCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCEECCHHCCEEEE
VYCDFYEIPYRRIPLRPDFTLDLEAMIENGGEPSCGMAFPNPNAPTGIALTLKQIEDLLN
EEEEHHHCCCEECCCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHH
RYPTDRVVVIDEAYIDFGGESAVGLIDRYANLLVARTFSKSFSLAGLRLGYALGSPELIR
HCCCCEEEEEEEHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCHHHHH
ALFVTKDSFNSYTVGRLTQTIGEIAIEDEAWFAEKIARIIEARDFFSEELKGQGWQVLPS
HHHHCCCCCCCEEHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
KANFVFVRKPGLTGQTIYETLKERGILVRYFNVEGIRDFVRVTIGKREDMARLLEELKRL
CCCEEEEECCCCCHHHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHH
F
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA