| Definition | Syntrophus aciditrophicus SB chromosome, complete genome. |
|---|---|
| Accession | NC_007759 |
| Length | 3,179,300 |
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The map label for this gene is thiDE [H]
Identifier: 85859111
GI number: 85859111
Start: 1288104
End: 1288985
Strand: Direct
Name: thiDE [H]
Synonym: SYN_01521
Alternate gene names: 85859111
Gene position: 1288104-1288985 (Clockwise)
Preceding gene: 85859110
Following gene: 85859112
Centisome position: 40.52
GC content: 62.13
Gene sequence:
>882_bases ATGAACAGAACACCGGCGCGCGTCCTGACGATTGCCGGATCGGATTCCGGAGGCGGAGCGGGGATTCAGGCCGATCTGAA AACGATCACCGTGCTGGGCGGTTTCGGGATGAGTGTGATCACCGCCCTGACGGCCCAGAATACCCTGGGGGTCCAGGGCA TCTTCGAGGTGCCGATTTCCTTCATCGAACAGCAGTTCGATGCCGTAGCCACCGATATCGGTGTGGACGCTGCCAAGACG GGCATGCTGGTCAGTGCCGCCGTTGTGCGCGCCGTGGCGGCAAAAATCCGGCAGCACCGCATCGAAAAGCTGGTGGTCGA TCCGGTTCTGACGGCCAAGGACGGTGTCCGGCTGATCGAAGATGAAGCGATGGAAACCCTGGTTTCGGACCTGCTCCCTC TGGCCTTCGTCGTGACGCCCAATGTGCCGGAGGCAGAAGTCATGGCGGAGATGACCATCTCATCCGTCGCCGATATGAAG GAAGCGGCGCGCAGGATCCGACGGTTCGGCGTTCCCAACGTAATCGTCAAGGGCGGTCATCTGCCTGGGGAGGCGCTGGA TATTCTTTACGACGGCAGCACATATCACGAATTTGCGGCCGAGCGGATCGAGACGAAGGACACCCACGGGACGGGATGCA CCTTTTCGGCTGCGCTTGCCACCGGCCTCGCCCTGGGAAAGCCTCTCCACGACTCGGTCCGGGAGGCGAAGTCCTACATT ACGGAAGTCATCCGCTACGCCTGGCGAATCGGCGGGGGGCACGGCCCGACGAATCATGCGGCCCCGCTTTTCAACGCCCT TGACCGCTGCAGGCGTCATTCCGATGGCGGATCAAATAAGAACCCGGAGCGGCGGGACGAGAGCGACTCCGGCATTCGGT GA
Upstream 100 bases:
>100_bases TCCTCACGGGAAAACAGGGCGTCATCTCCCTTTCCGACGGCATTCTGCTGGTCATTCATTACTATCGCAAGGGACATTTT CCCCAGGGGGCCTGATCCCG
Downstream 100 bases:
>100_bases CGGCCCCGGGGCCGTCAGGAAGCTGACGGCAAAGACGCTTTGATATGAAACAGCAATGATATATAAGATTCTGCGATGCA ATAACCAGGGAGGATGGTAG
Product: phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase
Products: NA
Alternate protein names: Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]
Number of amino acids: Translated: 293; Mature: 293
Protein sequence:
>293_residues MNRTPARVLTIAGSDSGGGAGIQADLKTITVLGGFGMSVITALTAQNTLGVQGIFEVPISFIEQQFDAVATDIGVDAAKT GMLVSAAVVRAVAAKIRQHRIEKLVVDPVLTAKDGVRLIEDEAMETLVSDLLPLAFVVTPNVPEAEVMAEMTISSVADMK EAARRIRRFGVPNVIVKGGHLPGEALDILYDGSTYHEFAAERIETKDTHGTGCTFSAALATGLALGKPLHDSVREAKSYI TEVIRYAWRIGGGHGPTNHAAPLFNALDRCRRHSDGGSNKNPERRDESDSGIR
Sequences:
>Translated_293_residues MNRTPARVLTIAGSDSGGGAGIQADLKTITVLGGFGMSVITALTAQNTLGVQGIFEVPISFIEQQFDAVATDIGVDAAKT GMLVSAAVVRAVAAKIRQHRIEKLVVDPVLTAKDGVRLIEDEAMETLVSDLLPLAFVVTPNVPEAEVMAEMTISSVADMK EAARRIRRFGVPNVIVKGGHLPGEALDILYDGSTYHEFAAERIETKDTHGTGCTFSAALATGLALGKPLHDSVREAKSYI TEVIRYAWRIGGGHGPTNHAAPLFNALDRCRRHSDGGSNKNPERRDESDSGIR >Mature_293_residues MNRTPARVLTIAGSDSGGGAGIQADLKTITVLGGFGMSVITALTAQNTLGVQGIFEVPISFIEQQFDAVATDIGVDAAKT GMLVSAAVVRAVAAKIRQHRIEKLVVDPVLTAKDGVRLIEDEAMETLVSDLLPLAFVVTPNVPEAEVMAEMTISSVADMK EAARRIRRFGVPNVIVKGGHLPGEALDILYDGSTYHEFAAERIETKDTHGTGCTFSAALATGLALGKPLHDSVREAKSYI TEVIRYAWRIGGGHGPTNHAAPLFNALDRCRRHSDGGSNKNPERRDESDSGIR
Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]
COG id: COG0351
COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the thiD family [H]
Homologues:
Organism=Escherichia coli, GI1788420, Length=259, Percent_Identity=44.4015444015444, Blast_Score=198, Evalue=4e-52, Organism=Saccharomyces cerevisiae, GI6325378, Length=300, Percent_Identity=32.6666666666667, Blast_Score=141, Evalue=1e-34, Organism=Saccharomyces cerevisiae, GI6324997, Length=301, Percent_Identity=35.2159468438538, Blast_Score=127, Evalue=2e-30, Organism=Saccharomyces cerevisiae, GI6324517, Length=296, Percent_Identity=33.445945945946, Blast_Score=119, Evalue=7e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013785 - InterPro: IPR013749 - InterPro: IPR004399 - InterPro: IPR022998 - InterPro: IPR003733 [H]
Pfam domain/function: PF08543 Phos_pyr_kin; PF02581 TMP-TENI [H]
EC number: =2.5.1.3; =2.7.1.49; =2.7.4.7 [H]
Molecular weight: Translated: 31169; Mature: 31169
Theoretical pI: Translated: 6.32; Mature: 6.32
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNRTPARVLTIAGSDSGGGAGIQADLKTITVLGGFGMSVITALTAQNTLGVQGIFEVPIS CCCCCCEEEEEECCCCCCCCCEEEHHHEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHH FIEQQFDAVATDIGVDAAKTGMLVSAAVVRAVAAKIRQHRIEKLVVDPVLTAKDGVRLIE HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHH DEAMETLVSDLLPLAFVVTPNVPEAEVMAEMTISSVADMKEAARRIRRFGVPNVIVKGGH HHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC LPGEALDILYDGSTYHEFAAERIETKDTHGTGCTFSAALATGLALGKPLHDSVREAKSYI CCCHHEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH TEVIRYAWRIGGGHGPTNHAAPLFNALDRCRRHSDGGSNKNPERRDESDSGIR HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure MNRTPARVLTIAGSDSGGGAGIQADLKTITVLGGFGMSVITALTAQNTLGVQGIFEVPIS CCCCCCEEEEEECCCCCCCCCEEEHHHEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHH FIEQQFDAVATDIGVDAAKTGMLVSAAVVRAVAAKIRQHRIEKLVVDPVLTAKDGVRLIE HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHH DEAMETLVSDLLPLAFVVTPNVPEAEVMAEMTISSVADMKEAARRIRRFGVPNVIVKGGH HHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC LPGEALDILYDGSTYHEFAAERIETKDTHGTGCTFSAALATGLALGKPLHDSVREAKSYI CCCHHEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH TEVIRYAWRIGGGHGPTNHAAPLFNALDRCRRHSDGGSNKNPERRDESDSGIR HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA