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The map label for this gene is ahcY [H]

Identifier: 85859084

GI number: 85859084

Start: 1258864

End: 1260423

Strand: Direct

Name: ahcY [H]

Synonym: SYN_00416

Alternate gene names: 85859084

Gene position: 1258864-1260423 (Clockwise)

Preceding gene: 85859083

Following gene: 85859087

Centisome position: 39.6

GC content: 53.33

Gene sequence:

>1560_bases
ATGGGGAGAAGTACAGGAAACTGCCGAAGACGCTTTTCCTTGATGACTACCCCTGGGAAAAAACGGACATGGTGGATTCA
CTCAAAAAGGCCGCTGACATATAAGCGCGGCCAGGCCAATGCGAAGGAGAAATACATGGAATTTCTGGAGATTGACGGTT
TACTGCCCTATCGGGTAGCCGACCTTTCCCTGGCGGAATGGGGATGGAAGGAGATGGCCCTGGCGGAGAATGAAATGCCG
GGACTGATGGCTGTGCGCGAGAAGTATGGGGATCAGAAGCCTCTGGCGGGCTTCAAGGTCATGGGCAGCCTCCATATGAC
CATTCAGACGGCGATGTTGATCGAGACTCTTAAAATTCTGGGTGCGGATATCCGCTGGGCCTCTTGCAATATCTTTTCGA
CGCAGGATCATGCCGCTGCGGCGATCGCGAAATCAGGAACGGCGGCAGTTTTTGCCTGGAAGGGTGAAACGCTGGAAGAG
TACTGGTGGTGCACCGAACAGGCCTTGACCTGGCCGGACGGCAGCGGTCCCGATCTTATCGTCGATGACGGAGGGGATGC
CACCCTGTTTATTCATCAGGGCGCACGTATTGAAAAGGAGTCCGATCTTCTGGATAAAAGGCAGGACAACAAAGAGATGC
AGATTATCATGGATCGACTGAAAAAATCCTTTGCCAGAGACTCAAATCGATGGACTCGGGTGGCCGCAGCGGTTCGCGGG
GTATCTGAAGAAACGACAACGGGAGTGCATCGCCTTTACCAGATGGCCAAAGCCGGGGAACTTCTCTTTCCAGCCATTAA
TGTGAATGATTCCGTGACGAAGTCGAAATTTGACAATCTTTACGGTTGCCGGGAATCCCTGGCCGACGGGATCAAGCGGG
CGACGGATATCATGGTTGCTGGCAAGGTTGTTGTCGTCTGCGGATACGGCGATGTCGGGAAGGGTTGTGTCCAGTCGATG
CGGGGATTCGGCGCCCGCGTCATTGTAACCGAAGTTGACCCGATCTGCGCGTTGCAGGCCGCCATGGAGGGATATGAGGT
AAAAACCCTGGAAGACGTGGTTGAAGAAGGGGATATATTCGTCACAGCCACCGGCTGTTGTGACGTTATCACCGGCGAGC
ACATGGAGCGCATGAAAAATGAAGCCATTGTCTGCAATATCGGTCATTTCGACAGTGAAATCGCCATGCACTACCTCGAG
GGAAATCCGGCCTGCAAAAAGGAATCCATCAAACCTCAGGTCGATAAATGGACCCTGGCATCGGGACGCTCCATTATCAT
GCTGGCTGAGGGCCGCCTTGTCAATCTGGGCTGTGCGACGGGTCATCCCAGTTTTGTCATGAGCAACAGCTTTACCAATC
AGTGTCTGGCGCAGATTGAGCTGGCCGGCAAGAATTACAAGCCGGGTGTTTACACCCTGCCGAAGAAGCTTGATGAAGAA
GTGGCCAGGCTTCATCTCGGGCGTCTTGGTGTGAAATTGACACGGCTTACTCCAAAACAGGCCGAATATCTCGGCATATC
CGTCGAGGGTCCTTATAAGGCTGAACATTATCGTTACTGA

Upstream 100 bases:

>100_bases
TTCGGGACAGGGGTCATATCCGATAACAAGATAGGAACGATCGTCAGAGAATACTTTGATCTGTCACCGCGGGGCATGAT
TGAGCGATTCAATCTCCTGG

Downstream 100 bases:

>100_bases
TTTATTGATGATCGGAAAAGCCTATGCTCCCGCGCCCGTTGCATTCAAAAGCAGGCCATCATCAGTGCGGGCGGGGAGAA
GGCGCATGGGAGGGTGCGGT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MGRSTGNCRRRFSLMTTPGKKRTWWIHSKRPLTYKRGQANAKEKYMEFLEIDGLLPYRVADLSLAEWGWKEMALAENEMP
GLMAVREKYGDQKPLAGFKVMGSLHMTIQTAMLIETLKILGADIRWASCNIFSTQDHAAAAIAKSGTAAVFAWKGETLEE
YWWCTEQALTWPDGSGPDLIVDDGGDATLFIHQGARIEKESDLLDKRQDNKEMQIIMDRLKKSFARDSNRWTRVAAAVRG
VSEETTTGVHRLYQMAKAGELLFPAINVNDSVTKSKFDNLYGCRESLADGIKRATDIMVAGKVVVVCGYGDVGKGCVQSM
RGFGARVIVTEVDPICALQAAMEGYEVKTLEDVVEEGDIFVTATGCCDVITGEHMERMKNEAIVCNIGHFDSEIAMHYLE
GNPACKKESIKPQVDKWTLASGRSIIMLAEGRLVNLGCATGHPSFVMSNSFTNQCLAQIELAGKNYKPGVYTLPKKLDEE
VARLHLGRLGVKLTRLTPKQAEYLGISVEGPYKAEHYRY

Sequences:

>Translated_519_residues
MGRSTGNCRRRFSLMTTPGKKRTWWIHSKRPLTYKRGQANAKEKYMEFLEIDGLLPYRVADLSLAEWGWKEMALAENEMP
GLMAVREKYGDQKPLAGFKVMGSLHMTIQTAMLIETLKILGADIRWASCNIFSTQDHAAAAIAKSGTAAVFAWKGETLEE
YWWCTEQALTWPDGSGPDLIVDDGGDATLFIHQGARIEKESDLLDKRQDNKEMQIIMDRLKKSFARDSNRWTRVAAAVRG
VSEETTTGVHRLYQMAKAGELLFPAINVNDSVTKSKFDNLYGCRESLADGIKRATDIMVAGKVVVVCGYGDVGKGCVQSM
RGFGARVIVTEVDPICALQAAMEGYEVKTLEDVVEEGDIFVTATGCCDVITGEHMERMKNEAIVCNIGHFDSEIAMHYLE
GNPACKKESIKPQVDKWTLASGRSIIMLAEGRLVNLGCATGHPSFVMSNSFTNQCLAQIELAGKNYKPGVYTLPKKLDEE
VARLHLGRLGVKLTRLTPKQAEYLGISVEGPYKAEHYRY
>Mature_518_residues
GRSTGNCRRRFSLMTTPGKKRTWWIHSKRPLTYKRGQANAKEKYMEFLEIDGLLPYRVADLSLAEWGWKEMALAENEMPG
LMAVREKYGDQKPLAGFKVMGSLHMTIQTAMLIETLKILGADIRWASCNIFSTQDHAAAAIAKSGTAAVFAWKGETLEEY
WWCTEQALTWPDGSGPDLIVDDGGDATLFIHQGARIEKESDLLDKRQDNKEMQIIMDRLKKSFARDSNRWTRVAAAVRGV
SEETTTGVHRLYQMAKAGELLFPAINVNDSVTKSKFDNLYGCRESLADGIKRATDIMVAGKVVVVCGYGDVGKGCVQSMR
GFGARVIVTEVDPICALQAAMEGYEVKTLEDVVEEGDIFVTATGCCDVITGEHMERMKNEAIVCNIGHFDSEIAMHYLEG
NPACKKESIKPQVDKWTLASGRSIIMLAEGRLVNLGCATGHPSFVMSNSFTNQCLAQIELAGKNYKPGVYTLPKKLDEEV
ARLHLGRLGVKLTRLTPKQAEYLGISVEGPYKAEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=467, Percent_Identity=61.4561027837259, Blast_Score=562, Evalue=1e-160,
Organism=Homo sapiens, GI239937451, Length=443, Percent_Identity=61.3995485327314, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI298286489, Length=466, Percent_Identity=47.2103004291845, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI195539337, Length=466, Percent_Identity=47.2103004291845, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI24308043, Length=466, Percent_Identity=47.2103004291845, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI195539349, Length=466, Percent_Identity=47.2103004291845, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=46.3519313304721, Blast_Score=414, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17506425, Length=468, Percent_Identity=60.2564102564103, Blast_Score=572, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6320882, Length=480, Percent_Identity=58.5416666666667, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24642172, Length=465, Percent_Identity=61.7204301075269, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24656245, Length=456, Percent_Identity=47.3684210526316, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45553387, Length=465, Percent_Identity=48.8172043010753, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45553385, Length=464, Percent_Identity=49.1379310344828, Blast_Score=416, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 57680; Mature: 57549

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00738 ADOHCYASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRSTGNCRRRFSLMTTPGKKRTWWIHSKRPLTYKRGQANAKEKYMEFLEIDGLLPYRVA
CCCCCCCHHHEEEEEECCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHCCCCCEEEE
DLSLAEWGWKEMALAENEMPGLMAVREKYGDQKPLAGFKVMGSLHMTIQTAMLIETLKIL
CCCHHHCCCHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GADIRWASCNIFSTQDHAAAAIAKSGTAAVFAWKGETLEEYWWCTEQALTWPDGSGPDLI
CCCCEEEEEEEECCCCHHHHHHHCCCCEEEEEECCCCHHHHHCCHHCEEECCCCCCCEEE
VDDGGDATLFIHQGARIEKESDLLDKRQDNKEMQIIMDRLKKSFARDSNRWTRVAAAVRG
EECCCCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
VSEETTTGVHRLYQMAKAGELLFPAINVNDSVTKSKFDNLYGCRESLADGIKRATDIMVA
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
GKVVVVCGYGDVGKGCVQSMRGFGARVIVTEVDPICALQAAMEGYEVKTLEDVVEEGDIF
CEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCEE
VTATGCCDVITGEHMERMKNEAIVCNIGHFDSEIAMHYLEGNPACKKESIKPQVDKWTLA
EEECCCHHHHCCHHHHHHCCCEEEEECCCCCCCHHEEEECCCCCCCCCCCCCCCCEEEEC
SGRSIIMLAEGRLVNLGCATGHPSFVMSNSFTNQCLAQIELAGKNYKPGVYTLPKKLDEE
CCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCEECHHHHHHH
VARLHLGRLGVKLTRLTPKQAEYLGISVEGPYKAEHYRY
HHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GRSTGNCRRRFSLMTTPGKKRTWWIHSKRPLTYKRGQANAKEKYMEFLEIDGLLPYRVA
CCCCCCHHHEEEEEECCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHCCCCCEEEE
DLSLAEWGWKEMALAENEMPGLMAVREKYGDQKPLAGFKVMGSLHMTIQTAMLIETLKIL
CCCHHHCCCHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GADIRWASCNIFSTQDHAAAAIAKSGTAAVFAWKGETLEEYWWCTEQALTWPDGSGPDLI
CCCCEEEEEEEECCCCHHHHHHHCCCCEEEEEECCCCHHHHHCCHHCEEECCCCCCCEEE
VDDGGDATLFIHQGARIEKESDLLDKRQDNKEMQIIMDRLKKSFARDSNRWTRVAAAVRG
EECCCCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
VSEETTTGVHRLYQMAKAGELLFPAINVNDSVTKSKFDNLYGCRESLADGIKRATDIMVA
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
GKVVVVCGYGDVGKGCVQSMRGFGARVIVTEVDPICALQAAMEGYEVKTLEDVVEEGDIF
CEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCEE
VTATGCCDVITGEHMERMKNEAIVCNIGHFDSEIAMHYLEGNPACKKESIKPQVDKWTLA
EEECCCHHHHCCHHHHHHCCCEEEEECCCCCCCHHEEEECCCCCCCCCCCCCCCCEEEEC
SGRSIIMLAEGRLVNLGCATGHPSFVMSNSFTNQCLAQIELAGKNYKPGVYTLPKKLDEE
CCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCEECHHHHHHH
VARLHLGRLGVKLTRLTPKQAEYLGISVEGPYKAEHYRY
HHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA