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The map label for this gene is fdhA [H]

Identifier: 85858924

GI number: 85858924

Start: 1103837

End: 1105447

Strand: Direct

Name: fdhA [H]

Synonym: SYN_02138

Alternate gene names: 85858924

Gene position: 1103837-1105447 (Clockwise)

Preceding gene: 85858923

Following gene: 85858925

Centisome position: 34.72

GC content: 54.87

Gene sequence:

>1611_bases
GTGTTCGGCTCCGGAGCCATGACGAATTCCATTCGGGAAGTTCCCGTCAGTGAAGGCTATCTCCTGATCGGAACCAATAC
GACGGACAATCATCCCGTGATCGGGTCCATGATCAAGGCCCAGGTCGTCAACAAAGGAAAGAAACTGATCGTGGCGGATC
CCCGCAGGATCGAACTGGCCAAATACGCGGACTATTTCTTCCAGATCAAGCCGGGGACAAACATCGCCATTCTCAACGGA
TTCATGCATGTCCTTGTTAAGGAAGGTCTTTACGACAGGAAATACGTTGCTGAGCGGTGCGAAGGATTCGATGAACTCGC
AAAGACCCTGGAAAAATACACGCCTGAATATGTCGCGGAAATCTGCGGTCTGGAAAACGGGGAAGACATTCCCAAAGCCG
CCCGCCTGATGGCCGCCTGCAAGCCCTTCGCGCTCTACTATGCCATGGGGATCACCCAGTTCATTTCCGGCGTGAACGGC
GTCAAATCCACAGCCAACCTGCAGATGCTCATGGGCAACCTGGGGATACCCGGCGGCGGCGTCAATCCGCTGCGCGGTCA
GAACAATGTCCAGGGCGCCTGCGACATGGGGGCGCTCAATGCCGTTTATCCCGCTTACCAGACTGTTGCCAGCGAAGAGA
ACAAGGCGAAGTTCGAGAAGGCCTGGGGCGCCTCCGGCCTCTCGATGAAACCGGGACTGACCGTGGTGGAAATGTTCAAC
GCGGCCATCGCCGGCCAGTTGAAGGCCGCTTATGTGATGGGGGAAAATCCTGTTGTTTCCGATCCCAATCAGCATCATAT
CATTGAAGGCCTGAATGCCTTGGAGTTTCTGGTCGTTCAGGACATCGTTCTCACGGAAACGGCTCAGTATGCCGATGTGG
TCCTCCCTGCCTATGCCTTCCTGGAAAAAGAAGGAACGGCAACGAATACCGAACGACGCGTCCAGCCCATGCACAAGGTG
GTTGCCCCGTGGGGCGAAGCCAGGGACGACTGGTGGATTATCATGCAGATTGCCAATCGGATGGGCATGAACTGGAATTA
CGGGAAAGCAGAGGATATCTTCGAAGAAATTCGAACGGTCACACCCTCTTATGCGGGAATCACTTACGACCGCATCGAGA
AGGAACTGATTCAGTGGCCCTGCCCCACGGAAGACCATCCGGGCACGCAGGTCCTCCACAAGGATAAATTCAGCCGGGGA
CTCGGCCTGCTAACGGCCATAGACTATACCCCCCCGGCGGAGGAAACGGATTCGGAATATCCGCTCATTCTGACAACCGG
CCGTCTGCTGGAGCATTTCCATACGGGAACCATGTCCCGGAACTCCCGGATTCTCGATGAGATCGTTCCGGAAGGGTACG
TTGAACTGAATCCGAACGAGGCTTCAAACTACAATATCGCCGATGGCGAGGTCATCTCCGTATCCACGAGGCGCGGCAGC
ATCCGCATCAAGGCGAAAATATCGGAAAAGCCGAAAGCCGGCGTGGTCTTTATGCCCTTCCATTTCTTTGAGACCTGCGC
GAATGTCCTGACGATTGACGCGCTGGATCCGGTCTGCAAGATCCCCGAATATAAGGTCTGTTCTTGCAAAATCGAAAAAA
TTTACCTGTAA

Upstream 100 bases:

>100_bases
TTACCTCATGCAGAAATTCATGCGCGCGGCGATCGGCACCAACAATGTGGATCACTGCGCCCGGCTCTGACACAGCTCCA
CCGTCGCCGGTCTGGCGGCA

Downstream 100 bases:

>100_bases
GGAGGGGATAGCGATGATTACGACGGAAAATATCCAAGAGGTGATTAATAACCGGGGAAAGGCCAGGGAACACCTGATGG
CCATTCTGCGGGATCTGGAA

Product: formate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MFGSGAMTNSIREVPVSEGYLLIGTNTTDNHPVIGSMIKAQVVNKGKKLIVADPRRIELAKYADYFFQIKPGTNIAILNG
FMHVLVKEGLYDRKYVAERCEGFDELAKTLEKYTPEYVAEICGLENGEDIPKAARLMAACKPFALYYAMGITQFISGVNG
VKSTANLQMLMGNLGIPGGGVNPLRGQNNVQGACDMGALNAVYPAYQTVASEENKAKFEKAWGASGLSMKPGLTVVEMFN
AAIAGQLKAAYVMGENPVVSDPNQHHIIEGLNALEFLVVQDIVLTETAQYADVVLPAYAFLEKEGTATNTERRVQPMHKV
VAPWGEARDDWWIIMQIANRMGMNWNYGKAEDIFEEIRTVTPSYAGITYDRIEKELIQWPCPTEDHPGTQVLHKDKFSRG
LGLLTAIDYTPPAEETDSEYPLILTTGRLLEHFHTGTMSRNSRILDEIVPEGYVELNPNEASNYNIADGEVISVSTRRGS
IRIKAKISEKPKAGVVFMPFHFFETCANVLTIDALDPVCKIPEYKVCSCKIEKIYL

Sequences:

>Translated_536_residues
MFGSGAMTNSIREVPVSEGYLLIGTNTTDNHPVIGSMIKAQVVNKGKKLIVADPRRIELAKYADYFFQIKPGTNIAILNG
FMHVLVKEGLYDRKYVAERCEGFDELAKTLEKYTPEYVAEICGLENGEDIPKAARLMAACKPFALYYAMGITQFISGVNG
VKSTANLQMLMGNLGIPGGGVNPLRGQNNVQGACDMGALNAVYPAYQTVASEENKAKFEKAWGASGLSMKPGLTVVEMFN
AAIAGQLKAAYVMGENPVVSDPNQHHIIEGLNALEFLVVQDIVLTETAQYADVVLPAYAFLEKEGTATNTERRVQPMHKV
VAPWGEARDDWWIIMQIANRMGMNWNYGKAEDIFEEIRTVTPSYAGITYDRIEKELIQWPCPTEDHPGTQVLHKDKFSRG
LGLLTAIDYTPPAEETDSEYPLILTTGRLLEHFHTGTMSRNSRILDEIVPEGYVELNPNEASNYNIADGEVISVSTRRGS
IRIKAKISEKPKAGVVFMPFHFFETCANVLTIDALDPVCKIPEYKVCSCKIEKIYL
>Mature_536_residues
MFGSGAMTNSIREVPVSEGYLLIGTNTTDNHPVIGSMIKAQVVNKGKKLIVADPRRIELAKYADYFFQIKPGTNIAILNG
FMHVLVKEGLYDRKYVAERCEGFDELAKTLEKYTPEYVAEICGLENGEDIPKAARLMAACKPFALYYAMGITQFISGVNG
VKSTANLQMLMGNLGIPGGGVNPLRGQNNVQGACDMGALNAVYPAYQTVASEENKAKFEKAWGASGLSMKPGLTVVEMFN
AAIAGQLKAAYVMGENPVVSDPNQHHIIEGLNALEFLVVQDIVLTETAQYADVVLPAYAFLEKEGTATNTERRVQPMHKV
VAPWGEARDDWWIIMQIANRMGMNWNYGKAEDIFEEIRTVTPSYAGITYDRIEKELIQWPCPTEDHPGTQVLHKDKFSRG
LGLLTAIDYTPPAEETDSEYPLILTTGRLLEHFHTGTMSRNSRILDEIVPEGYVELNPNEASNYNIADGEVISVSTRRGS
IRIKAKISEKPKAGVVFMPFHFFETCANVLTIDALDPVCKIPEYKVCSCKIEKIYL

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=538, Percent_Identity=40.3345724907063, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI3868720, Length=433, Percent_Identity=26.7898383371824, Blast_Score=145, Evalue=9e-36,
Organism=Escherichia coli, GI3868719, Length=476, Percent_Identity=26.0504201680672, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788534, Length=174, Percent_Identity=32.183908045977, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787778, Length=576, Percent_Identity=24.3055555555556, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081797, Length=615, Percent_Identity=21.6260162601626, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI87081994, Length=526, Percent_Identity=22.0532319391635, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1787870, Length=380, Percent_Identity=24.2105263157895, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1787231, Length=331, Percent_Identity=23.5649546827795, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 59289; Mature: 59289

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGSGAMTNSIREVPVSEGYLLIGTNTTDNHPVIGSMIKAQVVNKGKKLIVADPRRIELA
CCCCCCCCCCHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHH
KYADYFFQIKPGTNIAILNGFMHVLVKEGLYDRKYVAERCEGFDELAKTLEKYTPEYVAE
HHCCEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCHHHHHH
ICGLENGEDIPKAARLMAACKPFALYYAMGITQFISGVNGVKSTANLQMLMGNLGIPGGG
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
VNPLRGQNNVQGACDMGALNAVYPAYQTVASEENKAKFEKAWGASGLSMKPGLTVVEMFN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
AAIAGQLKAAYVMGENPVVSDPNQHHIIEGLNALEFLVVQDIVLTETAQYADVVLPAYAF
HHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LEKEGTATNTERRVQPMHKVVAPWGEARDDWWIIMQIANRMGMNWNYGKAEDIFEEIRTV
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEHEEHHHHCCCCCCCCCHHHHHHHHHHC
TPSYAGITYDRIEKELIQWPCPTEDHPGTQVLHKDKFSRGLGLLTAIDYTPPAEETDSEY
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
PLILTTGRLLEHFHTGTMSRNSRILDEIVPEGYVELNPNEASNYNIADGEVISVSTRRGS
CEEEEHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEEECCCE
IRIKAKISEKPKAGVVFMPFHFFETCANVLTIDALDPVCKIPEYKVCSCKIEKIYL
EEEEEEECCCCCCCEEEEHHHHHHHHHHHEEECCCCHHHCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MFGSGAMTNSIREVPVSEGYLLIGTNTTDNHPVIGSMIKAQVVNKGKKLIVADPRRIELA
CCCCCCCCCCHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHH
KYADYFFQIKPGTNIAILNGFMHVLVKEGLYDRKYVAERCEGFDELAKTLEKYTPEYVAE
HHCCEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCHHHHHH
ICGLENGEDIPKAARLMAACKPFALYYAMGITQFISGVNGVKSTANLQMLMGNLGIPGGG
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
VNPLRGQNNVQGACDMGALNAVYPAYQTVASEENKAKFEKAWGASGLSMKPGLTVVEMFN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
AAIAGQLKAAYVMGENPVVSDPNQHHIIEGLNALEFLVVQDIVLTETAQYADVVLPAYAF
HHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LEKEGTATNTERRVQPMHKVVAPWGEARDDWWIIMQIANRMGMNWNYGKAEDIFEEIRTV
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEHEEHHHHCCCCCCCCCHHHHHHHHHHC
TPSYAGITYDRIEKELIQWPCPTEDHPGTQVLHKDKFSRGLGLLTAIDYTPPAEETDSEY
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
PLILTTGRLLEHFHTGTMSRNSRILDEIVPEGYVELNPNEASNYNIADGEVISVSTRRGS
CEEEEHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEEECCCE
IRIKAKISEKPKAGVVFMPFHFFETCANVLTIDALDPVCKIPEYKVCSCKIEKIYL
EEEEEEECCCCCCCEEEEHHHHHHHHHHHEEECCCCHHHCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]