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The map label for this gene is cysS [H]

Identifier: 85858128

GI number: 85858128

Start: 294520

End: 296829

Strand: Direct

Name: cysS [H]

Synonym: SYN_00075

Alternate gene names: 85858128

Gene position: 294520-296829 (Clockwise)

Preceding gene: 85858127

Following gene: 85858129

Centisome position: 9.26

GC content: 51.43

Gene sequence:

>2310_bases
ATGCAGAAACTTTATGGGAACATTCTTGAAGCGATTGGAAATACGCCGCTTGTTGAGATTCGCAGGTTGAACCCGAACCC
GAACGTAAAAATCTATGCCAAGCTGGAAAGTTTCAATCCCGGGGGGTCCATCAAGGACCGGACCGCCCTTTATATGATCA
ATGAGGCAGAACGGCGCGGGGAACTCACCAAAGATAAAATCATCCTGGAAGCAACCAGCGGCAATACCGGCATTGGTCTG
GCCCTCATTGCGGCGGCAAAGGGTTATCGCGTCTGCTTTGCAATGGCGGAGTCGGCGAGTGACGAGAGGAAAAAAATACT
GAAGGCCCTGGGGGCGGAATTGCATTTTACTCCAGCCAGCCTGGGCACCGATGGTGCGATAGAAACAGTATACAGCATGA
TGCGGGAAAACCCGGACCGTTATTTCGTCCCTGATCAGTTTAACAATCCCGATAATATTCTGGCCCATTATCACGGGACG
GCCGAGGAAATCTGGCAGCAGACCGGGGGCCGTGTCACCATGGCGATTGCCACAATGGGGACAACGGGAACCGTCATGGG
GATTGCCAGGCGGTTGAAGGAGTATAATCCGGAAGTACGGATTGTCGGGGTGGAACCTTATCTGCAGCACAAGATTCAGG
GTCTGAAAAATATGAAGGAATCCTACCGTCCCGGAATCTACGACAAACGCTGCCTTGATGAAAAAGTCAATATTCTTGAT
GAGGATGCCTATGAGATGGCCAGAAGGCTGGCCAGAGAAGAAGGAATCCTGGCTGGAATGAGCTCCGGAGCGGCCATGCA
CGTGGCGGCACAAAAGGCAAAAGAAATGAAAGAGGGCGTGATCGTGGTTATTTTTCCGGACAGCGGCGAACGCTATCTCA
GTACAGAGCTCTTCATGGATAAGGAAGAATCGACCATACGATTCTACAATGTCCTGTCCCGGAGCAAAAACTTCTTCCGG
CCTGTTAATCCGGATAAGGTGCTGATGCATTCCTGCGGTCCCACGACCCACGAAGTTCCGCACATCGGCAGTTACCGCCG
GTTTGTGGTGTCCGACTTGATCCGGCGTTATCTGGAATTCCGGGGATATGAAGTGAAACATGTTCTCAATATCATCGATC
TGGCTGACCGGTCCATTCGAGGCGCCGAGCGGGAAGGGATGGATCTGGGTGTATACACTGCTCGCTGCGAAGAGGTATTC
CTTAATGATATCAATAAATTGAATATAAAAAAGGATGAAAGCTATCCACGGGCCAGTGAGAATTTTGACAGCATGGTGAA
GCTGGTGGAAAAGCTGGTTGACAAGGGATTTGCCTATGAAAAATTGAGATCCGTCTATTTTGATATATCCAAGCTGAGAG
ATTATGGATGCCTTTCCAATATTGACCTGGTCAGGGTGCAGCATGGCAGAAGGATCGATCTGGACGATTATGAAAAAGAC
AGCCCCGTGGATTTCACACTCCTTAAACGATCCACCCTGAGTGAACTGAAACGGGGGGTATTCTTCAAGACCCGCTGGGG
CAACGTCAGGCCGAGTTGGCACTTGGAATGCGCTGCCATCGCCCAGCACTATCTGGCGGATACCTTTGACATTCACGCGA
GCGGTTCCGATATTGTATTCCCTCACTGTGAAAATGTCATGGCAATCGGCAAGGCAGCCACGGGGAAAAGGATTGCAAAT
TACTGGATCAACACGGAACTGGTCATGGTCGGCGGGAAAAAGATGTCCCGCTCGCTCAACAACGCTCTGACCCTTGAGGA
TTTGGAAAAGAAGGGTTATTCCGGCAGGGAAGTCCGGTTCTTCCTGGTCAGCTCGCACTATCGGAAGCCGCTGAATTTTT
CCTTCGGCGCCCTGGATACGGCCAAGAATACGGTTTTGAAATTAAATGGGTTCATCCAGCGTCTGATCCGGTTAAAGGCC
GGGGAGGGCGATCCCGATCTTGAACAGAAGCTGTACGATCTTCGCCAGGGTTTCACAGCGGCCATGGATGATGATCTGAA
CATTTCCGGGGCTTTGGCCGTTCTGTTCGACTTTGTCAAAAAAGTCAGCAGCTCACTTGCTCAAGGCGTTCTGACCGTGG
AGCAGCGGGATCAGGTTCTGGAGGCCTTGAAAAAAATCGATGACGTGCTTGGCGTGATGAAGTTCGAGGAGGAACAAATC
AGTGAAGAGGCCCTGCAGCTAATGAAAAGGAGAGAAGCCTTGCGTCAGGAAGGCCGGTGGGCGCAGGCGGATGAAATTCG
CCAGAGGCTTCTGGACATGGGCGTTGTTGTGGCCGATACACCGGAAGGCATGGTTTGGCGCCTGAAATGA

Upstream 100 bases:

>100_bases
TCACAGGGAATAGCTCATTCCCCTCATACATAAGAGGAAAAAACAGGGCAGGGATAATGGTCATAATCGAAAGCCCGGTG
TATGGAAGAGAAAATTAAGC

Downstream 100 bases:

>100_bases
TTTGGGGCGGGATTGAGCTTCCCCAACCAAGGCATGGCGGCGTCGGGAGATCGGAACTTTTATCTGTCGCAGAAAATGCC
CTGGCCGCTCTATAGATTAG

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS [H]

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MQKLYGNILEAIGNTPLVEIRRLNPNPNVKIYAKLESFNPGGSIKDRTALYMINEAERRGELTKDKIILEATSGNTGIGL
ALIAAAKGYRVCFAMAESASDERKKILKALGAELHFTPASLGTDGAIETVYSMMRENPDRYFVPDQFNNPDNILAHYHGT
AEEIWQQTGGRVTMAIATMGTTGTVMGIARRLKEYNPEVRIVGVEPYLQHKIQGLKNMKESYRPGIYDKRCLDEKVNILD
EDAYEMARRLAREEGILAGMSSGAAMHVAAQKAKEMKEGVIVVIFPDSGERYLSTELFMDKEESTIRFYNVLSRSKNFFR
PVNPDKVLMHSCGPTTHEVPHIGSYRRFVVSDLIRRYLEFRGYEVKHVLNIIDLADRSIRGAEREGMDLGVYTARCEEVF
LNDINKLNIKKDESYPRASENFDSMVKLVEKLVDKGFAYEKLRSVYFDISKLRDYGCLSNIDLVRVQHGRRIDLDDYEKD
SPVDFTLLKRSTLSELKRGVFFKTRWGNVRPSWHLECAAIAQHYLADTFDIHASGSDIVFPHCENVMAIGKAATGKRIAN
YWINTELVMVGGKKMSRSLNNALTLEDLEKKGYSGREVRFFLVSSHYRKPLNFSFGALDTAKNTVLKLNGFIQRLIRLKA
GEGDPDLEQKLYDLRQGFTAAMDDDLNISGALAVLFDFVKKVSSSLAQGVLTVEQRDQVLEALKKIDDVLGVMKFEEEQI
SEEALQLMKRREALRQEGRWAQADEIRQRLLDMGVVVADTPEGMVWRLK

Sequences:

>Translated_769_residues
MQKLYGNILEAIGNTPLVEIRRLNPNPNVKIYAKLESFNPGGSIKDRTALYMINEAERRGELTKDKIILEATSGNTGIGL
ALIAAAKGYRVCFAMAESASDERKKILKALGAELHFTPASLGTDGAIETVYSMMRENPDRYFVPDQFNNPDNILAHYHGT
AEEIWQQTGGRVTMAIATMGTTGTVMGIARRLKEYNPEVRIVGVEPYLQHKIQGLKNMKESYRPGIYDKRCLDEKVNILD
EDAYEMARRLAREEGILAGMSSGAAMHVAAQKAKEMKEGVIVVIFPDSGERYLSTELFMDKEESTIRFYNVLSRSKNFFR
PVNPDKVLMHSCGPTTHEVPHIGSYRRFVVSDLIRRYLEFRGYEVKHVLNIIDLADRSIRGAEREGMDLGVYTARCEEVF
LNDINKLNIKKDESYPRASENFDSMVKLVEKLVDKGFAYEKLRSVYFDISKLRDYGCLSNIDLVRVQHGRRIDLDDYEKD
SPVDFTLLKRSTLSELKRGVFFKTRWGNVRPSWHLECAAIAQHYLADTFDIHASGSDIVFPHCENVMAIGKAATGKRIAN
YWINTELVMVGGKKMSRSLNNALTLEDLEKKGYSGREVRFFLVSSHYRKPLNFSFGALDTAKNTVLKLNGFIQRLIRLKA
GEGDPDLEQKLYDLRQGFTAAMDDDLNISGALAVLFDFVKKVSSSLAQGVLTVEQRDQVLEALKKIDDVLGVMKFEEEQI
SEEALQLMKRREALRQEGRWAQADEIRQRLLDMGVVVADTPEGMVWRLK
>Mature_769_residues
MQKLYGNILEAIGNTPLVEIRRLNPNPNVKIYAKLESFNPGGSIKDRTALYMINEAERRGELTKDKIILEATSGNTGIGL
ALIAAAKGYRVCFAMAESASDERKKILKALGAELHFTPASLGTDGAIETVYSMMRENPDRYFVPDQFNNPDNILAHYHGT
AEEIWQQTGGRVTMAIATMGTTGTVMGIARRLKEYNPEVRIVGVEPYLQHKIQGLKNMKESYRPGIYDKRCLDEKVNILD
EDAYEMARRLAREEGILAGMSSGAAMHVAAQKAKEMKEGVIVVIFPDSGERYLSTELFMDKEESTIRFYNVLSRSKNFFR
PVNPDKVLMHSCGPTTHEVPHIGSYRRFVVSDLIRRYLEFRGYEVKHVLNIIDLADRSIRGAEREGMDLGVYTARCEEVF
LNDINKLNIKKDESYPRASENFDSMVKLVEKLVDKGFAYEKLRSVYFDISKLRDYGCLSNIDLVRVQHGRRIDLDDYEKD
SPVDFTLLKRSTLSELKRGVFFKTRWGNVRPSWHLECAAIAQHYLADTFDIHASGSDIVFPHCENVMAIGKAATGKRIAN
YWINTELVMVGGKKMSRSLNNALTLEDLEKKGYSGREVRFFLVSSHYRKPLNFSFGALDTAKNTVLKLNGFIQRLIRLKA
GEGDPDLEQKLYDLRQGFTAAMDDDLNISGALAVLFDFVKKVSSSLAQGVLTVEQRDQVLEALKKIDDVLGVMKFEEEQI
SEEALQLMKRREALRQEGRWAQADEIRQRLLDMGVVVADTPEGMVWRLK

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=310, Percent_Identity=40, Blast_Score=217, Evalue=4e-56,
Organism=Homo sapiens, GI295821200, Length=310, Percent_Identity=40, Blast_Score=217, Evalue=4e-56,
Organism=Homo sapiens, GI4557415, Length=310, Percent_Identity=40, Blast_Score=217, Evalue=4e-56,
Organism=Homo sapiens, GI13375695, Length=377, Percent_Identity=29.973474801061, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI303304987, Length=313, Percent_Identity=29.7124600638978, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI21269877, Length=313, Percent_Identity=29.7124600638978, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI62240992, Length=313, Percent_Identity=29.7124600638978, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI10835051, Length=313, Percent_Identity=29.7124600638978, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1786737, Length=476, Percent_Identity=35.2941176470588, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI2367138, Length=289, Percent_Identity=45.6747404844291, Blast_Score=258, Evalue=1e-69,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=41.875, Blast_Score=203, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17562970, Length=314, Percent_Identity=40.4458598726115, Blast_Score=210, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=40.1993355481728, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=39.6825396825397, Blast_Score=202, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=40.7407407407407, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=38.4105960264901, Blast_Score=181, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25147552, Length=319, Percent_Identity=35.1097178683386, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17534315, Length=348, Percent_Identity=34.1954022988506, Blast_Score=159, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI32566672, Length=228, Percent_Identity=39.0350877192982, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17509797, Length=292, Percent_Identity=27.7397260273973, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17509795, Length=292, Percent_Identity=27.7397260273973, Blast_Score=99, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321594, Length=326, Percent_Identity=37.4233128834356, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=34.4615384615385, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324082, Length=344, Percent_Identity=29.0697674418605, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24643623, Length=340, Percent_Identity=38.5294117647059, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20129101, Length=340, Percent_Identity=38.5294117647059, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI19922218, Length=450, Percent_Identity=28.6666666666667, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19922364, Length=271, Percent_Identity=30.9963099630996, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080 [H]

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e [H]

EC number: =6.1.1.16 [H]

Molecular weight: Translated: 87122; Mature: 87122

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLYGNILEAIGNTPLVEIRRLNPNPNVKIYAKLESFNPGGSIKDRTALYMINEAERRG
CCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECHHHCC
ELTKDKIILEATSGNTGIGLALIAAAKGYRVCFAMAESASDERKKILKALGAELHFTPAS
CCCCCEEEEEECCCCCCHHHHHHHHCCCHHEEHHHHHCCCHHHHHHHHHCCCCEEECCCC
LGTDGAIETVYSMMRENPDRYFVPDQFNNPDNILAHYHGTAEEIWQQTGGRVTMAIATMG
CCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCHHHHHHHCCCEEEEEEEECC
TTGTVMGIARRLKEYNPEVRIVGVEPYLQHKIQGLKNMKESYRPGIYDKRCLDEKVNILD
CCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
EDAYEMARRLAREEGILAGMSSGAAMHVAAQKAKEMKEGVIVVIFPDSGERYLSTELFMD
HHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEEHHHHCC
KEESTIRFYNVLSRSKNFFRPVNPDKVLMHSCGPTTHEVPHIGSYRRFVVSDLIRRYLEF
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RGYEVKHVLNIIDLADRSIRGAEREGMDLGVYTARCEEVFLNDINKLNIKKDESYPRASE
CCCCHHHHHHHHHHHCHHCCCCCCCCCEEEHHHHHHHHHHHCCCHHCCCCCCCCCCCCCC
NFDSMVKLVEKLVDKGFAYEKLRSVYFDISKLRDYGCLSNIDLVRVQHGRRIDLDDYEKD
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCC
SPVDFTLLKRSTLSELKRGVFFKTRWGNVRPSWHLECAAIAQHYLADTFDIHASGSDIVF
CCCCEEHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCEEC
PHCENVMAIGKAATGKRIANYWINTELVMVGGKKMSRSLNNALTLEDLEKKGYSGREVRF
CCCCCHHHHCCCCCCCHHHHHEECEEEEEECCHHHHHHHHCCCCHHHHHHCCCCCCEEEE
FLVSSHYRKPLNFSFGALDTAKNTVLKLNGFIQRLIRLKAGEGDPDLEQKLYDLRQGFTA
EEEECCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
AMDDDLNISGALAVLFDFVKKVSSSLAQGVLTVEQRDQVLEALKKIDDVLGVMKFEEEQI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEEALQLMKRREALRQEGRWAQADEIRQRLLDMGVVVADTPEGMVWRLK
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCCCEEEEC
>Mature Secondary Structure
MQKLYGNILEAIGNTPLVEIRRLNPNPNVKIYAKLESFNPGGSIKDRTALYMINEAERRG
CCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECHHHCC
ELTKDKIILEATSGNTGIGLALIAAAKGYRVCFAMAESASDERKKILKALGAELHFTPAS
CCCCCEEEEEECCCCCCHHHHHHHHCCCHHEEHHHHHCCCHHHHHHHHHCCCCEEECCCC
LGTDGAIETVYSMMRENPDRYFVPDQFNNPDNILAHYHGTAEEIWQQTGGRVTMAIATMG
CCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCHHHHHHHCCCEEEEEEEECC
TTGTVMGIARRLKEYNPEVRIVGVEPYLQHKIQGLKNMKESYRPGIYDKRCLDEKVNILD
CCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
EDAYEMARRLAREEGILAGMSSGAAMHVAAQKAKEMKEGVIVVIFPDSGERYLSTELFMD
HHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEEHHHHCC
KEESTIRFYNVLSRSKNFFRPVNPDKVLMHSCGPTTHEVPHIGSYRRFVVSDLIRRYLEF
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RGYEVKHVLNIIDLADRSIRGAEREGMDLGVYTARCEEVFLNDINKLNIKKDESYPRASE
CCCCHHHHHHHHHHHCHHCCCCCCCCCEEEHHHHHHHHHHHCCCHHCCCCCCCCCCCCCC
NFDSMVKLVEKLVDKGFAYEKLRSVYFDISKLRDYGCLSNIDLVRVQHGRRIDLDDYEKD
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCC
SPVDFTLLKRSTLSELKRGVFFKTRWGNVRPSWHLECAAIAQHYLADTFDIHASGSDIVF
CCCCEEHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCEEC
PHCENVMAIGKAATGKRIANYWINTELVMVGGKKMSRSLNNALTLEDLEKKGYSGREVRF
CCCCCHHHHCCCCCCCHHHHHEECEEEEEECCHHHHHHHHCCCCHHHHHHCCCCCCEEEE
FLVSSHYRKPLNFSFGALDTAKNTVLKLNGFIQRLIRLKAGEGDPDLEQKLYDLRQGFTA
EEEECCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
AMDDDLNISGALAVLFDFVKKVSSSLAQGVLTVEQRDQVLEALKKIDDVLGVMKFEEEQI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEEALQLMKRREALRQEGRWAQADEIRQRLLDMGVVVADTPEGMVWRLK
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA