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The map label for this gene is kbl [C]

Identifier: 85858049

GI number: 85858049

Start: 210188

End: 211351

Strand: Direct

Name: kbl [C]

Synonym: SYN_02568

Alternate gene names: 85858049

Gene position: 210188-211351 (Clockwise)

Preceding gene: 85858048

Following gene: 85858050

Centisome position: 6.61

GC content: 56.36

Gene sequence:

>1164_bases
ATGGGCGGATTTACGAAACGGTTGAAAACACAATTGAAGCTCCACCGGCAGGCCGGTCTCTACCGGCAGCCGCCGGAAAT
CCTCGGCCGGGAGGGTGCTTCCCTTCACCTGGCCGAGGGCCGGGTCCTCAATTTCGCCTCCAACGACTATCTGGGACTAG
GGGCGTCGGAGGTCCTGCGGAAACAGGTTGCCCGCAACTTTTGTAAATACGGTTCTTCTTCCTCTTCATCCCGCCTCGTC
TCCGGCCATTATGCCCTGATTGCCGAAGCTGAAAGGGCATACGCCCGCTATTTCGGCTATGAGGAGGCTCTCTTCTTTCC
CAGCGGCTATCAGGCCAACCTTGCCCTGCTGTCCACTCTCTTCGATTCCGGAACGACGCTCTTTTTTGACAAGCATATCC
ATGCCAGCAGCGTCAAGGGTATGGCCCTCAGTTCCGCAGAACTTGTGGGCTACAATCACAGTTCCCTGACCCACCTTGAA
AAACGCCTGAAAAAAGCGGAAACAAGGGAGACCGTCGTCCTGACGGAATCCCTTTTCAGCATGGACGGCGACCTGCTGAA
TGTCTCCGGCCTGGCCGATCTCAAGGAGCATTACGGGTTTCTCTGCATTGTCGATGAAGCCCACGCCCTGGGCGTTCTGG
GGGAGAGGGGAATCGGCGTTGCCCTGCCGGTTGCCGACATCGCCGTGGGGACCTTTGGAAAGGCCTTGGGACTCTTCGGA
GCATTTCTTCTTATTCCGGCCCTGGTCAAGGAGTATCTCTTCAACTTCGCTTCCCCCCTCATCTACTCCACCACCCTTCC
CGAGGCGCACGCAGCCTCGGCCATCGACATCCTGACCCTGTTGGGCGATAGCGACGAGTCCAGAAGGCATCTCCGGGAAA
TCAGCTCCCTCATGAAAAACCGTCTGTATGCAGAGGGTTTTTCCGTGCAGGGGGACGCCCATATCCTGGCTGTGGAAATC
GGGCGGGAACAGAAGGCGCTGGAGATTTCAAACCGGCTTCGGAAAAAGGGAATATTCGTTTTGTCGGCACGCTATCCCAC
CGTTCCCCTGGGAAGAGCCATCCTGAGGATTGGAATGACGGCCCTGCACGGGGAGGAGGACGTCAATCACTTTATTTTGT
CCCTGAAGGAGGTTATGAAAGAATATGAAAACGGAAATTCCTGA

Upstream 100 bases:

>100_bases
AGAGCGGCAAAGCGGTTATCGAAGGGGAATTCGTCTTTGCGGCGGTTGCCTACGATTCAAACCTGCGGGAAGAAATCCTC
AAAAAACATTACGAGAAAAA

Downstream 100 bases:

>100_bases
CATCTATGTGATAGGCACGGATACAGGGGTCGGAAAGACCGTCCTGTCGTTCCTGTTGATGCGCTACTTCTTCGATCGGG
GGGCTGTCCCCTTTTATTTC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MGGFTKRLKTQLKLHRQAGLYRQPPEILGREGASLHLAEGRVLNFASNDYLGLGASEVLRKQVARNFCKYGSSSSSSRLV
SGHYALIAEAERAYARYFGYEEALFFPSGYQANLALLSTLFDSGTTLFFDKHIHASSVKGMALSSAELVGYNHSSLTHLE
KRLKKAETRETVVLTESLFSMDGDLLNVSGLADLKEHYGFLCIVDEAHALGVLGERGIGVALPVADIAVGTFGKALGLFG
AFLLIPALVKEYLFNFASPLIYSTTLPEAHAASAIDILTLLGDSDESRRHLREISSLMKNRLYAEGFSVQGDAHILAVEI
GREQKALEISNRLRKKGIFVLSARYPTVPLGRAILRIGMTALHGEEDVNHFILSLKEVMKEYENGNS

Sequences:

>Translated_387_residues
MGGFTKRLKTQLKLHRQAGLYRQPPEILGREGASLHLAEGRVLNFASNDYLGLGASEVLRKQVARNFCKYGSSSSSSRLV
SGHYALIAEAERAYARYFGYEEALFFPSGYQANLALLSTLFDSGTTLFFDKHIHASSVKGMALSSAELVGYNHSSLTHLE
KRLKKAETRETVVLTESLFSMDGDLLNVSGLADLKEHYGFLCIVDEAHALGVLGERGIGVALPVADIAVGTFGKALGLFG
AFLLIPALVKEYLFNFASPLIYSTTLPEAHAASAIDILTLLGDSDESRRHLREISSLMKNRLYAEGFSVQGDAHILAVEI
GREQKALEISNRLRKKGIFVLSARYPTVPLGRAILRIGMTALHGEEDVNHFILSLKEVMKEYENGNS
>Mature_386_residues
GGFTKRLKTQLKLHRQAGLYRQPPEILGREGASLHLAEGRVLNFASNDYLGLGASEVLRKQVARNFCKYGSSSSSSRLVS
GHYALIAEAERAYARYFGYEEALFFPSGYQANLALLSTLFDSGTTLFFDKHIHASSVKGMALSSAELVGYNHSSLTHLEK
RLKKAETRETVVLTESLFSMDGDLLNVSGLADLKEHYGFLCIVDEAHALGVLGERGIGVALPVADIAVGTFGKALGLFGA
FLLIPALVKEYLFNFASPLIYSTTLPEAHAASAIDILTLLGDSDESRRHLREISSLMKNRLYAEGFSVQGDAHILAVEIG
REQKALEISNRLRKKGIFVLSARYPTVPLGRAILRIGMTALHGEEDVNHFILSLKEVMKEYENGNS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=381, Percent_Identity=31.758530183727, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=32.463768115942, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI4502025, Length=358, Percent_Identity=28.2122905027933, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI40316939, Length=358, Percent_Identity=28.2122905027933, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI83977442, Length=352, Percent_Identity=29.2613636363636, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI83977440, Length=352, Percent_Identity=29.2613636363636, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI83977444, Length=352, Percent_Identity=29.2613636363636, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=25.414364640884, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI119220554, Length=362, Percent_Identity=25.414364640884, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI5454084, Length=370, Percent_Identity=22.7027027027027, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790046, Length=391, Percent_Identity=30.9462915601023, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=33.1378299120235, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=388, Percent_Identity=29.1237113402062, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=26.8292682926829, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=366, Percent_Identity=25.6830601092896, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17560914, Length=366, Percent_Identity=25.6830601092896, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71982617, Length=295, Percent_Identity=21.6949152542373, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71982625, Length=295, Percent_Identity=21.6949152542373, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320438, Length=381, Percent_Identity=27.5590551181102, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320267, Length=362, Percent_Identity=27.0718232044199, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323954, Length=272, Percent_Identity=24.6323529411765, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24662918, Length=380, Percent_Identity=28.4210526315789, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=31.2676056338028, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI17136286, Length=372, Percent_Identity=25.2688172043011, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24653280, Length=348, Percent_Identity=21.8390804597701, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24653276, Length=348, Percent_Identity=21.8390804597701, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24653278, Length=348, Percent_Identity=21.8390804597701, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42399; Mature: 42268

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGFTKRLKTQLKLHRQAGLYRQPPEILGREGASLHLAEGRVLNFASNDYLGLGASEVLR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCCEEEECCCCCCCCCHHHHHH
KQVARNFCKYGSSSSSSRLVSGHYALIAEAERAYARYFGYEEALFFPSGYQANLALLSTL
HHHHHHHHHCCCCCCCCCEEECCCCEEHHHHHHHHHHCCCHHEEECCCCCCHHHHHHHHH
FDSGTTLFFDKHIHASSVKGMALSSAELVGYNHSSLTHLEKRLKKAETRETVVLTESLFS
HCCCCEEEEECCCCHHCCCCCEECCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHH
MDGDLLNVSGLADLKEHYGFLCIVDEAHALGVLGERGIGVALPVADIAVGTFGKALGLFG
CCCCEEECCCHHHHHHCCCEEEEEECCCHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHH
AFLLIPALVKEYLFNFASPLIYSTTLPEAHAASAIDILTLLGDSDESRRHLREISSLMKN
HHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLYAEGFSVQGDAHILAVEIGREQKALEISNRLRKKGIFVLSARYPTVPLGRAILRIGMT
HHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHH
ALHGEEDVNHFILSLKEVMKEYENGNS
HHCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GGFTKRLKTQLKLHRQAGLYRQPPEILGREGASLHLAEGRVLNFASNDYLGLGASEVLR
CCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCCEEEECCCCCCCCCHHHHHH
KQVARNFCKYGSSSSSSRLVSGHYALIAEAERAYARYFGYEEALFFPSGYQANLALLSTL
HHHHHHHHHCCCCCCCCCEEECCCCEEHHHHHHHHHHCCCHHEEECCCCCCHHHHHHHHH
FDSGTTLFFDKHIHASSVKGMALSSAELVGYNHSSLTHLEKRLKKAETRETVVLTESLFS
HCCCCEEEEECCCCHHCCCCCEECCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHH
MDGDLLNVSGLADLKEHYGFLCIVDEAHALGVLGERGIGVALPVADIAVGTFGKALGLFG
CCCCEEECCCHHHHHHCCCEEEEEECCCHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHH
AFLLIPALVKEYLFNFASPLIYSTTLPEAHAASAIDILTLLGDSDESRRHLREISSLMKN
HHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLYAEGFSVQGDAHILAVEIGREQKALEISNRLRKKGIFVLSARYPTVPLGRAILRIGMT
HHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHH
ALHGEEDVNHFILSLKEVMKEYENGNS
HHCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA