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The map label for this gene is iorB [H]

Identifier: 85375072

GI number: 85375072

Start: 2268781

End: 2271030

Strand: Reverse

Name: iorB [H]

Synonym: ELI_11225

Alternate gene names: 85375072

Gene position: 2271030-2268781 (Counterclockwise)

Preceding gene: 85375073

Following gene: 85375071

Centisome position: 74.4

GC content: 64.58

Gene sequence:

>2250_bases
ATGAGCGAGCAAGCCGATACCAAGCCGGCGCGCAGCCGTACGGCCAAATGGACTAGGCGCGGGGTCATGGGTGCAGGCGT
GCTTGCCGGCGGCGCGTTGCTGATCGGGGTCGCGGTGCGGCCCGGCAATCCGGTAGGGCGGTTGAAGCCGCTGGTCGCGG
AAGGCGATGAGGAGCTCGTCAACAGCTGGGTCAAGATCGATACCGACAACACTGTCACCGCGATCGTCCCGCATTGCGAG
ATGGGGCAGGGCGCGCATTCGGTGCTGGGCCAGATGCTCGCGGACGAGCTCGATGCGGACTGGAATCTCGTCAAGGTGAT
GCAGGCGCCGGCGGATGGGAATTATGTCGTGACCGATACCGCCCGCATGTTCGTCGCGCCGTTCACGATGAACGCGGCGG
ACTGGATCGAGCCGACTTATGACGGCCTGTTCACCCAGATCGCGCGGCTCGCCGATGCCATGATCACCGGGGGCAGTTCC
TCGATCCGCACGACTGGGCAACACCAGATGCGTATCGCCGGGGCTGCGGCGCGGCAGATGCTGGTCGGCGCGGCTGCCGA
GGAGTGGGACGTTCCTGCAGGCGAAATCGAAACGCGTAACAGCATGTTGATCCATGCTGCTTCGGGGAAGGAAGCGCCCT
ATGCGCAGTTTGCCGCGGCTGCAGCCGAACAGCCGATGCCGCAGACGCCTCGGCTCAAGGACATCGGCGAATACAGGCTG
ATGGGCAAGAGCAAGGCGCGCACCGATATTCCGGCCAAGGTCAACGGCACGGCCACTTTCGGGATCGATGCCGAGATCCC
TGCCGACAATCTCTCCTATGCCGCGGTCATGCGGCCTCCGGTTCCGGGCACCGAAGTGGCATCGATGGATGCCGAAGCGG
CGAAGTCCATGGGGGGCGTATTGCAGATCCTCAACATGGGCGATCACGTTGCTGTCGTCGCGGACAGCTACTGGCAGGCC
GAGCAGGCGCTCGGCGCGATCGACGTCACGTGGACCCAGTCCGAGAGCAAAATCGCGACCATGGACGACCAGTTTGCCGC
ATTTGCCGCCGCACTCGACGCCGCGGGCGATGACGGAGGCAGCGAAGCGGCGTCGAAGGGCGATGCGCGCGATGCCTTCG
CCAATGCCGCCACAATTATCGAAGCGGAATATCGCGTGCCCTACCTGGCCCACGCGCCAATGGAGCCGATCAACTGCACG
GCCTGGGTGCATGACGGCAAATGCGAAATCTGGACCAGCACCCAGGTGCCGCTGATGGCGCGCAAGGAAGCAGCCAACGC
TATCGGGCTCGATGCCGACGATATCACGATCCATCATCCGATGCTGGGCGGCGGTTTCGGGCGGCGCCTGGTCAGCGAAT
ATGTCGGCATGGCGGCGCGGGTGGCGAAGGCGACGGGCTATCCGGTCAAGATGATCTGGAGCCGCGAGGAAGATACGCAA
AAGTCGATGTACCGCCCGGCCGACATGATCCGTTTCAAGGGCGGGCTCGACGCCGATGGCAAGCTTGTCAGCTACAACAG
CGTCTTCACCCAGCGCCACGATCCCGCGGAGGCCTGTGTGCCTGCGGGCTATGGCATCCCCAACCTATCGGTTCGCGTCG
CCGAAGCTCCGCTGCACCTGCCGTTTCAGGCCTGGCGTTCCGTCGACCATTCGCAGCATGGATTTTTCACCGAGAGCTTT
ATCGACGAAGCAGCCCATGCGGCCGGGGCCGACCCGCTCGACTATCGCATCGCCATGCTGGCCGATGCTCCGCGTCACAG
GGCCGTGCTGGAGAAACTGCAGCAGGTCAGCGGCTGGGACGAGCCGGCGGGCGACGGCAAGGGGCGCGGTGTCGCCATGG
TCGAGAGCTTCGGCACGATCGTGGCGGAAGCGGTCGAAGTCGATATGTCCGGCGGCAAGCCGCGCGCGACCAAGGTCTAC
GCGGTGGCCGATCCGGGCTATGCAATGAATCCCGATGGTTTCCGCAACCAGATCGAAGGCGGGATTGTGTTCGGTCTGAC
CGCCGCGCTTTACGGCGAGCTCGAGCTGGAAGGCGGCAGGGTCAAGCAGAGCAACTTCCACGATTACAAGATGCTGCGCA
TGAACGAGTGCCCGGAAATCGAAGTCGCCATCATCAACAGCGGTCCGGTGCCCATCGGCGGGGCCGGTGAACCGGGCACG
CCGCCCATCGCTCCGGCGTTCACCAACGCAATCTTTGCCGCCACAGGTCGCCGCATTCGCGACCTGCCCGTCGCCAGGCA
ATTCGCGTGA

Upstream 100 bases:

>100_bases
TGGCGGGCAATATCTGCCGCTGCGGCACTTACACCCGCATTCGCCGCGCCATCAAAGTCGCCGCCGGCCTGCAAGAGCCC
CGCAACGAGGAGGCGGAGGC

Downstream 100 bases:

>100_bases
CGGAGGCGGGGACAATGAAGCATTTTGCTGTGCCGGTTTTGTTGGCTTTCGTATTGATTGGCTGCGGCTCTGCGGAAGAG
CCGCCTGTGGAACAGATCGT

Product: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MSEQADTKPARSRTAKWTRRGVMGAGVLAGGALLIGVAVRPGNPVGRLKPLVAEGDEELVNSWVKIDTDNTVTAIVPHCE
MGQGAHSVLGQMLADELDADWNLVKVMQAPADGNYVVTDTARMFVAPFTMNAADWIEPTYDGLFTQIARLADAMITGGSS
SIRTTGQHQMRIAGAAARQMLVGAAAEEWDVPAGEIETRNSMLIHAASGKEAPYAQFAAAAAEQPMPQTPRLKDIGEYRL
MGKSKARTDIPAKVNGTATFGIDAEIPADNLSYAAVMRPPVPGTEVASMDAEAAKSMGGVLQILNMGDHVAVVADSYWQA
EQALGAIDVTWTQSESKIATMDDQFAAFAAALDAAGDDGGSEAASKGDARDAFANAATIIEAEYRVPYLAHAPMEPINCT
AWVHDGKCEIWTSTQVPLMARKEAANAIGLDADDITIHHPMLGGGFGRRLVSEYVGMAARVAKATGYPVKMIWSREEDTQ
KSMYRPADMIRFKGGLDADGKLVSYNSVFTQRHDPAEACVPAGYGIPNLSVRVAEAPLHLPFQAWRSVDHSQHGFFTESF
IDEAAHAAGADPLDYRIAMLADAPRHRAVLEKLQQVSGWDEPAGDGKGRGVAMVESFGTIVAEAVEVDMSGGKPRATKVY
AVADPGYAMNPDGFRNQIEGGIVFGLTAALYGELELEGGRVKQSNFHDYKMLRMNECPEIEVAIINSGPVPIGGAGEPGT
PPIAPAFTNAIFAATGRRIRDLPVARQFA

Sequences:

>Translated_749_residues
MSEQADTKPARSRTAKWTRRGVMGAGVLAGGALLIGVAVRPGNPVGRLKPLVAEGDEELVNSWVKIDTDNTVTAIVPHCE
MGQGAHSVLGQMLADELDADWNLVKVMQAPADGNYVVTDTARMFVAPFTMNAADWIEPTYDGLFTQIARLADAMITGGSS
SIRTTGQHQMRIAGAAARQMLVGAAAEEWDVPAGEIETRNSMLIHAASGKEAPYAQFAAAAAEQPMPQTPRLKDIGEYRL
MGKSKARTDIPAKVNGTATFGIDAEIPADNLSYAAVMRPPVPGTEVASMDAEAAKSMGGVLQILNMGDHVAVVADSYWQA
EQALGAIDVTWTQSESKIATMDDQFAAFAAALDAAGDDGGSEAASKGDARDAFANAATIIEAEYRVPYLAHAPMEPINCT
AWVHDGKCEIWTSTQVPLMARKEAANAIGLDADDITIHHPMLGGGFGRRLVSEYVGMAARVAKATGYPVKMIWSREEDTQ
KSMYRPADMIRFKGGLDADGKLVSYNSVFTQRHDPAEACVPAGYGIPNLSVRVAEAPLHLPFQAWRSVDHSQHGFFTESF
IDEAAHAAGADPLDYRIAMLADAPRHRAVLEKLQQVSGWDEPAGDGKGRGVAMVESFGTIVAEAVEVDMSGGKPRATKVY
AVADPGYAMNPDGFRNQIEGGIVFGLTAALYGELELEGGRVKQSNFHDYKMLRMNECPEIEVAIINSGPVPIGGAGEPGT
PPIAPAFTNAIFAATGRRIRDLPVARQFA
>Mature_748_residues
SEQADTKPARSRTAKWTRRGVMGAGVLAGGALLIGVAVRPGNPVGRLKPLVAEGDEELVNSWVKIDTDNTVTAIVPHCEM
GQGAHSVLGQMLADELDADWNLVKVMQAPADGNYVVTDTARMFVAPFTMNAADWIEPTYDGLFTQIARLADAMITGGSSS
IRTTGQHQMRIAGAAARQMLVGAAAEEWDVPAGEIETRNSMLIHAASGKEAPYAQFAAAAAEQPMPQTPRLKDIGEYRLM
GKSKARTDIPAKVNGTATFGIDAEIPADNLSYAAVMRPPVPGTEVASMDAEAAKSMGGVLQILNMGDHVAVVADSYWQAE
QALGAIDVTWTQSESKIATMDDQFAAFAAALDAAGDDGGSEAASKGDARDAFANAATIIEAEYRVPYLAHAPMEPINCTA
WVHDGKCEIWTSTQVPLMARKEAANAIGLDADDITIHHPMLGGGFGRRLVSEYVGMAARVAKATGYPVKMIWSREEDTQK
SMYRPADMIRFKGGLDADGKLVSYNSVFTQRHDPAEACVPAGYGIPNLSVRVAEAPLHLPFQAWRSVDHSQHGFFTESFI
DEAAHAAGADPLDYRIAMLADAPRHRAVLEKLQQVSGWDEPAGDGKGRGVAMVESFGTIVAEAVEVDMSGGKPRATKVYA
VADPGYAMNPDGFRNQIEGGIVFGLTAALYGELELEGGRVKQSNFHDYKMLRMNECPEIEVAIINSGPVPIGGAGEPGTP
PIAPAFTNAIFAATGRRIRDLPVARQFA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789230, Length=386, Percent_Identity=27.4611398963731, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1786478, Length=385, Percent_Identity=25.974025974026, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789246, Length=464, Percent_Identity=23.2758620689655, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 79795; Mature: 79664

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQADTKPARSRTAKWTRRGVMGAGVLAGGALLIGVAVRPGNPVGRLKPLVAEGDEELV
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCEEEEEEEECCCCCHHHCCHHHHCCCHHHH
NSWVKIDTDNTVTAIVPHCEMGQGAHSVLGQMLADELDADWNLVKVMQAPADGNYVVTDT
CCCEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEC
ARMFVAPFTMNAADWIEPTYDGLFTQIARLADAMITGGSSSIRTTGQHQMRIAGAAARQM
CEEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHEEEHHHHHHHH
LVGAAAEEWDVPAGEIETRNSMLIHAASGKEAPYAQFAAAAAEQPMPQTPRLKDIGEYRL
HHHCCHHHCCCCCCCEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHCCHHHC
MGKSKARTDIPAKVNGTATFGIDAEIPADNLSYAAVMRPPVPGTEVASMDAEAAKSMGGV
CCCCCCCCCCCCEECCEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHCCHHHHHHHHHH
LQILNMGDHVAVVADSYWQAEQALGAIDVTWTQSESKIATMDDQFAAFAAALDAAGDDGG
HHHHCCCCEEEEEECCHHHHHHCCCEEEEEEECCCCEEEECCHHHHHHHHHHHCCCCCCC
SEAASKGDARDAFANAATIIEAEYRVPYLAHAPMEPINCTAWVHDGKCEIWTSTQVPLMA
CHHHCCCCHHHHHHCCEEEEEECCCCCEEECCCCCCCEEEEEEECCEEEEEECCCCCHHH
RKEAANAIGLDADDITIHHPMLGGGFGRRLVSEYVGMAARVAKATGYPVKMIWSREEDTQ
HHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHH
KSMYRPADMIRFKGGLDADGKLVSYNSVFTQRHDPAEACVPAGYGIPNLSVRVAEAPLHL
HHHCCCCHHEEECCCCCCCCCEEEECHHHHCCCCCHHHHCCCCCCCCCCEEEEECCCCCC
PFQAWRSVDHSQHGFFTESFIDEAAHAAGADPLDYRIAMLADAPRHRAVLEKLQQVSGWD
CHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHEEEEEECCCCHHHHHHHHHHHHCCCC
EPAGDGKGRGVAMVESFGTIVAEAVEVDMSGGKPRATKVYAVADPGYAMNPDGFRNQIEG
CCCCCCCCCCEEHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHCC
GIVFGLTAALYGELELEGGRVKQSNFHDYKMLRMNECPEIEVAIINSGPVPIGGAGEPGT
CEEEEEHHHHEEEEEECCCEEECCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCC
PPIAPAFTNAIFAATGRRIRDLPVARQFA
CCCCHHHHHHHHHHCCCHHHCCCCHHCCC
>Mature Secondary Structure 
SEQADTKPARSRTAKWTRRGVMGAGVLAGGALLIGVAVRPGNPVGRLKPLVAEGDEELV
CCCCCCCCHHHHHHHHHHHCCCCCHHHHCCEEEEEEEECCCCCHHHCCHHHHCCCHHHH
NSWVKIDTDNTVTAIVPHCEMGQGAHSVLGQMLADELDADWNLVKVMQAPADGNYVVTDT
CCCEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEC
ARMFVAPFTMNAADWIEPTYDGLFTQIARLADAMITGGSSSIRTTGQHQMRIAGAAARQM
CEEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHEEEHHHHHHHH
LVGAAAEEWDVPAGEIETRNSMLIHAASGKEAPYAQFAAAAAEQPMPQTPRLKDIGEYRL
HHHCCHHHCCCCCCCEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHCCHHHC
MGKSKARTDIPAKVNGTATFGIDAEIPADNLSYAAVMRPPVPGTEVASMDAEAAKSMGGV
CCCCCCCCCCCCEECCEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHCCHHHHHHHHHH
LQILNMGDHVAVVADSYWQAEQALGAIDVTWTQSESKIATMDDQFAAFAAALDAAGDDGG
HHHHCCCCEEEEEECCHHHHHHCCCEEEEEEECCCCEEEECCHHHHHHHHHHHCCCCCCC
SEAASKGDARDAFANAATIIEAEYRVPYLAHAPMEPINCTAWVHDGKCEIWTSTQVPLMA
CHHHCCCCHHHHHHCCEEEEEECCCCCEEECCCCCCCEEEEEEECCEEEEEECCCCCHHH
RKEAANAIGLDADDITIHHPMLGGGFGRRLVSEYVGMAARVAKATGYPVKMIWSREEDTQ
HHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHH
KSMYRPADMIRFKGGLDADGKLVSYNSVFTQRHDPAEACVPAGYGIPNLSVRVAEAPLHL
HHHCCCCHHEEECCCCCCCCCEEEECHHHHCCCCCHHHHCCCCCCCCCCEEEEECCCCCC
PFQAWRSVDHSQHGFFTESFIDEAAHAAGADPLDYRIAMLADAPRHRAVLEKLQQVSGWD
CHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHEEEEEECCCCHHHHHHHHHHHHCCCC
EPAGDGKGRGVAMVESFGTIVAEAVEVDMSGGKPRATKVYAVADPGYAMNPDGFRNQIEG
CCCCCCCCCCEEHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHCC
GIVFGLTAALYGELELEGGRVKQSNFHDYKMLRMNECPEIEVAIINSGPVPIGGAGEPGT
CEEEEEHHHHEEEEEECCCEEECCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCC
PPIAPAFTNAIFAATGRRIRDLPVARQFA
CCCCHHHHHHHHHHCCCHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]