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The map label for this gene is tlyC [H]

Identifier: 85374529

GI number: 85374529

Start: 1742537

End: 1743406

Strand: Direct

Name: tlyC [H]

Synonym: ELI_08510

Alternate gene names: 85374529

Gene position: 1742537-1743406 (Clockwise)

Preceding gene: 85374528

Following gene: 85374530

Centisome position: 57.09

GC content: 63.1

Gene sequence:

>870_bases
ATGACCGCCTTTCGCAAATTATTCGACCCCCAGGCCGGCGACCGTTCGCTGCGCGCCCAGCTCGAAGAGAAGATCGACGA
ACACGAGGAAGACGAATCGTCGGGGCTCGAAGCGTCGGCCGATGGCGACCTTTCCCCCGTCGAGCGGCAGATGCTGCGCA
ACCTGCTCCATTTCAGCGAGCACGATGCGGACGACGTGGCCGTGCCGCGCGGCGAGATCGTCGCGGTCAGTGCCGCTGCA
ACCTGGCAAGACCTTCTCGACGTTTTCTCCGAGCACGGCCATTCACGCTTGCCGGTCTATCGCGACCAGCTCGACGACGT
GATCGGGATGATCCACATCAAGGACGTCTTTCCCTACCTGACCAATGGCAAGGCGCCACCGGACGACTGGACGGTGCTGA
TGCGCCAGCCGCTCTATGTGCCTCAGTCGCGCAATGCGCTCGATGTGCTGGCCGACATGCGCCAGAACCGGATGCACCTC
GCCATAGTGCTCGATGAATTTTCAGGTACCGACGGGATCATCACGATCGAAGACCTGGTCGAGGAAATCGTCGGCGATAT
CGAGGACGAACACGACGACGCGCCGGAGATCTGGATCGCCGATATCGGTGAAGGCATGTGGGATTGCGATGCCCGCGCAG
AACTGGATGATGTTGCCGAGCAGATCGACCCGCGCCTCGCCGAAGTGGACGAGGCGGTCGACACGCTGGGCGGCCTCACG
TTCGTGCTCGCCGAGCGGGTGCCACCGGTCGGAGAGGTCATCGAACACCCGAGCGGGTGGCGGATCGAAGTGACCGACGG
CGACGAGACGCATGTCAAACGCCTGAGGTTGCACGCCCCGCAACGGGAAGAGGTCGTCGCCGAGAGTTAG

Upstream 100 bases:

>100_bases
GAGACCGCACATGATACTGCATTCGATTCAGGGAGCACGTTGAAGGGCCATGCCCGACAGTGACCAATCCGCCGGAGATG
CGGAGAGTAGAAGCGGTCTG

Downstream 100 bases:

>100_bases
GGCATTCGGACTACGGCCTTTCTACCTTCTCGACATTGCAATTTTTGCACCCCACATAGGGACCATGCCCCTGCGACGCC
TCCCCCCGCTGCGCGCTCTC

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTAFRKLFDPQAGDRSLRAQLEEKIDEHEEDESSGLEASADGDLSPVERQMLRNLLHFSEHDADDVAVPRGEIVAVSAAA
TWQDLLDVFSEHGHSRLPVYRDQLDDVIGMIHIKDVFPYLTNGKAPPDDWTVLMRQPLYVPQSRNALDVLADMRQNRMHL
AIVLDEFSGTDGIITIEDLVEEIVGDIEDEHDDAPEIWIADIGEGMWDCDARAELDDVAEQIDPRLAEVDEAVDTLGGLT
FVLAERVPPVGEVIEHPSGWRIEVTDGDETHVKRLRLHAPQREEVVAES

Sequences:

>Translated_289_residues
MTAFRKLFDPQAGDRSLRAQLEEKIDEHEEDESSGLEASADGDLSPVERQMLRNLLHFSEHDADDVAVPRGEIVAVSAAA
TWQDLLDVFSEHGHSRLPVYRDQLDDVIGMIHIKDVFPYLTNGKAPPDDWTVLMRQPLYVPQSRNALDVLADMRQNRMHL
AIVLDEFSGTDGIITIEDLVEEIVGDIEDEHDDAPEIWIADIGEGMWDCDARAELDDVAEQIDPRLAEVDEAVDTLGGLT
FVLAERVPPVGEVIEHPSGWRIEVTDGDETHVKRLRLHAPQREEVVAES
>Mature_288_residues
TAFRKLFDPQAGDRSLRAQLEEKIDEHEEDESSGLEASADGDLSPVERQMLRNLLHFSEHDADDVAVPRGEIVAVSAAAT
WQDLLDVFSEHGHSRLPVYRDQLDDVIGMIHIKDVFPYLTNGKAPPDDWTVLMRQPLYVPQSRNALDVLADMRQNRMHLA
IVLDEFSGTDGIITIEDLVEEIVGDIEDEHDDAPEIWIADIGEGMWDCDARAELDDVAEQIDPRLAEVDEAVDTLGGLTF
VLAERVPPVGEVIEHPSGWRIEVTDGDETHVKRLRLHAPQREEVVAES

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=198, Percent_Identity=31.8181818181818, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI1786879, Length=232, Percent_Identity=31.8965517241379, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082033, Length=220, Percent_Identity=27.7272727272727, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693175, Length=238, Percent_Identity=24.7899159663866, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788119, Length=215, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790664, Length=267, Percent_Identity=22.8464419475655, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 32394; Mature: 32263

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFRKLFDPQAGDRSLRAQLEEKIDEHEEDESSGLEASADGDLSPVERQMLRNLLHFSE
CCHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
HDADDVAVPRGEIVAVSAAATWQDLLDVFSEHGHSRLPVYRDQLDDVIGMIHIKDVFPYL
CCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TNGKAPPDDWTVLMRQPLYVPQSRNALDVLADMRQNRMHLAIVLDEFSGTDGIITIEDLV
HCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCEEEHHHHH
EEIVGDIEDEHDDAPEIWIADIGEGMWDCDARAELDDVAEQIDPRLAEVDEAVDTLGGLT
HHHHHHCCCCCCCCCCEEEEHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHH
FVLAERVPPVGEVIEHPSGWRIEVTDGDETHVKRLRLHAPQREEVVAES
HHHHHCCCCHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
TAFRKLFDPQAGDRSLRAQLEEKIDEHEEDESSGLEASADGDLSPVERQMLRNLLHFSE
CHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
HDADDVAVPRGEIVAVSAAATWQDLLDVFSEHGHSRLPVYRDQLDDVIGMIHIKDVFPYL
CCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TNGKAPPDDWTVLMRQPLYVPQSRNALDVLADMRQNRMHLAIVLDEFSGTDGIITIEDLV
HCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCEEEHHHHH
EEIVGDIEDEHDDAPEIWIADIGEGMWDCDARAELDDVAEQIDPRLAEVDEAVDTLGGLT
HHHHHHCCCCCCCCCCEEEEHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHH
FVLAERVPPVGEVIEHPSGWRIEVTDGDETHVKRLRLHAPQREEVVAES
HHHHHCCCCHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA