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The map label for this gene is era

Identifier: 85373794

GI number: 85373794

Start: 997565

End: 998479

Strand: Reverse

Name: era

Synonym: ELI_04835

Alternate gene names: 85373794

Gene position: 998479-997565 (Counterclockwise)

Preceding gene: 85373795

Following gene: 85373785

Centisome position: 32.71

GC content: 61.86

Gene sequence:

>915_bases
ATGACTGAGAAAATTTCGAAATGCGGTGTCGTGGCCGTGCTGGGTGCGCCCAATGCAGGCAAGTCGACGCTGGTCAACCA
GCTGGTCGGCCAGAAGGTCGCGATCACCAGCGCCAAGGCGCAGACCACGCGTGCGCGCATGCTGGGCATTGCGCTGCACG
AAAGCGATGACGCGAAGACGCAGATGATCCTCGTCGATACGCCGGGCATTTTCGCGCCGCGGCGACGGCTCGACCGGGCG
ATGGTGAGCGCAGCCTGGGAAGGTGCCGAAAGCGCCGATGCCGTGCTGCTGCTGGTCGATCCGGTCAAGCAGCGGCGGCA
CGAGCTGGAGCCGTTGCTGGAAAGCCTGAAGGATCGGCCCGAGCGCAAGATCCTCGTCCTCAACAAAGTCGATGTCGCCA
AGAAGGAGCCGCTGCTGGCGCTGGCACAGGACCTGTCCCAAAAGGTCGACTTTGCCGAGATCTATTTCGTTTCCGCGCTT
ACAGGAGATGGTGTGCCGGAGATGAAAAATGCGCTCGCCGCGCTGATGCCCGAAGGCGTGTGGCACTACCCGGAAGATCA
GGTCTCCGACGCCAGCGAACGCCTGCTGGCGACCGAGATCACCCGCGAGCAATTATACCAGCAGCTGCACGAAGAACTGC
CCTATGACAGCGCGGTGCGTCCCGAACAGTACAAGCAGCGCCCGGATGGCAGTCTGGAAATCCACCAACAAATCGTCATC
GCCCGCGAAAGCCAGCGCCCGATCGTCCTCGGCAAGGGCGGAAGCCGCATCAAGGCCATCGGCGAAGCGGCACGCAAGGA
TCTGAGCGAGATTCTCGGCGTGACGGTCCACCTGTTCCTGCACGTGAAAGTCGACGAGAAGTGGGCCGAGAACAAAGAGG
TGTTTGAAGAAATCGGGCTGGATTGGGTGCGGTAG

Upstream 100 bases:

>100_bases
AGGCTCGCTCGAAGTCCGCTCGGGACGAACGGGGTCATTGACTGCCGTTCATCTCGAGCAGCAGCCGAGGCCGCAGGCCG
AGCGCGTGTCGAGAGATCAT

Downstream 100 bases:

>100_bases
GCTCTTTTAGCGTTCGGTAAGGTCGTCGACCACCTCATCTAAACTCCATGCAAGTTCTTCGAGATGGCTTTCGATCTCCA
TAAGTTTGAACTCCATCGCA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTEKISKCGVVAVLGAPNAGKSTLVNQLVGQKVAITSAKAQTTRARMLGIALHESDDAKTQMILVDTPGIFAPRRRLDRA
MVSAAWEGAESADAVLLLVDPVKQRRHELEPLLESLKDRPERKILVLNKVDVAKKEPLLALAQDLSQKVDFAEIYFVSAL
TGDGVPEMKNALAALMPEGVWHYPEDQVSDASERLLATEITREQLYQQLHEELPYDSAVRPEQYKQRPDGSLEIHQQIVI
ARESQRPIVLGKGGSRIKAIGEAARKDLSEILGVTVHLFLHVKVDEKWAENKEVFEEIGLDWVR

Sequences:

>Translated_304_residues
MTEKISKCGVVAVLGAPNAGKSTLVNQLVGQKVAITSAKAQTTRARMLGIALHESDDAKTQMILVDTPGIFAPRRRLDRA
MVSAAWEGAESADAVLLLVDPVKQRRHELEPLLESLKDRPERKILVLNKVDVAKKEPLLALAQDLSQKVDFAEIYFVSAL
TGDGVPEMKNALAALMPEGVWHYPEDQVSDASERLLATEITREQLYQQLHEELPYDSAVRPEQYKQRPDGSLEIHQQIVI
ARESQRPIVLGKGGSRIKAIGEAARKDLSEILGVTVHLFLHVKVDEKWAENKEVFEEIGLDWVR
>Mature_303_residues
TEKISKCGVVAVLGAPNAGKSTLVNQLVGQKVAITSAKAQTTRARMLGIALHESDDAKTQMILVDTPGIFAPRRRLDRAM
VSAAWEGAESADAVLLLVDPVKQRRHELEPLLESLKDRPERKILVLNKVDVAKKEPLLALAQDLSQKVDFAEIYFVSALT
GDGVPEMKNALAALMPEGVWHYPEDQVSDASERLLATEITREQLYQQLHEELPYDSAVRPEQYKQRPDGSLEIHQQIVIA
RESQRPIVLGKGGSRIKAIGEAARKDLSEILGVTVHLFLHVKVDEKWAENKEVFEEIGLDWVR

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=324, Percent_Identity=32.4074074074074, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=38.8513513513513, Blast_Score=197, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24646434, Length=308, Percent_Identity=30.1948051948052, Blast_Score=121, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_ERYLH (Q2NB82)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457856.1
- ProteinModelPortal:   Q2NB82
- SMR:   Q2NB82
- STRING:   Q2NB82
- GeneID:   3869045
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_04835
- NMPDR:   fig|314225.3.peg.2105
- eggNOG:   COG1159
- HOGENOM:   HBG561652
- OMA:   ITREQLF
- PhylomeDB:   Q2NB82
- ProtClustDB:   PRK00089
- BioCyc:   ELIT314225:ELI_04835-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 33788; Mature: 33657

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50823 KH_TYPE_2; PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKISKCGVVAVLGAPNAGKSTLVNQLVGQKVAITSAKAQTTRARMLGIALHESDDAKT
CCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHEEEEECCCCCCE
QMILVDTPGIFAPRRRLDRAMVSAAWEGAESADAVLLLVDPVKQRRHELEPLLESLKDRP
EEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCC
ERKILVLNKVDVAKKEPLLALAQDLSQKVDFAEIYFVSALTGDGVPEMKNALAALMPEGV
CCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHEEEEECCCCCCHHHHHHHHHHCCCCC
WHYPEDQVSDASERLLATEITREQLYQQLHEELPYDSAVRPEQYKQRPDGSLEIHQQIVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEHHHEEE
ARESQRPIVLGKGGSRIKAIGEAARKDLSEILGVTVHLFLHVKVDEKWAENKEVFEEIGL
EECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECHHHCCCHHHHHHHCC
DWVR
CCCC
>Mature Secondary Structure 
TEKISKCGVVAVLGAPNAGKSTLVNQLVGQKVAITSAKAQTTRARMLGIALHESDDAKT
CCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHEEEEECCCCCCE
QMILVDTPGIFAPRRRLDRAMVSAAWEGAESADAVLLLVDPVKQRRHELEPLLESLKDRP
EEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCC
ERKILVLNKVDVAKKEPLLALAQDLSQKVDFAEIYFVSALTGDGVPEMKNALAALMPEGV
CCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHEEEEECCCCCCHHHHHHHHHHCCCCC
WHYPEDQVSDASERLLATEITREQLYQQLHEELPYDSAVRPEQYKQRPDGSLEIHQQIVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEHHHEEE
ARESQRPIVLGKGGSRIKAIGEAARKDLSEILGVTVHLFLHVKVDEKWAENKEVFEEIGL
EECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECHHHCCCHHHHHHHCC
DWVR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA