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The map label for this gene is copA [H]

Identifier: 85373749

GI number: 85373749

Start: 953159

End: 954895

Strand: Direct

Name: copA [H]

Synonym: ELI_04610

Alternate gene names: 85373749

Gene position: 953159-954895 (Clockwise)

Preceding gene: 85373748

Following gene: 85373750

Centisome position: 31.23

GC content: 62.46

Gene sequence:

>1737_bases
ATGCCGGCCTGGGCGCGCGGCGCGGACATCCTGGCGGGTAACGCTAGGAAAGGACTGGACGAGGTAGCGGGGCCGAATAT
CGACCTCACTGTCGCACGTTCTGCCTTCGCGACGGGTAACAGGCGCGGCGGCGCCATCGCCGTCAACGGCACGATCCCCG
GTCCGCTGTTGCGTTTGCAAGAGGGCACGACCGTGCGGTTGAACGTTCATAATCAGCTCGAGGAAGATACCTCAATTCAC
TGGCACGGTCTGCTCGTGCCGTTCCAACTGGACGGTGTACCCGGCGTGAGCTTTCCCGGCGTCAAACCAGGCGAGACATT
CACAGCGGAATTTCCCGTGCGGCAGGCAGGAACTTATTGGTGGCACTCGCATAGCGGGTTGCAGGAACAGGCCGGGCACT
ACGGCGCTATCGTGGTCGATCCCGCCGGACCCGATCCGGTGCAGGCCGACCGCGAATATATCGTGGTGCTGAGCGAATTC
AGCGATATGTCGCCCCACACGATCTTCGACAAGCTCAAGAAGGGCGAAGGCTACTTCAACTACAACCAGAACACCTGGAC
CGACGATTATCCGCTTTCGGGCGGGGACCGCCGGATGTGGGCGAGGATGCGCATGATGCCGACCGACATCCTCGATGTGT
CGAGCGCTGCCTACACTTACCTCCTCAATGGTCACGGCCCGCTCGACAACCTGGAATATCTCTTCCGCCCCGGCGAGCGC
GTACGCCTGCGCTTCATCAATGCCGGAGCCATGACCTTTTTCAATATCCGTATTCCCGGCTTACCGATGACTGTCGTGCA
GGCGGACGGGAAGGATGTCGAACCGGTCGAGGTCGACGAGTTCCAGATCGGCGTTGCCGAAACCTACGATGTCGTCGTGA
CGCCGGGCGAGCAACAGGCTTACACGCTGGTGGCAGAGTCCATGGACCGCTCCGGCATGGGTATTGCCACACTTGCGAGC
ACACCCGGCGCGCGCGCCGCCATACCTCCGCTGCGCGATCCCCCGCTGCTGACCATGGCCGATATGGGCATGAGCGGCAT
GGACCATGGCTCCGGCGGCGATGCCGGCAAGACCGGAATGGACCACAGCAGTGGCGGTGACATGGCGGGAATGGACCATG
GTTCGTCCGGCGATTCGGATATGGCGGGCATGGCCGGAATGGCGGGAGGCATGCAGATGCGTGATATCTCGCGCTTGCCT
CCCGATGTGAAGGTCGGACCCGGGCTAGACATGGTCTCGATGAACCCGGTCGACCGAATGGGCGATCCCGGCATCGGCCT
CGCCGATGTCCCTCACCGCACGCTCGACTATCGCAAGCTCCGCTCGCTGACACCTCATCGGGAGGGCCGGACTCCCTCGC
GGCGGATGGAAATCCATCTCACCGGGAACATGGAACGCTACATGTGGTCGTTTGACGGCAAGAAGTTTTCCGCCGTCTCC
GACGAGCCGATCCGGTTCGCCTATAACGAACGCGTGCGCGTGAAGCTCATCAACGACACGATGATGGCGCACCCGATCCA
TCTGCACGGGCACTTCTTCGAGCTGGTCAATGGCGCCCCGGCCGACCGTCAACCGCTCAAGCACACAGTTATCCTGCAGC
CGGGTGGCAGCGCGCAGTTCGACCTGACGGCGGACGAGCCGGGCGACTGGGCCTTCCACTGCCACCTTCTCTACCACATG
CATGCCGGGATGTTTCAGATTGTCACGGTTGCCAATCCGGACGGGAGCGAAGCATGA

Upstream 100 bases:

>100_bases
GTATACGCATTTTCAGGAGCCCCCTATGCCTGCCCTCAATCGCCGAAAATTCCTTGGAACAAGTGCTAGCGGGCTGGGCC
TGCTTGGCCTCTCCGGTGCC

Downstream 100 bases:

>100_bases
AGACTTTCAATTTCAGCTTCTTCGCCTCCGTCGCAGCAGGTGCAGTCCTCGCTTCGCCCGCCGCAGCCCAGCATGCCGGT
CACTCGCCGGCGGAGCCGCA

Product: copper-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MPAWARGADILAGNARKGLDEVAGPNIDLTVARSAFATGNRRGGAIAVNGTIPGPLLRLQEGTTVRLNVHNQLEEDTSIH
WHGLLVPFQLDGVPGVSFPGVKPGETFTAEFPVRQAGTYWWHSHSGLQEQAGHYGAIVVDPAGPDPVQADREYIVVLSEF
SDMSPHTIFDKLKKGEGYFNYNQNTWTDDYPLSGGDRRMWARMRMMPTDILDVSSAAYTYLLNGHGPLDNLEYLFRPGER
VRLRFINAGAMTFFNIRIPGLPMTVVQADGKDVEPVEVDEFQIGVAETYDVVVTPGEQQAYTLVAESMDRSGMGIATLAS
TPGARAAIPPLRDPPLLTMADMGMSGMDHGSGGDAGKTGMDHSSGGDMAGMDHGSSGDSDMAGMAGMAGGMQMRDISRLP
PDVKVGPGLDMVSMNPVDRMGDPGIGLADVPHRTLDYRKLRSLTPHREGRTPSRRMEIHLTGNMERYMWSFDGKKFSAVS
DEPIRFAYNERVRVKLINDTMMAHPIHLHGHFFELVNGAPADRQPLKHTVILQPGGSAQFDLTADEPGDWAFHCHLLYHM
HAGMFQIVTVANPDGSEA

Sequences:

>Translated_578_residues
MPAWARGADILAGNARKGLDEVAGPNIDLTVARSAFATGNRRGGAIAVNGTIPGPLLRLQEGTTVRLNVHNQLEEDTSIH
WHGLLVPFQLDGVPGVSFPGVKPGETFTAEFPVRQAGTYWWHSHSGLQEQAGHYGAIVVDPAGPDPVQADREYIVVLSEF
SDMSPHTIFDKLKKGEGYFNYNQNTWTDDYPLSGGDRRMWARMRMMPTDILDVSSAAYTYLLNGHGPLDNLEYLFRPGER
VRLRFINAGAMTFFNIRIPGLPMTVVQADGKDVEPVEVDEFQIGVAETYDVVVTPGEQQAYTLVAESMDRSGMGIATLAS
TPGARAAIPPLRDPPLLTMADMGMSGMDHGSGGDAGKTGMDHSSGGDMAGMDHGSSGDSDMAGMAGMAGGMQMRDISRLP
PDVKVGPGLDMVSMNPVDRMGDPGIGLADVPHRTLDYRKLRSLTPHREGRTPSRRMEIHLTGNMERYMWSFDGKKFSAVS
DEPIRFAYNERVRVKLINDTMMAHPIHLHGHFFELVNGAPADRQPLKHTVILQPGGSAQFDLTADEPGDWAFHCHLLYHM
HAGMFQIVTVANPDGSEA
>Mature_577_residues
PAWARGADILAGNARKGLDEVAGPNIDLTVARSAFATGNRRGGAIAVNGTIPGPLLRLQEGTTVRLNVHNQLEEDTSIHW
HGLLVPFQLDGVPGVSFPGVKPGETFTAEFPVRQAGTYWWHSHSGLQEQAGHYGAIVVDPAGPDPVQADREYIVVLSEFS
DMSPHTIFDKLKKGEGYFNYNQNTWTDDYPLSGGDRRMWARMRMMPTDILDVSSAAYTYLLNGHGPLDNLEYLFRPGERV
RLRFINAGAMTFFNIRIPGLPMTVVQADGKDVEPVEVDEFQIGVAETYDVVVTPGEQQAYTLVAESMDRSGMGIATLAST
PGARAAIPPLRDPPLLTMADMGMSGMDHGSGGDAGKTGMDHSSGGDMAGMDHGSSGDSDMAGMAGMAGGMQMRDISRLPP
DVKVGPGLDMVSMNPVDRMGDPGIGLADVPHRTLDYRKLRSLTPHREGRTPSRRMEIHLTGNMERYMWSFDGKKFSAVSD
EPIRFAYNERVRVKLINDTMMAHPIHLHGHFFELVNGAPADRQPLKHTVILQPGGSAQFDLTADEPGDWAFHCHLLYHMH
AGMFQIVTVANPDGSEA

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=429, Percent_Identity=25.4079254079254, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17539950, Length=294, Percent_Identity=24.1496598639456, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=551, Percent_Identity=23.049001814882, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221330000, Length=618, Percent_Identity=25.2427184466019, Blast_Score=120, Evalue=4e-27,
Organism=Drosophila melanogaster, GI18859919, Length=564, Percent_Identity=23.758865248227, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24650186, Length=587, Percent_Identity=22.8279386712095, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281360167, Length=332, Percent_Identity=27.710843373494, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24585842, Length=336, Percent_Identity=28.2738095238095, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221329998, Length=336, Percent_Identity=28.2738095238095, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574104, Length=301, Percent_Identity=27.2425249169435, Blast_Score=93, Evalue=6e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 62985; Mature: 62854

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAWARGADILAGNARKGLDEVAGPNIDLTVARSAFATGNRRGGAIAVNGTIPGPLLRLQ
CCCCCCCCEEEECCCCCCHHHHCCCCEEEEEECHHHHCCCCCCCEEEECCCCCCCEEEEC
EGTTVRLNVHNQLEEDTSIHWHGLLVPFQLDGVPGVSFPGVKPGETFTAEFPVRQAGTYW
CCCEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCHHHCCCEE
WHSHSGLQEQAGHYGAIVVDPAGPDPVQADREYIVVLSEFSDMSPHTIFDKLKKGEGYFN
EECCCCHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEE
YNQNTWTDDYPLSGGDRRMWARMRMMPTDILDVSSAAYTYLLNGHGPLDNLEYLFRPGER
CCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCCHHHHHCCCCE
VRLRFINAGAMTFFNIRIPGLPMTVVQADGKDVEPVEVDEFQIGVAETYDVVVTPGEQQA
EEEEEEECCCEEEEEEEECCCCEEEEECCCCCCCCEEECEEEEEEECEEEEEEECCCCCE
YTLVAESMDRSGMGIATLASTPGARAAIPPLRDPPLLTMADMGMSGMDHGSGGDAGKTGM
EEHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
DHSSGGDMAGMDHGSSGDSDMAGMAGMAGGMQMRDISRLPPDVKVGPGLDMVSMNPVDRM
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEHHHHHCCCCCEECCCCCEEECCCHHHC
GDPGIGLADVPHRTLDYRKLRSLTPHREGRTPSRRMEIHLTGNMERYMWSFDGKKFSAVS
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCEEECCC
DEPIRFAYNERVRVKLINDTMMAHPIHLHGHFFELVNGAPADRQPLKHTVILQPGGSAQF
CCCEEEEECCEEEEEEECCCEEECEEEECHHHHHHHCCCCCCCCCCCEEEEEECCCCCEE
DLTADEPGDWAFHCHLLYHMHAGMFQIVTVANPDGSEA
EEECCCCCCEEEEEEEEEHHHCCEEEEEEEECCCCCCC
>Mature Secondary Structure 
PAWARGADILAGNARKGLDEVAGPNIDLTVARSAFATGNRRGGAIAVNGTIPGPLLRLQ
CCCCCCCEEEECCCCCCHHHHCCCCEEEEEECHHHHCCCCCCCEEEECCCCCCCEEEEC
EGTTVRLNVHNQLEEDTSIHWHGLLVPFQLDGVPGVSFPGVKPGETFTAEFPVRQAGTYW
CCCEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCHHHCCCEE
WHSHSGLQEQAGHYGAIVVDPAGPDPVQADREYIVVLSEFSDMSPHTIFDKLKKGEGYFN
EECCCCHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEE
YNQNTWTDDYPLSGGDRRMWARMRMMPTDILDVSSAAYTYLLNGHGPLDNLEYLFRPGER
CCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCCHHHHHCCCCE
VRLRFINAGAMTFFNIRIPGLPMTVVQADGKDVEPVEVDEFQIGVAETYDVVVTPGEQQA
EEEEEEECCCEEEEEEEECCCCEEEEECCCCCCCCEEECEEEEEEECEEEEEEECCCCCE
YTLVAESMDRSGMGIATLASTPGARAAIPPLRDPPLLTMADMGMSGMDHGSGGDAGKTGM
EEHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
DHSSGGDMAGMDHGSSGDSDMAGMAGMAGGMQMRDISRLPPDVKVGPGLDMVSMNPVDRM
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEHHHHHCCCCCEECCCCCEEECCCHHHC
GDPGIGLADVPHRTLDYRKLRSLTPHREGRTPSRRMEIHLTGNMERYMWSFDGKKFSAVS
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCEEECCC
DEPIRFAYNERVRVKLINDTMMAHPIHLHGHFFELVNGAPADRQPLKHTVILQPGGSAQF
CCCEEEEECCEEEEEEECCCEEECEEEECHHHHHHHCCCCCCCCCCCEEEEEECCCCCEE
DLTADEPGDWAFHCHLLYHMHAGMFQIVTVANPDGSEA
EEECCCCCCEEEEEEEEEHHHCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]