Click here to switch to the map view.

The map label for this gene is pyrH

Identifier: 85373584

GI number: 85373584

Start: 784232

End: 784948

Strand: Direct

Name: pyrH

Synonym: ELI_03785

Alternate gene names: 85373584

Gene position: 784232-784948 (Clockwise)

Preceding gene: 85373581

Following gene: 85373585

Centisome position: 25.69

GC content: 63.18

Gene sequence:

>717_bases
ATGGCTCTTCCCGAGATGAAACGCGTCCTGCTGAAGCTCTCCGGCGAAGTGCTGATGGGGGAGCAGGATTACGGTATCGA
TCCGGCCTTCGTCATGGAACTGGCGAAGGAAGTGAAGGCGGCCAGGGAGCAGGGTCTGCAGATCTGTCTTGTGATCGGCG
GCGGCAACATCTTCCGCGGGATGGCGGGCGCAGCGCAGGGGATGGAGCGCGCGCAGGCCGATTACATGGGCATGCTGGCA
ACCGTCATGAACGCGCTGGCGATGCAGAGCGCGCTCGAGCAGCTTGGCGTGCATACGCGTGTGCAGTCGGCGATCCAGAT
GGACCAGGTCTGCGAGCCGGTGATCCGTCGCCGCGCCGAACGGCATCTCGAAAAAGACCGCGTGGTGATCTTCGCTGCCG
GTGTCGGCGCGCCCTATTTCACCACCGACAGCGGGGCGGCATTGCGCGCGGCGGAAATGAATTGCGACGCGCTGCTCAAA
GGCACCAGCGTCGACGGGGTGTATGACAGCGATCCCAAGACCAACCCCGATGCCAAACGTTACGATACGGTGGGGTACGG
CAAGGTACTGGCCGACAACCTCAAGGTCATGGACGCCTCCGCCGTGGCGCTGTGCCGCGACAACGACATTCCGATCATCG
TATTCTCGATCCGCGAGAAGGGTAACCTGGCCCGTGTCCTCGCCGGCGAGGGTGTGCAGACGGTCGTGCAGAATTGA

Upstream 100 bases:

>100_bases
TGCCGCTCTCCCCCGATGCACAGCCTTTCCCTTTGCGCCACCCTAGCTTGCTCGCTAAGGGACGTGCCACCCTGAAATCG
TAACGGATTCTGCACCTCCC

Downstream 100 bases:

>100_bases
GATAGAACAAGAGTTTGCAAGGGGAAGTTTGAGATGGCGAAATACGACAAGGCCGATATCGAGCGCCGCATGGCGGGCGC
GGTCGAAAGCCTCAAGAGCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MALPEMKRVLLKLSGEVLMGEQDYGIDPAFVMELAKEVKAAREQGLQICLVIGGGNIFRGMAGAAQGMERAQADYMGMLA
TVMNALAMQSALEQLGVHTRVQSAIQMDQVCEPVIRRRAERHLEKDRVVIFAAGVGAPYFTTDSGAALRAAEMNCDALLK
GTSVDGVYDSDPKTNPDAKRYDTVGYGKVLADNLKVMDASAVALCRDNDIPIIVFSIREKGNLARVLAGEGVQTVVQN

Sequences:

>Translated_238_residues
MALPEMKRVLLKLSGEVLMGEQDYGIDPAFVMELAKEVKAAREQGLQICLVIGGGNIFRGMAGAAQGMERAQADYMGMLA
TVMNALAMQSALEQLGVHTRVQSAIQMDQVCEPVIRRRAERHLEKDRVVIFAAGVGAPYFTTDSGAALRAAEMNCDALLK
GTSVDGVYDSDPKTNPDAKRYDTVGYGKVLADNLKVMDASAVALCRDNDIPIIVFSIREKGNLARVLAGEGVQTVVQN
>Mature_237_residues
ALPEMKRVLLKLSGEVLMGEQDYGIDPAFVMELAKEVKAAREQGLQICLVIGGGNIFRGMAGAAQGMERAQADYMGMLAT
VMNALAMQSALEQLGVHTRVQSAIQMDQVCEPVIRRRAERHLEKDRVVIFAAGVGAPYFTTDSGAALRAAEMNCDALLKG
TSVDGVYDSDPKTNPDAKRYDTVGYGKVLADNLKVMDASAVALCRDNDIPIIVFSIREKGNLARVLAGEGVQTVVQN

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=47.6595744680851, Blast_Score=216, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_ERYLH (Q2NBU2)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457646.1
- ProteinModelPortal:   Q2NBU2
- SMR:   Q2NBU2
- STRING:   Q2NBU2
- GeneID:   3871398
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_03785
- NMPDR:   fig|314225.3.peg.2321
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   ELIT314225:ELI_03785-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25622; Mature: 25491

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPEMKRVLLKLSGEVLMGEQDYGIDPAFVMELAKEVKAAREQGLQICLVIGGGNIFRG
CCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
MAGAAQGMERAQADYMGMLATVMNALAMQSALEQLGVHTRVQSAIQMDQVCEPVIRRRAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKDRVVIFAAGVGAPYFTTDSGAALRAAEMNCDALLKGTSVDGVYDSDPKTNPDAKR
HHHCCCCEEEEEECCCCCEEECCCCCEEEEECCCCHHHEECCCCCCCCCCCCCCCCCCHH
YDTVGYGKVLADNLKVMDASAVALCRDNDIPIIVFSIREKGNLARVLAGEGVQTVVQN
HCCCCHHHHHHCCCEEECHHEEEEEECCCCCEEEEEECCCCCEEEEHHCCCHHHHHCC
>Mature Secondary Structure 
ALPEMKRVLLKLSGEVLMGEQDYGIDPAFVMELAKEVKAAREQGLQICLVIGGGNIFRG
CCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
MAGAAQGMERAQADYMGMLATVMNALAMQSALEQLGVHTRVQSAIQMDQVCEPVIRRRAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKDRVVIFAAGVGAPYFTTDSGAALRAAEMNCDALLKGTSVDGVYDSDPKTNPDAKR
HHHCCCCEEEEEECCCCCEEECCCCCEEEEECCCCHHHEECCCCCCCCCCCCCCCCCCHH
YDTVGYGKVLADNLKVMDASAVALCRDNDIPIIVFSIREKGNLARVLAGEGVQTVVQN
HCCCCHHHHHHCCCEEECHHEEEEEECCCCCEEEEEECCCCCEEEEHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA