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The map label for this gene is metC [H]

Identifier: 85373207

GI number: 85373207

Start: 425507

End: 426760

Strand: Reverse

Name: metC [H]

Synonym: ELI_01900

Alternate gene names: 85373207

Gene position: 426760-425507 (Counterclockwise)

Preceding gene: 85373208

Following gene: 85373206

Centisome position: 13.98

GC content: 67.3

Gene sequence:

>1254_bases
ATGGGGGGCCGATCCGGAAACGCCCAAGGCAACGGGAGTGGCAGGCTGAGCGACAAGAAAAAACTGCGCACGGGCACAAA
GCTGGTCGAAGCCGGTCGCCGCGAGGAATGGACCGGGCCGGTCGTCAATCCGCCGGTCTGGCGCGCCAGCACGCATCTCT
ATGCCAACGAGGCCGAGCGCAAAGCAGCGCAGGGCAACAATGTCGACGGGCAGTTCTATTACGGTCGCCGCGGCGCGCCG
ACCCAATGGTCGCTGTGCGAAGCGCTGACCGAGATCGAGCCGGGCGCGTTCGGCACTATCCTCTATCCCAGCGGCACCGC
GGCGATCGTGCAGGCGCTGATGGCGGTGTTGCGCCCCGGCGACGTGCTGCTGGTCACCGACAACGCCTACGAGCCGAGCC
GCACCATCGCATCGGGCATTCTCAAGCGCTTCGGCGTGGAGCCGCGCTTCTTCGATCCGATGGACGTCGCGGGGTTCCCA
GACGTGTTTTGCGACAGGACCAAGGCGGTCCTGTTCGAATGCCCCGGCAGCCTGACGATGGAAGTGCAGGACGTGCCCGC
CCTCACCGCCATCGCGCGCGAGAAGGGCGCGGTCTCGCTGGTGGACAATACCTGGGCCGGTCCGCTTGGCTTCCCCGCGC
TGGAACGCGGGTGCGACATCACGATCATGTCGCTGACCAAGCATGTCTCGGGCCATTCCGACGTCATGATGGGCTCGGCC
ACCGCGCGCGACGAGCGGCTCTATCGCCGCCTGCGCCGCACCGCGCAGCAGATGGGCACGATCGTCTCGCCCGACGATGC
CGCGCTGATGCTGCGGGGCCTCAGGACCATGGAGGTGCGCCTGCAGCGCGAGACCGCGAGCGCGCTGACCCTTGCGCGAT
GGCTGCGCGAACGGGACGAAGTCGCGCATGTGCTGTGCCCGCTGCTGGACGGCTCGCCCGGCCACGACATCTGGGCGCGC
GATTTCACCGGTGGCTGCGGGCTGTTCTCCTTCGTGCTCAAAGGCCGCACCAGCGAACAGCGCGCGGCCTTCATCGACGC
GCTCGACCTGTTTGGCATCGGCTACAGCTGGGGCGGGTTCGAAAGCCTCGTTATCCCCTTCGATCCCGCCGATATCCGCA
CCGCGACGCCGTGGCCGCCCGCAGGCTGGGCCGTAGACGAGCACCTCGGCATTCGGCTATCGATCGGGCTCGAAGACCCC
GAAGACCTGATCGCCGATCTCGATCAGGCGTTCACTGCCATGGGAACTGCATGA

Upstream 100 bases:

>100_bases
TGACCTCCTGCGGCAGCGGCGTCACCGCATCGGTGTTGATCTTTGCACTGCACCTGCTGGGCATCGAAGACGCCGCGCTC
TACGATGGCAGCTGGTCCGA

Downstream 100 bases:

>100_bases
CCACTTCCGCGCCTTCCACGACCGTGTCCGATACTGCACCTGCGCCGAGTCCATCGCCTTCGCCGGAGGCCGTTCCTCTC
GTCGATCCGGAAACCGGCGA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MGGRSGNAQGNGSGRLSDKKKLRTGTKLVEAGRREEWTGPVVNPPVWRASTHLYANEAERKAAQGNNVDGQFYYGRRGAP
TQWSLCEALTEIEPGAFGTILYPSGTAAIVQALMAVLRPGDVLLVTDNAYEPSRTIASGILKRFGVEPRFFDPMDVAGFP
DVFCDRTKAVLFECPGSLTMEVQDVPALTAIAREKGAVSLVDNTWAGPLGFPALERGCDITIMSLTKHVSGHSDVMMGSA
TARDERLYRRLRRTAQQMGTIVSPDDAALMLRGLRTMEVRLQRETASALTLARWLRERDEVAHVLCPLLDGSPGHDIWAR
DFTGGCGLFSFVLKGRTSEQRAAFIDALDLFGIGYSWGGFESLVIPFDPADIRTATPWPPAGWAVDEHLGIRLSIGLEDP
EDLIADLDQAFTAMGTA

Sequences:

>Translated_417_residues
MGGRSGNAQGNGSGRLSDKKKLRTGTKLVEAGRREEWTGPVVNPPVWRASTHLYANEAERKAAQGNNVDGQFYYGRRGAP
TQWSLCEALTEIEPGAFGTILYPSGTAAIVQALMAVLRPGDVLLVTDNAYEPSRTIASGILKRFGVEPRFFDPMDVAGFP
DVFCDRTKAVLFECPGSLTMEVQDVPALTAIAREKGAVSLVDNTWAGPLGFPALERGCDITIMSLTKHVSGHSDVMMGSA
TARDERLYRRLRRTAQQMGTIVSPDDAALMLRGLRTMEVRLQRETASALTLARWLRERDEVAHVLCPLLDGSPGHDIWAR
DFTGGCGLFSFVLKGRTSEQRAAFIDALDLFGIGYSWGGFESLVIPFDPADIRTATPWPPAGWAVDEHLGIRLSIGLEDP
EDLIADLDQAFTAMGTA
>Mature_416_residues
GGRSGNAQGNGSGRLSDKKKLRTGTKLVEAGRREEWTGPVVNPPVWRASTHLYANEAERKAAQGNNVDGQFYYGRRGAPT
QWSLCEALTEIEPGAFGTILYPSGTAAIVQALMAVLRPGDVLLVTDNAYEPSRTIASGILKRFGVEPRFFDPMDVAGFPD
VFCDRTKAVLFECPGSLTMEVQDVPALTAIAREKGAVSLVDNTWAGPLGFPALERGCDITIMSLTKHVSGHSDVMMGSAT
ARDERLYRRLRRTAQQMGTIVSPDDAALMLRGLRTMEVRLQRETASALTLARWLRERDEVAHVLCPLLDGSPGHDIWARD
FTGGCGLFSFVLKGRTSEQRAAFIDALDLFGIGYSWGGFESLVIPFDPADIRTATPWPPAGWAVDEHLGIRLSIGLEDPE
DLIADLDQAFTAMGTA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=341, Percent_Identity=31.6715542521994, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI299473759, Length=341, Percent_Identity=29.6187683284457, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI25453487, Length=340, Percent_Identity=29.1176470588235, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1789383, Length=399, Percent_Identity=43.3583959899749, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1790375, Length=391, Percent_Identity=32.7365728900256, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=381, Percent_Identity=32.5459317585302, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=383, Percent_Identity=31.0704960835509, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71980708, Length=393, Percent_Identity=29.0076335877863, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321170, Length=344, Percent_Identity=38.3720930232558, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319307, Length=404, Percent_Identity=28.4653465346535, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=384, Percent_Identity=28.90625, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323333, Length=414, Percent_Identity=25.3623188405797, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=416, Percent_Identity=26.4423076923077, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922554, Length=395, Percent_Identity=30.379746835443, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45329; Mature: 45198

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGRSGNAQGNGSGRLSDKKKLRTGTKLVEAGRREEWTGPVVNPPVWRASTHLYANEAER
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCHHHH
KAAQGNNVDGQFYYGRRGAPTQWSLCEALTEIEPGAFGTILYPSGTAAIVQALMAVLRPG
HHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCC
DVLLVTDNAYEPSRTIASGILKRFGVEPRFFDPMDVAGFPDVFCDRTKAVLFECPGSLTM
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCCCEE
EVQDVPALTAIAREKGAVSLVDNTWAGPLGFPALERGCDITIMSLTKHVSGHSDVMMGSA
EECCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCCEEEEEHHHHCCCCCCEEECCC
TARDERLYRRLRRTAQQMGTIVSPDDAALMLRGLRTMEVRLQRETASALTLARWLRERDE
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHVLCPLLDGSPGHDIWARDFTGGCGLFSFVLKGRTSEQRAAFIDALDLFGIGYSWGGF
HHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
ESLVIPFDPADIRTATPWPPAGWAVDEHLGIRLSIGLEDPEDLIADLDQAFTAMGTA
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GGRSGNAQGNGSGRLSDKKKLRTGTKLVEAGRREEWTGPVVNPPVWRASTHLYANEAER
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCHHHH
KAAQGNNVDGQFYYGRRGAPTQWSLCEALTEIEPGAFGTILYPSGTAAIVQALMAVLRPG
HHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCC
DVLLVTDNAYEPSRTIASGILKRFGVEPRFFDPMDVAGFPDVFCDRTKAVLFECPGSLTM
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCCCEE
EVQDVPALTAIAREKGAVSLVDNTWAGPLGFPALERGCDITIMSLTKHVSGHSDVMMGSA
EECCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCCEEEEEHHHHCCCCCCEEECCC
TARDERLYRRLRRTAQQMGTIVSPDDAALMLRGLRTMEVRLQRETASALTLARWLRERDE
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHVLCPLLDGSPGHDIWARDFTGGCGLFSFVLKGRTSEQRAAFIDALDLFGIGYSWGGF
HHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
ESLVIPFDPADIRTATPWPPAGWAVDEHLGIRLSIGLEDPEDLIADLDQAFTAMGTA
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]