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The map label for this gene is grxC [H]

Identifier: 85060164

GI number: 85060164

Start: 3802394

End: 3802645

Strand: Reverse

Name: grxC [H]

Synonym: SG2186

Alternate gene names: 85060164

Gene position: 3802645-3802394 (Counterclockwise)

Preceding gene: 85060165

Following gene: 85060163

Centisome position: 91.17

GC content: 53.17

Gene sequence:

>252_bases
ATGGCCAATATCAAAATTTATACTAAAGCAACCTGCCCCTATTGTCATCGCGCCAAAGCGTTAATCACCCGTAAAGGGGT
ACCTTTTCAGGAGATACCCATTGATGGCGACGTGGATTTGCGCGAAGAGATGATAAAGCGCAGCGGCCGCACCACTGTGC
CGCAAATTTTTATCGACGGCAAGCACGTGGGCGGGTGTGACGATTTGCATGCGCTCGATGCGCGCGGCGGCCTGGACCCC
CTGCTCAAATAA

Upstream 100 bases:

>100_bases
AACGGGTTTATGTGCTTAAAGAAGGCATATCCGGCTGGAGCGGGGAAAATTTACCGCTGGTCCGAGGTAAATAACTCTTT
TCCATCAAGAAGAGAAAACC

Downstream 100 bases:

>100_bases
TCAGAACCGACGGGTTGTGCGCCTTAGCCTTCGTACCCGGCACTTTAACCAAAGGGTTTTTCAATGTCAGAACAAAATAA
TAATGAGATGGCGTTTCAGA

Product: glutaredoxin 3

Products: NA

Alternate protein names: Grx3 [H]

Number of amino acids: Translated: 83; Mature: 82

Protein sequence:

>83_residues
MANIKIYTKATCPYCHRAKALITRKGVPFQEIPIDGDVDLREEMIKRSGRTTVPQIFIDGKHVGGCDDLHALDARGGLDP
LLK

Sequences:

>Translated_83_residues
MANIKIYTKATCPYCHRAKALITRKGVPFQEIPIDGDVDLREEMIKRSGRTTVPQIFIDGKHVGGCDDLHALDARGGLDP
LLK
>Mature_82_residues
ANIKIYTKATCPYCHRAKALITRKGVPFQEIPIDGDVDLREEMIKRSGRTTVPQIFIDGKHVGGCDDLHALDARGGLDPL
LK

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790039, Length=83, Percent_Identity=80.7228915662651, Blast_Score=149, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25147337, Length=84, Percent_Identity=38.0952380952381, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011900
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9190; Mature: 9059

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIKIYTKATCPYCHRAKALITRKGVPFQEIPIDGDVDLREEMIKRSGRTTVPQIFIDG
CCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEECC
KHVGGCDDLHALDARGGLDPLLK
CCCCCCCCCEECCCCCCCCCCCC
>Mature Secondary Structure 
ANIKIYTKATCPYCHRAKALITRKGVPFQEIPIDGDVDLREEMIKRSGRTTVPQIFIDG
CCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEECC
KHVGGCDDLHALDARGGLDPLLK
CCCCCCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]