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The map label for this gene is ubiA

Identifier: 85060121

GI number: 85060121

Start: 3721254

End: 3722126

Strand: Reverse

Name: ubiA

Synonym: SG2143

Alternate gene names: 85060121

Gene position: 3722126-3721254 (Counterclockwise)

Preceding gene: 162382790

Following gene: 85060119

Centisome position: 89.24

GC content: 54.87

Gene sequence:

>873_bases
TTGGATCACAGTCTGACACAGGATAGATGGCAGGCATGGTGCCGTTTGATGCGAATCGATAAGCCTATCGGTTCGCTGCT
GCTGCTGTGGCCGACGCTATGGGCTTTGTGGCTGGCGGGTATGGCTATACCTGCGCTGGGAACGTTAACGGTGTTCATTC
TGGGTGTCTTCTTCATGCGCGCCGCCGGCTGCGTGATAAACGATTATGCGGATCGAAAAATAGATGGTCATGTTAAACGC
ACCCGCGCCCGCCCGTTGCCCAGCGGCGCGATAGGTGAAAAAGAAGCCAAACTGTTGTTCGGCGCGCTGGTGGGGATCTC
TTTTGCGCTGGTGTTGACGCTAAATAGTATGACCATCGCGTTGTCGACGGTGGCGCTGGCGTTAGCCTGGGTTTACCCCT
TCATGAAGCGGTATACGCATTTGCCGCAGCTGGTGCTTGGTGCGGCGTTCGGCTGGTCGATACCGATGGTGTTTACCGCA
GTAAGTGAGTCTTTACCTTTAAGCTGTTGGTTGTTGTTCCTGGCGAATATTACCTGGACGGTGGCTTACGACACCCAATA
TGCCATGGTGGATCGGGATGATGATCTGCGCATCGGCGTCAAATCCACCGCCATCCTGTTTGGGCGTTTCGATAAGCTTA
TCATTGGGTTGCTGCAATTGGCGACGCTGCTGCTGCTAGGCGTTATCGGCTGGCAGCTCGGGCTTGGCAGGATCTACTAT
CTGGCGCTGGCGGGCGCGGCGGGGTTGTTCCTCTGGCAACAAAAGCTTATCGTCGACCGCGAACGGGAGGCCTGCTTCCG
GGCGTTTTTAAATAATAACCTCGTCGGGATGCTGATTTTTGTCGGCATTTTGCTGAGCTTACTGTCCTATTGA

Upstream 100 bases:

>100_bases
TACCGAGGGGCAACCGTTGCTGCTGACGGAAGCGTTTTTACCCGACTGCCCGCTGTATATTAGCGGCGGCGATGCGCCAC
AACAGTAAAGGAGAATTCCG

Downstream 100 bases:

>100_bases
CCCCTGTCTCAAACGCGTTTCAGCGCGTTAGCGCGGCGTTTGCACCAATGCGTCTTCCGGCAGATGTCGCCGGTGCGTAT
AAAGTAACGCCGGCGGTGAA

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDHSLTQDRWQAWCRLMRIDKPIGSLLLLWPTLWALWLAGMAIPALGTLTVFILGVFFMRAAGCVINDYADRKIDGHVKR
TRARPLPSGAIGEKEAKLLFGALVGISFALVLTLNSMTIALSTVALALAWVYPFMKRYTHLPQLVLGAAFGWSIPMVFTA
VSESLPLSCWLLFLANITWTVAYDTQYAMVDRDDDLRIGVKSTAILFGRFDKLIIGLLQLATLLLLGVIGWQLGLGRIYY
LALAGAAGLFLWQQKLIVDREREACFRAFLNNNLVGMLIFVGILLSLLSY

Sequences:

>Translated_290_residues
MDHSLTQDRWQAWCRLMRIDKPIGSLLLLWPTLWALWLAGMAIPALGTLTVFILGVFFMRAAGCVINDYADRKIDGHVKR
TRARPLPSGAIGEKEAKLLFGALVGISFALVLTLNSMTIALSTVALALAWVYPFMKRYTHLPQLVLGAAFGWSIPMVFTA
VSESLPLSCWLLFLANITWTVAYDTQYAMVDRDDDLRIGVKSTAILFGRFDKLIIGLLQLATLLLLGVIGWQLGLGRIYY
LALAGAAGLFLWQQKLIVDREREACFRAFLNNNLVGMLIFVGILLSLLSY
>Mature_290_residues
MDHSLTQDRWQAWCRLMRIDKPIGSLLLLWPTLWALWLAGMAIPALGTLTVFILGVFFMRAAGCVINDYADRKIDGHVKR
TRARPLPSGAIGEKEAKLLFGALVGISFALVLTLNSMTIALSTVALALAWVYPFMKRYTHLPQLVLGAAFGWSIPMVFTA
VSESLPLSCWLLFLANITWTVAYDTQYAMVDRDDDLRIGVKSTAILFGRFDKLIIGLLQLATLLLLGVIGWQLGLGRIYY
LALAGAAGLFLWQQKLIVDREREACFRAFLNNNLVGMLIFVGILLSLLSY

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=282, Percent_Identity=38.2978723404255, Blast_Score=175, Evalue=4e-44,
Organism=Escherichia coli, GI1790473, Length=286, Percent_Identity=70.2797202797203, Blast_Score=396, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17553718, Length=277, Percent_Identity=37.9061371841155, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI32565247, Length=281, Percent_Identity=37.3665480427046, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17553720, Length=341, Percent_Identity=30.2052785923754, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32565245, Length=139, Percent_Identity=43.8848920863309, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32565243, Length=138, Percent_Identity=43.4782608695652, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324370, Length=280, Percent_Identity=31.0714285714286, Blast_Score=138, Evalue=9e-34,
Organism=Drosophila melanogaster, GI21355567, Length=283, Percent_Identity=40.9893992932862, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_SODGM (Q2NR07)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455823.1
- STRING:   Q2NR07
- GeneID:   3868252
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2143
- NMPDR:   fig|343509.6.peg.4715
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- PhylomeDB:   Q2NR07
- ProtClustDB:   PRK12848
- BioCyc:   SGLO343509:SG2143-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32285; Mature: 32285

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10756e54)-; HASH(0x1085e7b4)-; HASH(0xb33151c)-; HASH(0x10a46b64)-; HASH(0x1081cad4)-; HASH(0x105c32dc)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHSLTQDRWQAWCRLMRIDKPIGSLLLLWPTLWALWLAGMAIPALGTLTVFILGVFFMR
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGCVINDYADRKIDGHVKRTRARPLPSGAIGEKEAKLLFGALVGISFALVLTLNSMTIA
HCCCHHHHHHCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTVALALAWVYPFMKRYTHLPQLVLGAAFGWSIPMVFTAVSESLPLSCWLLFLANITWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHEE
VAYDTQYAMVDRDDDLRIGVKSTAILFGRFDKLIIGLLQLATLLLLGVIGWQLGLGRIYY
EEECCEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALAGAAGLFLWQQKLIVDREREACFRAFLNNNLVGMLIFVGILLSLLSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MDHSLTQDRWQAWCRLMRIDKPIGSLLLLWPTLWALWLAGMAIPALGTLTVFILGVFFMR
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGCVINDYADRKIDGHVKRTRARPLPSGAIGEKEAKLLFGALVGISFALVLTLNSMTIA
HCCCHHHHHHCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTVALALAWVYPFMKRYTHLPQLVLGAAFGWSIPMVFTAVSESLPLSCWLLFLANITWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHEE
VAYDTQYAMVDRDDDLRIGVKSTAILFGRFDKLIIGLLQLATLLLLGVIGWQLGLGRIYY
EEECCEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALAGAAGLFLWQQKLIVDREREACFRAFLNNNLVGMLIFVGILLSLLSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA