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The map label for this gene is dsbC [H]

Identifier: 85059970

GI number: 85059970

Start: 3448755

End: 3449471

Strand: Reverse

Name: dsbC [H]

Synonym: SG1992

Alternate gene names: 85059970

Gene position: 3449471-3448755 (Counterclockwise)

Preceding gene: 85059971

Following gene: 85059969

Centisome position: 82.7

GC content: 56.49

Gene sequence:

>717_bases
GTGAACAAAAGCCTGGTACTGCTATCCTTTATAGCGCTGGCCCTTTCCCCGCTCGTCCACGCTGAAGACGCGGCCATTAA
GCATTCTCTGTCGCGCCTCGGCATTCATAGCGCCGACATTCAGCCGTCGCCGGTCGCCGGGCTGAAAACCGTCTTGACCG
AAAGCGGTGTATTGTATGTCTCCGACGACGGTCGCCATGTCATTCAAGGGCCGCTGTATGATGTGGGTAGCAACCATCCC
GTCAACGTCACCAATCAGCTCCTCAGCAAGCGCCTCAACGCCCTGCAAAAGGAGATGATTATCTTCAAAGCGCCGCAGGA
AAAGCAGGTGGTGACGGTGTTCACCGACACCACCTGCGGTTATTGCCACAAGCTGCACGAGCAAATCAAAGAGTATAACG
CGCTGGGGATCACTATCCGCTATCTGGCATTCCCGCGTCAGGGGCTGAATTCCCAGACGGAGAAAGACATGGCGTTGGTG
TGGTGCAGCGCCAATCCGAAAGACGCCTTTAACCGGGCGATGAACGGCGGCAACGTTCCGGCTGCCAGCTGCGATATTGA
TATCAGCAAACACTATACGCTTGGCGTGCAATATGGCATCCAGGGTACGCCGGCGTTGTTGCTGGATAACGGTACCCTCA
TCCCGGGCTATCAAAGCCCGAAAGAGCTGGCCGCTATCCTGGATCAGCAAGGATCGGGTCAGGCAACGGGCGGTTAA

Upstream 100 bases:

>100_bases
TCAGCAGCATCATCCCCGCGCCTGAGCGGTGGCGTTGAAACGAATTTAAGGCGTATGTATGCGCCGACCCCGACCCGGGT
GTTTAAATAAGGATTAAAAT

Downstream 100 bases:

>100_bases
CACGGCAGTGAATATGACAACGGAATTGCGTCGGCGTCCGCTGAGCGATAGCGCTGTTCTGGCTGAGGCGGATATCCCGC
CGCTGCTGAAACGATTGTAT

Product: thiol:disulfide interchange protein DsbC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNKSLVLLSFIALALSPLVHAEDAAIKHSLSRLGIHSADIQPSPVAGLKTVLTESGVLYVSDDGRHVIQGPLYDVGSNHP
VNVTNQLLSKRLNALQKEMIIFKAPQEKQVVTVFTDTTCGYCHKLHEQIKEYNALGITIRYLAFPRQGLNSQTEKDMALV
WCSANPKDAFNRAMNGGNVPAASCDIDISKHYTLGVQYGIQGTPALLLDNGTLIPGYQSPKELAAILDQQGSGQATGG

Sequences:

>Translated_238_residues
MNKSLVLLSFIALALSPLVHAEDAAIKHSLSRLGIHSADIQPSPVAGLKTVLTESGVLYVSDDGRHVIQGPLYDVGSNHP
VNVTNQLLSKRLNALQKEMIIFKAPQEKQVVTVFTDTTCGYCHKLHEQIKEYNALGITIRYLAFPRQGLNSQTEKDMALV
WCSANPKDAFNRAMNGGNVPAASCDIDISKHYTLGVQYGIQGTPALLLDNGTLIPGYQSPKELAAILDQQGSGQATGG
>Mature_238_residues
MNKSLVLLSFIALALSPLVHAEDAAIKHSLSRLGIHSADIQPSPVAGLKTVLTESGVLYVSDDGRHVIQGPLYDVGSNHP
VNVTNQLLSKRLNALQKEMIIFKAPQEKQVVTVFTDTTCGYCHKLHEQIKEYNALGITIRYLAFPRQGLNSQTEKDMALV
WCSANPKDAFNRAMNGGNVPAASCDIDISKHYTLGVQYGIQGTPALLLDNGTLIPGYQSPKELAAILDQQGSGQATGG

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=229, Percent_Identity=62.0087336244542, Blast_Score=324, Evalue=4e-90,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 25635; Mature: 25635

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSLVLLSFIALALSPLVHAEDAAIKHSLSRLGIHSADIQPSPVAGLKTVLTESGVLYV
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEE
SDDGRHVIQGPLYDVGSNHPVNVTNQLLSKRLNALQKEMIIFKAPQEKQVVTVFTDTTCG
ECCCCEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCHH
YCHKLHEQIKEYNALGITIRYLAFPRQGLNSQTEKDMALVWCSANPKDAFNRAMNGGNVP
HHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCC
AASCDIDISKHYTLGVQYGIQGTPALLLDNGTLIPGYQSPKELAAILDQQGSGQATGG
CCEEEEECCCCEEEEEEECCCCCCEEEEECCEECCCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNKSLVLLSFIALALSPLVHAEDAAIKHSLSRLGIHSADIQPSPVAGLKTVLTESGVLYV
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEE
SDDGRHVIQGPLYDVGSNHPVNVTNQLLSKRLNALQKEMIIFKAPQEKQVVTVFTDTTCG
ECCCCEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCHH
YCHKLHEQIKEYNALGITIRYLAFPRQGLNSQTEKDMALVWCSANPKDAFNRAMNGGNVP
HHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCC
AASCDIDISKHYTLGVQYGIQGTPALLLDNGTLIPGYQSPKELAAILDQQGSGQATGG
CCEEEEECCCCEEEEEEECCCCCCEEEEECCEECCCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609; 9370270 [H]