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The map label for this gene is guaB [H]

Identifier: 85059727

GI number: 85059727

Start: 2992271

End: 2993734

Strand: Reverse

Name: guaB [H]

Synonym: SG1749

Alternate gene names: 85059727

Gene position: 2993734-2992271 (Counterclockwise)

Preceding gene: 85059730

Following gene: 85059726

Centisome position: 71.77

GC content: 56.76

Gene sequence:

>1464_bases
ATGTTACGTATTGCTAAAGAAGCTCTGACATTCGACGACGTTCTGCTCCTTCCCGCCCACTCCACGGTTCTGCCCAACAC
CGCCGATCTCTGCACCCGATTGACTCAGAAAATTCGCCTGAATATTCCCATGCTGTCCGCGGCAATGGATACGGTAACTG
AATCCAGCCTGGCCATCGCTCTGGCGCAGGAAGGCGGTATCGGTTTCATTCACAAAAACATGTCTATCGAACGCCAGGCC
GAGGAAGTAGGTCGCGTAAAACGCCATGAAAGCGGCGTCGTAACCAATCCCCAGTGCGTCACGCCCAATACTACCCTGTC
CGAGGTGAAAGCACTGACCGCGCGCAACGGTTTTGCCGGCTACCCGGTGGTGACGGATGAAAATGAATTGGTAGGGATTA
TTACCGGCCGCGACATTCGCTTTGTCACCGACTTAAGCCAACCGGTTTCCGCCGTGATGACGCCGAAAGAACTCCTGGTG
ACGGTAAAAGAAGGTGAAGCCCGGGAAGTGGTGTTGGCAAAAATGCACGAGAGGCGCGTTGAAAAAGCGCTGGTAGTGGA
CGAACAGTTCCATCTGCTCGGCATGATTACGGTAAAAGACTTCCAAAAGGCCAAGCGCAAACCCAATGCCTGTAAGGATG
AACATGGCCGCTTGCGCGTCGGTGCCGCGGTGGGCGCAGGAGCCGGCAATGAAGAACGTATTGATGCCTTGGTGAGCGCC
GGCGTTGACATTTTACTTATCGACTCCTCCCACGGCCATTCCGAAGGCGTGCTGCAACGTATCCGCGAAACACGTGCCAA
ATACCCCGACCTGCAAATCATCGGCGGCAACGTCGCCACCGGCGCCGGCGCGCTCGCGCTGGTTGCGGCCGGCGTTAGCG
CGGTGAAAGTGGGCATCGGCCCCGGCTCTATCTGTACCACACGTATCGTAACCGGCGTGGGTGTGCCGCAGATCACTGCT
ATCTCTGATGCGGTGGAAGCCCTGGAAGGGACGGGGATTCCCGTCATCGCCGACGGCGGCATCCGTTTTTCCGGCGATAT
TGCCAAAGCCATTGCCGCCGGCGCCGCCTGTGTCATGGTGGGATCGCTTTTGGCAGGCACCGAAGAATCACCGGGAGAAA
TTGAACTGTTTCAGGGCCGATCCTTCAAATCTTACCGCGGCATGGGATCTCTTGGCGCAATGTCTAAAGGTTCGTCCGAC
CGGTATTTCCAGACCGATAACGCCGCCGACAAATTAGTGCCGGAAGGGATCGAGGGCCGCGTGGAGTATAAAGGACGCCT
GAAGGAAATCGTCCATCAAAAAATGGGCGGGTTGCGTTCCTGTATGGGGCTGACCGGTTGTTCTACTATCGACGACCTTC
GTACCAAAGCGGAGTTTGTCCGTATCAGCGGTGCCGGCATCCAGGAAAGCCACGTTCATGACGTCGCCATCACCAAAGAA
TCCCCGAACTACCGCCTGGGTTAA

Upstream 100 bases:

>100_bases
AGAGATTTTTGAAAATAACACTGGAGGCAACCGATTACGTTCTGTATAATGCCACGGCAATATTTTATCTGTTTCACATC
CACCTTGGTGAGATATTGCT

Downstream 100 bases:

>100_bases
CGAATTTCCCTCGGCGCGCGGGCCTCGCCGGTCCGCCGCCGTTCTGTCCAGTCTCTGACGACCGGGCATTGATACTTTTT
GCTACACGCTCTCGGAATAC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MLRIAKEALTFDDVLLLPAHSTVLPNTADLCTRLTQKIRLNIPMLSAAMDTVTESSLAIALAQEGGIGFIHKNMSIERQA
EEVGRVKRHESGVVTNPQCVTPNTTLSEVKALTARNGFAGYPVVTDENELVGIITGRDIRFVTDLSQPVSAVMTPKELLV
TVKEGEAREVVLAKMHERRVEKALVVDEQFHLLGMITVKDFQKAKRKPNACKDEHGRLRVGAAVGAGAGNEERIDALVSA
GVDILLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGALALVAAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
ISDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAACVMVGSLLAGTEESPGEIELFQGRSFKSYRGMGSLGAMSKGSSD
RYFQTDNAADKLVPEGIEGRVEYKGRLKEIVHQKMGGLRSCMGLTGCSTIDDLRTKAEFVRISGAGIQESHVHDVAITKE
SPNYRLG

Sequences:

>Translated_487_residues
MLRIAKEALTFDDVLLLPAHSTVLPNTADLCTRLTQKIRLNIPMLSAAMDTVTESSLAIALAQEGGIGFIHKNMSIERQA
EEVGRVKRHESGVVTNPQCVTPNTTLSEVKALTARNGFAGYPVVTDENELVGIITGRDIRFVTDLSQPVSAVMTPKELLV
TVKEGEAREVVLAKMHERRVEKALVVDEQFHLLGMITVKDFQKAKRKPNACKDEHGRLRVGAAVGAGAGNEERIDALVSA
GVDILLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGALALVAAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
ISDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAACVMVGSLLAGTEESPGEIELFQGRSFKSYRGMGSLGAMSKGSSD
RYFQTDNAADKLVPEGIEGRVEYKGRLKEIVHQKMGGLRSCMGLTGCSTIDDLRTKAEFVRISGAGIQESHVHDVAITKE
SPNYRLG
>Mature_487_residues
MLRIAKEALTFDDVLLLPAHSTVLPNTADLCTRLTQKIRLNIPMLSAAMDTVTESSLAIALAQEGGIGFIHKNMSIERQA
EEVGRVKRHESGVVTNPQCVTPNTTLSEVKALTARNGFAGYPVVTDENELVGIITGRDIRFVTDLSQPVSAVMTPKELLV
TVKEGEAREVVLAKMHERRVEKALVVDEQFHLLGMITVKDFQKAKRKPNACKDEHGRLRVGAAVGAGAGNEERIDALVSA
GVDILLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGALALVAAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
ISDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAACVMVGSLLAGTEESPGEIELFQGRSFKSYRGMGSLGAMSKGSSD
RYFQTDNAADKLVPEGIEGRVEYKGRLKEIVHQKMGGLRSCMGLTGCSTIDDLRTKAEFVRISGAGIQESHVHDVAITKE
SPNYRLG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=41.648590021692, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI217035146, Length=466, Percent_Identity=40.5579399141631, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI34328928, Length=466, Percent_Identity=40.5579399141631, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI34328930, Length=466, Percent_Identity=40.5579399141631, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI156616279, Length=466, Percent_Identity=40.5579399141631, Blast_Score=318, Evalue=8e-87,
Organism=Homo sapiens, GI217035152, Length=455, Percent_Identity=40.8791208791209, Blast_Score=312, Evalue=6e-85,
Organism=Homo sapiens, GI217035148, Length=466, Percent_Identity=39.9141630901288, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI217035150, Length=466, Percent_Identity=37.3390557939914, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=34.8178137651822, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=34.412955465587, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=34.412955465587, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=34.412955465587, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=34.412955465587, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=89.5277207392197, Blast_Score=838, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=225, Percent_Identity=36, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=479, Percent_Identity=35.6993736951983, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=37.9716981132075, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=37.8995433789954, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=39.5061728395062, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6323585, Length=465, Percent_Identity=39.7849462365591, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=448, Percent_Identity=41.5178571428571, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.9356725146199, Blast_Score=250, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=38.135593220339, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=39.5876288659794, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=39.5876288659794, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=40.1805869074492, Blast_Score=286, Evalue=3e-77,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51566; Mature: 51566

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAKEALTFDDVLLLPAHSTVLPNTADLCTRLTQKIRLNIPMLSAAMDTVTESSLAIA
CCCCHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHCCCCEEEE
LAQEGGIGFIHKNMSIERQAEEVGRVKRHESGVVTNPQCVTPNTTLSEVKALTARNGFAG
EECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHCCCCCC
YPVVTDENELVGIITGRDIRFVTDLSQPVSAVMTPKELLVTVKEGEAREVVLAKMHERRV
CCEEECCCCEEEEEECCCEEEEECCCHHHHHHCCCHHHEEEECCCCCHHHHHHHHHHHHH
EKALVVDEQFHLLGMITVKDFQKAKRKPNACKDEHGRLRVGAAVGAGAGNEERIDALVSA
HHHHHCCCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDILLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGALALVAAGVSAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAISDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAACVMV
CCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHHHHHHHHH
GSLLAGTEESPGEIELFQGRSFKSYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCC
VEYKGRLKEIVHQKMGGLRSCMGLTGCSTIDDLRTKAEFVRISGAGIQESHVHDVAITKE
EEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCCEEEEEECC
SPNYRLG
CCCCCCC
>Mature Secondary Structure
MLRIAKEALTFDDVLLLPAHSTVLPNTADLCTRLTQKIRLNIPMLSAAMDTVTESSLAIA
CCCCHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHCCCCEEEE
LAQEGGIGFIHKNMSIERQAEEVGRVKRHESGVVTNPQCVTPNTTLSEVKALTARNGFAG
EECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHCCCCCC
YPVVTDENELVGIITGRDIRFVTDLSQPVSAVMTPKELLVTVKEGEAREVVLAKMHERRV
CCEEECCCCEEEEEECCCEEEEECCCHHHHHHCCCHHHEEEECCCCCHHHHHHHHHHHHH
EKALVVDEQFHLLGMITVKDFQKAKRKPNACKDEHGRLRVGAAVGAGAGNEERIDALVSA
HHHHHCCCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDILLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGALALVAAGVSAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAISDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAACVMV
CCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHHHHHHHHH
GSLLAGTEESPGEIELFQGRSFKSYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCC
VEYKGRLKEIVHQKMGGLRSCMGLTGCSTIDDLRTKAEFVRISGAGIQESHVHDVAITKE
EEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCCEEEEEECC
SPNYRLG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]