Click here to switch to the map view.

The map label for this gene is guaA

Identifier: 85059726

GI number: 85059726

Start: 2990586

End: 2992163

Strand: Reverse

Name: guaA

Synonym: SG1748

Alternate gene names: 85059726

Gene position: 2992163-2990586 (Counterclockwise)

Preceding gene: 85059727

Following gene: 85059725

Centisome position: 71.73

GC content: 56.53

Gene sequence:

>1578_bases
ATGACAGAAAATATCCATAAACACCGCATTCTGATTCTGGACTTCGGCTCGCAATACACCCAACTGGTGGCTCGCCGGGT
GCGCGAATTGGGCGTCTATTGCGAACTTTGGGCATGGGATGTAACCGAAGCACAAATACGCGAATTCAACCCCAGCGGCA
TCATCCTTTCCGGCGGTCCGGAAAGCACCACCGAGCAGGACAGCCCGCGCGCGCCGGATTATGTGTTTCAGGCAGGCGTG
CCGGTGCTGGGCGTTTGCTACGGCATGCAAACCATGGCGATGCAGCTTGGCGGCAAAGTCCAGGGTTCGACGCAGCGCGA
GTTTGGTTATGCCCAGGTAGAAGTGTTGACTGACAGCTTACTGGTGCGCGACATCCAGGACGACATCGGCACCGGCGGAG
CGCCACTGCTGGATGTCTGGATGAGCCATGGCGACAAAGTTACCGCCATTCCGGCGGATTTTGTCACCGTTGCCAGCACC
GAAACCTGCCACTTCGCCATTATGGCCAATGAAGAAAAACGGTTCTACGGCGTGCAATTTCACCCCGAAGTCACCCATAC
TCGTCAGGGTCAGCGCATGCTGGAACGCTTCGTACTTGATATTTGCCGGTGCACGCCGCTGTGGACGCCGGCCAAAATCA
TCGAAGATGCCGTCGCCCGTATCCGCGAACAGGTTGGCAACGATCGGGTCATTCTCGGTTTATCCGGCGGCGTAGATTCG
TCGGTTACCGCCATGCTGTTGCACCGGGCCATCGGCGAACGGCTGACCTGCGTGTTCGTCGATAACGGTCTGCTGCGCCT
TAACGAAGCCAGTCAGGTGATGGAAATGTTTGGCGATCACTACGGCTTGAACATTATCGCTGTACCGGCGGAAGACAGGT
TTCTTTCCGCGCTGGCCGGCATTGACGATCCGGAAACAAAACGGAAAACCATCGGCCGGGTATTTGTCGAGGTGTTTGAC
GAACAGGCTCTGAGCCTCTCCGACGTGAAATGGCTGGCGCAGGGCACCATTTACCCGGACGTCATCGAATCTGCCGCGTC
CGCCACCGGCAAAGCCCATGTCATCAAGTCGCACCATAACGTTGGCGGCCTGCCGAAAGAGATGAAAATGGGCTTGGTGG
AGCCGTTGAAAGAGCTGTTCAAGGATGAAGTACGCAAGATAGGCCTGGAACTCGGCCTGCCTTACGATATGCTTTATCGC
CATCCGTTCCCCGGACCGGGTTTGGGCGTGCGGGTGCTGGGTGAGGTGAAGAAAGAGTATTGCGATTTGCTGCGCCGCGC
CGATGCTATCTTTATCGAAGAACTGTACAAGGCGGATCTGTACAACAAAGTCAGCCAGGCCTTTACCGTCTTTTTGCCCG
TGCGCTCCGTCGGTGTCATGGGCGACGGCCGCAAATACGACTGGGTGGTTTCGCTGCGAGCGGTTGAAACCATCGACTTT
ATGACCGCCCATTGGGCGCACTTGCCTTATGATTTCCTGGGCCGCGTTTCCAACCGTATTATCAATGAGATCGACGGTAT
TTCCCGGGTCGTGTATGACATTTCCGGCAAACCGCCGGCGACGATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
CCCTCGGCGCGCGGGCCTCGCCGGTCCGCCGCCGTTCTGTCCAGTCTCTGACGACCGGGCATTGATACTTTTTGCTACAC
GCTCTCGGAATACTCCATCA

Downstream 100 bases:

>100_bases
AGACCGTAGTCATACATGTTAATTTAGAAAATGCCGACCATTATTTAATGGTTGGCATTTTCTCGCCCTGCTTTATTGTA
TATACAATTGAGATTTTGTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGPESTTEQDSPRAPDYVFQAGV
PVLGVCYGMQTMAMQLGGKVQGSTQREFGYAQVEVLTDSLLVRDIQDDIGTGGAPLLDVWMSHGDKVTAIPADFVTVAST
ETCHFAIMANEEKRFYGVQFHPEVTHTRQGQRMLERFVLDICRCTPLWTPAKIIEDAVARIREQVGNDRVILGLSGGVDS
SVTAMLLHRAIGERLTCVFVDNGLLRLNEASQVMEMFGDHYGLNIIAVPAEDRFLSALAGIDDPETKRKTIGRVFVEVFD
EQALSLSDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELYKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGPESTTEQDSPRAPDYVFQAGV
PVLGVCYGMQTMAMQLGGKVQGSTQREFGYAQVEVLTDSLLVRDIQDDIGTGGAPLLDVWMSHGDKVTAIPADFVTVAST
ETCHFAIMANEEKRFYGVQFHPEVTHTRQGQRMLERFVLDICRCTPLWTPAKIIEDAVARIREQVGNDRVILGLSGGVDS
SVTAMLLHRAIGERLTCVFVDNGLLRLNEASQVMEMFGDHYGLNIIAVPAEDRFLSALAGIDDPETKRKTIGRVFVEVFD
EQALSLSDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELYKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE
>Mature_524_residues
TENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGPESTTEQDSPRAPDYVFQAGVP
VLGVCYGMQTMAMQLGGKVQGSTQREFGYAQVEVLTDSLLVRDIQDDIGTGGAPLLDVWMSHGDKVTAIPADFVTVASTE
TCHFAIMANEEKRFYGVQFHPEVTHTRQGQRMLERFVLDICRCTPLWTPAKIIEDAVARIREQVGNDRVILGLSGGVDSS
VTAMLLHRAIGERLTCVFVDNGLLRLNEASQVMEMFGDHYGLNIIAVPAEDRFLSALAGIDDPETKRKTIGRVFVEVFDE
QALSLSDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRH
PFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELYKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFM
TAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=562, Percent_Identity=35.9430604982206, Blast_Score=291, Evalue=8e-79,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=89.9047619047619, Blast_Score=986, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=581, Percent_Identity=34.07917383821, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI71992710, Length=581, Percent_Identity=34.07917383821, Blast_Score=291, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI133901714, Length=581, Percent_Identity=33.9070567986231, Blast_Score=291, Evalue=7e-79,
Organism=Saccharomyces cerevisiae, GI6323873, Length=523, Percent_Identity=47.9923518164436, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI281365319, Length=566, Percent_Identity=35.6890459363958, Blast_Score=293, Evalue=3e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_SODGM (Q2NS52)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455428.1
- ProteinModelPortal:   Q2NS52
- SMR:   Q2NS52
- STRING:   Q2NS52
- GeneID:   3866493
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1748
- NMPDR:   fig|343509.6.peg.3731
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q2NS52
- ProtClustDB:   PRK00074
- BioCyc:   SGLO343509:SG1748-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 58605; Mature: 58474

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 86-86 ACT_SITE 181-181 ACT_SITE 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCCCEEEEECCC
ESTTEQDSPRAPDYVFQAGVPVLGVCYGMQTMAMQLGGKVQGSTQREFGYAQVEVLTDSL
CCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHH
LVRDIQDDIGTGGAPLLDVWMSHGDKVTAIPADFVTVASTETCHFAIMANEEKRFYGVQF
HHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCEEEEECCCCEEEEEEECCCCEEEEEEE
HPEVTHTRQGQRMLERFVLDICRCTPLWTPAKIIEDAVARIREQVGNDRVILGLSGGVDS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCH
SVTAMLLHRAIGERLTCVFVDNGLLRLNEASQVMEMFGDHYGLNIIAVPAEDRFLSALAG
HHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHC
IDDPETKRKTIGRVFVEVFDEQALSLSDVKWLAQGTIYPDVIESAASATGKAHVIKSHHN
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCC
VGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELYKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC
>Mature Secondary Structure 
TENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGP
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCCCEEEEECCC
ESTTEQDSPRAPDYVFQAGVPVLGVCYGMQTMAMQLGGKVQGSTQREFGYAQVEVLTDSL
CCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHH
LVRDIQDDIGTGGAPLLDVWMSHGDKVTAIPADFVTVASTETCHFAIMANEEKRFYGVQF
HHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCEEEEECCCCEEEEEEECCCCEEEEEEE
HPEVTHTRQGQRMLERFVLDICRCTPLWTPAKIIEDAVARIREQVGNDRVILGLSGGVDS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCH
SVTAMLLHRAIGERLTCVFVDNGLLRLNEASQVMEMFGDHYGLNIIAVPAEDRFLSALAG
HHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHC
IDDPETKRKTIGRVFVEVFDEQALSLSDVKWLAQGTIYPDVIESAASATGKAHVIKSHHN
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCC
VGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELYKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA