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The map label for this gene is nuoC

Identifier: 85059577

GI number: 85059577

Start: 2745611

End: 2747410

Strand: Reverse

Name: nuoC

Synonym: SG1599

Alternate gene names: 85059577

Gene position: 2747410-2745611 (Counterclockwise)

Preceding gene: 85059578

Following gene: 85059576

Centisome position: 65.87

GC content: 57.28

Gene sequence:

>1800_bases
ATGACAGAGTTGATGACGCAGAATTCCGCCCTGCCGGTCTGGCAATCACAGGATCATCAAGATGATCCTGTGATTGCCGA
GTTGCGTAACCATTTCGGGCCGGACGCTTTCAGCGTGCAGCCGACCCGTACCGGTATTCCGGTCGTTTGGGTGAAGCGCG
AGCAAATTCTCAAGGTGCTGACCTTTCTGAAGAAGCTGCCAAAACCGTACGTGATGCTTTATGACCTGCACGGGGTGGAC
GAGCGCCTGCGTACCCACCGCCAGGGCTTGCCAGCAGCGGATTTTACCGTTTTCTATCATCTGATTTCCATCGATCGCAA
TCGCGACATCATGCTGAAGGTGGCGCTGTCGGAAAACGACCTGCATCTGCCTACCTGCACCCGCATTTTCCCCAACGCCA
ACTGGTATGAGCGTGAAACCTGGGAAATGTTCGGCATGACCTTTGATGGCCACACGCACCTGACCCGTATCATGATGCCG
AAAAGCTGGGAAGGACACCCGCTGCGCAAGGATTATCCGGCGCGCGCCACCGAATTCGATCCTTTCGTCCTCACCAAACA
AAAAGAAGATCTGGAGATGGAAGGGCTGACCTTCAAGCCGGAAGAGTGGGGAATGAAGCGTGGCAAAGACAATGAGGACT
TCATGTTCCTCAACCTGGGGCCGAACCATCCTTCCGCACACGGCGCGTTCCGCATCATTTTGCAGCTCGACGGCGAAGAG
ATCGTCGATTGCGTGCCCGATATCGGTTATCACCACCGCGGCGCCGAAAAGATGGGCGAGCGCCAGTCCTGGCATAGCTA
TATCCCTTATACCGACCGTGTCGAGTACCTCGGCGGCTGCGTCAACGAAATGCCTTACGTGCTGGCGGTAGAAAAGCTGG
CCGGCATCGTGGTGCCCGATCGCGTTAATGTGATCCGGGTGATGCTGTCGGAGCTGTTCCGCATCAACAGCCACCTGCTG
TACATCAGTACCTATATTCAGGACGTGGGCGGGATGACGCCGGTATTCCTGGCGTTTACTGACCGTCAGAAGATTTATGA
TGTGGTCGAGGCGATCACCGGTTTTCGTATGCATCCGGCCTGGTTCCGCATCGGCGGCGTGGCGCACGATTTGCCGCGCG
GTTGGGAAGGGTTGCTGCGCGAGTTCCTCGACTGGCTGCCGAAGCGTCTGGACAGCTATGTCAAAGTGGCGCTCCGCAAC
AGCGTACTGCGCGCCCGCGCCGAGGGCGTCGCCGCCTATGGCGCGAAAGAGGCGCTGGACTGGGGCGTGACCGGCGCTGC
GCTGCGCGCCACCGGCATCGATTTTGACGTGCGTAAATGGCGTCCTTATTCCGGCTATGAAAACTTCAACTTTGAAGTGC
CGGTGGGCGATGGCGTGAGCGACTGCTATAGCCGCGTGATGTTGAAGGTGGAGGAGATGCGCCAAAGTCTGCGCATCCTT
GAGCAGTGCCTGAACAACATGCCGGCAGGCCCTTTCAAAGCCGATCATCCGCTGACCACGCCGCCGCCGAAAGAGCGCAC
CTTGCAGCATATCGAGACGCTTATCACGCACTTCCTGCAGGTCTCGTGGGGACCGGTGATGCCGGCTAACGAATCATTCC
AGATGATCGAGGCGACCAAAGGCATCAACAGCTATTACCTGACCAGCGATGGCAGCACAATGAGTTACCGGACGCGTATC
CGCACGCCCAGTTTCCCTCATTTGCAGCAAATCCCCTCGGTTATTCGCGGCAGCCTGGTATCGGATTTGATCGTATACCT
GGGCAGTATTGATTTCGTTATGTCAGATGTGGACCGCTAA

Upstream 100 bases:

>100_bases
CGCACCTCCGACGAAATTTAACGCGCGGATACGCATGCTGGTCGCGGCTGAATAAGTGGGGCGGCATGTGCCGTCACAGC
CAAATGTGGTGAAGATAACT

Downstream 100 bases:

>100_bases
TTATGCAGCAACAGCAAGATACCCCCAAGTATGCGGCGGCGGCGGGGCTGGACGCCGCCACCGAAACGTTCGAGCTGAGT
CGCGAAGAGCGCGAAGCCAT

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTELMTQNSALPVWQSQDHQDDPVIAELRNHFGPDAFSVQPTRTGIPVVWVKREQILKVLTFLKKLPKPYVMLYDLHGVD
ERLRTHRQGLPAADFTVFYHLISIDRNRDIMLKVALSENDLHLPTCTRIFPNANWYERETWEMFGMTFDGHTHLTRIMMP
KSWEGHPLRKDYPARATEFDPFVLTKQKEDLEMEGLTFKPEEWGMKRGKDNEDFMFLNLGPNHPSAHGAFRIILQLDGEE
IVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRVEYLGGCVNEMPYVLAVEKLAGIVVPDRVNVIRVMLSELFRINSHLL
YISTYIQDVGGMTPVFLAFTDRQKIYDVVEAITGFRMHPAWFRIGGVAHDLPRGWEGLLREFLDWLPKRLDSYVKVALRN
SVLRARAEGVAAYGAKEALDWGVTGAALRATGIDFDVRKWRPYSGYENFNFEVPVGDGVSDCYSRVMLKVEEMRQSLRIL
EQCLNNMPAGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRI
RTPSFPHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR

Sequences:

>Translated_599_residues
MTELMTQNSALPVWQSQDHQDDPVIAELRNHFGPDAFSVQPTRTGIPVVWVKREQILKVLTFLKKLPKPYVMLYDLHGVD
ERLRTHRQGLPAADFTVFYHLISIDRNRDIMLKVALSENDLHLPTCTRIFPNANWYERETWEMFGMTFDGHTHLTRIMMP
KSWEGHPLRKDYPARATEFDPFVLTKQKEDLEMEGLTFKPEEWGMKRGKDNEDFMFLNLGPNHPSAHGAFRIILQLDGEE
IVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRVEYLGGCVNEMPYVLAVEKLAGIVVPDRVNVIRVMLSELFRINSHLL
YISTYIQDVGGMTPVFLAFTDRQKIYDVVEAITGFRMHPAWFRIGGVAHDLPRGWEGLLREFLDWLPKRLDSYVKVALRN
SVLRARAEGVAAYGAKEALDWGVTGAALRATGIDFDVRKWRPYSGYENFNFEVPVGDGVSDCYSRVMLKVEEMRQSLRIL
EQCLNNMPAGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRI
RTPSFPHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR
>Mature_598_residues
TELMTQNSALPVWQSQDHQDDPVIAELRNHFGPDAFSVQPTRTGIPVVWVKREQILKVLTFLKKLPKPYVMLYDLHGVDE
RLRTHRQGLPAADFTVFYHLISIDRNRDIMLKVALSENDLHLPTCTRIFPNANWYERETWEMFGMTFDGHTHLTRIMMPK
SWEGHPLRKDYPARATEFDPFVLTKQKEDLEMEGLTFKPEEWGMKRGKDNEDFMFLNLGPNHPSAHGAFRIILQLDGEEI
VDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRVEYLGGCVNEMPYVLAVEKLAGIVVPDRVNVIRVMLSELFRINSHLLY
ISTYIQDVGGMTPVFLAFTDRQKIYDVVEAITGFRMHPAWFRIGGVAHDLPRGWEGLLREFLDWLPKRLDSYVKVALRNS
VLRARAEGVAAYGAKEALDWGVTGAALRATGIDFDVRKWRPYSGYENFNFEVPVGDGVSDCYSRVMLKVEEMRQSLRILE
QCLNNMPAGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRIR
TPSFPHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=40.7310704960835, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=40.4825737265416, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI4758788, Length=126, Percent_Identity=36.5079365079365, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI145693162, Length=599, Percent_Identity=86.644407345576, Blast_Score=1108, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=514, Percent_Identity=26.0700389105058, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788832, Length=503, Percent_Identity=26.441351888668, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17555284, Length=428, Percent_Identity=40.1869158878505, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17568379, Length=428, Percent_Identity=39.9532710280374, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI32563621, Length=152, Percent_Identity=28.2894736842105, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71990788, Length=148, Percent_Identity=29.0540540540541, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24638644, Length=385, Percent_Identity=41.038961038961, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=39.0625, Blast_Score=316, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24656494, Length=126, Percent_Identity=36.5079365079365, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOCD_SODGM (Q2NSK1)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455279.1
- HSSP:   Q56220
- ProteinModelPortal:   Q2NSK1
- STRING:   Q2NSK1
- GeneID:   3867894
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1599
- NMPDR:   fig|343509.6.peg.3407
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   PHLQQIP
- PhylomeDB:   Q2NSK1
- ProtClustDB:   PRK11742
- BioCyc:   SGLO343509:SG1599-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01359
- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01961
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 68796; Mature: 68665

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELMTQNSALPVWQSQDHQDDPVIAELRNHFGPDAFSVQPTRTGIPVVWVKREQILKVL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCEEEECHHHHHHHH
TFLKKLPKPYVMLYDLHGVDERLRTHRQGLPAADFTVFYHLISIDRNRDIMLKVALSEND
HHHHHCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCC
LHLPTCTRIFPNANWYERETWEMFGMTFDGHTHLTRIMMPKSWEGHPLRKDYPARATEFD
CCCCHHHHHCCCCCCCCCHHHHHHCEEECCCHHEEEEECCCCCCCCCCCCCCCCCCCCCC
PFVLTKQKEDLEMEGLTFKPEEWGMKRGKDNEDFMFLNLGPNHPSAHGAFRIILQLDGEE
CEEEECCCCCCCCCCCEECCHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHH
IVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRVEYLGGCVNEMPYVLAVEKLAGIVVPD
HHHHHCCCCCCCCCHHHHCCHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCEECCC
RVNVIRVMLSELFRINSHLLYISTYIQDVGGMTPVFLAFTDRQKIYDVVEAITGFRMHPA
HHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCH
WFRIGGVAHDLPRGWEGLLREFLDWLPKRLDSYVKVALRNSVLRARAEGVAAYGAKEALD
HHEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
WGVTGAALRATGIDFDVRKWRPYSGYENFNFEVPVGDGVSDCYSRVMLKVEEMRQSLRIL
CCCCCHHHEECCCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
EQCLNNMPAGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATK
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHC
GINSYYLTSDGSTMSYRTRIRTPSFPHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR
CCCEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TELMTQNSALPVWQSQDHQDDPVIAELRNHFGPDAFSVQPTRTGIPVVWVKREQILKVL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCEEEECHHHHHHHH
TFLKKLPKPYVMLYDLHGVDERLRTHRQGLPAADFTVFYHLISIDRNRDIMLKVALSEND
HHHHHCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCC
LHLPTCTRIFPNANWYERETWEMFGMTFDGHTHLTRIMMPKSWEGHPLRKDYPARATEFD
CCCCHHHHHCCCCCCCCCHHHHHHCEEECCCHHEEEEECCCCCCCCCCCCCCCCCCCCCC
PFVLTKQKEDLEMEGLTFKPEEWGMKRGKDNEDFMFLNLGPNHPSAHGAFRIILQLDGEE
CEEEECCCCCCCCCCCEECCHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHH
IVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRVEYLGGCVNEMPYVLAVEKLAGIVVPD
HHHHHCCCCCCCCCHHHHCCHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCEECCC
RVNVIRVMLSELFRINSHLLYISTYIQDVGGMTPVFLAFTDRQKIYDVVEAITGFRMHPA
HHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCH
WFRIGGVAHDLPRGWEGLLREFLDWLPKRLDSYVKVALRNSVLRARAEGVAAYGAKEALD
HHEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
WGVTGAALRATGIDFDVRKWRPYSGYENFNFEVPVGDGVSDCYSRVMLKVEEMRQSLRIL
CCCCCHHHEECCCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
EQCLNNMPAGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATK
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHC
GINSYYLTSDGSTMSYRTRIRTPSFPHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR
CCCEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA